| 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab (NCT07124884) | Federation Francophone de Cancerologie Digestive | 2025-08-31 |
| Combination Immunotherapy Targeting Melanoma (NCT06739226) | Shenzhen Geno-Immune Medical Institute | 2025-08-31 |
| Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks (NCT05641766) | Yale University | 2025-08-31 |
| Radiotherapy Combined QL1706, TAS-102 and Bevacizumab in mCRC (NCT07116577) | Jinan Central Hospital | 2025-08-31 |
| Evaluating the Efficacy and Safety of GB08 Injection in Pediatric Patients With Growth Hormone Deficiency (NCT07126288) | Shenzhen Kexing Pharmaceutical Co., Ltd. | 2025-08-31 |
| Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City (NCT07673380) | Washington University School of Medicine | 2025-08-31 |
| Evaluate the Efficacy and Safety of XKH001 Injection in Patients With Moderate-to-Severe Atopic Dermatitis (NCT07054736) | Zhejiang Kanova Biopharmaceutical Co., LTD | 2025-08-31 |
| Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial (NCT07106034) | Shanghai Pudong Hospital | 2025-08-31 |
| A Study of GR1803 Injection in Combination With Anti-CD38 Monoclonal Antibody for the Treatment of Participants With Multiple Myeloma (NCT07090954) | Genrix (Shanghai) Biopharmaceutical Co., Ltd. | 2025-08-31 |
| Menstrual Blood-Derived Mesenchymal Stem Cell Injection (SC01009) in the Treatment of Idiopathic Pulmonary Fibrosis (NCT07131150) | Ruijin Hospital | 2025-08-31 |
| QL1706 With Olaparib for Previously Treated HER2-negative Breast Cancer Patients With Homologous Recombination Deficiency (HRD) (NCT07113964) | The First Affiliated Hospital with Nanjing Medical University | 2025-08-30 |
| Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial (NCT07230639) | Sixth Affiliated Hospital, Sun Yat-sen University | 2025-08-30 |
| Using Xe MRI to Guide Radiation Therapy for Lung Cancer (NCT06925295) | Sean Fain | 2025-08-30 |
| SYS6002 Plus JMT101 and Enlonstobart Injection in Participants With HNSCC (NCT06989671) | CSPC Megalith Biopharmaceutical Co.,Ltd. | 2025-08-30 |
| Dexrazoxane to Protect Against Hemorrhagic STEMI (NCT07502521) | Rohan Dharmakumar | 2025-08-30 |
| Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases (NCT07100600) | Henan Cancer Hospital | 2025-08-30 |
| Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan (NCT07207434) | Aga Khan University | 2025-08-30 |
| Efficacy and Safety of Two Bladder-preserving Treatment Durations With Disitamab Vedotin Plus Toripalimab Combination in Her2-expressing Muscle-invasive Bladder Cancer: A Phase II, Open-Label, Randomized Clinical Trial (NCT07151560) | Renmin Hospital of Wuhan University | 2025-08-30 |
| Disitamab Vedotin Plus Lenvatinib and PD-1 Inhibitors for Treating HER2-positive Advanced Biliary Tract Cancer (NCT07159217) | Peking Union Medical College Hospital | 2025-08-30 |
| Plans4Care: Personalized Dementia Care on Demand (NCT07115251) | Plans4Care Inc | 2025-08-30 |
| Evaluation of Exosomes Injection in Treatment of Male Androgenetic Alopecia: Clinical and Immunohistochemical Study (NCT07112586) | Ain Shams University | 2025-08-30 |
| A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45 (NCT07038824) | Entrada Therapeutics, Inc. | 2025-08-30 |
| SHR-A1811 Combine With Pyrotinib for Locally Advanced/Metastatic HER2 Positive Breast Cancer (NCT07132242) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-08-30 |
| A Study of SKB518 in Patients With Lung Cancer (NCT07019675) | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | 2025-08-29 |
| Sirolimus for Injection (Albumin Bound) Combined With Octreotide Long-acting Injection in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors (NCT07165886) | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 2025-08-29 |
