| A Phase 3, Multi-Center Study Evaluating PL9643 in Patients with Dry Eye (NCT05201170) | Palatin Technologies, Inc | 2021-12-30 |
| MTX Hold During Covid-19 Booster (NCT05313061) | Seoul National University Hospital | 2021-12-29 |
| Phase III Study of KX-826 With Adult Male Patients With AGA (NCT06126965) | Suzhou Kintor Pharmaceutical Inc, | 2021-12-29 |
| The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients (NCT04365517) | University of Milan | 2021-12-29 |
| A Study of Replagal in Treatment-naïve Adults With Fabry Disease (NCT04840667) | Shire | 2021-12-28 |
| Efficacy and Safety Study of Peginterferon Alfacon-2 to Treat Chronic Hepatitis B Virus Infection (NCT06544551) | Beijing Kawin Technology Share-Holding Co., Ltd. | 2021-12-28 |
| Inhaled Recombinant Non-immunogenic Staphylokinase vs Placebo in Patients With COVID-19 - FORRIF Trial (NCT05135546) | Supergene, LLC | 2021-12-27 |
| Reducing Acute Kidney Injury Occurence by Administering Angiotensin II (NCT05199493) | Universität Münster | 2021-12-27 |
| Reducing Abundance of Human Papilloma Virus in Women by Taking Probiotic (NCT05316064) | Universiti Sains Malaysia | 2021-12-27 |
| Olanzapine Anorexia Cachexia (NCT05243251) | Cairo University | 2021-12-25 |
| A Study of S-268019 for the Prevention of COVID-19 (NCT05212948) | Shionogi | 2021-12-25 |
| Rescues On Reperfusion Damage In Cerebral Infarction by Nelonemdaz (NCT05041010) | GNT Pharma | 2021-12-25 |
| Neoadjuvant HAIC of TACE Plus Donafenib in BCLC B Stage HCC: a Multi-center Randomized Controlled Trial. (NCT05171166) | Peking University | 2021-12-24 |
| Evaluate the Efficacy and Safety of MT921 in Subjects With Moderate to Severe Submental Fat (NCT05195112) | Medy-Tox | 2021-12-24 |
| Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva (NCT05364515) | Fundación Eduardo Anitua | 2021-12-23 |
| A Study of Lebrikizumab in Combination With Topical Corticosteroids in Patients With Atopic Dermatitis (AD) That Are Not Adequately Controlled With or Are Non-eligible for Cyclosporine (NCT05149313) | Almirall, S.A. | 2021-12-23 |
| Plasma Exchange in Covid-19 Patients With Anti-interferon Autoantibodies (NCT05182515) | Centre Hospitalier St Anne | 2021-12-22 |
| Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (NCT05269394) | Washington University School of Medicine | 2021-12-22 |
| Regeneration in Cervical Degenerative Myelopathy (NCT04631471) | Cambridge University Hospitals NHS Foundation Trust | 2021-12-22 |
| Sitagliptin for Prevention of aGVHD After Alternative Donor Transplation (NCT05149365) | The First Affiliated Hospital of Soochow University | 2021-12-22 |
| Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults (NCT04265105) | Royal College of Surgeons in Ireland - Medical University of Bahrain | 2021-12-22 |
| A Randomized, Open-label, Multi-center, Phase III Study of Orelabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) vs. R-CHOP Alone in Patients With Treatment-naїve Mantle Cell Lymphoma (NCT05051891) | Beijing InnoCare Pharma Tech Co., Ltd. | 2021-12-22 |
| Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway (NCT05194124) | Rhythm Pharmaceuticals, Inc. | 2021-12-21 |
| A Study of Baricitinib (LY3009104) in Children With COVID-19 (NCT05074420) | Eli Lilly and Company | 2021-12-21 |
| A Multi-Center Study to Evaluate the Efficacy and Safety of KX01 Ointment 1% on Actinic Keratosis on Face or Scalp (NCT05231044) | PharmaEssentia | 2021-12-21 |
| S086 Tablets for Chronic Heart Failure With Reduced Ejection Fraction (NCT05553886) | Shenzhen People's Hospital | 2021-12-21 |
| Phase 3 Study to Evaluate the Efficacy and Safety of Peginterferon Lambda for 48 Weeks in Patients With Chronic HDV (NCT05070364) | Eiger BioPharmaceuticals | 2021-12-21 |
| A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder. (NCT05169710) | Sumitomo Pharma America, Inc. | 2021-12-21 |
| Ultrasound-Guided Lumbar Erector Spinae Plane Block Versus Caudal Block for Postoperative Analgesia in Hip and Proximal Femur Surgery in Pediatric Patients (NCT05157516) | Cairo University | 2021-12-21 |
| A Study to Evaluate Efficacy of Dotinurad and Febuxostat for the Treatment of Participants With Gout (NCT05007392) | Eisai Co., Ltd. | 2021-12-21 |
| Evaluate the Efficacy and Safety of Goofice® (Elobixibat) in Patients With Chronic Constipation (NCT05895877) | Synmosa Biopharma Corp. | 2021-12-21 |
| Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE (NCT04919226) | ITM Solucin GmbH | 2021-12-21 |
