| Neoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE-CC) (NCT07055399) | Fujian Cancer Hospital | 2025-08-21 |
| A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029) (NCT07058077) | Merck Sharp & Dohme LLC | 2025-08-21 |
| Evaluation of Microbiota Transplant Therapy in Patients With Alopecia Areata (NCT06747611) | University of Minnesota | 2025-08-21 |
| A Study of SPY072 in Rheumatic Disease (NCT07148414) | Spyre Therapeutics, Inc. | 2025-08-21 |
| Engaging T-cells to Eliminate MRD in Newly Diagnosed Myeloma Optimizing Response With Talquetmab and Teclistamab (ROTATE) (NCT06993675) | Noffar Bar | 2025-08-21 |
| A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06) (NCT07082686) | Beijing InnoCare Pharma Tech Co., Ltd. | 2025-08-21 |
| Neoadjuvant Nivolumab + Relatlimab (Opdualag) Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma (NCT06624475) | University of California, San Diego | 2025-08-21 |
| Neoadjuvant Treatment of Locally Advanced Hypopharyngeal Cancer With Adebrelimab Combined With TP Chemotherapy Regimen (NCT07137039) | The First Affiliated Hospital of Xiamen University | 2025-08-20 |
| Sacituzumab Tirumotecan in Neoadjuvant Treatment of Early-Stage TNBC (NCT07007780) | Xijing Hospital | 2025-08-20 |
| A Single-Arm, Multicenter, Exploratory Clinical Study of Transarterial Chemoembolization (TACE) Combined With Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection for the Treatment of Unresectable, Non-Metastatic Hepatocellular Carcinoma (HCC) (NCT07128251) | Anhui Provincial Hospital | 2025-08-20 |
| A Platform Trial Evaluating New Drugs or Combination in R/R Peripheral T-cell Lymphomas (NCT07018752) | The Lymphoma Academic Research Organisation | 2025-08-20 |
| Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis (NCT07129629) | Shanghai Pulmonary Hospital, Shanghai, China | 2025-08-20 |
| Phase 2b Controlled Study (NCT07140380) | IVIEW Therapeutics Inc. | 2025-08-20 |
| A Pilot Study to Assess How Safe and Effective Oral Roflumilast is for Treating Moderate to Severe Psoriasis in Adults (NCT07233291) | Ahmed Ibrahim | 2025-08-20 |
| An Open-label Long-term Follow-up Study of SAT-3247 for Participants With Duchenne Muscular Dystrophy Including Those Who Participated in SAT-3247-CL-101 (NCT06867107) | Satellos Bioscience, Inc. | 2025-08-20 |
| Propranolol for the Treatment of Kaposi Sarcoma in Adults (NCT06445166) | Washington University School of Medicine | 2025-08-20 |
| Cryoablation Combined With Lenvatinib Plus QL1706 (Iparomlimab/Tuvonralimab) in Patients With Advanced Intrahepatic Cholangiocarcinoma (NCT07070700) | Fudan University | 2025-08-20 |
| ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors (NCT06998407) | Avenzo Therapeutics, Inc. | 2025-08-20 |
| The Efficacy and Safety of Neoadjuvant Therapy With Iparomlimab and Tuvonralimab in Locally Advanced MSI-H/dMMR Colorectal Cancer: An Prospective, Single-Arm Study (Neo-IT) (NCT07160647) | Sir Run Run Shaw Hospital | 2025-08-20 |
| Safety and Immunogenicity of Cat-allergen Intralymphatic Immunotherapy in Patients With Cat Allergy With and Without Asthma (NCT06960382) | University of Zurich | 2025-08-20 |
| EBV Lytic Reactivation Therapy Combined With PD-1 Antibody in Recurrent/Metastatic Nasopharyngeal Carcinoma (NCT07138989) | Sun Yat-sen University | 2025-08-19 |
| Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer (NCT07076485) | M.D. Anderson Cancer Center | 2025-08-19 |
| DZD8586 Combination Therapy in Patients With Diffuse Large B-cell Lymphoma (TAI-SHAN12) (NCT07059650) | Dizal Pharmaceuticals | 2025-08-19 |
| PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer (NCT07133750) | Biotheus Inc. | 2025-08-19 |
| Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity (NCT07001748) | ECOG-ACRIN Cancer Research Group | 2025-08-19 |