| A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa (NCT06628947) | Kiora Pharmaceuticals, Inc. | 2025-08-29 |
| The Efficacy and Safety of the Combination of PD-1 With Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients (NCT07138755) | The Third Xiangya Hospital of Central South University | 2025-08-29 |
| The Study is Being Conducted to Evaluate the Efficacy and Safety of Dexmedetomidine Hydrochloride Microneedles for Preoperative Sedation in Children (NCT07168720) | Guangzhou Novaken Pharm Co., Ltd. | 2025-08-29 |
| A Study to Investigate the Effects of AZD0901 Monotherapy in Adult Participants With 2L+ Advanced or Metastatic Gastric or GEJ Adenocarcinoma Expressing CLDN18.2 (NCT07143604) | AstraZeneca | 2025-08-29 |
| Clinical Study to Evaluate the Efficacy and Safety of Huperzine A Controlled-Release Tablets in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type (NCT07066826) | Wanbangde Pharmaceutical Group Co., LTD | 2025-08-29 |
| External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease (NCT06572605) | City of Hope Medical Center | 2025-08-29 |
| A Study of LM-350 in Subjects With Advanced Solid Tumours (NCT07112222) | LaNova Medicines Limited | 2025-08-28 |
| Study of Re-Treatment With ALXN2220 in Patients With ATTR-CM (NCT07213583) | Neurimmune AG | 2025-08-28 |
| A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy (NCT06866964) | Wake Forest University Health Sciences | 2025-08-28 |
| Utidelone Capsule Combined With Fluoropyrimidine- and Platinum-containing Therapy in First-line Treatment of Patients With Gastric or Gastroesophageal Junction Adenocarcinoma (NCT06841679) | Beijing Biostar Pharmaceuticals Co., Ltd. | 2025-08-28 |
| An Open-Label Extension Study of Batoclimab in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (NCT07188844) | Immunovant Sciences GmbH | 2025-08-28 |
| Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer (NCT06954831) | City of Hope Medical Center | 2025-08-28 |
| A Trial of Adebrelimab Plus (SHR-A1811/SHR-A1904 With Chemotherapy) or SHR-8068 as Treatment for Gastric/GEJ Cancer (NCT07110571) | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 2025-08-28 |
| Continuous or Intermittent Pyrotinib for HER2-positive Advanced Breast Cancer (NCT07180082) | Wenjin Yin | 2025-08-28 |
| Personalized Antisense Oligonucleotide Therapy for a Single Participant With PRPH2 Mutation Associated With Retinal Dystrophy (NCT07177196) | n-Lorem Foundation | 2025-08-28 |
| Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease (NCT06989359) | ADARx Pharmaceuticals, Inc. | 2025-08-28 |
| Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) (NCT07150949) | Fudan University | 2025-08-28 |
| 24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs (NCT07543822) | Children's Hospital of Philadelphia | 2025-08-27 |
| Epicardial Delivery of XC001 Gene Therapy to Promote Angiogenesis in CAD Patients Undergoing Treatment With CABG (NCT07118449) | XyloCor Therapeutics, Inc. | 2025-08-27 |
| Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1 (NCT06188741) | University of Alabama at Birmingham | 2025-08-27 |
| 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs (NCT07549646) | Children's Hospital of Philadelphia | 2025-08-27 |
| Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA） (NCT07127042) | ScinnoHub Pharmaceutical Co., Ltd. | 2025-08-27 |
| A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as Monotherapy or in Combination With BNT327 in Adults With Advanced Solid Tumors (NCT07147348) | BioNTech SE | 2025-08-27 |
| mFOLFOX/mFOLFIRI vs. mFOLFOX in Advanced or Recurrent Biliary Tract Cancer Second-line (NCT07062536) | Seoul National University Bundang Hospital | 2025-08-27 |
| Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients (NCT07338682) | German University in Cairo | 2025-08-27 |
| A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia (NCT07191483) | Kynexis B.V. | 2025-08-27 |
| Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer (NCT07073794) | Mayo Clinic | 2025-08-27 |
| Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma (NCT07093710) | Sun Yat-sen University | 2025-08-27 |
| A Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Intravenous Infusion of hUC-MSCs in Patients With AIS (NCT07084012) | Shenzhen Wingor Biotechnology Co., Ltd. | 2025-08-27 |
| Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors (NCT07030257) | Tasca Therapeutics | 2025-08-27 |
| Phase 2b Study of EVO756 in Adults With Atopic Dermatitis (NCT07150845) | Evommune, Inc. | 2025-08-26 |
| Repurposing Siponimod for Alzheimer's Disease (NCT06639282) | St. Joseph's Hospital and Medical Center, Phoenix | 2025-08-26 |
| A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors (NCT07169734) | Alentis Therapeutics AG | 2025-08-26 |
| A Study Evaluating TRIV-509 in Atopic Dermatitis (NCT07167758) | Triveni Bio | 2025-08-26 |
| Phase 2 Study Assessing the Clinical Activity and Safety of Obecabtagene Autoleucel as a Consolidation in Patients With Newly Diagnosed High-risk B-cell Acute Lymphocytic Leukemia (ALL) (NCT07053059) | M.D. Anderson Cancer Center | 2025-08-26 |
| IBI363 Combined With Chemotherapy or Pembrolizumab Combined With Chemotherapy as Neoadjuvant Therapy in Resectable Stage IB-III Non-Squamous Non-Small Cell Lung Cancer (NCT07122687) | Innovent Biologics (Suzhou) Co. Ltd. | 2025-08-26 |
| A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE) (NCT07164833) | Bilix Co.,Ltd. | 2025-08-26 |
| Golidocitinib and Chidamide for Cutaneous T-Cell Lymphoma (NCT07754890) | Peking Union Medical College Hospital | 2025-08-26 |
| 3°C Saline Injection at the Duodenal Papilla to Prevent Post-ERCP Pancreatitis (NCT07381478) | Universidad Nacional de Colombia | 2025-08-26 |
| Study to Evaluate Efficacy and Dose Response of Imapextide (STEADI) (NCT07029412) | MBX Biosciences | 2025-08-26 |
| Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare (NCT07145229) | Atom Therapeutics Co., Ltd | 2025-08-26 |
| A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations (NCT06906562) | Sameek Roychowdhury | 2025-08-26 |
| Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial (NCT07025369) | Mayo Clinic | 2025-08-25 |
| A Study of Anti-CD38 Monoclonal Antibody (SG301) Subcutaneous Injection in Children With Nephrotic Syndrome With Frequent Relapses or Steroid Dependence (NCT07087314) | Mao Jianhua | 2025-08-25 |
| A Study to Assess the Immune Response and Safety of a Vaccine Against Influenza in Adults 18 Years of Age and Older (NCT07121192) | GlaxoSmithKline | 2025-08-25 |
| Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer (NCT06388369) | University Hospital, Essen | 2025-08-25 |
| Intracochlear Injection of Glucocorticoid (NCT07134075) | Eye & ENT Hospital of Fudan University | 2025-08-25 |
| A Study to Evaluate the Long-Term Safety and Efficacy of HSK39297 Tablets in Primary IgA Nephropathy (NCT07616700) | Haisco Pharmaceutical Group Co., Ltd. | 2025-08-25 |
| Envafolimab Combined With Neoadjuvant Chemotherapy Treat Stage IIb Resectable Osteosarcoma Patients (NCT07142863) | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 2025-08-25 |
| Modulation Effect of tACS on Chronic Low Back Pain (NCT06568198) | Massachusetts General Hospital | 2025-08-25 |
| Loncastuximab Tesirine and Rituximab as Bridging Therapy Before Standard-of-care CAR-T Therapy in Patients With Large B-cell Lymphoma (CORAL) (NCT06788964) | University of Utah | 2025-08-25 |