| Neoadjuvant Treatment Pegylated Liposomal Doxorubicin Plus Cyclophosphamide Sequential Docetaxel Plus Trastuzumab and Pertuzumab Versus Docetaxel Plus Carboplatin Combined With Trastuzumab and Pertuzumab in HER-2 Positive Breast Cancer (NCT05159193) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2021-12-20 |
| The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy. (NCT05160493) | Beijing Tiantan Hospital | 2021-12-20 |
| A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC) (NCT04819100) | Eli Lilly and Company | 2021-12-20 |
| A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension (NCT05022004) | Sun Pharmaceutical Industries Limited | 2021-12-20 |
| The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI (NCT05063500) | Drug Induced Liver Disease Study Group | 2021-12-20 |
| Effect of PRM-125 on Ambulatory Blood Pressure (NCT05195827) | PRM Pharma, LLC | 2021-12-20 |
| Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome (NCT05348278) | Mahidol University | 2021-12-20 |
| Chiauranib Plus Weekly Paclitaxel in Patients with Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer (NCT04921527) | Chipscreen Biosciences, Ltd. | 2021-12-20 |
| A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT) (NCT04770753) | Agios Pharmaceuticals, Inc. | 2021-12-20 |
| Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE) (NCT05155137) | Hospital Moinhos de Vento | 2021-12-20 |
| Bone Graft Cultivation by Periosteal Elevation (NCT05270317) | Jordanian Royal Medical Services | 2021-12-19 |
| Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Volunteers Aged From 3 to 5 Months (NCT05252715) | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 2021-12-18 |
| Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) Based on Different COVID-19 Inactivated Vaccine in Adults Aged 18 Years and Above (NCT05163652) | Chinese Academy of Medical Sciences | 2021-12-18 |
| Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL (NCT05164341) | Chiesi Farmaceutici S.p.A. | 2021-12-17 |
| Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects (NCT05223478) | Ocuphire Pharma, Inc. | 2021-12-17 |
| Safety and Efficacy Study of YZJ-1139 in Insomnia Disorder (NCT05525637) | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 2021-12-17 |
| Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior (NCT05767385) | University of Utah | 2021-12-17 |
| A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2) (NCT05192382) | Crinetics Pharmaceuticals Inc. | 2021-12-17 |
| Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor. (NCT05038735) | Novartis Pharmaceuticals | 2021-12-17 |
| Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1) (NCT05147220) | Novartis Pharmaceuticals | 2021-12-16 |
| Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) in Adults Aged 18 Years and Above (NCT05164731) | Chinese Academy of Medical Sciences | 2021-12-16 |
| Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients (NCT04854486) | Larkin Community Hospital | 2021-12-16 |
| A Trial to Investigate Long Term Efficacy and Safety of Lonapegsomatropin in Adults With Growth Hormone Deficiency (NCT05171855) | Ascendis Pharma Endocrinology Division A/S | 2021-12-16 |
| Study to Evaluate Safety and Immunogenicity of nOPV2 at Different Intervals in Infants (NCT05033561) | Fidec Corporation | 2021-12-16 |
| The Role of Dexmedetomidine As Myocardial Protection In Pediatric Cyanotic Congenital Heart Disease Undergoing Open Cardiac Surgery Using Cardiopulmonary Bypass Machine: A Preliminary Study (NCT05300802) | National Cardiovascular Center Harapan Kita Hospital Indonesia | 2021-12-16 |
| An Open-label Study to Investigate the Clinical Efficacy of Different Dosing Regimens of Efgartigimod IV in Patients With Generalized Myasthenia Gravis (NCT04980495) | argenx | 2021-12-16 |
| Efficacy of Soluble Dexamethasone in Refractory Sciatica (NCT05000658) | Nantes University Hospital | 2021-12-16 |
| Study of Postoperative ICC Analgesia (NCT04939545) | University Hospital, Basel, Switzerland | 2021-12-15 |
| Mirtazapine in Cancer-related Poly-symptomatology (NCT04763135) | Hospices Civils de Lyon | 2021-12-15 |
| Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19 (NCT05137795) | APR Applied Pharma Research s.a. | 2021-12-15 |
| Cannabidiol for the Treatment of Anxiety Disorders: An 8-Week Pilot Study (NCT03549819) | McMaster University | 2021-12-15 |
| Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE (NCT05001737) | Swedish Orphan Biovitrum | 2021-12-15 |
| Study to Evaluate the inHaled Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) On the Protective-Efficacy in Adults (SeiHOPE) (NCT05124561) | CanSino Biologics Inc. | 2021-12-15 |
