| Efficacy and Safety of the Proposed Biosimilar Pertuzumab (PERT-IJS) Versus EU-Perjeta® Along With Trastuzumab and Chemotherapy (Carboplatin and Docetaxel) as Neoadjuvant Treatment in Chemotherapy naïve Patients With Early Stage or Locally Advanced HR Negative and HER2 Positive Breast Cancer (NCT06038539) | Biocon Biologics UK Ltd | 2025-01-06 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II) (NCT06192615) | Massachusetts General Hospital | 2025-01-06 |
| Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease (NCT06760637) | Pfizer | 2025-01-06 |
| Evaluation of Somatostatin Receptor Expression in PET 68Ga-DOTATOC in Patients Followed for Metastatic Breast Cancer (NCT06611891) | University Hospital, Grenoble | 2025-01-06 |
| Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose (NCT06316830) | Rhode Island Hospital | 2025-01-06 |
| Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Eculizumab in Chinese Adults With gMG (NCT06764160) | Alexion Pharmaceuticals, Inc. | 2025-01-06 |
| A Phase 3 Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis (NCT06745531) | Taisho Pharmaceutical Co., Ltd. | 2025-01-06 |
| Study Comparing BEBT-908 Combined With R to SOC for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma (NCT06792253) | BeBetter Med Inc | 2025-01-06 |
| Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. (NCT06758830) | National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos | 2025-01-06 |
| Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis. (NCT06882564) | Al-Mustansiriyah University | 2025-01-05 |
| Newly-diagnosed Intermediate/High Risk Pediatric B-cell ALL Protocol (NCT06764238) | Institute of Hematology & Blood Diseases Hospital, China | 2025-01-03 |
| Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese Patients (NCT07036172) | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 2025-01-03 |
| To Evaluate the Efficacy and Safety of QLM2010 for Prevention of Chemotherapy-induced Nausea and Vomiting After Highly Emetogenic Chemotherapy. (NCT07081256) | Qilu Pharmaceutical Co., Ltd. | 2025-01-03 |
| A Phase 3 Study to Evaluate Efficacy & Safety of Subcutaneous CT-P13 in Patients With Moderate to Severe Active Rheumatoid Arthritis (NCT06738719) | Celltrion | 2025-01-03 |
| A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease (NCT06227910) | Takeda | 2025-01-02 |
| RCT of Efficacy and Safety of CP003 on CFS/ME or Post-COVID Fatigue (NCT06739720) | The University of Hong Kong | 2025-01-02 |
| RAPA-501 Therapy for ALS (NCT04220190) | Rapa Therapeutics LLC | 2025-01-02 |
| Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma (NCT06585410) | Regeneron Pharmaceuticals | 2025-01-02 |
| Disease Modifying Therapies Withdrawal in Inactive Relapsing-remitting Multiple Sclerosis Patients Aged 55 and Over (TWINS : Therapies Withdrawal IN Relapsing Multiple Sclerosis) (NCT06663189) | University Hospital, Strasbourg, France | 2025-01-01 |
| Early Amiodarone in Shockable Cardiac Arrest (NCT06680869) | Oregon Health and Science University | 2025-01-01 |
| Female Sexual Dysfunction Assessment and Managment of Vaginismus (NCT06755099) | Assiut University | 2025-01-01 |
| Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients (NCT06477939) | Institut de cancérologie Strasbourg Europe | 2025-01-01 |
| A Clinical Trial Assessing the Safety and Efficacy of Biodegradable Magnesium Embolic Microspheres for Primary Hepatocellular Carcinoma (NCT06779461) | InnoBM Pharmaceuticals Co., Ltd. | 2025-01-01 |
| The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK) (NCT06960629) | University Hospital Dubrava | 2025-01-01 |
| Nano-crystalline Megestrol Acetate for Adjuvant Treatment in High-risk Head and Neck Squamous Cell Carcinoma After Surgery. (NCT06772428) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-01-01 |
