| FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage (NCT06409364) | The George Institute | 2025-08-13 |
| Pain Reprocessing Therapy in Post-Operative Knee Pain (NCT06800209) | Weill Medical College of Cornell University | 2025-08-13 |
| Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG) (NCT06030193) | Qlaris Bio, Inc. | 2025-08-13 |
| Second-Line Sacituzumab Tirumotecan Plus Anlotinib for Advanced Driver Gene-Negative Non-Squamous NSCLC (NCT07703228) | Nanfang Hospital, Southern Medical University | 2025-08-13 |
| Evaluation of the Safety and Efficacy of HSK39004 Dry Powder Inhaler in Chinese Patients With Chronic Obstructive Pulmonary Disease (COPD) (NCT07108699) | Haisco Pharmaceutical Group Co., Ltd. | 2025-08-13 |
| Ozanimod in Patients With Alzheimer's Disease (NCT06862960) | ChenXiaoChun | 2025-08-13 |
| A Phase I/II Trial of HCB101 in Combination With Pembrolizumab for Patients With Platinum-Refractory, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (SirH&N Trial) (NCT07136545) | Taipei Veterans General Hospital, Taiwan | 2025-08-13 |
| Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood (NCT06904482) | Case Comprehensive Cancer Center | 2025-08-13 |
| A Phase 2 Study to Describe the Safety and Immunogenicity of Respiratory Syncytial Virus Vaccine IN006 in Healthy Participants Aged 60 Years and Older (NCT07128121) | Shenzhen Shenxin Biotechnology Co., Ltd | 2025-08-13 |
| A Study of Epcoritamab With Lenalidomide and Tafasitamab in People With Diffuse Large B Cell Lymphoma (NCT07030699) | Memorial Sloan Kettering Cancer Center | 2025-08-13 |
| Safety and Efficacy of Asimadoline (TP0052) in Patients With Vasomotor Symptoms (VMS). (NCT07042516) | Tioga Pharmaceuticals | 2025-08-13 |
| Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (NCT07160179) | AbbVie | 2025-08-13 |
| A Clinical Study Evaluating the Efficacy and Safety of HRS-7249 in Treating Patients With Hyperlipidemia (NCT07100418) | Fujian Shengdi Pharmaceutical Co., Ltd. | 2025-08-12 |
| Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD) (NCT06940154) | Connect Biopharm LLC | 2025-08-12 |
| Pharmacogenomics ANDA SNP Clinical Study - Topotecan and Single Nucleotide Polymorphisms (NCT07145333) | Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair | 2025-08-12 |
| Food Effect, Efficacy and Safety of MKP10241 in Healthy and Obese Adult Participants, With and Without Diabetes (NCT07098663) | Mankind Pharma Limited | 2025-08-12 |
| A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors (NCT07070232) | BioNTech SE | 2025-08-12 |
| A Study of STRO4 in Patients Amyotrophic Lateral Sclerosis (ALS) (NCT06910384) | New England Cell Therapeutics, Inc. | 2025-08-12 |
| A Study of K-645 in the Treatment of Multiple Migraine Attacks (NCT07116499) | Kallyope Inc. | 2025-08-12 |
| A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia (NCT07096674) | Centessa Pharmaceuticals (UK) Limited | 2025-08-12 |
| A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV) (NCT06985147) | Disc Medicine, Inc | 2025-08-12 |
| Long-Term Outcomes of Early Communication Intervention for Deaf/Hard of Hearing Toddlers (NCT07205484) | Northwestern University | 2025-08-12 |
| Tb-PSMA-I&T Radionuclide Before Radical Prostatectomy in Patients With Locally Advanced Prostate Cancer - TbeforePROST Trial. (NCT07208240) | Rabin Medical Center | 2025-08-12 |
| Efgartigimod for the Treatment of Acute Optic Neuritis (NCT06453694) | Anastasia Vishnevetsky, MD, MPH | 2025-08-12 |
| Focused Orticumab Research for Treating Inflammation in Coronary Arteries (NCT06927739) | Abcentra | 2025-08-11 |
| Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma (NCT07460362) | Peking University Third Hospital | 2025-08-11 |
| E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers (NCT05639972) | Christian Hinrichs | 2025-08-11 |
| Feasibility of Chemotherapy De-escalation in Early-Stage HER2 Positive Breast Cancer (NCT04419181) | University of Rochester | 2025-08-11 |
| A Single-Arm, Multicenter, Exploratory Clinical Study of TACE Combined With Iparomlimab and Tuvonralimab Injection (QL1706) and Lenvatinib for Perioperative Treatment of Resectable Hepatocellular Carcinoma (NCT07131501) | The First Affiliated Hospital with Nanjing Medical University | 2025-08-11 |
| Clinical Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SYS6045 in Patients With HER2-Positive, Expressing, or Mutated Advanced Malignant Solid Tumors (NCT07122063) | CSPC Megalith Biopharmaceutical Co.,Ltd. | 2025-08-11 |
| Choline and Iron Deficiency (NCT06527391) | University of Minnesota | 2025-08-11 |
| A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) (NCT06979596) | Merck Sharp & Dohme LLC | 2025-08-11 |
| Testing the Investigational Agent Combination of Daratumumab, Bortezomib, and Dexamethasone Compared to the Usual Treatment of Cyclophosphamide, Bortezomib, and Dexamethasone in Newly Diagnosed Multiple Myeloma Patients With Kidney Failure (NCT07085728) | Eastern Cooperative Oncology Group | 2025-08-11 |
| Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS) (NCT06901687) | NYU Langone Health | 2025-08-11 |
| A Safety, Tolerability, and Efficacy Study of E-islet 01 in Participants With Type 1 Diabetes (NCT07126873) | EndoCell Therapeutics, Inc. | 2025-08-11 |
| A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors (NCT07105215) | RemeGen Co., Ltd. | 2025-08-11 |
| L-Carnitine Protective Effect in Nephrotoxicity (NCT07108777) | Tanta University | 2025-08-10 |
| A Randomized Controlled Study Comparing the Safety and Efficacy of Irinotecan Hydrochloride Liposome Injection Combined With Temozolomide and Vincristine (NALIRI-VT) Versus Irinotecan Combined With Temozolomide and Vincristine (VIT) in Patients With Advanced Ewing's Sarcoma (NCT07092306) | Tang Xiaodong | 2025-08-10 |
| ASCT Combined With BCMA CAR-T and GPRC5D/CD3 BiTEs Maintenance for Transplant-Eligible Primary Plasma Cell Leukemia (NCT07106684) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-10 |
| A Phase II Clinical Study of Induction Adebrelimab Combined With Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC) (NCT07112833) | Hebei Medical University Fourth Hospital | 2025-08-10 |
| MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma (NCT07106736) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-10 |
| A Phase II Study of Siltuximab for CRS/ICANs After CAR-T in Multiple Myeloma (NCT07106671) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-10 |
| AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer (NCT07021950) | Sun Yat-sen University | 2025-08-10 |
| ASCT Combined With BCMA CAR-T and GPRC5D/CD3 BiTEs Maintenance for Transplant-Eligible Ultra-High-Risk Multiple Myeloma (NCT07106710) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-10 |
| Efficacy and Safety of LM-302 Combined With Gemcitabine CLDN 18.2 Positive Unresectable Locally Advanced or Metastatic Pancreatic Cancer (NCT07108504) | Shanghai Zhongshan Hospital | 2025-08-10 |
| BCMA/CD3 BsAb Therapy for POEMS Syndrome (NCT07115654) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-10 |
| Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma (NCT06974786) | SCRI Development Innovations, LLC | 2025-08-08 |
| Umbilical Cord Mesenchymal Stem Cells as Adjuvant Therapy in Group E COPD Patients (NCT07441226) | RSUP Persahabatan | 2025-08-08 |
| A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) (NCT07170644) | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 2025-08-08 |
| Accelerated rTMS vs. Sham for Stroke Apathy (NCT07113067) | Medical University of South Carolina | 2025-08-08 |
| Rademikibart Add-on Treatment of an Acute Asthma Exacerbation (Seabreeze STAT Asthma) (NCT06940141) | Connect Biopharm LLC | 2025-08-08 |
| TSPO Modulation in AD (NCT07191821) | Imperial College London | 2025-08-08 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Moderate to Severe Acute Pain After Surgery (NCT07147049) | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. | 2025-08-08 |
| Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose) (NCT06912763) | M.D. Anderson Cancer Center | 2025-08-08 |
| Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive (NCT07063329) | Avistone Pharmaceutical（Ningbo）Co., LTD. | 2025-08-08 |
| A Study to Compare the Efficacy and Safety of GZR102 Injection and GZR18 Injection in Type 2 Diabetes Mellitus (NCT07055386) | Gan & Lee Pharmaceuticals. | 2025-08-07 |
| Long-Term Safety of Pirtobrutinib in Participants With Previously Treated Types of Blood Cancers (NCT07162181) | Eli Lilly and Company | 2025-08-07 |
| COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY (NCT07102836) | Quaid-e-Azam Medical College | 2025-08-07 |
| Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis (NCT06699849) | CSL Behring | 2025-08-07 |
| A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC) (NCT07098338) | AstraZeneca | 2025-08-07 |
| CRF2 Agonist for the Treatment of Worsening Heart Failure (NCT06815471) | Corteria Pharmaceuticals | 2025-08-07 |
| Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV (NCT06691243) | University of Maryland, Baltimore | 2025-08-07 |
| Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy (NCT06854159) | University of California, Davis | 2025-08-07 |
| Evaluation of Efficacy and Safety of Cemiplimab as First Line Treatment for Advanced Basal Cell Carcinoma (BCC) Patients (NCT06981325) | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 2025-08-07 |
| A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease (NCT07094516) | Novartis Pharmaceuticals | 2025-08-07 |
| HM2023-43:Ph 2 Trial of Tafasitamab With Lenalidomide+Rituximab in Treatment-naive FL and MZL (NCT06792825) | Masonic Cancer Center, University of Minnesota | 2025-08-07 |
| Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer (NCT06865339) | Montefiore Medical Center | 2025-08-07 |
| Chemoimmunotherapy for ALK+ Relapsed/Refractory ALCL (NCT07013565) | New York Medical College | 2025-08-07 |
| Phase II Study of Radiotherapy Followed by Durvalumab and Ceralasertib in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen (NCT06680050) | Mario Negri Institute for Pharmacological Research | 2025-08-07 |
| Axatilimab for Sclerotic Chronic Graft-versus-Host Disease (NCT07011810) | Fred Hutchinson Cancer Center | 2025-08-06 |
| ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors (NCT07158918) | ABL Bio, Inc. | 2025-08-06 |
| Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases (NCT06712927) | Stanford University | 2025-08-06 |
| A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil (NCT07199946) | Johnny Ludvigsson | 2025-08-06 |
| Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis (NCT07029581) | ACADIA Pharmaceuticals Inc. | 2025-08-06 |
| A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the Leg (NCT06965998) | Ottawa Hospital Research Institute | 2025-08-06 |
| A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant (NCT07092865) | GlaxoSmithKline | 2025-08-06 |
| A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months (NCT07036159) | GlaxoSmithKline | 2025-08-06 |
| A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma (NCT07142421) | First Affiliated Hospital of Zhejiang University | 2025-08-06 |
| A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma (NCT06624644) | Linnaeus Therapeutics, Inc. | 2025-08-06 |
| Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease (NCT07027072) | NeuroBiogen Co., Ltd | 2025-08-06 |
| A Clinical Study on the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of SHR-1819 Injection in Patients With Seasonal Allergic Rhinitis (NCT07091357) | Guangdong Hengrui Pharmaceutical Co., Ltd | 2025-08-06 |
| Efficacy of Integrated Induction-Consolidation Chemotherapy and Transplantation for Adult Acute Myeloid Leukemia: Multicenter Study (NCT07108530) | Shanxi Bethune Hospital | 2025-08-06 |
| Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease (NCT06607458) | Delcath Systems Inc. | 2025-08-05 |
| Durvalumab and Tremelimumab With Lenvatinib as First-line Treatment in Patients With Unresectable Hepatocellular Carcinoma (NCT07081633) | AstraZeneca | 2025-08-05 |
| Pirtobrutinib in Combination With Rituximab, Gemcitabine, Oxaliplatin With or Without Polatuzumab Vedotin in Covalent BTK Inhibitor-Pretreated Relapsed/Refractory Diffuse Large B-Cell Lymphoma (NCT07122609) | Ruijin Hospital | 2025-08-05 |
| A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection (NCT07142811) | Vir Biotechnology, Inc. | 2025-08-05 |
| Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease (NCT06876363) | Ensoma | 2025-08-05 |
| Therapeutic Effect of Microfragmented Adipose Tissue (Lipogems) Injection on Maximum Interincisal Opening Versus Injectable Platelet-rich Plasma (PRP) for the Treatment of Anterior Disc Displacement With Reduction : A Randomized Clinical Trial (NCT07107399) | Cairo University | 2025-08-05 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Human Sialidase Fusion Protein (HLX79) in Combination With Rituximab Injection Versus Placebo in Patients With Active Glomerulonephritis (NCT07038382) | Shanghai Henlius Biotech | 2025-08-05 |
| A Study of Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (NCT07060989) | Nutshell Therapeutics (Shanghai) Co., LTD. | 2025-08-04 |
| Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD. (NCT07079761) | Massachusetts General Hospital | 2025-08-04 |
| An Immunogenicity and Safety Trial of MVA-BN in Adults Living With HIV for the Prevention of Mpox Infection, in Kinshasa, DRC (NCT06839989) | Institute of Tropical Medicine, Belgium | 2025-08-04 |
| A Study of YL202 in Patients With Advanced Solid Tumors (NCT07202364) | MediLink Therapeutics (Suzhou) Co., Ltd. | 2025-08-04 |
| Randomized, Double Blind, Placebo-controlled Phase 2 Study in Adults With Celiac Disease (NCT06982963) | Forte Biosciences, Inc. | 2025-08-04 |
| Triple Negative Breast Cancer and Celecoxib. Pilot Study (NCT07104266) | Université de Sherbrooke | 2025-08-04 |
| A Study Evaluating OBI-902 in Participants With Advanced Solid Tumors (NCT07124117) | OBI Pharma, Inc | 2025-08-04 |
| A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia (NCT07145918) | AbbVie | 2025-08-04 |
| Safety and Efficacy of ZVS203e in the Treatment of Retinitis Pigmentosa Caused by RHO Gene Mutation (NCT06952842) | Chigenovo Co., Ltd | 2025-08-04 |
| Safety and Efficacy Study of Zamtocabtagene Autoleucel (MB-CART2019.1) in Pediatric Patients With R/R B-Cell Neoplasms (NCT06508931) | Miltenyi Biomedicine GmbH | 2025-08-04 |
| Efficacy of Carminal in Helicobacter Pylori Gastritis (NCT07179237) | Catalysis SL | 2025-08-04 |