| Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49 (NCT07284654) | Vaxcyte, Inc. | 2025-12-01 |
| A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes (NCT07271251) | Novo Nordisk A/S | 2025-12-01 |
| A Study Comparing the Clinical Benefit of Finerenone Versus a Fixed Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients With Hypertension and Chronic Kidney Disease (NCT07223502) | Sarfez Pharmaceuticals, Inc. | 2025-12-01 |
| An Efficacy and Safety Study of DFL24498 in the Treatment of AKC (NCT07395232) | Dompé Farmaceutici S.p.A | 2025-12-01 |
| Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash (NCT07263698) | Colgate Palmolive | 2025-12-01 |
| Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial (NCT06931340) | Alliance for Clinical Trials in Oncology | 2025-12-01 |
| Acetyl-leucine in Post-stroke Ataxia (NCT07275749) | Kafrelsheikh University | 2025-12-01 |
| Immunogenicity and Safety of DTP-HB-Hib Using New Hepatitis B Bulk (Bio Farma) (NCT05482282) | PT Bio Farma | 2025-12-01 |
| DEB-TACE vs cTACE in HCC After TIPS (NCT07322848) | First Affiliated Hospital, Sun Yat-Sen University | 2025-12-01 |
| RaSOLVE: 125I Radioactive Seed Marking Effects on Pathological Complete Response Rate and Prognosis Post-Neoadjuvant Therapy in Early/Advanced Breast Cancer (NCT07269691) | Pengfei Qiu | 2025-12-01 |
| DV+BCG in HER2-Expressing, BCG-Naïve High-Risk NMIBC (NCT07207824) | Fudan University | 2025-12-01 |
| Clinical Efficacy and Safety of MB LuxuryⓇ Product Containing Epigallocathecin Gallate (EGCG) on Erythema, Melanin, and Skin Hydration (NCT07725900) | Naniek Widyaningrum | 2025-12-01 |
| Butylphthalide for Long-term Efficacy in Minor Stroke Study (NCT07230587) | Peking Union Medical College Hospital | 2025-12-01 |
| Post-exposure Influenza Prophylaxis in a Hospital Setting (NCT07496736) | University Medical Centre Ljubljana | 2025-12-01 |
| Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study (NCT07264010) | Nanfang Hospital, Southern Medical University | 2025-12-01 |
| Mecobalamin in Promoting Recurrent Laryngeal Nerve Function Recovery After Thyroid Surgery (NCT07274696) | West China Hospital | 2025-12-01 |
| Avatrombopag Combined With All-trans Retinoic Acid in the Treatment of Primary Immune Thrombocytopenia (NCT07278908) | Institute of Hematology & Blood Diseases Hospital, China | 2025-12-01 |
| Levosimendan in Acute Decompensated Heart Failure (NCT07262723) | Chittagong Medical College | 2025-12-01 |
| Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients (NCT07274020) | Assiut University | 2025-12-01 |
| CD19 CAR-T vs DLI for Post-HSCT MRD in Ph- ALL: A RCT (NCT07441291) | Peking University People's Hospital | 2025-11-30 |
| Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window. (NCT07201688) | CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd. | 2025-11-30 |
| Cilostazol for Preventing Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage (NCT07249853) | Beijing Tiantan Hospital | 2025-11-30 |
| DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. (NCT05770544) | Cancer Research UK | 2025-11-30 |
| A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE) (NCT07218146) | Zai Lab (Shanghai) Co., Ltd. | 2025-11-30 |
| Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC (NCT07239674) | West China Hospital | 2025-11-30 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities (NCT07144852) | Sun Pharmaceutical Industries, Inc. | 2025-11-29 |
| A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (NCT07213674) | Amgen | 2025-11-28 |
| Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer (NCT07166094) | Genmab | 2025-11-28 |
| Suraxavir Marboxil And Oseltamivir for Influenza Prophylaxis Under a Hospital-based Setting (NCT07236814) | Capital Medical University | 2025-11-28 |
| Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia (NCT04851015) | Todd C. Lee MD MPH FIDSA | 2025-11-28 |
| HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial (NCT06719947) | Universidade Federal do Rio Grande do Norte | 2025-11-28 |
| Efficacy of Nebulised Inhalational Steroids in Neonates With Meconium Aspiration Syndrome (NCT07763119) | Khyber Teaching Hospital | 2025-11-28 |
| Phase III Study to Evaluate the Safety, Efficacy, and Impact on Quality of Life of Capivasertib Alongside Standard-of-care Endocrine Treatment in Patients With HR+/HER2- Advanced Breast Cancer and Progression on Prior Endocrine-based Treatment (NCT07281833) | Women's Cancer Study Group GmbH | 2025-11-27 |
| Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN (NCT06994845) | Novartis Pharmaceuticals | 2025-11-27 |
