| This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1. (NCT06758401) | Pfizer | 2025-07-23 |
| A Phase 3 Study of HRS-8080 Versus Treatment Chosen by Physicians in Locally Advanced and Metastatic Breast Cancer (NCT07024173) | Shandong Suncadia Medicine Co., Ltd. | 2025-07-23 |
| Personalizing the Use of Pembrolizumab for Patients Who Have a Strong Response in Early Triple Negative Breast Cancer (NCT06606730) | UNICANCER | 2025-07-23 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement (NCT07475546) | AgelessRx | 2025-07-23 |
| Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI) (NCT07297290) | University Of Nigeria Teaching Hospital | 2025-07-23 |
| MHB018A Treatment in Patients With Active Thyroid Eye Disease (NCT06989918) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-07-22 |
| EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease (NCT07064473) | Boehringer Ingelheim | 2025-07-22 |
| Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP) (NCT07047716) | Gilead Sciences | 2025-07-22 |
| Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration (NCT07064759) | 4D Molecular Therapeutics | 2025-07-22 |
| Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients (NCT06798909) | University of California, San Francisco | 2025-07-22 |
| A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2) (NCT06976203) | Bristol-Myers Squibb | 2025-07-21 |
| A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016) (NCT07060807) | Merck Sharp & Dohme LLC | 2025-07-21 |
| Continuation of First-line Therapy With Radiotherapy Versus Early Switch to Second-line Therapy in Oligoprogressive HCC (NCT06841172) | Shandong Cancer Hospital and Institute | 2025-07-21 |
| Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC） (NCT06910072) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-07-21 |
| Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors (NCT06943755) | Exelixis | 2025-07-21 |
| Perioperative Tislelizumab Plus Chemotherapy Versus Chemotherapy Alone in MHC-II-Positive Gastric/GEJ Cancer (NCT07068516) | Xiangdong Cheng | 2025-07-20 |
| Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer (NCT07081360) | Minia University | 2025-07-20 |
| Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer (NCT07074353) | Zhejiang Cancer Hospital | 2025-07-20 |
| A Study of SKB264 Versus Investigator's Choice of Chemotherapy in Subjects With Unresectable Locally Advanced, Relapsed, or Metastatic HR+/HER2- Breast Cancer Who Have Previously Failed Endocrine Therapy (NCT07071337) | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | 2025-07-18 |
| A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma (NCT07011056) | Chengdu Zenitar Biomedical Technology Co., Ltd | 2025-07-18 |
| V-IMMUNE® for Immune Thrombocytopenia (NCT06962631) | On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA. | 2025-07-18 |
| Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and Metformin (NCT07093476) | Celltrion | 2025-07-18 |
| A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) (NCT06929273) | Bristol-Myers Squibb | 2025-07-18 |
| P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk (NCT06468033) | PharmaEssentia | 2025-07-18 |
| Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (NCT06605105) | Cybin IRL Limited | 2025-07-18 |
| Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis (NCT06950385) | Rapamycin Holdings Inc. | 2025-07-18 |
| Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy (NCT07000084) | Alliance for Clinical Trials in Oncology | 2025-07-17 |
| Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC (NCT06765109) | Nuvalent Inc. | 2025-07-17 |
| Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency (NCT06851754) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 2025-07-17 |
| Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia (NCT07658508) | Alexandria University | 2025-07-16 |
| Intranasal Dexmedetomidine on Blood Pressure in Elderly Hypertensive Patients Undergoing Cataract Surgery (NCT07080229) | Suez Canal University | 2025-07-16 |
| A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) (NCT06997497) | Merck Sharp & Dohme LLC | 2025-07-16 |
| Pharmacogenomics ANDA SNP Clinical Study - Etoposide and Single Nucleotide Polymorphisms (NCT01064466) | Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair | 2025-07-16 |
| Evaluation of 611 in Chinese Adults Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (NCT07039669) | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 2025-07-16 |
