| A Study to Evaluate the Efficacy and Safety of ONO-4538 in Combination With Ipilimumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer) (NCT05144854) | Ono Pharmaceutical Co., Ltd. | 2021-11-05 |
| Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD) (NCT04968184) | KBP Biosciences | 2021-11-05 |
| Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain (NCT05137041) | Sanofi | 2021-11-04 |
| A Study to Evaluate the Long-term Efficacy and Safety of AK102 in Patients With Hyperlipidemia (NCT05255458) | Akeso | 2021-11-04 |
| Nonpharmacologic Pain Management in FQHC Primary Care Clinics (NCT04923334) | University of Utah | 2021-11-04 |
| A Study to Evaluate the Efficacy and Safety of AK102 in Patients With Hyperlipidemia (NCT05255094) | Akeso | 2021-11-03 |
| Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Study (NCT05096832) | Livzon Pharmaceutical Group Inc. | 2021-11-03 |
| Simufilam 100 mg for Mild-to-Moderate Alzheimer's Disease (NCT04994483) | Cassava Sciences, Inc. | 2021-11-03 |
| Evaluate the Safety and Efficacy of Ferric Maltol Oral Suspension vs. Ferrous Sulfate Oral Liquid in Children and Adolescents Aged 2 to 17 Years With Iron-deficiency Anaemia, With a Single Arm Study in Infants Aged 1 Month to Less Than 2 Years (NCT05126901) | Shield Therapeutics | 2021-11-03 |
| Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults (NCT05114486) | Eyenovia Inc. | 2021-11-03 |
| Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment (NCT04198649) | University Hospital, Strasbourg, France | 2021-11-02 |
| Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS. (NCT05120752) | Universitair Ziekenhuis Brussel | 2021-11-02 |
| A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) (NCT05093933) | Merck Sharp & Dohme LLC | 2021-11-02 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity (NCT04815967) | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 2021-11-02 |
| A Study of Ad26.COV2.S and Influenza Vaccines in Healthy Adults (NCT05091307) | Janssen Vaccines & Prevention B.V. | 2021-11-02 |
| Laser vs Clobetasol for Lichen Sclerosus (NCT05010421) | Ruhr University of Bochum | 2021-11-02 |
| Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia (NCT04994717) | Amgen | 2021-11-02 |
| Efficacy & Safety of Nintedanib in Patients With Progressive Fibrosing Coal Mine Dust-Induced Interstitial Lung Disease (NCT05067517) | West Virginia University | 2021-11-01 |
| Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars (NCT05116306) | Ain Shams University | 2021-11-01 |
| The Hemophilia Inhibitor Eradication Trial (NCT04303572) | Margaret Ragni | 2021-11-01 |
| Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level (NCT05425914) | University of Faisalabad | 2021-11-01 |
| Neurobiology of Treatment Responses in MDD (NCT03068247) | University of Utah | 2021-11-01 |
| Yinhu Qingwen Granula for the Treatment of Severe CoVID-19 (NCT04310865) | Zhong Wang | 2021-11-01 |
| Efficacy and Safety Study of MYOBLOC in the Treatment of Sialorrhea in Pediatric Subjects (NCT05097079) | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 2021-11-01 |
| Atorvastatin in Management of Newly Diagnosed ITP (NCT03692754) | Shandong University | 2021-11-01 |
| Clinical Trial for Oral Formula of Vanillin and Wheat Germ Oil for Treatment of Mild and Moderate COVID-19 Viral Disease (NCT05157139) | Alexandria University | 2021-11-01 |
| PRP-HA Versus HA in Knee Osteoarthritis (NCT05076526) | Singapore General Hospital | 2021-11-01 |
| Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder (NCT05015881) | University of Pennsylvania | 2021-11-01 |
| Compare the Efficacy and Safety of HLX04-O with Ranibizumab in Subjects with WAMD (NCT05003245) | Shanghai Henlius Biotech | 2021-11-01 |
| A Study of an Ad26.RSV.PreF-based Regimen at the End of Shelf-life in Adults Aged 60 to 75 Years (NCT05101486) | Janssen Vaccines & Prevention B.V. | 2021-11-01 |
| MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function (NCT04128462) | Mallinckrodt | 2021-11-01 |
| Optimal Duration of Oxaliplatin in Adjuvant XELOX for Gastric Cancer Patients (EXODOX) (NCT04787354) | Hallym University Medical Center | 2021-11-01 |
| Effect Of Semaglutide In Coronary Atheroma Plaque (NCT05071417) | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | 2021-11-01 |