| A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD (NCT06847542) | Hoffmann-La Roche | 2025-11-27 |
| A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs (NCT06930625) | Debiopharm International SA | 2025-11-26 |
| A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033) (NCT07227402) | Merck Sharp & Dohme LLC | 2025-11-26 |
| A Study Comparing TAK-928 With Docetaxel in Adults With Non-Small Cell Lung Cancer (NCT07217301) | Takeda | 2025-11-26 |
| A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI) (NCT07012629) | Aarhus University Hospital | 2025-11-26 |
| Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (NCT07256392) | Celldex Therapeutics | 2025-11-25 |
| Darbepoetin in Patients Candidates for Liver Transplant. (EPO-LT Trial) (NCT07169643) | Fundacion Clinic per a la Recerca Biomédica | 2025-11-25 |
| Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy (NCT07226765) | Amgen | 2025-11-25 |
| Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial) (NCT07195149) | Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o. | 2025-11-25 |
| RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome) (NCT07236606) | REGENXBIO Inc. | 2025-11-25 |
| Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation (NCT07211958) | Syndax Pharmaceuticals | 2025-11-25 |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections (NCT06736691) | Swiss Tropical & Public Health Institute | 2025-11-25 |
| Effectiveness of 10% Lidocaine on Relieving Pain Caused by Intravenous Intubation (NCT07212192) | Phenikaa University | 2025-11-24 |
| Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months (NCT06904274) | Bayer | 2025-11-24 |
| An Open-label Study of Intravenous Immunoglobulin (5%) for the Treatment of Primary Immune Thrombocytopenia (NCT07233213) | Grand Shuyang Life Sciences (Chengdu) Co., Ltd. | 2025-11-24 |
| Photodynamic Therapy Associated With Sonodynamic Therapy for the Treatment of Nodular Basal Cell Carcinoma (NCT07381972) | University of Sao Paulo | 2025-11-24 |
| A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease (NCT07174310) | Hoffmann-La Roche | 2025-11-24 |
| REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants (NCT07213778) | Regeneron Pharmaceuticals | 2025-11-24 |
| Efficacy and Safety of ZSP1273 in Children 2-11 Years Old With Influenza A (NCT07229807) | Guangdong Raynovent Biotech Co., Ltd | 2025-11-22 |
| A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension (NCT07650084) | GlaxoSmithKline | 2025-11-21 |
| HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer (NCT07232875) | Jiangsu HengRui Medicine Co., Ltd. | 2025-11-21 |
| Phase IIIb Clinical Trial of Quadrivalent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) for Age/Immunization Schedule Bridging (NCT06632912) | National Vaccine and Serum Institute, China | 2025-11-21 |
| Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy (NCT07231419) | Vertex Pharmaceuticals Incorporated | 2025-11-21 |
| A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS]) (NCT07208058) | TJ Biopharma Co., Ltd. | 2025-11-21 |
| IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study (NCT07217873) | Columbia University | 2025-11-21 |
| Single Dose Double-blind, Placebo-controlled Cross-over (SDDBPCCO) Shiftability Study, Will be Followed by a 10-week Open-label Study With Arbaclofen (4 Weeks of Titration and Then 6 Weeks of Active/Stable Treatment). The Effects of Arbaclofen on Target EEG and ERG Metrics Will be Associated With th (NCT07655115) | Hospital General Universitario Gregorio Marañon | 2025-11-20 |
| 40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal Carcinoma (NCT07328854) | Ming-Yuan Chen | 2025-11-20 |
| SYS6002 vs Chemotherapy in Recurrent or Metastatic Cervical Cancer (NCT07230626) | CSPC Megalith Biopharmaceutical Co.,Ltd. | 2025-11-20 |
| Efficacy and Safety of DMB-I (INN: Latrepirdine) in Patients With Alzheimer Type Dementia (NCT07251023) | Bigespas LTD | 2025-11-20 |
| Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes (NCT07252778) | Krzysztof Durkalec-Michalski | 2025-11-20 |
| PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Salvage Locoregional Radiotherapy in De Novo Metastatic NPC (NCT07235319) | Sun Yat-sen University | 2025-11-20 |
| Perirenal Adipose Tissue Modification Therapy for Resistant Hypertension (NCT07232966) | Yan Li | 2025-11-20 |
| Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing. (NCT07276672) | Colgate Palmolive | 2025-11-20 |
| Comparison Between the Analgesic Effect of Fascia Transversalis Block vs Caudal Block (NCT07235475) | Cairo University | 2025-11-20 |