| Opening the "Black Box" on Tezepelumab's Effect on Chronic Rhinosinusitis With Severe Asthma (NCT06740045) | Dr. Andrew Thamboo, MD | 2025-01-01 |
| A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With Thyroid Cancer. (NCT06791005) | Second Affiliated Hospital of Xi'an Jiaotong University | 2025-01-01 |
| Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease (NCT05082571) | Akebia Therapeutics | 2025-01-01 |
| Buttock Augmentation With Polymethylmethacrylate (NCT06544304) | MTC MEDICAL COMERCIO INDUSTRIA IMPORTACAO E EXPORTACAO DE PRODUTOS BIOMEDICOS LTDA | 2025-01-01 |
| Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB) (NCT06712420) | Rajiv Gandhi Cancer Institute & Research Center, India | 2025-01-01 |
| To Evaluate the Efficacy and Safety of QL2109 and DARZALEX FASPRO® in Multiple Myeloma (NCT06742138) | Qilu Pharmaceutical Co., Ltd. | 2025-01-01 |
| Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes (NCT06989697) | Seoul National University Bundang Hospital | 2025-01-01 |
| Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC (NCT06752239) | Jiangxi Provincial Cancer Hospital | 2025-01-01 |
| HVA vs IA/DA or VA in the Treatment of ND HR-AML (NCT06810791) | Nanfang Hospital, Southern Medical University | 2025-01-01 |
| Phase 3 Trial to Evaluate the Efficacy and Safety of DKP21102_B Added on to DKP21102_A Compared With DKP21102_A (NCT05809687) | Dongkwang Pharm. Co., Ltd. | 2025-01-01 |
| Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents (NCT05082584) | Akebia Therapeutics | 2025-01-01 |
| Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction (NCT06712030) | Puerta de Hierro University Hospital | 2025-01-01 |
| Investigation of Impact of Indocyanine Green on Volume of Lymphadenectomy in Resectable Gastric Cancer (NCT06755554) | Ukrainian Society of Clinical Oncology | 2025-01-01 |
| Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA (NCT05517434) | University Health Network, Toronto | 2025-01-01 |
| Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries (NCT07350668) | Benha University | 2025-01-01 |
| CTV Delineation Based Solely on Geometric Expansion From GTV in Nasopharyngeal Carcinoma (NCT06095154) | Fujian Cancer Hospital | 2025-01-01 |
| Prophylactic IV Paracetamol in Extremely Premature Infants (NCT07067177) | Al-Quds University | 2025-01-01 |
| Study to Evaluate the Safety and Tolerability of KRX-0502 (Ferric Citrate) in Children With Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease (NCT04649411) | Keryx Biopharmaceuticals | 2025-01-01 |
| Role of Ondansetron in Spinal Anaesthesia Induced Hypotension (NCT06727201) | Assiut University | 2025-01-01 |
| The Effect of ColcHicine on the Incidence of Knee or Hip Replacements (NCT06578182) | Sint Maartenskliniek | 2025-01-01 |
| Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS (NCT07323589) | PAEC general hospital | 2025-01-01 |
| InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS (NCT05960929) | ONY | 2025-01-01 |
| Efficacy and Safety of Tirzepatide for Weight Management (NCT06918405) | Chittagong Medical College | 2025-01-01 |
| Two Group Experimental Trial Promoting Sports and Exercise Among Female University Students in Saudi Arabia (NCT06873126) | University of Jazan | 2025-01-01 |
| The Effect of High-thoracic Erector Spinae Plane Block on Postoperative Pain and Diaphragmatic Function in Posterior Cervical Spine Surgery (NCT06721832) | Benha University | 2025-01-01 |
| Dexmedetomidine in Attenuation of Haemodynamic Response to Laryngoscopy in Controlled Hypertensive Patients (NCT07557680) | Sindh Institute of Urology and Transplantation | 2025-01-01 |
