| Efficacy and Safety of Nitrazine in the Treatment of ALS (NCT04950647) | Peking University Third Hospital | 2020-07-01 |
| Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients (NCT03766321) | Azienda Ospedaliero-Universitaria di Modena | 2020-07-01 |
| The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules (NCT04950933) | Peking University Third Hospital | 2020-06-01 |
| Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). (NCT04393467) | Campus Bio-Medico University | 2020-05-31 |
| Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS (NCT04057898) | MediciNova | 2020-05-28 |
| A Mindful Community for People With ALS and Their Primary Caregivers (NCT05595850) | Harvard University | 2020-05-15 |
| Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS) (NCT04288856) | Biogen | 2020-04-28 |
| NuroSleeve Powered Brace & Stimulation System to Restore Arm Function (NCT04798378) | Thomas Jefferson University | 2020-04-16 |
| The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2) (NCT04051333) | Massachusetts General Hospital | 2020-03-30 |
| An Efficacy and Safety Study of Ravulizumab in ALS Participants (NCT04248465) | Alexion Pharmaceuticals, Inc. | 2020-03-30 |
| Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland China (NCT04328675) | Peking University Third Hospital | 2020-03-20 |
| Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001 (NCT04313166) | Collaborative Medicinal Development Pty Limited | 2020-03-19 |
| A Study to Explore the Role of Gut Flora in ALS (NCT04150809) | ProgenaBiome | 2020-03-02 |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) (NCT04363684) | Mayo Clinic | 2020-03-01 |
| 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) (NCT03843710) | Clene Nanomedicine | 2020-03-01 |
| Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis (NCT04245709) | Dwight Koeberl, M.D., Ph.D. | 2020-02-10 |
| New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways. (NCT03984708) | University Hospital, Tours | 2020-01-27 |
| Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients (NCT04226144) | Escola Superior de Ciencias da Saude | 2020-01-06 |
| Low Dose IL-2 in the Treatment of Immune-associated ALS Syndrome (NCT04952155) | Peking University Third Hospital | 2020-01-01 |
| Study of Safety and Proof of the Mechanism of BLZ945 in ALS Patients (NCT04066244) | Novartis Pharmaceuticals | 2019-12-30 |
| Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS) (NCT04098406) | Clene Nanomedicine | 2019-12-19 |
| Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients (NCT03377309) | American University of Beirut Medical Center | 2019-12-01 |
| Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS) (NCT04172792) | Albert Christian Ludolph, Prof. | 2019-11-26 |
| Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS (NCT04165850) | NeuroSense Therapeutics Ltd. | 2019-11-25 |
| Repetitive Transcranial Magnetic Stimulation as Therapy for Depression in Amyotrophic Lateral Sclerosis (NCT03892863) | Jagiellonian University | 2019-11-15 |
| Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis (NCT03892382) | Jagiellonian University | 2019-11-15 |
| Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) (NCT04454892) | Peking University Third Hospital | 2019-11-01 |
| Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS) (NCT04259255) | Shionogi | 2019-10-21 |
| A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) (NCT03981536) | AL-S Pharma | 2019-10-10 |
| Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone (NCT04097158) | Loma Linda University | 2019-10-08 |
| CuATSM Compared With Placebo for Treatment of ALS/MND (NCT04082832) | Collaborative Medicinal Development Pty Limited | 2019-09-30 |
| Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trial (NCT03836716) | ZevraDenmark | 2019-09-19 |
| IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS) (NCT03474263) | Implicit Bioscience | 2019-09-01 |
| Genetic Study of Amyotrophic Lateral Sclerosis in Norway (NCT05119387) | Sykehuset Telemark | 2019-08-01 |
| Multimodal Brain Imaging Study (NCT04960540) | Peking University Third Hospital | 2019-08-01 |
| A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease (NCT04031469) | ProgenaBiome | 2019-07-11 |
| Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS) (NCT04233099) | Fondazione Don Carlo Gnocchi ETS | 2019-07-01 |
| Dietary Approach to Improving Quality of Life in Amyotrophic Lateral Sclerosis (NCT03659422) | Terry L. Wahls | 2019-07-01 |
| Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension (NCT03948178) | Orion Corporation, Orion Pharma | 2019-06-26 |
| The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT04140136) | University of Malaya | 2019-06-17 |
| Real World Testing of a Brain-Computer Interface (NCT04026581) | University of Pittsburgh | 2019-06-05 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis (NCT03945279) | Biogen | 2019-05-30 |
| Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis (NCT03929068) | Washington University School of Medicine | 2019-05-13 |
| Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx (NCT03986671) | Powell Mansfield Inc. | 2019-04-30 |
| Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS (NCT03573466) | Assistance Publique - Hôpitaux de Paris | 2019-04-10 |
| Colchicine for Amyotrophic Lateral Sclerosis (NCT03693781) | Azienda Ospedaliero-Universitaria di Modena | 2019-04-10 |
| HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) (NCT02437110) | National Institute of Neurological Disorders and Stroke (NINDS) | 2019-04-01 |
| A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT03705390) | University of Birmingham | 2019-03-29 |
| Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway (NCT03887338) | Tiina Maarit Andersen | 2019-03-21 |
| iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Study (NCT04744532) | Kyoto University | 2019-03-19 |
| Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface (NCT03900247) | University of Aarhus | 2019-03-18 |
| Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 2) (NCT03806634) | Taipei Veterans General Hospital, Taiwan | 2019-03-01 |
| Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS (NCT03792490) | University Medical Center Goettingen | 2019-02-20 |
| Speech Analysis in ALS Patients (NCT03868345) | Barrow Neurological Institute | 2019-02-18 |
| Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis (NCT03293069) | University Hospital, Lille | 2019-01-30 |
| TRIAL READY (Clinical Trial Readiness) (NCT03912987) | University of Miami | 2019-01-22 |
| Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease (NCT03690791) | Gold Coast Hospital and Health Service | 2019-01-09 |
| Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis (NCT03757351) | Sanofi | 2018-12-14 |
| Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis (NCT03793868) | Mayo Clinic | 2018-12-04 |
| Outcomes Mandate National Integration With Cannabis as Medicine (NCT03944447) | OMNI Medical Services, LLC | 2018-12-01 |
| Brain Excitability and Connectivity in Sensory-motor Pathways in ALS (NCT03694132) | Institut National de la Santé Et de la Recherche Médicale, France | 2018-11-26 |
| Therapy in Amyotrophic Lateral Sclerosis (TAME) (NCT02118727) | University of Kansas Medical Center | 2018-11-07 |
| Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral Sclerosis (NCT03683875) | Hospital General Universitario Santa Lucia | 2018-10-01 |
| Study of ALS Reversals 4: LifeTime Exposures (NCT03706391) | Duke University | 2018-09-26 |
| Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1) (NCT03806647) | Taipei Veterans General Hospital, Taiwan | 2018-09-01 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of ILB in Patients With Amyotrophic Lateral Sclerosis (NCT03613571) | TikoMed AB | 2018-08-15 |
| A Study of IPL344 in the Treatment of ALS Patients (NCT03652805) | Immunity Pharma Ltd. | 2018-08-01 |
| Reducing Disparities in the Quality of Advance Care Planning for Older Adults (NCT03516994) | Duke University | 2018-08-01 |
| Arimoclomol in Amyotropic Lateral Sclerosis (NCT03491462) | ZevraDenmark | 2018-07-31 |
| Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) (NCT03560661) | Assistance Publique - Hôpitaux de Paris | 2018-07-05 |
| Study of ALS Reversals 2: Genetic Analyses (NCT03464903) | Duke University | 2018-06-22 |
| Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS (NCT03505021) | Orion Corporation, Orion Pharma | 2018-06-21 |
| Application of Motor Unit Estimation Index in Amyotrophic Lateral Sclerosis and Related Diseases (NCT04956822) | Peking University Third Hospital | 2018-06-01 |
| Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease (NCT04240925) | Ospedale San Raffaele | 2018-05-25 |
| ALS Spinal Cord Gray and White Matter Study (NCT05764434) | University Hospital, Basel, Switzerland | 2018-05-01 |
| Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis (NCT03321487) | InSightec | 2018-04-13 |
| Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS (NCT03334786) | Flex Pharma, Inc. | 2018-04-05 |
| Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS) (NCT03679975) | Aquestive Therapeutics | 2018-04-04 |
| Open Label Extension Study of AMX0035 in Patients With ALS (NCT03488524) | Amylyx Pharmaceuticals Inc. | 2018-03-29 |
| Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS (NCT03202017) | University of Minnesota | 2018-03-01 |
| Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy (NCT03664206) | Sándor Beniczky | 2018-02-16 |
| Clinical Procedures to Support Research in ALS (NCT03489278) | University of Miami | 2018-02-15 |
| Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS (NCT03520517) | Biohaven Pharmaceuticals, Inc. | 2018-02-02 |
| Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis (NCT03481348) | University of Ulm | 2018-02-01 |
| Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis (NCT03427086) | American University of Beirut Medical Center | 2018-01-29 |
| ALS Treatment Extension Study (NCT03136809) | Collaborative Medicinal Development Pty Limited | 2018-01-18 |
| Cervical Electrical Stimulation for ALS (NCT03411863) | VA Office of Research and Development | 2018-01-04 |
| Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis (NCT03377868) | American University of Beirut Medical Center | 2018-01-03 |
| Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment (NCT03452618) | University Hospital, Toulouse | 2017-12-14 |
| Biomarkers of Synaptic Damage in Multiple Sclerosis (NCT03217396) | Neuromed IRCCS | 2017-11-22 |
| [BrainConnexion] - Neurodevice Phase I Trial (NCT03811301) | National Neuroscience Institute | 2017-11-21 |
| Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALS (NCT03338114) | Flex Pharma, Inc. | 2017-11-01 |
| Physiological Flow of Liquids Used in Dysphagia Management (Neuro) (NCT03192358) | University Health Network, Toronto | 2017-11-01 |
| Clinical Trial of Ultra-high Dose Methylcobalamin for ALS (NCT03548311) | Eisai Co., Ltd. | 2017-11-01 |
| A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT03272503) | University of Calgary | 2017-10-27 |
| Brown Adipose Tissue in ALS (NCT03150290) | Institut National de la Santé Et de la Recherche Médicale, France | 2017-10-26 |
| Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (NCT03225144) | National Institute of Neurological Disorders and Stroke (NINDS) | 2017-10-11 |
| Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) (NCT03268603) | Mayo Clinic | 2017-10-10 |
| Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis (NCT03293394) | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 2017-10-02 |
| Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS) (NCT03168711) | Massachusetts General Hospital | 2017-10-01 |