| Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone) (NCT07218796) | SpyGlass Pharma, Inc. | 2025-10-28 |
| Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease (NCT07151378) | University Hospital Tuebingen | 2025-10-27 |
| PRO-232 in Patients Subjected to Cataract Surgery (NCT07305987) | Laboratorios Sophia S.A de C.V. | 2025-10-27 |
| A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD) (NCT06405087) | Takeda | 2025-10-27 |
| A Study in Healthy Adults to Compare the Bioavailability of EPA + DHA From Two Microalgal Sources to One Fish Source and Placebo (NCT07241377) | RDC Clinical Pty Ltd | 2025-10-27 |
| Confirmatory Clinical Study of HEC585 Tablets in Patients With IPF (NCT07082842) | Sunshine Lake Pharma Co., Ltd. | 2025-10-27 |
| Clinical Trial of Vormatrigine in Adult Patients With Epilepsy (NCT07287163) | Praxis Precision Medicines | 2025-10-27 |
| Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients (NCT07461948) | Jonsson Comprehensive Cancer Center | 2025-10-27 |
| Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection (NCT06968806) | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2025-10-27 |
| A Clinical Study of BAT4406F Injection in Patients With Minimal Change Disease/Focal Segmental Glomerulosclerosis (NCT07499700) | Bio-Thera Solutions | 2025-10-26 |
| A Study to Assess the Safety and Effectiveness of ELAPR002f Injectable Gel in Adult Participants With Atrophic Acne Scars (NCT07207369) | AbbVie | 2025-10-24 |
| A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH (NCT07221227) | GlaxoSmithKline | 2025-10-24 |
| A Phase Ⅱ/Ⅲ Study of HRS-2129 for Postsurgical Pain Management in Abdominal Surgery (NCT07185594) | Shandong Suncadia Medicine Co., Ltd. | 2025-10-24 |
| Study to Evaluate a Pegcetacoplan (Syfovre®) Prefilled Syringe (NCT07214740) | Apellis Pharmaceuticals, Inc. | 2025-10-24 |
| A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer (NCT06793215) | Hoffmann-La Roche | 2025-10-24 |
| Ropivacaine and Fentanyl for Labor Epidural Initiation (NCT07076368) | University of California, San Francisco | 2025-10-24 |
| Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer (NCT06899126) | Daiichi Sankyo | 2025-10-24 |
| Study to Evaluate the Efficacy and Safety of Oral Rilzabrutinib in Adults With Immune Thrombocytopenia (ITP) Who Failed First-line Treatment (NCT07007962) | Sanofi | 2025-10-24 |
| A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30) (NCT07076121) | Bristol-Myers Squibb | 2025-10-23 |
| Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury (NCT07086755) | Paul Potnuru | 2025-10-23 |
| A Trial of SHR-A1811 Compared to Other Antitumor Therapies as Neoadjuvant Treatments in Early-stage or Locally Advanced HER2-positive Breast Cancer (NCT07196774) | Jiangsu HengRui Medicine Co., Ltd. | 2025-10-23 |
| Phase 3 Single Arm, Open Study on vYF in Adults (NCT07222059) | Sanofi Pasteur, a Sanofi Company | 2025-10-23 |
| Inhaled Molgramostim in Pediatric Participants With Autoimmune Pulmonary Alveolar Proteinosis (aPAP). (NCT06431776) | Savara Inc. | 2025-10-22 |
| A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer (NCT07213804) | Eli Lilly and Company | 2025-10-22 |
| Dexmedetomidine vs Ketamine as Adjuvants to Bupivacaine in Transversus Abdominus Plane Block in Inguinal Hernioplasty (NCT07194694) | Ain Shams University | 2025-10-22 |
| A Study of SGT-003 Gene Therapy in Ambulant Males With Duchenne Muscular Dystrophy (IMPACT DUCHENNE) (NCT07160634) | Solid Biosciences Inc. | 2025-10-22 |
| Phase III Clinical Trial of the Recombinant Respiratory Syncytial Virus Vaccine ( CHO Cell) (NCT07272434) | MAXVAX Biotechnology Limited Liability Company | 2025-10-22 |
| Phase III Study of SHR-8068 Combined With Adebrelimab and Chemotherapy Versus Tislelizumab Combined With Chemotherapy in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer (NCT07170995) | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 2025-10-22 |
| Low-Intensity Pulsed Ultrasound as an Adjunctive Therapy for Bone Regeneration Following Jaw Cyst Enucleation (NCT07210983) | Sadam Elayah | 2025-10-22 |
| Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome (NCT07168434) | Biocodex | 2025-10-22 |
| Treatment of Basal Cell Carcinoma (BCC) of the Skin, of the Morpheiform, Infiltrative, and Noduloulcerative Types in Inoperable Patients and Not Suitable for Radiotherapy Using Formulated Methylene Blue (NCT07311070) | Daryoush Hamidi Alamdari, PhD | 2025-10-21 |
| Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window (NCT06987305) | Xinqiao Hospital of Chongqing | 2025-10-21 |
