| Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (NCT07184801) | Post Graduate Institute of Medical Education and Research, Chandigarh | 2025-10-01 |
| Treated Umbilical Vein Allograft (UVT) Versus Autologous Fascial Pubovaginal Sling in the Treatment of Female Stress Urinary Incontinence (NCT06678984) | TBF Genie Tissulaire | 2025-10-01 |
| PERT in Acute Necrotizing Pancreatitis (NCT07211568) | Asian Institute of Gastroenterology, India | 2025-10-01 |
| Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias Repair (NCT07197203) | Assiut University | 2025-10-01 |
| Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study (NCT07163611) | Radboud University Medical Center | 2025-10-01 |
| Lenalidomide vs Methotrexate in Difficult-to-treat Cutaneous Lupus Erythematosus (NCT06965244) | Assistance Publique - Hôpitaux de Paris | 2025-10-01 |
| A Study of Vortioxetine in Japanese Pediatric Patients With Major Depressive Disorder (NCT07204314) | Takeda | 2025-10-01 |
| Ketamine Sedation in the ICU (KANINE) RCT (NCT06767358) | McMaster University | 2025-10-01 |
| Study to Compare the Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of MAB-22 Versus Prolia® (NCT06504966) | Xentria, Inc. | 2025-10-01 |
| Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3 (NCT07167134) | Centre Paul Strauss | 2025-10-01 |
| Efficacy of Targeted Drugs Combined With Chemotherapy in the Treatment of T-ALL (NCT07203352) | Nanfang Hospital, Southern Medical University | 2025-10-01 |
| REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults (NCT07155265) | Yancheng First People's Hospital | 2025-10-01 |
| Semaglutide Treatment in Type 1 Diabetes (NCT06909006) | Nordsjaellands Hospital | 2025-10-01 |
| A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis (NCT07196748) | Janssen Research & Development, LLC | 2025-10-01 |
| Nuvastatic® Phase III Trial for Fatigue in Triple-Negative Breast Cancer (NCT07669467) | Natureceuticals Sdn Bhd | 2025-10-01 |
| Clinical Efficacy and Safety of Microwave Ablation Combined With Huaier Granules in Patients With Inoperable Stage IA Non-Small Cell Lung Cancer: A Prospective, Single-Center, Randomized Controlled Clinical Trial (NCT07197853) | Xin Ye | 2025-10-01 |
| Segmentectomy vs Lobectomy for 2 - 3cm IASLC Grade 1-2 Lung Adenocarcinoma: A Multi-center RCT (NCT07169903) | Shanghai Pulmonary Hospital, Shanghai, China | 2025-10-01 |
| Efficacy of Gemcitabine Submucosal Injection for Preventing Recurrence in Intermediate- and High-Risk Non-Muscle-Invasive Bladder Cancer: A Randomized Trial (NCT07198451) | Shanghai University of Traditional Chinese Medicine | 2025-10-01 |
| Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression (NCT06866236) | Ebima Clifford Okundaye | 2025-10-01 |
| A Randomized, Double-blind, Placebo-controlled, Parallel-group, Comparative, Phase III Study to Evaluate the Efficacy and Safety of Nuvastatic® 300mg Capsule in Reducing Cancer-Tumor in Patients With Metastatic Colorectal Cancer Receiving Standard Chemotherapy. (NCT07669454) | Natureceuticals Sdn Bhd | 2025-10-01 |
| Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer (NCT07134218) | Changhai Hospital | 2025-10-01 |
| A Phase 3 Trial to Demonstrate the Superiority of 1% OPA-15406 Foam to the Vehicle in Adult Patients With Atopic Dermatitis (NCT07173478) | Otsuka Pharmaceutical Co., Ltd. | 2025-10-01 |
| A Clinical Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma. (NCT06364904) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-10-01 |
| Efficacy and Safety of LB1410 Plus Lenvatinib With or Without LB4330 in Advanced Recurrent/Metastatic Cervical Cancer (NCT07177716) | L & L Bio Co., Ltd., Ningbo, China | 2025-10-01 |
| Safety and Efficacy of Very Short DAPT in Older Patients Undergoing PCI (NCT07164859) | Vincent ROULE | 2025-10-01 |
| An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease (NCT07184931) | Sanofi | 2025-10-01 |
| Combination Therapy of Tadalafil 2.5mg Plus Sildenafil 25mg Versus Tadalafil 5 mg Monotherapy for Treatment of Erectile Dysfunction: A Randomized, Placebo-Controlled Double-Blinded Cross-Over Study (NCT07177326) | Assiut University | 2025-10-01 |
| Neoadjuvant CAPOX Plus Tislelizumab vs CAPOX in MSS High-Risk Locally Advanced Colon Cancer (NCT07132008) | First Affiliated Hospital of Guangxi Medical University | 2025-10-01 |
| Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease (NCT07039175) | VA Office of Research and Development | 2025-10-01 |
| Topical Versus Injection PRP for Olfactory Dysfunction (NCT07151703) | Taipei Veterans General Hospital, Taiwan | 2025-10-01 |
