| Glutamate Emotion Memory Study (NCT05809609) | University of Oxford | 2022-07-01 |
| A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD (NCT05113771) | Denovo Biopharma LLC | 2022-06-29 |
| Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression (NCT05422417) | Taipei Veterans General Hospital, Taiwan | 2022-06-07 |
| Enhanced Spatial Targeting in ECT Utilizing FEAST (NCT04099342) | University of Minnesota | 2022-06-01 |
| Personalized Therapeutic Neuromodulation for Anhedonic Depression (NCT05144789) | Stanford University | 2022-05-31 |
| An Intervention Study of Anhedonia and Pain Empathy in Depression (NCT05355142) | Anhui Medical University | 2022-04-01 |
| The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation (NCT05220410) | Sheppard Pratt Health System | 2022-03-28 |
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression (NCT05045378) | Taipei Veterans General Hospital, Taiwan | 2022-03-15 |
| Intensive TMS for Bipolar Depression (NCT05228457) | University of Pennsylvania | 2022-03-01 |
| Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One Day (NCT03986658) | NeuroQore Inc. | 2022-03-01 |
| A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD (NCT05414422) | Perception Neuroscience | 2022-02-01 |
| Phase 2 Study of NV-5138 in Adults With Treatment Resistant Depression (NCT05066672) | Navitor Pharmaceuticals, Inc. | 2022-01-18 |
| A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients (NCT04996433) | University of Greifswald | 2021-12-01 |
| Psilocybin for Treatment-Resistant Depression (NCT05029466) | Brain and Cognition Discovery Foundation | 2021-11-19 |
| Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG) (NCT05095792) | Entheon Biomedical Corp. | 2021-11-09 |
| Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial (NCT04957368) | Unity Health Toronto | 2021-11-03 |
| Accelerated TBS in Late Life Depression (NCT05119699) | Centre for Addiction and Mental Health | 2021-10-14 |
| PCS in Severe Treatment Resistant Depression (NCT04124341) | University of Minnesota | 2021-09-29 |
| Stellate Ganglion Block for Major Depressive Disorder. (NCT04727229) | Unity Health Toronto | 2021-09-23 |
| Biomarker-guided rTMS for Treatment Resistant Depression (NCT04041479) | Weill Medical College of Cornell University | 2021-09-17 |
| Investigational TMS Treatment for Depression (NCT03175887) | White River Junction Veterans Affairs Medical Center | 2021-09-01 |
| Reward Emotion Learning and Ketamine Study (NCT04850911) | University of Oxford | 2021-08-25 |
| Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression (NCT04936126) | All India Institute of Medical Sciences, Bhubaneswar | 2021-08-07 |
| ECT vs. Esketamine (NCT04924257) | Medical University Innsbruck | 2021-07-28 |
| Virtual Neuro-Navigation System for Personalized Community Based TMS (NCT04956081) | Soterix Medical | 2021-07-01 |
| Cannabidiol for Treatment Resistant Depression (NCT04732169) | University of Alabama at Birmingham | 2021-07-01 |
| Development of Neuro-Navigated Transcranial Magnetic Stimulation (TMS) Using MRI (NCT05598931) | Soterix Medical | 2021-07-01 |
| Antidepressant Effects of Nitrous Oxide (NCT05357040) | University of Chicago | 2021-06-30 |
| Rapid Acting Transcranial Magnetic Stimulation (NCT04739969) | Stanford University | 2021-06-15 |
| Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation (NCT04243798) | Stanford University | 2021-06-15 |
| Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006) (NCT04663321) | Merck Sharp & Dohme LLC | 2021-05-20 |
| Psilocybin Versus Ketamine in Treatment-Resistant Depression (NCT05383313) | National Institute of Mental Health, Czech Republic | 2021-05-01 |
| MAO-B Occupancy in Depressed Patients (NCT04841798) | Centre for Addiction and Mental Health | 2021-04-15 |
| An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients (NCT04971291) | Axsome Therapeutics, Inc. | 2021-04-14 |
| The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive Episodes (NCT04753385) | LivaNova | 2021-03-23 |
| The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder (NCT04805879) | University of Calgary | 2021-03-04 |
| The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. (NCT04433845) | Sheppard Pratt Health System | 2021-03-01 |
| An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) (NCT04433858) | Sheppard Pratt Health System | 2021-03-01 |
| Home-administered tDCS for Treatment of Depression (NCT04781127) | Soterix Medical | 2021-02-10 |
| Pharmacogenetics Associated With IV Ketamine (NCT04695405) | Brain and Cognition Discovery Foundation | 2021-01-21 |
| Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I (NCT04680910) | Washington University School of Medicine | 2021-01-14 |
| Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression (NCT06953362) | University of California, San Francisco | 2021-01-01 |
| University of Iowa Interventional Psychiatry Service Patient Registry (NCT04480918) | Mark Niciu | 2020-11-02 |
| Tianeptine for Treatment Resistant Depression (NCT04249596) | Jonathan A. Javitch, MD, PhD | 2020-10-14 |
| CET- REM (Correlating ECT Response to EEG Markers) (NCT04451135) | Washington University School of Medicine | 2020-10-09 |
| Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE) (NCT04634669) | Axsome Therapeutics, Inc. | 2020-09-23 |
| Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality (NCT04101474) | Assiut University | 2020-09-01 |
| Mechanistic Evaluation of Response in TRD (MERIT) (NCT04608396) | Axsome Therapeutics, Inc. | 2020-08-13 |
| The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression (NCT04739865) | COMPASS Pathways | 2020-08-10 |
| Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU) (NCT04519957) | COMPASS Pathways | 2020-07-20 |
| Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression (NCT03977038) | Sunnybrook Health Sciences Centre | 2020-05-30 |
| Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder (NCT04226352) | Johns Hopkins University | 2020-03-15 |
| Computational Psychiatric Approach to Depression (NCT04189939) | Wake Forest University Health Sciences | 2020-03-09 |
| Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote) (NCT04199143) | University Hospital, Tours | 2020-02-20 |
| Compressed Intermittent Theta Burst Stimulation (NCT04684706) | University of Pennsylvania | 2020-02-20 |
| Minocycline as Adjunctive Treatment for Treatment Resistant Depression (NCT03947827) | Centre for Addiction and Mental Health | 2020-02-01 |
| DBS for TRD With the Medtronic Summit RC+S (NCT04106466) | Helen Mayberg, MD | 2020-01-21 |
| A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders (NCT04226963) | Medical University of Gdansk | 2019-12-04 |
| Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent (NCT04171193) | University of Sao Paulo | 2019-12-01 |
| Clinical Study of GH001 in Depression (NCT04698603) | GH Research Ireland Limited | 2019-11-12 |
| A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (NCT03887715) | LivaNova | 2019-09-26 |
| RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) (NCT05531591) | Centre for Addiction and Mental Health | 2019-08-01 |
| Neurobiological Analyses Within the FORESEE III Study (NCT04021823) | University Hospital Freiburg | 2019-08-01 |
| Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation (NCT04076124) | Taipei Veterans General Hospital, Taiwan | 2019-07-24 |
| Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients (NCT04037592) | Taipei Veterans General Hospital, Taiwan | 2019-07-24 |
| Open-Label Safety Study of AXS-05 in Subjects With Depression (NCT04039022) | Axsome Therapeutics, Inc. | 2019-07-08 |
| Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression (NCT03953417) | Stanford University | 2019-07-01 |
| Antidepressant Discontinuation in Treatment Resistant Depression (NCT03786614) | University of Louisville | 2019-06-20 |
| Deep Brain Stimulation for Treatment Resistant Depression (NCT04009928) | Sunnybrook Health Sciences Centre | 2019-06-15 |
| Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression (NCT03833063) | Helse Stavanger HF | 2019-05-01 |
| Neural and Antidepressant Effects of Propofol (NCT03684447) | University of Utah | 2019-04-21 |
| Neural and Antidepressant Effects of Propofol (Phase 2) (NCT03923361) | University of Utah | 2019-04-16 |
| Nitrous Oxide for Major Depressive Disorder (NCT03932825) | Lingjiang Li | 2019-04-01 |
| The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression (NCT03775200) | COMPASS Pathways | 2019-03-01 |
| Psychotherapeutic Augmentation of Brain Stimulation Effects (NCT04159285) | Charite University, Berlin, Germany | 2019-01-05 |
| Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: (NCT03573349) | Mayo Clinic | 2019-01-03 |
| Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. (NCT03435744) | Pakistan Institute of Living and Learning | 2019-01-01 |
| Salicylic Augmentation in Depression (NCT03152409) | Jessica Harder | 2018-11-15 |
| Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression (NCT03701724) | Nantes University Hospital | 2018-11-05 |
| Evaluation of Schemes of Administration of Intravenous Ketamine in Depression (NCT03742557) | National Institute of Neurology and Neurosurgery, Mexico | 2018-10-01 |
| Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression (NCT03653858) | University Hospital Freiburg | 2018-09-03 |
| Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine (NCT04856124) | Psych Atlanta | 2018-09-01 |
| SSM vs HEP in Late-Life Depression (NCT03564041) | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2018-08-20 |
| Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression (NCT03191058) | University of Texas Southwestern Medical Center | 2018-06-26 |
| Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression (NCT03606395) | Navitor Pharmaceuticals, Inc. | 2018-06-06 |
| Deep Brain Stimulation to Relieve Depression (NCT02889250) | Jordan F. Karp | 2018-06-01 |
| PF-04995274 and Emotional Processing in Treatment Resistant Depression (NCT03515733) | University of Oxford | 2018-05-31 |
| Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study (NCT03680781) | Stanford University | 2018-04-13 |
| Efficacy and Safety of TAK-653 in Treatment-Resistant Depression (NCT03312894) | Millennium Pharmaceuticals, Inc. | 2018-02-15 |
| Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant Depression (NCT03329391) | National Taiwan University Hospital | 2018-01-09 |
| rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism (NCT03991572) | Anhui Medical University | 2018-01-01 |
| A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression. (NCT03320304) | LivaNova | 2017-12-14 |
| Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine (NCT03290963) | William V. Bobo, M.D. | 2017-11-30 |
| Allogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant Depression (NCT02675556) | Joshua M Hare | 2017-10-31 |
| Stepped Care AiTBS 2 Depression Study (Ghent) (NCT03288675) | University Hospital, Ghent | 2017-10-05 |
| ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression (NCT03272698) | University of Saskatchewan | 2017-09-01 |
| TBS in Major Depression (NCT03257397) | Rupert Lanzenberger | 2017-08-01 |
| Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression: OL Cohort (NCT03240692) | Stanford University | 2017-05-01 |
| Neuroimaging in Patients Undergoing TMS for Depression (NCT02974296) | New York State Psychiatric Institute | 2017-04-30 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) (NCT03113968) | Bo Hu | 2017-04-07 |