| To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia (NCT05140863) | Haisco Pharmaceutical Group Co., Ltd. | 2021-11-01 |
| Smartphones for Opiate Addiction Recovery (NCT05033028) | NYU Langone Health | 2021-11-01 |
| Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy (NCT05117853) | Onze Lieve Vrouw Hospital | 2021-11-01 |
| The Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial Infarction (NCT04912167) | West China Hospital | 2021-11-01 |
| Effect of Personality Traits on Reporting Outcomes of Orthodontic Treatment (NCT05398328) | University of Rijeka | 2021-11-01 |
| Cetuximab Maintenance Treatment Versus Continuation After Induction Therapy in mCRC (NCT02942706) | Ruijin Hospital | 2021-11-01 |
| Dental Biofilm Control During Orthodontic Treatment (NCT05532241) | University of Rijeka | 2021-11-01 |
| PRP Versus Saline in Lateral Epicondylitis (NCT05125705) | Singapore General Hospital | 2021-11-01 |
| Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis (NCT04543643) | Tianjin Second People's Hospital | 2021-11-01 |
| Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial (NCT04982419) | VA Office of Research and Development | 2021-11-01 |
| Study of Anti-CEA CAR-T + Chemotherapy VS Chemotherapy Alone in Patients With CEA+Pancreatic Cancer & Liver Metastases (NCT04037241) | Sorrento Therapeutics, Inc. | 2021-11-01 |
| EUS-guided Intra-tumour Injection of OncoSil for Locally Advanced Pancreatic Carcinoma. (NCT05131776) | Chinese University of Hong Kong | 2021-11-01 |
| Nitric Oxide Nasal Spray (NONS) To Treat and Prevent the Exacerbation of Infection in Individuals With Mild COVID-19 (NCT05599919) | Sanotize Research and Development corp. | 2021-11-01 |
| A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension (NCT04863365) | pH Pharma | 2021-11-01 |
| The Effects of Hydroxychloroquine in Patients with Inflammatory Cardiomyopathy (NCT05961202) | Tongji Hospital | 2021-11-01 |
| Prophylaxis of COVID-19 Disease With Ivermectin in COVID-19 Contact Persons [German: Prophylaxe Der COVID-19-Erkrankung Mit Ivermectin Bei COVID-19 Kontaktpersonen] (NCT05060666) | Infectopharm Arzneimittel GmbH | 2021-11-01 |
| A Trial of SHR3680 in Prostate Cancer Patients Who Are Candidates for Radical Prostatectomy (NCT05009290) | Jiangsu HengRui Medicine Co., Ltd. | 2021-11-01 |
| Study of PK and Safety of the LicartTM Topical System in Pediatric and Adult Participants with Minor Soft Tissue Injury (NCT05171673) | IBSA Institut Biochimique SA | 2021-10-31 |
| Study of the Therapeutic Effect of Atorvastatin on the Clinical Outcomes in HER2 Negative Breast Cancer Patients" (NCT05103644) | Beni-Suef University | 2021-10-30 |
| Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke (NCT05175547) | ProMedica Health System | 2021-10-30 |
| Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin (NCT05201079) | Mikrobiomik Healthcare Company S.L. | 2021-10-29 |
| A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause (OASIS-2) (NCT05099159) | Bayer | 2021-10-29 |
| A Sub-study of Cabotegravir (CAB) and Rilpivirine (RPV) in Human Immunodeficiency Viruses (HIV)-Infected Participants (NCT05896761) | ViiV Healthcare | 2021-10-28 |
| A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations (NCT05048797) | AstraZeneca | 2021-10-28 |
| Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (NCT04064346) | Palladio Biosciences | 2021-10-28 |
| Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis (NCT05142774) | Organon and Co | 2021-10-28 |
| A Phase III Trial of Neoadjuvant Sintilimab and Chemotherapy for NSCLC Harboring No Driver Mutations (NCT05157776) | Tongji University | 2021-10-28 |
| Novaferon in Non-hospitalized Adult Patients With Mild COVID-19 (NCT05172037) | Genova Inc. | 2021-10-28 |
| Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC (NCT05043090) | AstraZeneca | 2021-10-28 |
| Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment (NCT05021536) | Amylyx Pharmaceuticals Inc. | 2021-10-28 |
| KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent (NCT05001724) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 2021-10-28 |
| A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome (NCT04940624) | Takeda | 2021-10-28 |
| Bupivacaine in Tonsillectomy (NCT04825704) | Nordlandssykehuset HF | 2021-10-27 |