| A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (NCT07011745) | Bristol-Myers Squibb | 2025-07-16 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE (NCT06996080) | Kodiak Sciences Inc | 2025-07-16 |
| Fecal Microbiome Transplantation in Cirrhosis: Trial in Patients With Decompensated Cirrhosis (NCT06533852) | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 2025-07-16 |
| A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy (NCT06963827) | Takeda | 2025-07-15 |
| Evaluate the Efficacy and Safety of DWP712 With Moderate to Severe Glabellar Lines (NCT07013279) | Daewoong Pharmaceutical Co. LTD. | 2025-07-15 |
| A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa (NCT07082855) | Zhongshan Ophthalmic Center, Sun Yat-sen University | 2025-07-15 |
| VEN+DAC+Bu2Flu4 vs Bu2Flu5 Conditioning Regimen for Elderly Myeloid Malignancies Undergoing Allo-HSCT (NCT07052422) | Nanfang Hospital, Southern Medical University | 2025-07-15 |
| Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab (NCT07013123) | University Hospital, Montpellier | 2025-07-15 |
| Non-Narcotic Pain Control After ACL Reconstruction (NCT06973785) | The Cleveland Clinic | 2025-07-15 |
| A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (NCT06976216) | Bristol-Myers Squibb | 2025-07-14 |
| Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin (NCT07084116) | James Thomas Pathoulas | 2025-07-14 |
| Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity (NCT07257042) | Colgate Palmolive | 2025-07-14 |
| Efficacy & Safety of Minoxidil SL Tablets in Men With AGA (NCT06924632) | Samson Clinical Operations Pty Ltd | 2025-07-14 |
| A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus (NCT07082114) | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 2025-07-14 |
| A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised (NCT07013474) | Pfizer | 2025-07-14 |
| Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) (NCT06898515) | Reprieve Cardiovascular, Inc | 2025-07-14 |
| A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines (NCT06868212) | Novartis Pharmaceuticals | 2025-07-11 |
| Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT (NCT07047456) | Anhui Provincial Hospital | 2025-07-11 |
| NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia (NCT07114874) | Neurocrine Biosciences | 2025-07-11 |
| A Phase III Control Study of the Safety and Immunogenicity of vYF in Pediatric Population (NCT07103148) | Sanofi | 2025-07-11 |
| Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX) (NCT07100990) | Mayo Clinic | 2025-07-11 |
| A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1) (NCT07011732) | Bristol-Myers Squibb | 2025-07-10 |
| SWE-NEO: Swedish NeoAdjuvant Trial Comparing Monotherapy to Combined Immunotherapy in Resectable Stage III Melanoma (NCT06794775) | Hildur Helgadottir | 2025-07-10 |
| Ketamine Augmentation of ECT in Treatment-Resistant Depression (NCT07088380) | Università Vita-Salute San Raffaele | 2025-07-10 |
| Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC (NCT07186621) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-07-10 |
| A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients (NCT07036419) | Jiangsu HengRui Medicine Co., Ltd. | 2025-07-10 |
| Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer (NCT06915025) | Imunon | 2025-07-09 |
| A Study to Assess the Efficacy and Safety of Weekly Doses of GLM101 in Participants With PMM2-CDG (NCT06892288) | Glycomine, Inc. | 2025-07-09 |
| A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis (NCT06973291) | Takeda | 2025-07-09 |
| A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine (NCT07010471) | Praxis Precision Medicines | 2025-07-09 |
| Elranatamab/Lenalidomide Consolidation and/or Elranatamab Maintenance Versus Standard of Care After D-VRd Induction in Transplant-eligible NDMM Patients (NCT06918002) | Intergroupe Francophone du Myelome | 2025-07-09 |
| A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Radiological and Clinical Effects of Subcutaneous Ublituximab in Participants With Relapsing Multiple Sclerosis (RMS) (NCT07211633) | TG Therapeutics, Inc. | 2025-07-09 |
| Prevention of Secondary Infections by Interferon Gamma in ICU-acquired Sustained Immune-suppression (NCT06774235) | University Hospital, Limoges | 2025-07-09 |
| Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ (NCT06414499) | Beijing Tiantan Hospital | 2025-07-09 |
| A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) (NCT07076407) | Xenon Pharmaceuticals Inc. | 2025-07-08 |
