| Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717) | NRG Oncology | 2021-01-21 |
| Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer (NCT04415853) | Sunshine Lake Pharma Co., Ltd. | 2021-01-21 |
| Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers (NCT04251819) | University of Alabama at Birmingham | 2021-01-21 |
| A Phase III Study of Bevacizumab and Paclitaxel in Combination With Atezolizumab as a Treatment for Locally Advanced Unresectable or Metastatic Hormone Receptor-positive HER2 Negative Breast Cancer (NCT04732598) | Japanese Foundation for Cancer Research | 2021-01-21 |
| 18F-DOPA II - PET Imaging Optimization (NCT04706910) | University of Alberta | 2021-01-20 |
| Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors (NCT04669496) | Shanghai Zhongshan Hospital | 2021-01-20 |
| Efficacy and Safety of First-line Anti-PD-1/PD-L1 Monoclonal Antibody in Combination With Chemotherapy and Bronchoscopy-assisted Interventional Therapy in Patients With Advanced Central Non-small Cell Lung Cancer (NCT04702009) | Shanghai Pulmonary Hospital, Shanghai, China | 2021-01-20 |
| Liraglutide Improve Cognitive Function in Patients With Type 2 Diabetes Mellitus (NCT05360147) | Third Military Medical University | 2021-01-20 |
| Evaluation of Ivermectin Mucoadhesive Nanosuspension as Nasal Spray in Management of Early Covid-19 (NCT04716569) | South Valley University | 2021-01-20 |
| A Long-term Follow-up Study in Participants Who Received CTX001 (NCT04208529) | Vertex Pharmaceuticals Incorporated | 2021-01-20 |
| Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677) | European Organisation for Research and Treatment of Cancer - EORTC | 2021-01-20 |
| Hidroxicloroquina With Azitromicina Versus Hidroxicloroquina and Placebo Int Patients With Mild COVID-19 (NCT04964583) | Coordinación de Investigación en Salud, Mexico | 2021-01-20 |
| Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH (NCT04813471) | Lebanese American University Medical Center | 2021-01-20 |
| Study of Ralinepag on Exercise Capacity by Cardiopulmonary Exercise Testing (CPET) in WHO Group 1 PH Subjects (NCT04084678) | United Therapeutics | 2021-01-20 |
| Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men and Using Oral Tenofovir Disoproxil Fumarate/ Emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP) (NCT04597424) | ANRS, Emerging Infectious Diseases | 2021-01-19 |
| Extension Study of P1101 After Completion of Phase 2 Study in PV Patients or Phase 3 Study in ET Patients (NCT04655092) | PharmaEssentia Japan K.K. | 2021-01-19 |
| Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms (NCT04727424) | Cardresearch | 2021-01-19 |
| Treating Tuberculosis With the Lipid Lowering Drug Atorvastatin in Nigeria(ATORvastatin in Pulmonary TUBerculosis) (NCT04721795) | Obafemi Awolowo University Teaching Hospital | 2021-01-19 |
| Sentinel Node Biopsy in Endometrial Cancer (NCT04073706) | Queensland Centre for Gynaecological Cancer | 2021-01-18 |
| Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953) | The George Institute | 2021-01-18 |
| Efficacy and Safety of a Solution for Endoscopic Mucosal Resection of Colonic Lesions (NCT06910514) | Nakafarma S.L. | 2021-01-18 |
| Ivermectin to Prevent SARS-CoV-2 (COVID-19) Hospitalisation in Subjects Over 50 (NCT05993143) | Insud Pharma | 2021-01-18 |
| Study to Evaluate the Immunogenicity, Safety, and Tolerability of a Tick-Borne Encephalitis (TBE) Vaccine in Healthy Japanese Participants 1 Year of Age and Older (NCT04648241) | Pfizer | 2021-01-18 |
| Efficacy and Safety of Zerafil® (Omalizumab) in Participants With Uncontrolled Moderate to Severe Allergic Asthma (NCT05813470) | Cinnagen | 2021-01-18 |
| Allogenic UCMSCs as Adjuvant Therapy for Severe COVID-19 Patients (NCT05132972) | Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia | 2021-01-17 |
| A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus. (NCT04711603) | Kissei Pharmaceutical Co., Ltd. | 2021-01-16 |
| Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery (NCT04711642) | Fundación Oftalmológica Los Andes | 2021-01-15 |
| Posoleucel (ALVR105, Formerly Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant (NCT04693637) | AlloVir | 2021-01-15 |
| Efficacy of Statin Addition to Neoadjuvant Chemotherapy Protocols for Breast Cancer (NCT04705909) | Mansoura University | 2021-01-15 |
| A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema (NCT04654351) | Takeda | 2021-01-15 |
| Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients (NCT04673422) | Phramongkutklao College of Medicine and Hospital | 2021-01-15 |