| Assessment of Effectiveness and Safety of Luspatercept in Patients Suffering From Lower-risk Myelodysplastic Syndrome. (NCT05181592) | GWT-TUD GmbH | 2021-10-27 |
| DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS) (NCT04709705) | Cellphire Therapeutics, Inc. | 2021-10-27 |
| Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants (NCT04988386) | Eidos Therapeutics, a BridgeBio company | 2021-10-27 |
| A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma (NCT04712097) | Hoffmann-La Roche | 2021-10-27 |
| A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation (NCT05076149) | Vertex Pharmaceuticals Incorporated | 2021-10-27 |
| A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) (NCT05096221) | Sarepta Therapeutics, Inc. | 2021-10-27 |
| Phase III Study on HMPL-523 for Treatment of ITP (NCT05029635) | Hutchmed | 2021-10-27 |
| Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis (NCT04833894) | argenx | 2021-10-26 |
| A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age (NCT05085366) | ModernaTX, Inc. | 2021-10-26 |
| A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus (NCT04963296) | Hoffmann-La Roche | 2021-10-26 |
| Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles (NCT05139121) | Mylan Technologies Inc. | 2021-10-26 |
| Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis (NCT04569942) | Australian and New Zealand Intensive Care Research Centre | 2021-10-26 |
| tTF-NGR Randomized Study - STS (NCT05597917) | Universität Münster | 2021-10-26 |
| A Phase III Study to Assess the Lot-to-lot Consistency of GSK's Investigational RSV Maternal Vaccine and the Immune Response and Safety of RSV Maternal Vaccine When Given Alone or Co-administered With GSK's Influenza D-QIV Vaccine in Healthy Non-pregnant Women. (NCT05045144) | GlaxoSmithKline | 2021-10-26 |
| The PREVENT AGITATION Trial II - Children ≤1 Year (NCT05091242) | Rigshospitalet, Denmark | 2021-10-25 |
| Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy (NCT05116813) | Addex Pharma S.A. | 2021-10-25 |
| A Study to Evaluate Efficacy and Safety of Casirivimab+Imdevimab (Monoclonal Antibodies) for Prevention of COVID-19 in Immunocompromised Adolescents and Adults (NCT05074433) | Regeneron Pharmaceuticals | 2021-10-25 |
| Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer (NCT05113251) | AstraZeneca | 2021-10-25 |
| Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU (NCT04163536) | Versailles Hospital | 2021-10-25 |
| Robotic-arm Assisted 68 Ga PSMA PET/CT Guided Prostate Biopsy Versus MR Directed Cognitive Fusion TRUS Guided Prostate Biopsy (PROBIOP) (NCT05137561) | Post Graduate Institute of Medical Education and Research, Chandigarh | 2021-10-25 |
| Open Label Extension of TUDCA-ALS Study (NCT05753852) | Humanitas Mirasole SpA | 2021-10-25 |
| A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia (NCT05079919) | Ionis Pharmaceuticals, Inc. | 2021-10-25 |
| Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation (NCT04901689) | Hospital Israelita Albert Einstein | 2021-10-23 |
| Predictive Value of Hydrogen/Methane Lactose Breath Testing on the Therapeutic Effect of Lactose-free Diet in Moderate to Severe ROME IV IBS. (NCT04974593) | Universitair Ziekenhuis Brussel | 2021-10-22 |
| The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery (NCT05171179) | Northwestern University | 2021-10-22 |
| A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET (NCT05050942) | Camurus AB | 2021-10-22 |
| A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed (NCT05091619) | China National Biotec Group Company Limited | 2021-10-22 |
| A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS) (NCT04861259) | Hoffmann-La Roche | 2021-10-22 |
| Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects (NCT04987229) | Alkermes, Inc. | 2021-10-22 |
| A Phase III Confirmatory Study of K-237 (NCT05056883) | Kowa Company, Ltd. | 2021-10-22 |
| Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance (NCT04578652) | University of Alberta | 2021-10-22 |
| CHIlled Platelet Study "CHIPS" (NCT04834414) | Philip Spinella | 2021-10-21 |
| Landiolol for Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery (NCT05084118) | Medical University of Vienna | 2021-10-21 |
| Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge (NCT05054023) | University of Monastir | 2021-10-21 |