| Stratified Treatment in Unresectable Locally Advanced ESCC Without Progression After Chemoimmunotherapy Induction Plus CCRT: Toripalimab Consolidation vs observation--a Prospective, Randomized, Controlled Phase III Multicenter Study (NCT07246330) | Tianjin Medical University Cancer Institute and Hospital | 2025-12-15 |
| Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC) (NCT07252232) | Revolution Medicines, Inc. | 2025-12-15 |
| Near-infrared Light Therapy Device for Mild-Moderate Alzheimer's Disease (NirsCure-03A) (NCT07262645) | Danyang Huichuang Medical Equipment Co., Ltd. | 2025-12-15 |
| A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes (NCT07282600) | Eli Lilly and Company | 2025-12-15 |
| Adjuvant Oxaliplatin Plus S-1 Versus Docetaxel Plus S-1 for Stage III Gastric Cancer (NCT07366528) | Ruijin Hospital | 2025-12-15 |
| DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes (NCT07241897) | Second Affiliated Hospital of Soochow University | 2025-12-15 |
| FIREFLY Trial: Fenofibrate Intervention---Randomized Evaluation in First-Line PBC Therapy (NCT07296458) | Xijing Hospital of Digestive Diseases | 2025-12-15 |
| Bovis Calculus Stativus Treat Acute Cerebral Ischemic Stroke With Impaired Consciousness (NCT07240467) | Xiang Luo | 2025-12-15 |
| A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease (NCT07284381) | AbbVie | 2025-12-15 |
| Trifluridine/Tipiracil + Fruquintinib Versus Trifluridine/Tipiracil Alone for Metastatic Oeso-gastric Adenocarcinoma (NCT07270991) | Federation Francophone de Cancerologie Digestive | 2025-12-15 |
| Probiotics Against Erythropoietin Resistance in Chronic Kidney Disease Patients. (NCT07296146) | Badr University | 2025-12-15 |
| Proton vs Photon IMRT in Locally Advanced Nasopharyngeal Carcinoma: A Phase III Trial (NCT07340515) | Man Hu | 2025-12-15 |
| A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH (NCT07221188) | GlaxoSmithKline | 2025-12-12 |
| A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract (NCT07218380) | Eli Lilly and Company | 2025-12-12 |
| Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia (NCT07595003) | Valenta Pharm JSC | 2025-12-12 |
| Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Gemcitabine Combined With Paclitaxel Protein-bound (NCT07716228) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-12-12 |
| A Randomized Phase III Study of Management of Treatment Naive Primary Melanoma in Elderly Patients (NCT07068074) | Eastern Cooperative Oncology Group | 2025-12-12 |
| Study Comparing ZG006 With Investigator-Selected Chemotherapy in Participants With Relapsed Small Cell Lung Cancer (NCT07189455) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2025-12-12 |
| Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Trastuzumab Deruxtecan (NCT07716189) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-12-12 |
| Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Docetaxel Plus Cyclophosphamide (NCT07716176) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-12-12 |
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders (NCT07221851) | Ascendis Pharma A/S | 2025-12-12 |
| TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (NCT07223203) | Alnylam Pharmaceuticals | 2025-12-12 |
| Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection in the Treatment of Adult Upper Limb Spasticity . (NCT07242300) | JHM BioPharma (Tonghua) Co. , Ltd. | 2025-12-11 |
| A Study to Evaluate the Effect of Obicetrapib/Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome (NCT07219602) | NewAmsterdam Pharma | 2025-12-11 |
| Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Pancreatic Ductal Adenocarcinoma (PDAC) (NCT07217717) | SOFIE | 2025-12-11 |
| A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia (NCT07144163) | Crinetics Pharmaceuticals Inc. | 2025-12-11 |
| Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma (NCT06947928) | TuHURA Biosciences, Inc. | 2025-12-11 |
| Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer (NCT07222800) | Pfizer | 2025-12-11 |
| Efficacy and Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome (NCT07228403) | Zealand Pharma | 2025-12-11 |
| Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans (NCT06488144) | VA Office of Research and Development | 2025-12-10 |
| A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation (NCT07342205) | Shanghai University of Traditional Chinese Medicine | 2025-12-10 |
| SGLT2 Inhibition for Cardiovascular Endpoint Reduction in Hypertension (NCT06804161) | Prof. Dr. med. Ingo Eitel | 2025-12-10 |