| The Efficacy and Safety of Combined Teriflunomide and High-dose Dexamethasone in Newly Diagnosed Primary Immune Thrombocytopenia (TEMPO-2) (NCT07065968) | Peking University People's Hospital | 2025-08-19 |
| A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis (NCT06989645) | Synartro AB | 2025-08-19 |
| Study of CM512 Injection in Subjects With Moderate-to-severe Asthma (NCT07011524) | Keymed Biosciences Co.Ltd | 2025-08-19 |
| A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes (NCT07112872) | Hoffmann-La Roche | 2025-08-19 |
| Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer (NCT06727773) | UNC Lineberger Comprehensive Cancer Center | 2025-08-19 |
| The COSMYC Trial (COmbined Suppression of MYC) (NCT06922318) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2025-08-19 |
| Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer. (NCT07039526) | John Waters | 2025-08-19 |
| A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer (NCT07005154) | Astellas Pharma Global Development, Inc. | 2025-08-19 |
| A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients (NCT06845553) | Glaceum | 2025-08-19 |
| Interleukin-15 to Promote Post-ART Control of HIV (NCT07145164) | Michael Peluso, MD | 2025-08-19 |
| Study of HuL001 in Relapsed/Refractory Multiple Myeloma Patients (NCT07210047) | HuniLife Biotechnology, Inc. | 2025-08-18 |
| A Clinical Trial of CAP-003 Gene Therapy in Adult Patients With GBA1 Associated Parkinson's Disease (NCT07011771) | Capsida Biotherapeutics, Inc. | 2025-08-18 |
| A Study of Narmafotinib Given in Combination With Modified FOLFIRINOX in Patients With Metastatic Pancreatic Cancer (NCT07026279) | Amplia Therapeutics Limited | 2025-08-18 |
| An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM) (NCT06961344) | Tisento Therapeutics | 2025-08-18 |
| A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer (NCT06868485) | Wayshine Biopharm, Inc. | 2025-08-18 |
| Efficacy and Safety of HK-660S in the Treatment of Primary Sclerosing Cholangitis (NCT06975150) | CuromeBiosciences | 2025-08-18 |
| A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis. (NCT07081646) | Alexion Pharmaceuticals, Inc. | 2025-08-18 |
| Efficacy and Safety of Trastuzumab Rezetecan Followed by CDK4/6 Inhibitors and Endocrine Therapy in HR+/HER2-Low/Ultra-Low Advanced Breast Cancer (NCT07037199) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-08-18 |
| A Study to Evaluate the Efficacy and Safety of HTMC0658 Tablets in the Treatment of Chronic Rhinosinusitis Without Nasal Polyps (NCT07174115) | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. | 2025-08-18 |
| Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma (NCT06070012) | Diwakar Davar | 2025-08-18 |
| Study of How Safe and Effective Tarlatamab is in Brain Cancers (NCT06776250) | University Health Network, Toronto | 2025-08-18 |
| Implementing Food Referrals for Equity and Sustained Health (NCT06661538) | University of California, San Diego | 2025-08-18 |
| Topical Menthol For Tear Secretion (NCT07109609) | Reinhold Vieth | 2025-08-17 |
| JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma (NCT07081022) | Shanghai Junshi Bioscience Co., Ltd. | 2025-08-17 |
| Effect of Ebastine in Patients With Diarrhea Predominant Irritable Bowel Syndrome (NCT07114055) | Md. Hazrat Ali | 2025-08-15 |
| A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis (NCT06887192) | MapLight Therapeutics | 2025-08-15 |
| Ivonescimab (AK112) Plus Paclitaxel as Second-line Therapy in Patients With Advanced G/GEJ Cancer (NCT06904300) | Sun Yat-sen University | 2025-08-15 |
| Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/ III Colorectal Cancer (NCT07095309) | Metanoic Health Ltd. | 2025-08-15 |
