| The Efficacy of HLX208 (BRAF V600E Inhibitor) for Refractory Primary Brain Tumors With BRAF Mutation After First-line Treatment (NCT05092802) | Shanghai Henlius Biotech | 2021-12-23 |
| A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma (NCT05147558) | Memorial Sloan Kettering Cancer Center | 2021-12-23 |
| Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Sub-study 3 (NCT06926673) | GlaxoSmithKline | 2021-12-23 |
| Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis (NCT05163886) | OrphAI Therapeutics | 2021-12-23 |
| Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (NCT04939701) | Astellas Pharma Global Development, Inc. | 2021-12-23 |
| APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma (NCT04942067) | Ascentage Pharma Group Inc. | 2021-12-23 |
| Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study (NCT04685590) | Washington University School of Medicine | 2021-12-22 |
| A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors (NCT05148195) | Jiangsu Simcere Pharmaceutical Co., Ltd. | 2021-12-22 |
| The Safety and Immunogenicity of SCTV01C in Healthy Population Aged ≥18 Years Previously Vaccinated With mRNA COVID-19 Vaccine. (NCT05043311) | Sinocelltech Ltd. | 2021-12-22 |
| A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer. (NCT05205252) | Epizyme, Inc. | 2021-12-22 |
| Efficacy Assessment of Chinese Herbal Medicine Jiangtang Tiaozhi Recipe Treating Participants With Glucose and Lipid Metabolism Disturbances (NCT04623567) | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 2021-12-22 |
| Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (NCT05269394) | Washington University School of Medicine | 2021-12-22 |
| Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors (NCT05145907) | TJ Biopharma Co., Ltd. | 2021-12-22 |
| The Safety and Immunogenicity of SCTV01C in Healthy Population Aged ≥18 Years Previously Vaccinated With Inactivated COVID-19 Vaccine. (NCT05043285) | Sinocelltech Ltd. | 2021-12-22 |
| Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Anal Fistula (NCT05402748) | Tehran University of Medical Sciences | 2021-12-22 |
| A Randomized Phase II Study to Compare the Potential Long-Lasting Positive Effect of Decidual Stromal Cells to the Best Available Treatment in Graft Versus Host Disease (NCT05132166) | University Health Network, Toronto | 2021-12-22 |
| A Study to Evaluate the Efficacy and Safety of Rosnilimab (ANB030) in Treatment of Subjects With Moderate-to-Severe Alopecia Areata (NCT05205070) | AnaptysBio, Inc. | 2021-12-22 |
| Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL) (NCT05218668) | Woolsey Pharmaceuticals | 2021-12-22 |
| Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors (NCT05071209) | National Cancer Institute (NCI) | 2021-12-22 |
| HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome (NCT05127226) | Ionis Pharmaceuticals, Inc. | 2021-12-22 |
| A Trial of Centanafadine Efficacy, Safety, and Tolerability in Adult Subjects With Binge Eating Disorder (NCT05113953) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2021-12-22 |
| Tislelizumab Plus TKI as Adjuvant Therapy Versus Active Surveillance in Patients With HCC (NCT06059885) | Beijing 302 Hospital | 2021-12-22 |
| Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults (NCT04265105) | Royal College of Surgeons in Ireland - Medical University of Bahrain | 2021-12-22 |
| A Clinical Study of SI-B001 in Combination With Paclitaxel in the Treatment of Recurrent and Metastatic HNSCC (NCT05054439) | Sichuan Baili Pharmaceutical Co., Ltd. | 2021-12-22 |
| A Study of Lerociclib in Participants With Advanced Breast Cancer (NCT05085002) | EQRx, Inc. | 2021-12-21 |
| Foundation and Clinical About the Expression of PD-1 in Peripheral Blood T Lymphocytes (NCT05792995) | Xin-Hua Xu | 2021-12-21 |
| Targeted Alpha-emitter Therapy of PRRT Naïve and Previous PRRT Neuroendocrine Tumor Patients (NCT05153772) | Orano Med LLC | 2021-12-21 |
| Camrelizumab Combination With SBRT and Concurrent Chemotherapy Treated Stage IV Oligometastatic Non-small Cell Lung Cancer (NCT05472467) | Sichuan Cancer Hospital and Research Institute | 2021-12-21 |
| Study of Screening Brain MRIs in Stage IV Breast Cancer (NCT05115474) | H. Lee Moffitt Cancer Center and Research Institute | 2021-12-21 |
| Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT) (NCT05130827) | Memorial Sloan Kettering Cancer Center | 2021-12-21 |
| A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma. (NCT05228470) | Pfizer | 2021-12-21 |
| Addition of Probenecid to Penicillin-V Therapy (NCT05082909) | Imperial College London | 2021-12-21 |
| A Phase II Trial to Evaluate the Efficacy and Safety of QL1706 in Patients With Cervical Cancer (NCT05557565) | Qilu Pharmaceutical Co., Ltd. | 2021-12-21 |