| Weaning Approaches for Vasopressin in Sepsis (NCT07067866) | Hospital Nossa Senhora da Conceicao | 2025-10-01 |
| The Study of JMT101 Combined With Irinotecan as a ≥3rd-Line Treatment in Metastatic Colorectal Cancer (NCT07134205) | Shanghai JMT-Bio Inc. | 2025-10-01 |
| Study of COYA 302 for the Treatment of ALS (NCT07161999) | Coya Therapeutics | 2025-10-01 |
| A Long-Term Study of Navenibart in Participants With Hereditary Angioedema (NCT07204938) | Astria Therapeutics, Inc. | 2025-10-01 |
| Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma (NCT02887040) | Burzynski Research Institute | 2025-10-01 |
| Safety of Antimalarials in the FIRst trimEster (NCT06962319) | Liverpool School of Tropical Medicine | 2025-09-30 |
| A Phase 3 Study of HS-20094 in Patients With T2DM Inadequately Controlled With Diet and Exercise Alone (NCT07156500) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2025-09-30 |
| A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight (NCT07202884) | Eli Lilly and Company | 2025-09-30 |
| Safety and Efficacy of FETO in CDH Phase III (NCT07187206) | Children's Hospital Medical Center, Cincinnati | 2025-09-30 |
| Extended-field Proton Therapy for Cervical Cancer (NCT07298642) | National Taiwan University Hospital | 2025-09-30 |
| A Phase 3 Study of HS-20094 in Patients With T2DM (NCT07156539) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2025-09-30 |
| Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN) (NCT07204275) | Vertex Pharmaceuticals Incorporated | 2025-09-30 |
| Study of MT1013 for the Treatment of Patients With Secondary Hyperparathyroidism (NCT07122401) | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 2025-09-30 |
| A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure (NCT06694727) | Tor Biering-Sørensen | 2025-09-30 |
| Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy (NCT07106762) | Bristol-Myers Squibb | 2025-09-30 |
| Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer (NCT07022483) | Daiichi Sankyo | 2025-09-30 |
| A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis (NCT06865417) | Alfasigma S.p.A. | 2025-09-29 |
| A Study to Evaluate the Efficacy and Safety of Different Doses of CB03-154 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT07082192) | Shanghai Zhimeng Biopharma, Inc. | 2025-09-29 |
| A Study of BL-M07D1 vs Pembrolizumab-platinum Chemotherapy in First-line Treatment of HER2-mutant Advanced or Metastatic Non-squamous NSCLC (NCT07178795) | Sichuan Baili Pharmaceutical Co., Ltd. | 2025-09-29 |
| A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC) (NCT07144280) | Pfizer | 2025-09-29 |
| A Study to Assess the Safety of HSK31858 in Participants With Non-Cystic Fibrosis Bronchiectasis (NCT07616375) | Haisco Pharmaceutical Group Co., Ltd. | 2025-09-28 |
| This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve. (NCT07028853) | Pfizer | 2025-09-28 |
| GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study) (NCT07083154) | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2025-09-27 |
| Immunogenicity and Safety Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Healthy Children and Adolescents in China (NCT07135986) | Sanofi | 2025-09-26 |
| A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease (NCT07190196) | Sanofi | 2025-09-26 |
| Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML (NCT07007312) | Kura Oncology, Inc. | 2025-09-26 |
| Multiple Micronutrient Supplementation (MMS) Iron Dose Acceptability Crossover Trial (NCT06069869) | George Washington University | 2025-09-26 |
| Mechanisms of Stimulation for Pain Alleviation (NCT06741579) | Stanford University | 2025-09-26 |
| Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma (NCT07129993) | Daiichi Sankyo | 2025-09-26 |
| A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI (NCT07165418) | Peking University Cancer Hospital & Institute | 2025-09-25 |
| Guided Meditation During Radiation Therapy for Breast and Gynecological Malignancies (NCT07166042) | University of Utah | 2025-09-25 |
| A Study of GR1802 Injection in Patients With Seasonal Allergic Rhinitis. (NCT07199257) | Genrix (Shanghai) Biopharmaceutical Co., Ltd. | 2025-09-25 |
| A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza (NCT07159763) | Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2025-09-25 |
| Serplulimab Combined With Induction Chemotherapy and Radiotherapy in Nasopharyngeal Carcinoma (NCT07177443) | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2025-09-25 |
| Clinical Trial of TQC2731 Injection in Patients With Chronic Sinusitis and Nasal Polyps (NCT07107256) | Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. | 2025-09-25 |
| Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer (NCT06123156) | University Hospital, Rouen | 2025-09-25 |
| Microbiote's Evolution After Use of Nitrous Oxide on Pediatric Patient Needing Airway Samples (NCT07118644) | University Hospital, Brest | 2025-09-24 |
| A Study of BL-M07D1 Versus Investigator's Choice of Chemotherapy in Patients With HER2-positive Locally Advanced or Metastatic Gastric or Gastro-esophageal Junction Adenocarcinoma (NCT07152405) | Sichuan Baili Pharmaceutical Co., Ltd. | 2025-09-24 |
| Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome (NCT06776783) | Aerogen Pharma Limited | 2025-09-24 |
| Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects (NCT07150975) | Gan & Lee Pharmaceuticals. | 2025-09-23 |
| A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) (NCT06760546) | Rhythm Pharmaceuticals, Inc. | 2025-09-23 |
| Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal Cancer (NCT07372300) | Shih-Kai Hung | 2025-09-23 |
| A Study to Compare the Efficacy, Safety and Pharmacokinetics of Trifarotene 50 mcg/g Cream in Chinese Subjects With Acne Vulgaris (NCT07186413) | Galderma R&D | 2025-09-23 |
| JYP0322 Versus Platinum Based Doublet Chemotherapy in ROS1 Positive Patients Previously Treated With ROS1-TKIs. (NCT07154368) | Guangzhou JOYO Pharma Co., Ltd | 2025-09-23 |
| Phase 3 Study of the Efficacy and Safety of MR Arthrography Using the NEMO-103 Injection in Patients With Known or Suspected Shoulder Joint Diseases (NCT07057037) | Inventera Inc. | 2025-09-23 |
| Clinical Comparison of Xenograft With Hydrogel Versus Xenograft Alone in the Socket Preservation After Tooth Extraction: A Randomized Controlled Clinical Trial (NCT06957197) | Cairo University | 2025-09-22 |
| Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK) (NCT07116967) | Bristol-Myers Squibb | 2025-09-22 |
| Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery (NCT07200180) | Negovsky Reanimatology Research Institute | 2025-09-22 |
| Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder (NCT07221578) | Vanda Pharmaceuticals | 2025-09-22 |
| Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease (NCT07181109) | Alnylam Pharmaceuticals | 2025-09-22 |
| Study to Evaluate the Efficacy and Safety of IN-B00009 Injection in Adults With Obesity or Overweight Without Diabetes Mellitus (NCT07192263) | HK inno.N Corporation | 2025-09-22 |
| Oral Iron for the Management of Iron Deficiency Anemia in SGLT2i-Treated Heart Failure Patients (NCT07708025) | Universidade do Porto | 2025-09-20 |
| A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole (NCT07199504) | Yunfeng Xia | 2025-09-20 |
| Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI (NCT06870370) | Tanta University | 2025-09-20 |
| Contrast-enhanced Ultrasound for Sentinel Node Detection (NCT07310758) | The Netherlands Cancer Institute | 2025-09-18 |
| Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB Treatment (NCT06497465) | Johns Hopkins University | 2025-09-18 |
| Evaluate the Efficacy and Safety of D-2570 in Subjects With Moderate to Severe Plaque Psoriasis (NCT07130604) | InventisBio Co., Ltd | 2025-09-18 |
| Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype (NCT07190222) | Sanofi | 2025-09-17 |
| AI and Safety in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (NCT07186803) | University Health Network, Toronto | 2025-09-17 |
| A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease (NCT07169578) | Hoffmann-La Roche | 2025-09-17 |
| ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab (NCT06876714) | Alliance for Clinical Trials in Oncology | 2025-09-17 |
| The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA. (NCT07535554) | Universitaire Ziekenhuizen KU Leuven | 2025-09-17 |
| Atropine in the Treatment of Myopia Study in Malaysia (NCT07329777) | IDB VisionCare SDN BHD | 2025-09-17 |
| A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP (NCT07091630) | argenx | 2025-09-16 |
| A Long-term Trial of EB-1020 in Pediatric Patients With ADHD (NCT07087327) | Otsuka Pharmaceutical Co., Ltd. | 2025-09-16 |
| Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach (NCT05969457) | University Hospital, Rouen | 2025-09-16 |
| Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype (NCT07190209) | Sanofi | 2025-09-16 |
| Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice (NCT07215767) | HALEON | 2025-09-16 |
| PCSK9 Inhibitors in Acute Ischemic Stroke Patients Undergoing Endovascular Therapy (NCT07174375) | Nanfang Hospital, Southern Medical University | 2025-09-15 |
| A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee (NCT07153471) | Eli Lilly and Company | 2025-09-15 |