| A Randomized, Parallel-arm, Double Blind, Placebo-controlled Study to Assess the Efficacy of Fampridine for Patients With Spinocerebellar Ataxia SCA27B Caused by a GAA Expansion in the FGF14 Gene (NCT07185347) | Assistance Publique - Hôpitaux de Paris | 2025-10-21 |
| A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP) (NCT07194850) | argenx | 2025-10-20 |
| Desflurane vs. Propofol for Cardiac Anesthesia (NCT07116733) | Xijing Hospital | 2025-10-20 |
| A Study of JNT-517 in Participants With Phenylketonuria (PKU) (NCT06971731) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2025-10-20 |
| The Efficacy of Sequential Treatment With Bevacizumab Combined With Atezolizumab in Advanced Liver Cancer With MASLD (NCT07285850) | Eastern Hepatobiliary Surgery Hospital | 2025-10-20 |
| Risankizumab for Fibrostenotic Crohn's Disease Treatment (NCT07177118) | First Affiliated Hospital of Wenzhou Medical University | 2025-10-20 |
| eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation (NCT07177339) | GlaxoSmithKline | 2025-10-20 |
| A Study of Fludarabine Dosing in Children and Young Adults With B-cell Acute Lymphoblastic Leukemia (NCT07223021) | Memorial Sloan Kettering Cancer Center | 2025-10-20 |
| DOAC - Dosing Options in AntiCoagulation Prophylaxis (NCT07005024) | University of Vermont | 2025-10-17 |
| A Phase III Clinical Study of Adebrelimab Combined With Concurrent Chemoradiotherapy Versus Placebo Combined With Concurrent Chemoradiotherapy for the Treatment of Locally Advanced Cervical Cancer (NCT07168200) | Shanghai Shengdi Pharmaceutical Co., Ltd | 2025-10-17 |
| A Phase IIIb Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin (NCT07165223) | Gan & Lee Pharmaceuticals. | 2025-10-17 |
| A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary Tuberculosis (NCT07209761) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2025-10-16 |
| Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant IR Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency (NCT07266805) | Pharvaris Netherlands B.V. | 2025-10-16 |
| Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants (NCT06878703) | Assistance Publique - Hôpitaux de Paris | 2025-10-16 |
| A Study of Brenipatide in Participants With Alcohol Use Disorder (NCT07219953) | Eli Lilly and Company | 2025-10-16 |
| The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series (NCT06048263) | Washington University School of Medicine | 2025-10-15 |
| Patient-Reported Symptom Care Versus Usual Care After Esophageal Cancer Surgery: A Single-Center Phase 3 Randomized Trial (NCT07211009) | Sichuan University | 2025-10-15 |
| Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD) (NCT07115004) | Vega Therapeutics, Inc | 2025-10-15 |
| Immunogenicity and Safety of Meningococcal Conjugate Vaccine (EG-MCV4) in Healthy Adults Aged 19 to 55 Years Old (NCT07204457) | EyeGene Inc. | 2025-10-15 |
| A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) (NCT07165028) | Eli Lilly and Company | 2025-10-15 |
| Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors (NCT07018869) | SWOG Cancer Research Network | 2025-10-15 |
| Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis (NCT07140211) | Marc Blondon | 2025-10-15 |
| Rilzabrutinib for the Adult Participants With Chronic ITP Who Have Completed Phase 3 Study in Japan (NCT07216079) | Sanofi | 2025-10-15 |
| Real World Clinical Effectiveness & Safety of Vesemnogene Lantuparvovec for Spinal Muscular Atrophy (SMA) in Low-middle Income Countries (LMIC). (NCT07265232) | Lantu Biopharma | 2025-10-15 |
| Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine) (NCT07218783) | SpyGlass Pharma, Inc. | 2025-10-15 |
| A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder (NCT07219966) | Eli Lilly and Company | 2025-10-15 |
| Rezafungin Prophylaxis in Liver Transplant (NCT06774144) | Fernanda P Silveira, MD, MS | 2025-10-15 |
| Efficacy and Safety of HDM1005 in Chinese Obesity or Overweight Patients Without Diabetes (NCT07279194) | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 2025-10-14 |
| ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer (NCT07188025) | Erasmus Medical Center | 2025-10-14 |
| A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (NCT07219771) | Doron Therapeutics Inc. | 2025-10-14 |
| The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis (NCT07224828) | Colgate Palmolive | 2025-10-14 |
| Study to Assess the Safety and Efficacy of ZX-7101A for Oral Suspension in Chinese Pediatric Participants 2 to 11 Years of Age With Influenza (NCT07095257) | Nanjing Zenshine Pharmaceuticals | 2025-10-13 |