| MLC1501 Study Assessing Efficacy in STROke Recovery (NCT05046106) | Moleac Pte Ltd. | 2025-01-01 |
| SBRT Combined with Camrelizumab and Apatinib for Conversion Therapy in Patients with Unresectable Hepatocellular Carcinoma. (NCT06739317) | Sun Yat-sen University | 2025-01-01 |
| Human Umbilical Cord Mesenchymal Stem Cells for Alport Syndrome (NCT06731192) | Guangzhou Women and Children's Medical Center | 2025-01-01 |
| A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.). (NCT06719479) | SUNHO（China）BioPharmaceutical CO., Ltd. | 2025-01-01 |
| Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section (NCT06765473) | Assiut University | 2025-01-01 |
| Empiric Calcium in Massive Transfusion (NCT05953376) | University of California, Irvine | 2025-01-01 |
| Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial (NCT06622564) | Hamilton Health Sciences Corporation | 2025-01-01 |
| Electroacupuncture Combined With Immune Checkpoint Inhibitors as Adjuvant Therapy After Surgery for Early-stage Non-small Cell Lung Cancer (NCT07034326) | Kong Fanming | 2025-01-01 |
| Effects of Standardized Boswellia Carterii Extract on Irritable Bowel Syndrome Patients (NCT07576634) | Mansoura University | 2025-01-01 |
| Study Comparing Reduced Versus Standard Dose Post-transplantation Cyclophosphamide in Combination With Post-engraftment Anti-thymoglobin as Graft Versus Host Disease Prophylaxis in Alternative Donor Peripheral Stem Cell Transplantation (NCT06705062) | Shanghai Jiao Tong University School of Medicine | 2025-01-01 |
| Efficacy and Safety of OMA102 in the Treatment of Female Pattern Hair Loss (NCT05824065) | EMS | 2025-01-01 |
| Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome. (NCT05463679) | Aytu BioPharma, Inc. | 2025-01-01 |
| Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures (NCT06337292) | Major Extremity Trauma Research Consortium | 2025-01-01 |
| Anti-Xa Guided Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism Following Traumatic Injury: a Multicentre Pilot Randomized Trial (NCT06662253) | Alexandre Tran | 2025-01-01 |
| A Phase III Study of YL201 in Recurrent or Metastatic Nasopharyngeal Carcinoma (NCT06629597) | MediLink Therapeutics (Suzhou) Co., Ltd. | 2024-12-31 |
| A Randomized Controlled Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined with Systemic Therapy for Early-stage Breast Cancer (NCT06769919) | Xijing Hospital | 2024-12-31 |
| Efficacy and Safety of SJP-0132 Eye Drops in Chinese Patients With Dry Eye Disease (NCT06717152) | Senju Pharmaceutical Science & Technology (Beijing) Co., Ltd. | 2024-12-30 |
| Phase III Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis (NCT06723080) | Jiangsu vcare pharmaceutical technology co., LTD | 2024-12-30 |
| A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination (NCT05911061) | WestVac Biopharma Co., Ltd. | 2024-12-30 |
| A Study to Evaluate the Use of Durvalumab in Combination With Platinum-based Chemotherapy Followed by Durvalumab With Olaparib as First-line Treatment in Advanced or Recurrent Endometrial Cancer in Spain (NCT06746116) | AstraZeneca | 2024-12-30 |
| Efficacy and Safety of Changkang Granules in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea (Liver qi Affecting the Spleen Pattern) (NCT06753890) | Tasly Pharmaceutical Group Co., Ltd | 2024-12-30 |
| An Open-label, Single-arm Study to Evaluate Pharmacokinetics and Safety of Subcutaneous Sonelokimab in Adolescents With Moderate to Severe Hidradenitis Suppurativa (VELA-TEEN) (NCT06768671) | MoonLake Immunotherapeutics AG | 2024-12-30 |
| Acute Agitation in Emergency Psychiatry (NCT06752616) | Lone Baandrup | 2024-12-30 |
| A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Obese/Overweight Subjects (NCT06728124) | Gan & Lee Pharmaceuticals. | 2024-12-30 |