| Irinotecan Liposome II + 5-FU/LV + Oxaliplatin + Karelizumab in Neoadjuvant Treatment of Gastric Cancer (NCT07085273) | The First Affiliated Hospital of Zhengzhou University | 2025-08-15 |
| A Study Comparing the Efficacy and Safety of HB1801 With Taxotere® in Advanced Breast Cancer (NCT07083505) | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 2025-08-15 |
| Neoadjuvant Chemotherapy Before Surgery vs Surgery Alone for UTUC: A Randomized Trial (NCT07492225) | Changhai Hospital | 2025-08-15 |
| HAIC Combined With Camrelizumab Plus Rivoceranib for Advanced Mixed Hepatocellular-cholangiocarcinoma (HCC-CCA) (NCT07105748) | Fudan University | 2025-08-15 |
| Anti-TNFα Therapy for Improving Pregnancy Rates in Endometriosis Patients With Failed ICSI (NCT07509411) | Benha University | 2025-08-15 |
| [68Ga]Ga-FAPI Total Body PET/CT for Better and Faster Imaging in Cancer (NCT07215182) | Barbara Malene Fischer | 2025-08-15 |
| Ivonescimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy Followed by Type A Hysterectomy in Stage IB2 and IIA1 Cervical Cancer (NCT07130240) | Obstetrics & Gynecology Hospital of Fudan University | 2025-08-15 |
| Cemiplimab for the Treatment of Incurable Metastatic or Unresectable NUT Carcinoma (NCT07050186) | Northwestern University | 2025-08-15 |
| Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers (NCT06216366) | BioAegis Therapeutics Inc. | 2025-08-15 |
| Phase 2, Single-arm Trial of BMS-986340 in Association With Nivolumab, Trifluridine/Tipiracil and Bevacizumab for Patients Refractory to Standard of Care Treatment and With Microsatellite-stable Colorectal Cancer (NCT07011550) | M.D. Anderson Cancer Center | 2025-08-15 |
| A Double-Blind, Randomized, Placebo-Controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of L2-01 in Subjects With Crohn's Disease (NCT07010926) | L2 Bio, LLC | 2025-08-15 |
| A Single-center, Phase II Clinical Trial Evaluating the Efficacy of Sacituzumab Tirumotecan in Combination With Tagitanlimab as Neoadjuvant Therapy for PD-L1-positive, Resectable Stage II to IIIB Non-small Cell Lung Cancer (NSCLC) (NCT07108816) | Henan Cancer Hospital | 2025-08-15 |
| Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin (NCT07047040) | Assiut University | 2025-08-15 |
| A First-in-human Clinical Trial Using a Gene Therapy With Patient's Own Stem Cells to Treat Early Type 1 Diabetes (NCT06938334) | Altheia Science | 2025-08-15 |
| Sacituzumab Tirumotecan Plus Anlotinib for Metastatic Triple Negative Breast Cancer (NCT07139470) | Tianjin Medical University Cancer Institute and Hospital | 2025-08-15 |
| A Prospective, Open-label, Exploratory Basket Trial to Evaluate the Efficacy and Safety of Sintilimab Combined With Pyrotinib ± Chemotherapy in Patients With Advanced Digestive System Tumors (NCT07053150) | Tongji Hospital | 2025-08-15 |
| KinesioTaping for Thoracic Drain Support (NCT07098962) | Kastamonu University | 2025-08-15 |
| Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON Trial (NCT06866262) | University of Michigan Rogel Cancer Center | 2025-08-15 |
| Hyperthermia Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Gastrointestinal Malignancies With Liver Metastases (NCT07118566) | China Medical University, China | 2025-08-15 |
| Aleniglipron Phase 2 Body Composition Study (NCT07169942) | Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | 2025-08-15 |
| Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study (NCT07137858) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-08-15 |
| Lorlatinib in ROS1+ NSCLC With Brain Metastasis (NCT07083687) | Hunan Cancer Hospital | 2025-08-15 |
| Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC) (NCT06603818) | National Cancer Institute (NCI) | 2025-08-15 |
