| Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases (NCT05346367) | Haaglanden Medical Centre | 2022-07-18 |
| Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE) (NCT05465343) | Peking Union Medical College | 2022-07-11 |
| Evaluation of the CONVIVO System (NCT05139277) | Dartmouth-Hitchcock Medical Center | 2022-06-28 |
| A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain (NCT05419076) | Memorial Sloan Kettering Cancer Center | 2022-06-10 |
| TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases (NCT04512261) | Reva Basho | 2022-06-01 |
| REMASTer: REcurrent Brain Metastases After SRS Trial (NCT05124912) | Monteris Medical | 2022-05-10 |
| Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery (NCT04689048) | Baptist Health South Florida | 2022-04-04 |
| Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation (NCT05146219) | TYK Medicines, Inc | 2022-04-02 |
| Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife (NCT05177185) | Ottawa Hospital Research Institute | 2022-04-01 |
| HyperArc Registry Study (NCT05270707) | Varian, a Siemens Healthineers Company | 2022-03-31 |
| Preop fSRS for Resectable Brain Metastases (NCT05267587) | H. Lee Moffitt Cancer Center and Research Institute | 2022-03-11 |
| (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations (NCT05241873) | Blueprint Medicines Corporation | 2022-03-04 |
| The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? (NCT05378633) | University Hospital Heidelberg | 2022-02-24 |
| Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma (NCT04955743) | Yale University | 2022-02-09 |
| NTS-WBRT in Brain Metastases (NCT05013892) | Massachusetts General Hospital | 2022-02-08 |
| Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis (NCT05762172) | Centre Hospitalier Universitaire, Amiens | 2022-02-01 |
| Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases (NCT05064280) | M.D. Anderson Cancer Center | 2022-01-20 |
| Preclinical Brain Tumor Models (NCT06045065) | Assistance Publique Hopitaux De Marseille | 2022-01-02 |
| Efficacy and Safety Evaluation of Percutaneous Ommaya Capsule Injection of Autologous Bi-dimensional Specific T Cells in the Treatment of Glioma and in Combination With Pemetrexed in the Treatment of Brain/Meningeal Metastases (NCT05459441) | Shanghai Pudong Hospital | 2022-01-01 |
| Dose-escalation by Hypofractionated Stereotactic Radiotherapy for Brain Metastases in Non Small Cell Lung Cancer (NCT05588206) | First People's Hospital of Hangzhou | 2022-01-01 |
| Radiotherapy Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of NSCLC Patients With Symptomatic Brain Metastases (NCT05638425) | Xiangya Hospital of Central South University | 2021-12-31 |
| Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases (NCT04890028) | Institut Cancerologie de l'Ouest | 2021-12-03 |
| Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases (NCT04923542) | H. Lee Moffitt Cancer Center and Research Institute | 2021-11-30 |
| Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer (NCT04856475) | Jules Bordet Institute | 2021-11-24 |
| Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique (NCT05045950) | Medical College of Wisconsin | 2021-11-17 |
| TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN) (NCT04760431) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2021-10-01 |
| Pre- Versus Post-operative SRS for Resectable Brain Metastases (NCT04474925) | AHS Cancer Control Alberta | 2021-09-27 |
| Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions (NCT05358340) | University Health Network, Toronto | 2021-09-24 |
| Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases (NCT04899908) | Brigham and Women's Hospital | 2021-09-15 |
| BRIANSTORM - Early Identification of Patients With Brain Metastases (NCT05185557) | Aarhus University Hospital | 2021-08-16 |
| Tislelizumab Plus Chemotherapy as First-Line Treatment for Advanced Squamous NSCLC With Brain Metastases (NCT05207904) | Sun Yat-sen University | 2021-06-17 |
| Intraoperative Radiotherapy in Patients With Brain Metastases (NCT04847284) | Parc de Salut Mar | 2021-05-05 |
| the Efficacy and Safety of Anlotinib Combined With Almonertinib in the First-line Treatment of Patients With Brain Metastases From EGFR Mutation-positive Non-small Cell Lung Cancer (NCT04978753) | Li-kun Chen | 2021-05-01 |
| Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases (NCT03698162) | University of Southern California | 2021-04-13 |
| Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study) (NCT04365374) | GT Medical Technologies, Inc. | 2021-04-06 |
| Use of Non-invasive Optical Analysis in Neurosurgery (NCT04712214) | Imperial College London | 2021-03-28 |
| A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY) (NCT04778800) | Henan Cancer Hospital | 2021-03-20 |
| A Study to Assess the Efficacy of Cerebellar IMRT Combined With Cerebral SRS in Patients With Brain Metastases (NCT05477316) | Hadassah Medical Organization | 2021-02-11 |
| Preoperative Stereotactic Radiosurgery for Brain Metastases (NCT04503772) | Centre Jean Perrin | 2021-02-04 |
| Hypofractionated Versus Single Fraction Stereotactic Adjuvant Radiotherapy to the Resection Cavity of Brain Metastases (NCT05160818) | Technical University of Munich | 2021-02-01 |
| Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases (NCT04545814) | Medical College of Wisconsin | 2021-01-15 |
| Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases (NCT04610684) | Jeffrey Clarke | 2021-01-05 |
| Hippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost for BMs of NSCLC (NCT06557187) | Yatian Liu | 2021-01-01 |
| Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases (NCT04700748) | Lund University Hospital | 2020-12-28 |
| Central Nervous System(CNS) Efficacy of Dacomitinib (NCT04675008) | Samsung Medical Center | 2020-12-07 |
| Palbociclib, Trastuzumab,Pyrotinib and Fulvestrant Treatment in Patients With Brain Metastasis From ER/PR Positive, HER-2 Positive Breast Cancer: A Multi-center, Prospective Study in China (NCT04334330) | Sun Yat-sen University | 2020-12-04 |
| A Phase II Trial of Upfront Radiotherapy Plus Almonertinib for Epidermal Growth Factor Receptor(EGFR)-Mutant Non-small-cell Lung Cancer(NSCLC) Patients With Brain Metastases (NCT04643847) | First People's Hospital of Hangzhou | 2020-11-30 |
| Brigatinib Before Brain Irradiation Trial (B3i Trial) (NCT04634110) | University of Colorado, Denver | 2020-11-17 |
| Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (NCT04410133) | Blue Earth Diagnostics | 2020-10-26 |
| Keynatinib in Treated Patients With NSCLC and Brain Metastases (NCT04824079) | Medolution Ltd. | 2020-10-21 |
| Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases (NCT03775330) | Sunnybrook Health Sciences Centre | 2020-10-20 |
| FLT-PET / MRI Brain Mets (NCT04244019) | University Health Network, Toronto | 2020-10-01 |
| Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLC (NCT04507217) | Sun Yat-sen University | 2020-09-15 |
| Perfexion Registration Using CBCT (NCT04170777) | University Health Network, Toronto | 2020-09-01 |
| Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE) (NCT04410367) | Blue Earth Diagnostics | 2020-08-31 |
| Preoperative SRS/SRT vs Postoperative SRS/SRT for Brain Metastases (NCT04422639) | University of Arkansas | 2020-08-24 |
| Phase 1 Trial for Tumor Treating Field for Drug/Radiation Resistant Brain Metastases (NCT04967027) | Xiangya Hospital of Central South University | 2020-08-01 |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S (NCT04430842) | Quadriga Biosciences, Inc. | 2020-07-20 |
| Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation (NCT04233021) | Intergroupe Francophone de Cancerologie Thoracique | 2020-07-16 |
| Dosimetric Validation of Scans Generated by GAN From Pre-therapeutic MRI in Stereotactic Cerebral Radiotherapy (NCT04525053) | University Hospital, Brest | 2020-07-16 |
| Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection (NCT04857905) | Medical University of Vienna | 2020-07-01 |
| Single vs Multi-fraction SRS Patients on Immunotherapy (NCT04427228) | University of Chicago | 2020-06-29 |
| Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT (NCT04452084) | National Cancer Centre, Singapore | 2020-06-15 |
| Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC) (NCT04654975) | Universitaire Ziekenhuizen KU Leuven | 2020-06-02 |
| DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease (NCT04420598) | MedSIR | 2020-05-25 |
| GM1 Prophylaxis for WBRT Related Cognitive Dysfunction (NCT04395339) | Sun Yat-sen University | 2020-05-15 |