| Evaluating the Efficacy and Safety of QL0911 in Chemotherapy- Induced Thrombocytopenia (NCT05851027) | Qilu Pharmaceutical Co., Ltd. | 2021-01-15 |
| Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes (NCT04707469) | Novo Nordisk A/S | 2021-01-15 |
| Randomized Study in Children and Adolescents With Migraine: Acute Treatment (NCT04649242) | Pfizer | 2021-01-15 |
| G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for RAEB-1,REAB-2 and AML Secondary to MDS Undergoing Allo-HSCT (NCT04713956) | Nanfang Hospital, Southern Medical University | 2021-01-15 |
| A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma (NCT04657991) | Pfizer | 2021-01-15 |
| Fast Track Protocol After Radical Cystectomy and Urinary Diversion: A Randomised Controlled Trial. (NCT04939194) | Mansoura University | 2021-01-15 |
| Dupilumab in Japanese Patients With Atopic Dermatitis (NCT04678882) | Sanofi | 2021-01-15 |
| A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF) (NCT04599465) | Vertex Pharmaceuticals Incorporated | 2021-01-15 |
| Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases (NCT04687631) | Fudan University | 2021-01-14 |
| Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis (NCT04709575) | Regeneron Pharmaceuticals | 2021-01-14 |
| Comparing Two Different Surgical Techniques for Breast Reconstruction (NCT04716959) | Memorial Sloan Kettering Cancer Center | 2021-01-14 |
| Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old (NCT04684238) | Sedana Medical | 2021-01-14 |
| Does Tranexamic Acid Improve Visualization During Arthroscopic Rotator Cuff Repair (NCT04865380) | University of Saskatchewan | 2021-01-13 |
| New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy (NCT04564157) | Fundación GECP | 2021-01-13 |
| Study of Sacituzumab Govitecan Versus Physician's Choice of Treatment in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread (NCT04527991) | Gilead Sciences | 2021-01-13 |
| Oxaliplatin Combined With S-1(SOX) Neoadjuvant Chemotherapy for Different Cycles in Patients With Gastric Cancer (NCT04483076) | Chinese PLA General Hospital | 2021-01-13 |
| A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL) (NCT04628494) | Genmab | 2021-01-13 |
| The Effect of Ganglion Sphenopalatine Block Versus Placebo on Persistent Headache Following COVID-19 Infection (NCT04636034) | University Hospital Bispebjerg and Frederiksberg | 2021-01-12 |
| BEOVU Versus Eylea in the Treatment of Diabetic Macular Edema (NCT04955171) | Benha University | 2021-01-12 |
| Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough (NCT04468542) | University of South Florida | 2021-01-12 |
| Discontinuation of Methotrexate in Rheumatoid Arthritis Patients Achieving Clinical Remission by Treatment With Upadacitinib Plus Methotrexate (NCT05121298) | Atsushi Kawakami | 2021-01-12 |
| Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2). (NCT04472429) | Incyte Corporation | 2021-01-12 |
| Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease (NCT04277247) | University of Calgary | 2021-01-12 |
| Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19 (NCT04732949) | Synairgen Research Ltd. | 2021-01-12 |
| Evaluation of Sequencing of Anthracyclines and Taxanes for Locally Advanced HER2-negative Breast Cancer (NCT04540692) | Latin American Cooperative Oncology Group | 2021-01-12 |
| A Study to Compare the Efficacy and Safety of CT-P43 to Stelara in Patients With Plaque Psoriasis (NCT04673786) | Celltrion | 2021-01-11 |
| Interventional Study to Assess Efficacy and Safety of Velmanase Alfa in Patients With Alpha Mannosidosis (NCT04031066) | Chiesi Farmaceutici S.p.A. | 2021-01-11 |
| A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes (NCT04545515) | Vertex Pharmaceuticals Incorporated | 2021-01-11 |
| Metformin Plus Megestrol Acetate As a Fertility-sparing Treatment in Patients with Atypical Endometrial Hyperplasia (NCT04607252) | Fudan University | 2021-01-11 |
| A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN) (NCT04204616) | Galderma R&D | 2021-01-11 |
| Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis (NCT04539964) | SetPoint Medical Corporation | 2021-01-11 |
| Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery (NCT04739709) | Formosa Pharmaceuticals, Inc. | 2021-01-11 |
| Corticosteroids and Myocardial Injury in CAP (COLOSSEUM TRIAL) (NCT03745664) | University of Roma La Sapienza | 2021-01-10 |
| Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC (NCT04631536) | Lebanese American University Medical Center | 2021-01-10 |
| Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053) (NCT04634877) | Merck Sharp & Dohme LLC | 2021-01-10 |
| ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL (NCT04578613) | Beijing InnoCare Pharma Tech Co., Ltd. | 2021-01-08 |