| HRS-4642 in Combination With Gemcitabine and Albumin-bound Paclitaxel and Adebrelimab for Neoadjuvant and Adjuvant Treatment of Pancreatic Cancer (NCT07131514) | Ruijin Hospital | 2025-08-25 |
| Radiation Combined With BCMA/CD3 Bispecific Antibody Therapy for Solitary Bone Plasmacytoma With Mild Bone Marrow Infiltration (NCT07115667) | Institute of Hematology & Blood Diseases Hospital, China | 2025-08-25 |
| A Study to Assess Safety and Tolerability and to Explore Efficacy of NSC001 in Mild to Moderate Alzheimer's Disease (NCT06995573) | NSC-Therapeutics | 2025-08-25 |
| The Efficacy and Safety of Efsubaglutide Alfa in Overweight/Obesity（SPARKLE） (NCT07114419) | Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. | 2025-08-25 |
| Gene Therapy for SLC6A1 Neurodevelopmental Disorder (NCT07173153) | Emily de los Reyes | 2025-08-25 |
| A Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal Toxicity (NCT06830863) | Azitra Inc. | 2025-08-25 |
| A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy (NCT06987968) | Genfit | 2025-08-25 |
| Adebrelimab Combine With Etoposide Capsules in ES-SCLC Maintenance Therapy (NCT07141264) | Tang-Du Hospital | 2025-08-25 |
| A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy (NCT07096843) | Climb Bio, Inc. | 2025-08-25 |
| Study of YK012 in Moderate to Severe Systemic Lupus Erythematosus (NCT07010835) | Excyte Biopharma Ltd | 2025-08-25 |
| DRonabinol Treatment of OSA (NCT06477952) | VA Office of Research and Development | 2025-08-25 |
| A Phase II Single-Arm Study of Iparomlimab and Tuvonralimab (QL1706) in Combination With Lenvatinib and TACE for Advanced Hepatocellular Carcinoma (NCT07150377) | The Second Affiliated Hospital of Shandong First Medical University | 2025-08-24 |
| To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of KN060 in ESRD Dialysis Patients (NCT07201467) | Suzhou Alphamab Co., Ltd. | 2025-08-22 |
| Pfs230D1 + R21 in Matrix-M1 in African School Children and Adults (NCT07147400) | Serum Institute of India Pvt. Ltd. | 2025-08-22 |
| Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease (NCT04774536) | Mark Walters, MD | 2025-08-22 |
| A Study of Yttrium [90Y] Microsphere Injection in Combination With Targeted Immunotherapy in the Treatment of HCC (NCT07334483) | GrandPharma (China) Co., Ltd. | 2025-08-22 |
| Study of Epcoritamab as a Consolidation Therapy in CLL/SLL (NCT07108998) | Zulfa Omer | 2025-08-22 |
| HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM (NCT06822972) | Duke University | 2025-08-22 |
| Toripalimab, Induction Chemotherapy, Radiation Therapy With Omega-3 for Locally Advanced Nasopharyngeal Carcinoma (NCT07136519) | Affiliated Hospital of Guangdong Medical University | 2025-08-22 |
| Lparomlimab and Tuvonralimab Injection in Combination With TACE and Lenvatinib in the Treatment of Second-Line Therapy for Unresectable Intermediate-to-Advanced Hepatocellular Carcinoma (NCT07099274) | Tianjin Medical University Cancer Institute and Hospital | 2025-08-22 |
| Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors (NCT07151040) | One-carbon Therapeutics AB | 2025-08-22 |
| Adjunctive Doxycycline for Central Nervous System Tuberculosis (NCT06446245) | National University Hospital, Singapore | 2025-08-21 |
| A Study of BL-B01D1 + Pembrolizumab ± Bevacizumab in Patients With Recurrent or Metastatic Cervical Cancer and Endometrial Cancer (NCT07054567) | Sichuan Baili Pharmaceutical Co., Ltd. | 2025-08-21 |
| A Study Investigating the Efficacy and Safety of BGB-45035 Versus Placebo in Adults With Moderate to Severe Active Rheumatoid Arthritis (NCT07100938) | BeiGene | 2025-08-21 |