| A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer (NCT07155187) | AbbVie | 2025-12-10 |
| Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care (NCT07195591) | GT Medical Technologies, Inc. | 2025-12-10 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (NCT06793397) | Cybin IRL Limited | 2025-12-10 |
| A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older (NCT07282665) | Pfizer | 2025-12-10 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) (NCT07245264) | St. Olavs Hospital | 2025-12-10 |
| Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support (NCT06910943) | Protara Therapeutics | 2025-12-10 |
| A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age (NCT07300839) | BioNTech SE | 2025-12-10 |
| Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated (NCT06908993) | Intergroupe Francophone de Cancerologie Thoracique | 2025-12-09 |
| A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids) (NCT07107945) | Boehringer Ingelheim | 2025-12-09 |
| Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression (NCT07214779) | Incyte Corporation | 2025-12-09 |
| [KJ-TFC-005] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension (NCT07662759) | Kukje Pharma | 2025-12-09 |
| PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301) (NCT06602271) | Ensysce Biosciences | 2025-12-09 |
| Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of Acute Bronchitis in Adult Patients (NCT07650227) | Materia Medica Holding | 2025-12-09 |
| Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer (NCT07226999) | Pfizer | 2025-12-09 |
| Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas (NCT06346197) | Centre Leon Berard | 2025-12-08 |
| Risk-adapted Adjuvant Chemotherapy Guided by the Tumour Stage for Operated Pancreatic Adenocarcinoma Following Neoadjuvant Chemotherapy With mFOLFIRINOX (NCT07044453) | University Hospital, Rouen | 2025-12-08 |
| A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced/Metastatic NSCLC (NCT06908304) | Maia Biotechnology | 2025-12-08 |
| A Study to Evaluate the Mucosal Intestinal Immunity to Poliovirus Type-2 of nOPV2 at Birth Dose in Healthy IPV Vaccinated Infants (NCT07010822) | Fidec Corporation | 2025-12-08 |
| Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain (NCT07100782) | University of Michigan | 2025-12-08 |
| Phase III Clinical Trial of SHPL-49 Injection in the Treatment of Acute Ischemic Stroke (NCT07241520) | Shanghai Hutchison Pharmaceuticals Limited | 2025-12-08 |
| Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart Failure (NCT07038356) | Christian Schulze | 2025-12-08 |
| Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries (NCT06723392) | NICHD Global Network for Women's and Children's Health | 2025-12-08 |
| Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution (NCT04792034) | Noden Pharma | 2025-12-06 |
| A Study to Assess the Efficacy and Safety of ZL-1109 in Chinese Participants With Active Thyroid Eye Disease (NCT07211776) | Zai Lab (Shanghai) Co., Ltd. | 2025-12-05 |
| A Phase III Clinical Study of Rezvilutamide in Patients With Metastatic Hormone-Sensitive Prostate Cancer (NCT07241416) | Jiangsu HengRui Medicine Co., Ltd. | 2025-12-05 |
| Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2 (NCT07263776) | Capital Medical University | 2025-12-05 |
| A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis (NCT07250802) | Takeda | 2025-12-04 |
| Influenza Vaccination Strategy for Patients With Hematologic Malignancy (NCT07485855) | Asan Medical Center | 2025-12-04 |
| Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer (NCT07262567) | Genfleet Therapeutics (Shanghai) Inc. | 2025-12-04 |
| A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02) (NCT07221253) | AstraZeneca | 2025-12-04 |
| A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1) (NCT07276724) | Generate Biomedicines | 2025-12-03 |
| A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy (NCT07218926) | GlaxoSmithKline | 2025-12-03 |
| A Study to Evaluate Efficacy and Safety of IBI112 in Adolescent Participants With Moderate to Severe Plaque Psoriasis (NCT07265284) | Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. | 2025-12-03 |
| Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis. (NCT06902805) | Assistance Publique - Hôpitaux de Paris | 2025-12-03 |
| A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis (NCT06979453) | Bristol-Myers Squibb | 2025-12-03 |
| A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer (NCT07276399) | Janssen Research & Development, LLC | 2025-12-03 |