| WP1066 in Children With Refractory and Progressive or Recurrent Malignant Brain Tumors (NCT04334863) | Emory University | 2020-05-04 |
| Evaluation of the Best Treatment in Terms of Quality of Life for Patients Having a Brain Metastasis (NCT04358666) | University Hospital, Caen | 2020-03-06 |
| HA-WBRT vs SRS in Patients With Multiple Brain Metastases (NCT04277403) | Medical University Innsbruck | 2020-02-15 |
| Study of Laser Interstitial Thermal Therapy (LITT) Treatment Response Assessment With Fluciclovine PET MR (NCT05054400) | M.D. Anderson Cancer Center | 2020-02-05 |
| Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases (NCT04094077) | Centre Leon Berard | 2020-01-17 |
| Camrelizumab With AC in Patients With Brain Metastases of Driven Gene-negative,NSCLC (NCT04211090) | Sun Yat-sen University | 2020-01-15 |
| Pyrotinib Combined With Brain Radiotherapy in Breast Cancer Patients With Brain Metastases (NCT04582968) | Fudan University | 2020-01-02 |
| Camrelizumab Combined With Local Treatment in NSCLC Patients With BM (NCT04291092) | Zhejiang Cancer Hospital | 2020-01-01 |
| Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study (NCT04047602) | Indiana University | 2019-12-12 |
| Closed vs. Open Face Masks for Cranial Radiotherapy (NCT04079595) | University of Zurich | 2019-12-09 |
| GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases (NCT04192981) | Memorial Sloan Kettering Cancer Center | 2019-12-06 |
| The Role of Brain Radiotherapy in Patients With Asymptomatic Brain Metastasis in the Era of Targeted Therapy for NSCLC (NCT04193007) | Second Affiliated Hospital of Nanchang University | 2019-12-01 |
| Glucocorticoids, Immunotherapy and Radiosurgery for Brain Metastases (NCT04042220) | Medical University of Vienna | 2019-11-01 |
| SRS Sequential Sindilimab in Brain Metastasis of NSLSC (NCT04180501) | Xiaorong Dong | 2019-11-01 |
| Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection (NCT04040400) | University of Louisville | 2019-10-23 |
| Stereotactic Magnetic Resonance Guided Radiation Therapy (NCT04115254) | Dana-Farber Cancer Institute | 2019-10-22 |
| Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases (NCT04001725) | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 2019-10-15 |
| Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study (NCT03951142) | Kyrre Eeg Emblem | 2019-10-01 |
| Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases (NCT03714243) | InSightec | 2019-09-18 |
| Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain (NCT03488472) | Drexell Hunter Boggs | 2019-08-09 |
| Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain (NCT03898908) | Grupo Español Multidisciplinar de Melanoma | 2019-07-18 |
| Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases (NCT04084431) | University Hospital Heidelberg | 2019-07-01 |
| FSRT in Breast Cancer Patients With Brain Metastases (NCT04061408) | Fudan University | 2019-07-01 |
| Neurosurgical Transitional Care Programme (NCT03593330) | Barts & The London NHS Trust | 2019-05-30 |
| An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis (NCT03911869) | Pfizer | 2019-04-30 |
| Sintilimab Combined With Bevacizumab for Brain Metastases From Non-small Cell Lung Cancer (NCT04213170) | Sun Yat-sen University | 2019-04-29 |
| Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With NSCLC (NCT03769103) | British Columbia Cancer Agency | 2019-03-19 |
| Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases (NCT03807765) | H. Lee Moffitt Cancer Center and Research Institute | 2019-01-30 |
| DM-CHOC-PEN for Brain Tumors in AYA Subjects (NCT03668847) | DEKK-TEC, Inc. | 2019-01-01 |
| A Study of Pyrotinib Plus Vinorelbine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer (NCT03933982) | Chinese Academy of Medical Sciences | 2018-12-22 |
| HFSRT With Concurrent TMZ for Large BMs (NCT03778541) | Chinese Academy of Medical Sciences | 2018-12-03 |
| Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation (NCT03754530) | Betta Pharmaceuticals Co., Ltd. | 2018-12-01 |
| Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases (NCT03550391) | Canadian Cancer Trials Group | 2018-11-22 |
| Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients (NCT03449238) | Weill Medical College of Cornell University | 2018-11-15 |