| Ivonescimab in Combination With Docetaxel in Advanced Non-Small Cell Lung Cancer (NCT06928389) | Akeso | 2025-07-08 |
| A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years (NCT07069309) | BioNTech SE | 2025-07-08 |
| QA108 Phase III Study in Subjects With Intermediate AMD (NCT07189169) | Smilebiotek Zhuhai Limited | 2025-07-08 |
| The MOM-CARE Trial : Evaluating Antenatal and Postnatal MMSPlus for Improved Infant Birth and Growth Outcomes (NCT07029282) | Aga Khan University | 2025-07-08 |
| Patiromer and Diet/hrQoL in Chronic Dialysis (NCT06858280) | Mario Negri Institute for Pharmacological Research | 2025-07-08 |
| A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS) (NCT06992882) | Fudan University | 2025-07-08 |
| Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial) (NCT06440694) | Ottawa Hospital Research Institute | 2025-07-07 |
| Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Surgery for Resectable Hepatocellular Carcinoma. (NCT07027436) | Hamilton Health Sciences Corporation | 2025-07-07 |
| A Randomized Controlled Study of the Efficacy and Safety of Lenalidomide in the Treatment of Active IgG4-related Disease (NCT07068165) | Peking Union Medical College Hospital | 2025-07-07 |
| Clinical Trial of TQB2102 for Injection Versus Trastuzumab Emtansine for Injection in HER2-positive Advanced Breast Cancer (NCT07008976) | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 2025-07-07 |
| A Phase 3 Study to Assess the Immune Response And Safety Of Rmenb+Omv Nz In Primed Healthy Participants (10 To 20 Years Old) (NCT06995430) | GlaxoSmithKline | 2025-07-07 |
| A Study of Vebreltinib and Platinum-Containing Double Agents in Subjects With MET-Positive (NCT06930794) | Beijing Pearl Biotechnology Limited Liability Company | 2025-07-07 |
| Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact (NCT07013240) | University Hospital, Bordeaux | 2025-07-05 |
| Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children (NCT05448807) | Cairo University | 2025-07-05 |
| Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX) (NCT07035405) | Beijing Tiantan Hospital | 2025-07-04 |
| A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia (NCT07064486) | BrightGene Bio-Medical Technology Co., Ltd. | 2025-07-04 |
| Limited Versus Extended Trophic Feeding (LET-FEED) Trial (NCT06893939) | University of Washington | 2025-07-03 |
| [18F]F-FAPI PET/CT and Laparoscopy in Staging Advanced Gastric Cancer (NCT07018661) | Leiden University Medical Center | 2025-07-03 |
| PRODIGE 98 : Randomized, Multicenter Phase 3 Trial of Adjuvant Chemotherapy With Modified FOLFIRINOX Versus Capecitabine or Gemcitabine in Patients With Resected Ampullary Adenocarcinoma (NCT06813976) | Centre Hospitalier Universitaire Dijon | 2025-07-02 |
| TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (NCT07052903) | Alnylam Pharmaceuticals | 2025-07-02 |
| Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies (NCT07177352) | Hoffmann-La Roche | 2025-07-02 |
| Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children (NCT07046611) | Sohag University | 2025-07-02 |
| Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy (NCT06996951) | Indiana University | 2025-07-02 |
| Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial (NCT06980025) | The George Washington University Biostatistics Center | 2025-07-01 |
| Rifaximin for Treatment of Bloating in Children and Adults With Cystic Fibrosis (NCT05408910) | Wake Forest University Health Sciences | 2025-07-01 |
| Efficacy, Safety and Pharmacokinetic of Virchow IVIG in PID Patients (NCT07017036) | Virchow Group | 2025-07-01 |
| QL1706 Injection Plus Bevacizumab and XELOX vs Placebo Plus Bevacizumab and XELOX as First-Line Treatment of Unresectable Metastatic Colorectal Cancer (NCT07025239) | Qilu Pharmaceutical Co., Ltd. | 2025-07-01 |
| Efficacy of Gou-Teng-San (GTS) in Patients With Episodic Migraine (NCT07496034) | Tsai, Chueh-Yi, MD | 2025-07-01 |
| Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease (NCT06254469) | CereMark Pharma, LLC | 2025-07-01 |
| PARP (Poly (ADP-ribose) Polymerase) Inhibitor With or Without Angiogenesis Inhibitor in Homologous Recombination Deficient Primary Ovarian Cancer, Fallopian-Tube Cancer, or Primary Peritoneal Cancer (NCT07472140) | N.N. Alexandrov National Cancer Centre | 2025-07-01 |
| Intraoperative Pectoral Block vs IV Analgesia for Pain After Modified Radical Mastectomy (NCT07257874) | Islamabad Medical and Dental College | 2025-07-01 |