| EPI-7386 in Combination with Enzalutamide Compared with Enzalutamide Alone in Subjects with MCRPC (NCT05075577) | ESSA Pharmaceuticals | 2021-12-21 |
| Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC (NCT04958811) | Georgetown University | 2021-12-21 |
| Grapiprant and Eribulin for the Treatment of Metastatic Inflammatory Breast Cancer (NCT05041101) | M.D. Anderson Cancer Center | 2021-12-21 |
| Basket Study to Assess Efficacy, Safety and PK of Iptacopan (LNP023) in Autoimmune Benign Hematological Disorders (NCT05086744) | Novartis Pharmaceuticals | 2021-12-21 |
| Repurposed Drugs to Improve Haematological Responses in Myelodysplastic Syndromes (NCT04997811) | Prof. Janet Dunn | 2021-12-21 |
| Effect of Oral (Z)-Endoxifen in Premenopausal Women With Measurable Breast Density (NCT05068388) | Atossa Therapeutics, Inc. | 2021-12-21 |
| A Study of RC48-ADC for the Treatment of HER2-expressing Gynecological Malignancies (NCT04965519) | RemeGen Co., Ltd. | 2021-12-21 |
| Orelabrutinib Combined With Pemetrexed For Relapsed/Refractory Central Nervous System Lymphoma (NCT05209620) | Henan Cancer Hospital | 2021-12-21 |
| An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Study (NCT05192200) | Pfizer | 2021-12-20 |
| Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma (NCT04510636) | University Health Network, Toronto | 2021-12-20 |
| Therapeutic Effect of PBF-680 in Patients With COPD (NCT05262218) | Palobiofarma SL | 2021-12-20 |
| Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide (NCT05060627) | PETHEMA Foundation | 2021-12-20 |
| The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy. (NCT05160493) | Beijing Tiantan Hospital | 2021-12-20 |
| Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans (NCT04769206) | Vanderbilt University Medical Center | 2021-12-20 |
| Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome (NCT05348278) | Mahidol University | 2021-12-20 |
| Immunomodulation by OM-85 (Broncho-Vaxom) in Early AD (NCT05222516) | OM Pharma SA | 2021-12-20 |
| Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD (NCT05210803) | AbbVie | 2021-12-20 |
| ALTO-100 in MDD and/or PTSD (NCT05117632) | Alto Neuroscience | 2021-12-20 |
| Ad26.COV2.S as a Heterologous Booster in Adults After Single- or Two-Dose of Inactivated COVID-19 Vaccine (NCT05109559) | Mahidol University | 2021-12-20 |
| Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia. (NCT05123755) | Vasomune Therapeutics, Inc. | 2021-12-20 |
| Study of Tafasitamab and Lenalinomide Associated to Rituximab in Frontline Diffuse Large B-Cell Lymphoma Patients of 80 y/o or Older (NCT04974216) | The Lymphoma Academic Research Organisation | 2021-12-20 |
| Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer（RC48-C018） (NCT05113459) | Guoxin Li | 2021-12-18 |
| Treatment of Cancer-Related Bone Pain by Using Bone-Targeted Radiation-Based Therapy (Sn-117m-DTPA) in Patients With Prostate Cancer That Has Spread to Bones (NCT04616547) | National Cancer Institute (NCI) | 2021-12-18 |
| Study of CBP501/Cisplatin/Nivolumab Combinations in Advanced Pancreatic Cancer (NCT04953962) | CanBas Co. Ltd. | 2021-12-18 |
| TACE Combined With Camrelizumab and Apatinib in the Treatment of Advanced Liver Cancer (NCT05550025) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2021-12-17 |
| A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema (NCT05151744) | Hoffmann-La Roche | 2021-12-17 |
| Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer (NCT05007132) | Dominik Paul Modest | 2021-12-17 |
| Safety and Efficacy of Low Dose MM120 for ADHD Proof of Concept Trial (NCT05200936) | Definium Therapeutics US, Inc. | 2021-12-17 |
| Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior (NCT05767385) | University of Utah | 2021-12-17 |
| Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer (NCT05041842) | UNICANCER | 2021-12-17 |
| Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1 (NCT04874194) | M.D. Anderson Cancer Center | 2021-12-17 |
| Study Investigating NTLA-5001 in Subjects With Acute Myeloid Leukemia (NCT05066165) | Intellia Therapeutics | 2021-12-17 |
| Preventing Anaphylaxis With Acalabrutinib (NCT05038904) | Johns Hopkins University | 2021-12-16 |
| Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer (NCT04989946) | University of Wisconsin, Madison | 2021-12-16 |
| Imgatuzumab in Patients With Advanced Cutaneous Squamous Cell Carcinoma (NCT04985825) | Pega-One S.A.S. | 2021-12-16 |
| Pharmacokinetics, Pharmacodynamics, and Safety of Single-dose Sotrovimab in High-risk Pediatric Participants With Mild to Moderate COVID-19 (NCT05124210) | GlaxoSmithKline | 2021-12-16 |