| A Study of Amphotericin B Liposome for Injection in Patients With Persistent Neutropenia and Fever (NCT05108545) | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 2021-12-15 |
| Immunogenicity and Safety of a Booster Dose of the SpikoGen COVID-19 Vaccine (NCT05175625) | Cinnagen | 2021-12-15 |
| Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste) (NCT05176717) | Laboratoires Thea | 2021-12-15 |
| Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies (NCT05142722) | NewAmsterdam Pharma | 2021-12-15 |
| Tadalafil as Adjuvant Therapy for DMD (NCT05195775) | University of Florida | 2021-12-14 |
| Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) (NCT04996017) | Gruppo Oncologico Italiano di Ricerca Clinica | 2021-12-14 |
| Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS) (NCT05089084) | Arrowhead Pharmaceuticals | 2021-12-14 |
| Effectiveness of an Immediate Postoperative Intravesical Instillation With Either Gemcitabine or Epirubicin in Patients With Urinary Bladder Cancer (Gemcitabine Epirubicin Normal SAline) (NCT04947059) | University of Thessaly | 2021-12-14 |
| A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis (NCT05070858) | Regeneron Pharmaceuticals | 2021-12-14 |
| The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder (NCT04984512) | Sunshine Lake Pharma Co., Ltd. | 2021-12-14 |
| The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette (NCT05205811) | Rose Research Center, LLC | 2021-12-14 |
| TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients (NCT05316922) | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 2021-12-13 |
| Effect of Paracetamol on Kidney Function in Severe Malaria (NCT04251351) | University of British Columbia | 2021-12-13 |
| Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2) (NCT05156281) | Novartis Pharmaceuticals | 2021-12-13 |
| Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65). (NCT05116189) | Merck Sharp & Dohme LLC | 2021-12-13 |
| Safety and Efficacy of 50 mg NYX-783 QD vs. Placebo in PTSD (NCT05181995) | Aptinyx | 2021-12-13 |
| Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia (NCT04952610) | Milestone Pharmaceuticals Inc. | 2021-12-13 |
| Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years (NCT05156528) | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 2021-12-11 |
| EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway (NCT05093634) | Rhythm Pharmaceuticals, Inc. | 2021-12-10 |
| JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC (NCT04892173) | Johnson & Johnson Enterprise Innovation Inc. | 2021-12-10 |
| Oraverse Versus Laser (NCT05473858) | sara nabil | 2021-12-10 |
| RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee (NCT05318521) | Overseas Pharmaceuticals, Ltd. | 2021-12-10 |
| Immunogenicity and Safety of MCV4 in Volunteers Aged 6 Months-5 Years (NCT06314685) | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 2021-12-10 |
| Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa (NCT04618198) | University of Virginia | 2021-12-10 |
| A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises (NCT04927247) | Pfizer | 2021-12-09 |
| Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF (NCT04702256) | Assistance Publique - Hôpitaux de Paris | 2021-12-09 |
| Non-inferiority Trial on Monoclonal Antibodies in COVID-19 (NCT05205759) | Azienda Ospedaliera Universitaria Integrata Verona | 2021-12-09 |
| Study to Determine the Efficacy and Safety of TG-C in Subjects With Kellgren/Lawrence Grade 2 or 3 OA of the Knee (NCT03291470) | Kolon TissueGene, Inc. | 2021-12-09 |
| Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab in First Line Metastatic Non-squamous NSCLC (NCT04786964) | Checkpoint Therapeutics, Inc. | 2021-12-08 |
| Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes (NCT06286878) | University of Sao Paulo | 2021-12-08 |
| Idebenone for the Preventive Treatment of Migraine (NCT04151472) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2021-12-08 |
| Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2 (NCT04610801) | Larkin Community Hospital | 2021-12-08 |
| Early Infant Micronutrition and Development (NCT05005897) | Sykehuset Innlandet HF | 2021-12-08 |
| MInimal Residual Disease Adapted Strategy (NCT04934475) | Intergroupe Francophone du Myelome | 2021-12-08 |
| Immunogenicity and Reactogenicity Following a Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNtech) and Two Adjuvanted Sub-unit Vaccines (SP/GSK) Administered in Adults Who Received 2 Doses of Pfizer-BioNTech mRNA Vaccine as a Primary Vaccination (NCT05124171) | Assistance Publique - Hôpitaux de Paris | 2021-12-08 |