| A Study of Recombinant Von Willebrand Factor (rVWF) in Chinese Participants With Von Willebrand Disease (vWD) (NCT07129343) | Takeda | 2025-10-13 |
| Influenza Vaccine (Split Virion), Inactivated, Quadrivalent in Pregnant Women (NCT07211152) | Sinovac Biotech Co., Ltd | 2025-10-13 |
| Clinical Study of DA-007 for the Treatment of Chemotherapy Induced Alopecia (NCT06762548) | Applied Biology, Inc. | 2025-10-10 |
| Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization (NCT07323329) | Beni-Suef University | 2025-10-10 |
| Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model (NCT07134231) | Colgate Palmolive | 2025-10-09 |
| A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098) (NCT06655883) | Merck Sharp & Dohme LLC | 2025-10-09 |
| OPtimizing REperfusion by Intra-Arterial ThRomboLysis as Adjunct to Endovascular Treatment for Medium Vessel Occlusion (NCT07137832) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-10-09 |
| Safety and Immunogenicity of NVX-CoV2705 (NCT07079670) | Sanofi | 2025-10-09 |
| An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis (NCT07184996) | Sanofi | 2025-10-08 |
| Magnesium Trial in Acute Asthma in Emergency Department (NCT06785272) | Suzanne Schuh | 2025-10-08 |
| A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) (NCT07190248) | Merck Sharp & Dohme LLC | 2025-10-08 |
| A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine (NCT07140913) | Bristol-Myers Squibb | 2025-10-08 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study (NCT07097142) | NRG Oncology | 2025-10-07 |
| CDK4/6 Inhibitor Intensification and Chemotherapy De-Escalation for Early-stage Luminal-HER2 Breast Cancer (NCT07213206) | Fudan University | 2025-10-07 |
| Trial to Evaluate irAEs With Different Standard of Care Dosing Strategies of Standard of Care Immunotherapies (NCT07174453) | University of Kansas Medical Center | 2025-10-07 |
| PREVENT HPV -Related Cancers Trial (NCT07217145) | University of Utah | 2025-10-06 |
| A Pilot Clinical Trial Comparing Topical Fluorouracil to Fluorouracil Plus Calcipotriene Field Treatments in Patients With Multiple Actinic Keratoses (NCT06851507) | M.D. Anderson Cancer Center | 2025-10-06 |
| Concurrent Chemoradiotherapy With or Without Metronomic Capecitabine in High-Risk T1-2N1M0 NPC (NCT07248670) | Chongqing University Cancer Hospital | 2025-10-04 |
| Clinical Study to Evaluate SIIPL qHPV Vaccine (CERVAVAC®) in Women Living With HIV Aged 15-25 Years (NCT06281119) | Serum Institute of India Pvt. Ltd. | 2025-10-03 |
| A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease (NCT07196722) | Janssen Research & Development, LLC | 2025-10-03 |
| Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes (NCT07102628) | Novartis Pharmaceuticals | 2025-10-03 |
| Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis (NCT06441006) | University of California, San Francisco | 2025-10-03 |
| Efficacy and Safety of Rengalin in the Treatment of ARVI Cough in Children (NCT07171099) | Materia Medica Holding | 2025-10-03 |
| A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue (NCT06989437) | Pfizer | 2025-10-03 |
| CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis (NCT07207811) | Novo Nordisk A/S | 2025-10-02 |
| Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In (NCT06745908) | ImmunityBio, Inc. | 2025-10-01 |
| Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL (NCT07185373) | Huashan Hospital | 2025-10-01 |
| Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery (NCT07113483) | Romanian Society for Enteral and Parenteral Nutrition | 2025-10-01 |
| Levetiracetam Three Times Daily in Epilepsy (NCT07490769) | Waad Alkathiri | 2025-10-01 |
| Continuation of Cetuximab Beyond First-Line Progression in Metastatic Colorectal Cancer (NCT07389265) | University of Campania Luigi Vanvitelli | 2025-10-01 |
| A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis (NCT07136805) | VivaVision Biotech, Inc | 2025-10-01 |
| Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma (NCT07189572) | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2025-10-01 |
| Orthodontic Pain Alleviation With Chewing Gum (NCT07210697) | West Virginia University | 2025-10-01 |
| A Study to Evaluate the Safety and Effectiveness of MSP01-T for Bowel Cleansing Before a Colonoscopy (NCT07181148) | Mather's Pharm. Co., Ltd. | 2025-10-01 |
| Intraoperative Lidocaine Infusion (NCT07150481) | Assiut University | 2025-10-01 |
| A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU) (NCT07210463) | Merz Aesthetics GmbH | 2025-10-01 |