| Symptom-driven ICS/LABA Therapy for Patients With Asthma Non-adherent to Daily Maintenance Inhalers (NCT05111262) | Washington University School of Medicine | 2021-12-16 |
| The Role of Dexmedetomidine As Myocardial Protection In Pediatric Cyanotic Congenital Heart Disease Undergoing Open Cardiac Surgery Using Cardiopulmonary Bypass Machine: A Preliminary Study (NCT05300802) | National Cardiovascular Center Harapan Kita Hospital Indonesia | 2021-12-16 |
| Allogeneic Engineered Hematopoietic Stem Cell Transplant (HCT) Lacking the CD33 Protein, and Post-HCT Treatment With Mylotarg, for Patients With CD33+ AML or MDS (NCT04849910) | Vor Biopharma | 2021-12-16 |
| A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis (NCT05037760) | Takeda | 2021-12-16 |
| Targeted Alpha Therapy With 225Actinium-Prostate Specific Membrane Antigen (PSMA)-I&T of Castration-resISTant Prostate Cancer (TATCIST). (NCT05219500) | Fusion Pharmaceuticals Inc. | 2021-12-16 |
| Screening Protocol for Preliminary Eligibility Determination for Adoptive Cell Therapy Trials (NCT05100316) | GlaxoSmithKline | 2021-12-16 |
| Comparing 3 vs 6 Cycles of Platinum-based Chemotherapy Prior to Maintenance Avelumab in Advanced Urothelial Cancer (NCT06892860) | Queen Mary University of London | 2021-12-16 |
| Anlotinib Combined With Niraparib Dual Therapy in Platinum-resistant Recurrent Ovarian Clear Cell Carcinoma. (NCT05130515) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2021-12-15 |
| Tucatinib With Chemotherapy and Trastuzumab in Advanced Her-2-neu Overexpressing, Previously Treated Breast Cancer. (NCT04896320) | Providence Health & Services | 2021-12-15 |
| Venetoclax in Addition to Blinatumomab in Adult Patients With Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) (NCT05182385) | Goethe University | 2021-12-15 |
| Allogeneic Mitochondria (PN-101) Transplantation for Refractory Polymyositis or Dermatomyositis (NCT04976140) | Paean Biotechnology Inc. | 2021-12-15 |
| Olaparib, Durvalumab and UV1 in Relapsed Ovarian Cancer (NCT04742075) | Nordic Society of Gynaecological Oncology - Clinical Trials Unit | 2021-12-15 |
| CASCADE: CAnnabidiol Study in Children With Autism Spectrum DisordEr (NCT04520685) | University of Colorado, Denver | 2021-12-15 |
| Metabolic Effects of Chronic Ketosis (KETO-CHF Metabolic) (NCT05161676) | University of Aarhus | 2021-12-15 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CB1 Antagonist ANEB-001 in a THC Challenge Test (NCT05282797) | Anebulo Pharmaceuticals | 2021-12-15 |
| Velusetrag for the Treatment of Chronic Intestinal Pseudo-Obstruction (CIPO). (NCT05724069) | Alfasigma S.p.A. | 2021-12-15 |
| MR-Guided Adaptive SBRT of Primary Tumor for Pain Control in Metastatic PDAC (NCT05114213) | Ludwig-Maximilians - University of Munich | 2021-12-15 |
| Ketone Administration During Inactivity and Retraining (NCT05398042) | KU Leuven | 2021-12-15 |
| Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma (NCT05170334) | H. Lee Moffitt Cancer Center and Research Institute | 2021-12-15 |
| Evaluate the Efficacy and Safety of SHR1459 Tablets in Patients With Primary Membranous Nephropathy (NCT05136456) | Reistone Biopharma Company Limited | 2021-12-15 |
| A Study of Oleogel-S10 Gel for the Treatment of Radiation Dermatitis in People With Breast Cancer (NCT05190770) | Memorial Sloan Kettering Cancer Center | 2021-12-15 |
| Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer (NCT04941287) | National Cancer Institute (NCI) | 2021-12-15 |
| Association of Thoraco-mediastinal Radiotherapy With Maintenance Immunotherapy Treatment With Atezolizumab (NCT06771518) | Regina Elena Cancer Institute | 2021-12-15 |
| Pentoxifylline for Treatment of Resistant Major Depression (NCT05324735) | Hawler Medical University | 2021-12-15 |
| XTR003 PET Radiotracer for the Detection of Viable Myocardium (NCT05885854) | Sinotau Pharmaceutical Group | 2021-12-15 |
| A Clinical Trial of ICP-192 in Treated Patients With Advanced Solid Tumors With FGF/FGFR Gene Alterations (NCT05372120) | Beijing InnoCare Pharma Tech Co., Ltd. | 2021-12-15 |
| Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection (NCT05152849) | Axcella Health, Inc | 2021-12-15 |
| An Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005) (NCT05223920) | Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA) | 2021-12-15 |
| AZD4573 as Monotherapy or in Combinations With Anti-cancer Agents in Patients With r/r PTCL or r/r cHL (NCT05140382) | AstraZeneca | 2021-12-15 |
| A Study of MT-101 in Subjects With CD5+ Relapsed/Refractory TCL (NCT05138458) | Myeloid Therapeutics | 2021-12-15 |
| Acalabrutinib and Rituximab in Elderly Patients With Untreated Mantle Cell Lymphoma (NCT05214183) | Nordic Lymphoma Group | 2021-12-15 |