| Radiotherapy Omitting Prophylactic Neck Irradiation With Neoadjuvant and Adjuvant Toripalimab in Nasopharyngeal Carcinoma (NCT07110558) | Sun Yat-sen University | 2025-08-15 |
| Clinical Study of XNW5004 Combined With CHOP/CHOEP in the Treatment of Untreated Peripheral T-Cell Lymphoma (NCT07730515) | Evopoint Biosciences Inc. | 2025-08-15 |
| Orelabrutinib Combined With Zebetuzumab and Lenalidomide for the Treatment of Newly Diagnosed MZL (NCT07208981) | The First Affiliated Hospital with Nanjing Medical University | 2025-08-14 |
| A New Intervention to Improve Function in Veterans With Anxiety and Depression (NCT06188923) | VA Office of Research and Development | 2025-08-14 |
| Efficacy of Stereotactic Body Radiotherapy (SBRT) Combined With Maintenance Therapy Compared to Maintenance Therapy Alone in Advanced Pancreatic Cancer (NCT07600268) | Shandong Cancer Hospital and Institute | 2025-08-14 |
| Efficacy and Safety of BT200 (Rondaptivon Pegol) in Patients With Type 2B Von Willebrand Disease (NCT07273721) | Medical University of Vienna | 2025-08-14 |
| Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) (NCT06571708) | Columbia University | 2025-08-14 |
| A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) (NCT06661915) | National Cancer Institute (NCI) | 2025-08-14 |
| An Open-label Study to Evaluate Safety, Tolerability, and Efficacy of CB03-154 in Subjects Diagnosed With Epilepsy (NCT07238868) | Shanghai Zhimeng Biopharma, Inc. | 2025-08-14 |
| Nal-IRI (ONIVYDE® ) and Carboplatin in Patients With Advanced or Metastatic GEP-NET (NCT05385861) | National Health Research Institutes, Taiwan | 2025-08-14 |
| Open-label Extension Study in Participants With Early Alzheimer's Disease (NCT07105709) | GlaxoSmithKline | 2025-08-14 |
| Efficacy And Safety Of Anti-PD-1/PD-L1 Antibodies In Combination With Bevacizumab And Metronomic Cyclophosphamide In Patients With Non-Small Cell Lung Cancer And Cutaneous Melanoma Previously Treated With Immune Checkpoint Blockade (NCT07130032) | EuroCityClinic LLC | 2025-08-14 |
| A Single-arm, Multicenter, Exploratory Study of Adebrelimab Combined With Apatinib and Systemic Chemotherapy for Initially Unresectable Biliary Tract Cancer (NCT07135544) | Yongjun Chen | 2025-08-14 |
| Empowering Cessation ACS South Region (NCT06820034) | University of Oklahoma | 2025-08-14 |
| Study of the Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of BCD-261 in Subjects With Moderate to Severe Active Ulcerative Colitis (NCT07080034) | Biocad | 2025-08-14 |
| Clinical Study of the Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of BCD-261 in Subjects With Moderate to Severe Active Crohn's Disease (NCT07078994) | Biocad | 2025-08-14 |
| A Phase I/IIa Study of GKL-006 Injection in Patients With Advanced Pancreatic Cancer (NCT07777211) | Beijing Gene Key Life Technology Co., Ltd | 2025-08-14 |
| Tauroursodeoxycholic Acid (TUDCA) Plus Camrelizumab and Regorafenib in Hepatocellular Carcinoma Previously Treated With Anti-PD1/PD-L1 and Bevacizumab (NCT07100392) | Fudan University | 2025-08-14 |
| ELISA in Relapsed/Refractory MM (NCT06832865) | Massachusetts General Hospital | 2025-08-14 |
| Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery (NCT07050771) | The Methodist Hospital Research Institute | 2025-08-14 |
| A Mobile Intervention to Reduce Pain and Improve Health-III (NCT06623669) | Wake Forest University | 2025-08-14 |
| Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery (NCT07020312) | Rush University Medical Center | 2025-08-14 |
| A Study of HB0025 Plus Nab-paclitaxel as First Line Therapy for TNBC (NCT07376629) | Huabo Biopharm Co., Ltd. | 2025-08-14 |
| IN10018 Combination Therapy in Previously-treated Solid Tumors (NCT05982522) | InxMed (Shanghai) Co., Ltd. | 2025-08-13 |