| A Study of AND017 to Evaluate Efficacy and Safety in Patients With Anemia Due to Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (NCT07487727) | Kind Pharmaceuticals LLC | 2025-12-03 |
| Dapagliflozin for Cardio-renal Protection After ICU Discharge (NCT07025629) | Assistance Publique - Hôpitaux de Paris | 2025-12-02 |
| Irinotecan Hydrochloride Liposome Injection (II)in Combination With Oxaliplatin, 5-FU/LV Versus AG for First-line Treatment of Metastatic Pancreatic Cancer (NCT07238283) | Jiangsu HengRui Medicine Co., Ltd. | 2025-12-02 |
| Clinical Trial Comparing TQB2868 Injection Combined With Anlotinib Hydrochloride Capsules With Placebo Combined With Chemotherapy as First-line Treatment for Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) (NCT07165951) | Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. | 2025-12-02 |
| A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema (NCT06807281) | Pfizer | 2025-12-02 |
| A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) (NCT06937229) | Bristol-Myers Squibb | 2025-12-02 |
| A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer (NCT06524544) | National Cancer Institute (NCI) | 2025-12-02 |
| Hypertonic Saline in Posterior Spinal Fusion (NCT06822374) | Joseph D. Tobias | 2025-12-01 |
| Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) (NCT07252544) | Beijing Tiantan Hospital | 2025-12-01 |
| Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis：BLMZ Chinese Cohort (NCT07268664) | Beijing Chest Hospital | 2025-12-01 |
| Mobilization of Stem Cells With Motixafortide (BL-8040) in Combination With G-CSF in Multiple Myeloma Patients (NCT06514508) | Guangzhou Gloria Biosciences Co., Ltd. | 2025-12-01 |
| Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention (NCT07228663) | McMaster University | 2025-12-01 |
| Bridge Study to Evaluate the Efficacy and Safety of IN-B00009 Injection in Patients With T2DM Inadequately Controlled by Diet and Exercise Alone (NCT07308184) | HK inno.N Corporation | 2025-12-01 |
| A Study of TPST-1120 With Atezolizumab Plus Bevacizumab in Patients With Unresectable or Metastatic HCC Not Previously Treated With Systemic Therapy (NCT06680258) | Tempest Therapeutics | 2025-12-01 |
| Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations (NCT07188142) | Beenish Hassan | 2025-12-01 |
| EFG vs IVIG in TAMG (NCT07231523) | Shanghai Zhongshan Hospital | 2025-12-01 |
| Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) (NCT07212582) | Mahidol University | 2025-12-01 |
| A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects With Dry Eye Disease (NCT07111013) | Bausch & Lomb Incorporated | 2025-12-01 |
| A Long-term Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis (NCT07285304) | Taisho Pharmaceutical Co., Ltd. | 2025-12-01 |
| Prevention of Cisplatin-induced Nephrotoxicity (NCT06196853) | Mahidol University | 2025-12-01 |
| A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer. (NCT07268339) | The Christie NHS Foundation Trust | 2025-12-01 |
| A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes) (NCT07241390) | Eli Lilly and Company | 2025-12-01 |
| Study Assessing the Efficacy and Safety of cANnabidiol Oral Solution for Joint Pain of Adjuvant enDOcrine theRApy in Patients With Early Breast Cancer (NCT06787118) | Gustave Roussy, Cancer Campus, Grand Paris | 2025-12-01 |
| Phase III Trial of EBV-DNA-Guided Adaptive Immunotherapy for Advanced Nasopharyngeal Carcinoma (NCT07238569) | Sun Yat-sen University | 2025-12-01 |
| Efficacy and Safety of RPH-104 Treatment in Patients With Recurrent Pericarditis (NCT05107934) | R-Pharm Overseas, Inc. | 2025-12-01 |
| Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance (NCT06936774) | University Hospital, Basel, Switzerland | 2025-12-01 |
| Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation Care (NCT07239908) | Siriraj Hospital | 2025-12-01 |
| A Study of CS0159 in Patients With PBC With Inadequate Response or Intolerance to UDCA (NCT07282353) | Cascade Pharmaceuticals, Inc | 2025-12-01 |
| Intravenous Tirofiban After Delayed Thrombolysis in Stroke (NCT07111806) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-12-01 |
| Finerenone and Cardiac Remodeling (NCT07270367) | Subodh Verma | 2025-12-01 |
| A Phase 3 Study of Sunvozertinib Versus Placebo as Adjuvant Therapy in Patients With Early-Stage Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations or PACC Mutations After Radical Surgery (NCT07182682) | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | 2025-12-01 |
| Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial (NCT07260825) | TriHealth Inc. | 2025-12-01 |