| A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults (NCT07226882) | Pfizer | 2025-11-19 |
| A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction (NCT07188805) | Bayer | 2025-11-19 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp (NCT07144345) | Sun Pharmaceutical Industries, Inc. | 2025-11-19 |
| Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and Ganglioneuroblastoma (NCT07375563) | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 2025-11-19 |
| Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen (NCT07087054) | Crinetics Pharmaceuticals Inc. | 2025-11-19 |
| Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy (NCT07328841) | Ming-Yuan Chen | 2025-11-18 |
| Taurine Supplementation in Long COVID (NCT06721949) | University of Alberta | 2025-11-18 |
| Lattice Radiation Therapy Versus Conventional Radiation Therapy for the Palliation of Large Tumors (NCT07444775) | University Health Network, Toronto | 2025-11-18 |
| Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer (NCT07228832) | Summit Therapeutics | 2025-11-18 |
| Reduced-dose vs Standard-dose Irradiation for Low-risk Clinical Target Volume in Nasopharyngeal Carcinoma. (NCT07201337) | Sun Yat-sen University | 2025-11-17 |
| A Study of TLC590 for Postsurgical Pain Following Bunionectomy (NCT07222748) | TLC Biopharmaceuticals, Inc. | 2025-11-17 |
| A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy (NCT07235085) | Ocular Therapeutix, Inc. | 2025-11-17 |
| Efficacy of EXPAREL vs. Bupivacaine (NCT07212114) | Emory University | 2025-11-17 |
| A Study of a Gadolinium-Based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Central Nervous System (CNS) Lesions (NCT07275814) | Shanghai Shengdi Pharmaceutical Co., Ltd | 2025-11-17 |
| A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight (NCT07232719) | Eli Lilly and Company | 2025-11-17 |
| BabySTrong II taVNS Feeding Trial (NCT07049952) | Medical University of South Carolina | 2025-11-16 |
| A Multicenter Phase III Clinical Study and Translational Research on Adaptive Neoadjuvant Therapy of De-escalation and Escalation for HER2-Positive Breast Cancer Based on Multi-Omics Response Evaluation Model (NCT07239271) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-11-16 |
| SGLT2 Inhibitors in Adult Primary Nephrotic Syndrome (NCT07214818) | Mansoura University | 2025-11-15 |
| Dalpiciclib Combined With Endocrine Therapy and Metronomic Capecitabine vs Dalpiciclib Combined With Endocrine Therapy for First-line Treatment (NCT07467330) | Fujian Cancer Hospital | 2025-11-15 |
| INVIGORATE: A Study of QL1706 and Bevacizumab in Advanced First-Line Ovarian Clear Cell Carcinoma (NCT07002346) | Tongji Hospital | 2025-11-15 |
| Firstline Sequential AG and mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Advanced Pancreatic Cancer (NCT07235930) | Zhejiang Cancer Hospital | 2025-11-15 |
| Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer. (NCT07217704) | SOFIE | 2025-11-14 |
| Durvalumab and Tremelimumab With or Without Hepatic Arterial Infusion of Chemotherapy in Hepatocellular Carcinoma (NCT06904170) | UNICANCER | 2025-11-14 |
| R.E.C.K vs Exparel in Robotic Nephrectomy (NCT07092566) | Wake Forest University Health Sciences | 2025-11-14 |
| A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis (NCT07219420) | UCB Biopharma SRL | 2025-11-14 |
| Comparison of Diagnostic Accuracy Between XTR004 PET MPI and the Composite Index of Quantitative Coronary Angiography (QCA) and Fractional Flow Reserve (FFR) (NCT07439133) | Sinotau Pharmaceutical Group | 2025-11-14 |
| A Study to Evaluate the Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine (PCV13i) in Healthy Infants Aged 2 Months (Minimum 6 Weeks) (NCT07017777) | CanSino Biologics Inc. | 2025-11-14 |
| Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis (NCT07095465) | ACADIA Pharmaceuticals Inc. | 2025-11-14 |
| A Study of a Gadolinium-Based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Body Parts (Non-Central Nervous System) Lesions (NCT07275723) | Shanghai Shengdi Pharmaceutical Co., Ltd | 2025-11-14 |
| A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Safety and Efficacy of Onradivir Tablets in Participants Aged 12 to 17 Years With Uncomplicated Influenza A. (NCT07229547) | Ruijin Hospital | 2025-11-14 |
| Adaptive Immunotherapy for Nasopharyngeal Carcinoma (NCT07154069) | Sun Yat-sen University | 2025-11-13 |
| A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis (NCT07223138) | MoonLake Immunotherapeutics AG | 2025-11-13 |