| Platinum and Taxane Chemo in Met Castration Resistant Prostate Cancer Patients With Alterations in DNA Damage Response Genes (NCT06439225) | Canadian Cancer Trials Group | 2024-12-30 |
| Efficacy and Safety of Isosorbide Oral Solution in Patients With Meniere's Disease (NCT06765993) | Lunan Better Pharmaceutical Co., LTD. | 2024-12-30 |
| LIDRISE Study: A Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops, Single Dose) in the Treatment of Acquired Blepharoptosis. (NCT06514612) | Santen SAS | 2024-12-30 |
| QR12000 Compound Tablets in Patients with Moderate to Severe Essential Hypertension (NCT06716970) | Wuhan Createrna Science and Technology Co., Ltd | 2024-12-30 |
| A Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB12 (Proposed Pembrolizumab Biosimilar) to Keytruda® in Non-small Cell Lung Cancer (BENITO Study) (NCT06687369) | mAbxience Research S.L. | 2024-12-30 |
| Effect of Metformin as Add-on Therapy in Levodopa Treated Parkinson's Disease Patients (NCT07055958) | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 2024-12-29 |
| Cardio Protective Effect of SGL2I in Hemodialysis Patients and Its Impact on Patient Quality of Life (NCT06759077) | Al-Azhar University | 2024-12-28 |
| Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections (NCT06702878) | Ondine Biomedical Inc. | 2024-12-27 |
| Efficacy and Safety of ZVS101e in Patients With Bietti 's Crystalline Dystrophy (NCT06743646) | Chigenovo Co., Ltd | 2024-12-27 |
| Zinc Supplementation for Young Infants With Clinical Severe Infection in Tanzania (NCT06102044) | Harvard School of Public Health (HSPH) | 2024-12-27 |
| A Study to Evaluate the Efficacy and Safety of REL-1017 As Adjunctive Treatment of Major Depressive Disorder (MDD) (NCT06735079) | MGGM LLC | 2024-12-27 |
| Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III) (NCT06489028) | RHEACELL GmbH & Co. KG | 2024-12-26 |
| A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases (NCT06699212) | Rakuten Medical, Inc. | 2024-12-24 |
| A Research Study of VCT220 in Adult Chinese Participants With Obesity (NCT06939296) | Vincentage Pharma Co., Ltd | 2024-12-24 |
| Trop2-targeted immunoPET Imaging of Solid Tumors (NCT06851663) | RenJi Hospital | 2024-12-23 |
| A Two-Part, Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of Hyperkalemia (NCT07251309) | Waterstone Pharmaceutical (Wuhan) Co., LTD. | 2024-12-23 |
| PREDICATE Trial For Respiratory Tract Infections (NCT06472219) | The University of Hong Kong | 2024-12-23 |
| Safety and Efficacy of Upadacitinib in Combination With Topical Corticosteroids in Children From 2 to Less Than 12 Years of Age in Japan With Moderate to Severe Atopic Dermatitis (NCT06701331) | AbbVie | 2024-12-22 |
| D-BACE in Combination With Chemotherapy and Carelizumab for Resectable II-IIIA or Potentially Resectable T3-4N2 Stage IIIB NSCLC (NCT07016126) | Guangdong Provincial People's Hospital | 2024-12-22 |
| Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection (NCT06525571) | Johns Hopkins University | 2024-12-20 |
| Clinical and Metabolomics Studies on the Improvement of Ovarian Reserve by Acupoint Photodynamic Therapy and Traditional Chinese Medicine Treatment (NCT07376824) | Peking Union Medical College Hospital | 2024-12-20 |
| Dose Efficacy in Adhesive Capsulitis (NCT06848374) | University Health Network, Toronto | 2024-12-20 |
| Upfront Surgery Vs Induction Chemotherapy Followed By Surgery In Oral Cancers: (NCT06737822) | All India Institute of Medical Sciences, Jodhpur | 2024-12-20 |
| Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma (NCT06560255) | Professor Klaus Bønnelykke | 2024-12-20 |
| ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial (NCT06828861) | Aardvark Therapeutics, Inc. | 2024-12-20 |