| A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD) (NCT04630145) | Janssen Pharmaceutical K.K. | 2021-01-08 |
| Clinical Efficacy and Long Term Effects of Transcranial Direct Current Stimulation (tDCS) in Children With Attention Deficit/Hyperactivity Disorder (ADHD) (NCT04704687) | Centre Hospitalier Universitaire, Amiens | 2021-01-08 |
| Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation (NCT04467086) | Ottawa Hospital Research Institute | 2021-01-08 |
| A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) (NCT04688164) | Relmada Therapeutics, Inc. | 2021-01-08 |
| Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face (NCT04523961) | Mayo Clinic | 2021-01-08 |
| A COMPARATIVE STUDY BETWEEN 1MG AND 3 MG OF GRANISETRON IN THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN STRABISMUS OPHTHALMIC SURGERIES DURING GENERAL ANESTHESIA (NCT04918862) | Cairo University | 2021-01-08 |
| Malaria as a Risk Factor for COVID-19 in Western Kenya and Burkina Faso (NCT04695197) | Liverpool School of Tropical Medicine | 2021-01-08 |
| EPA-FFA to Treat Hospitalised Patients With COVID-19 (SARS-CoV-2) (NCT04335032) | S.L.A. Pharma AG | 2021-01-08 |
| BUN/Cr-based Hydration Therapy to Improve Outcome of Patients With Acute Ischemic Stroke (NCT05121389) | Chang Gung Memorial Hospital | 2021-01-07 |
| A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1 (NCT04534205) | BioNTech SE | 2021-01-07 |
| Anti-FGF23 (Burosumab) in Adult Patients With XLH (NCT04695860) | Wuerzburg University Hospital | 2021-01-07 |
| Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT (NCT04318886) | University of Alabama at Birmingham | 2021-01-07 |
| Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial (NCT04402788) | National Cancer Institute (NCI) | 2021-01-07 |
| Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care (NCT04581447) | Assistance Publique - Hôpitaux de Paris | 2021-01-07 |
| PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer (NCT04557501) | Centre hospitalier de l'Université de Montréal (CHUM) | 2021-01-06 |
| The Effect of Synbiotic Consumption on Glycemic, Inflammatory Markers and Body Composition on Prediabetic and Diabetic Patients (NCT04552002) | Imam Abdulrahman Bin Faisal University | 2021-01-06 |
| Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC): (NCT04607668) | G1 Therapeutics, Inc. | 2021-01-06 |
| Hip Denervation in Juvenile Idiopathic Arthritis With Hip Arthritis (NCT04775225) | Sohag University | 2021-01-06 |
| Thoracoscopic Ablation for Lone Atrial Fibrillation (NCT05708027) | Federal Research Clinical Center of Federal Medical & Biological Agency, Russia | 2021-01-06 |
| Futibatinib Versus Gemcitabine-Cisplatin Chemotherapy as First-Line Treatment of Patients With Advanced Cholangiocarcinoma Harboring FGFR2 Gene Rearrangements (NCT04093362) | Taiho Oncology, Inc. | 2021-01-06 |
| A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Study Participants With Persistent or Chronic Primary Immune Thrombocytopenia (ITP) (NCT04596995) | UCB Biopharma SRL | 2021-01-06 |
| Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) (NCT04095858) | Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2021-01-05 |
| Survival TRial Using CytoKines in COVID-19 (STRUCK Trial) (NCT04724629) | University of Sao Paulo | 2021-01-05 |
| A Study of the Efficacy and Safety of Pomalidomide Capsules Combined With Low-Dose Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (NCT05236621) | Qilu Pharmaceutical Co., Ltd. | 2021-01-04 |
| Opioid Analgesic Reduction Study (NCT04452344) | Rutgers, The State University of New Jersey | 2021-01-04 |
| DORA: A Doravirine-based First-line Antiretroviral Therapy for Women of Reproductive Potential Living With HIV (NCT04433780) | Professor Francois Venter | 2021-01-04 |
| Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2) (NCT03941132) | University of British Columbia | 2021-01-04 |
| Efficacy of Local Anesthetic Through Continuous Infusion (NCT04173312) | Ascension Health | 2021-01-04 |
| The MASTER Study (MAmmary Cancer STatin ER Positive Study) (NCT04601116) | Aarhus University Hospital | 2021-01-04 |
| CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease in Subjects Who Completed CYS-004 (NCT04523142) | Novaliq GmbH | 2021-01-04 |
| Intranasal Insulin for COVID-19-related Smell Loss (NCT05461365) | Universidad Panamericana | 2021-01-04 |
| Furosemide vs. Placebo for Severe Antepartum Hypertension (NCT04615624) | Melanie Maykin, MD | 2021-01-04 |
| Rivaroxaban Plus Aspirin to Manage Recurrent Venous Thromboembolic Events (NCT05515120) | Instituto Mexicano del Seguro Social | 2021-01-03 |