| Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging Biomarkers (NCT05358431) | Assistance Publique - Hôpitaux de Paris | 2022-07-21 |
| Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients (NCT07178067) | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | 2022-07-21 |
| Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit (NCT04468919) | Oregon Health and Science University | 2022-07-15 |
| QCT in ALS Diagnosis, Mechanistic Understanding and Follow-up (NCT06284161) | University Hospital, Clermont-Ferrand | 2022-06-28 |
| Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II) (NCT05404867) | Dartmouth-Hitchcock Medical Center | 2022-06-08 |
| Virtual Peer-to-peer Support Programme for Carers of MND (NCT04695210) | King's College London | 2022-06-07 |
| A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS (NCT05357950) | NeuroSense Therapeutics Ltd. | 2022-05-31 |
| A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS Patients (NCT05407428) | NeuraLight | 2022-05-31 |
| Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS (NCT05349721) | PTC Therapeutics | 2022-05-15 |
| CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS (NCT05306457) | Cedars-Sinai Medical Center | 2022-05-08 |
| COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis (NCT05035823) | Synchron Medical, Inc. | 2022-04-27 |
| SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis (NCT05041114) | Synchron Medical, Inc. | 2022-04-21 |
| Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (NCT05237284) | Sanofi | 2022-04-13 |
| Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT04820478) | University of Ulm | 2022-04-01 |
| mGluR5 Imaging in ALS Using PET (NCT05340660) | Nathalie Braun | 2022-04-01 |
| Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (NCT05328492) | University Hospitals Coventry and Warwickshire NHS Trust | 2022-03-15 |
| A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS (NCT05279755) | ProJenX | 2022-02-26 |
| HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose (NCT05136885) | Merit E. Cudkowicz, MD | 2022-02-21 |
| A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to Healthy Adult Male and Female Participants (Part A); and the Effect of Itraconazole on the Test Medicine (SAR443820) When Given Orally as Capsules to Healthy Adult Male Participants (Part B) (NCT05797753) | Sanofi | 2022-02-18 |
| Remote Speech and Swallowing Assessment in ALS (NCT04889898) | Milton S. Hershey Medical Center | 2022-01-01 |
| Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study (NCT06209515) | Kuopio University Hospital | 2022-01-01 |
| Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis (NCT05163886) | OrphAI Therapeutics | 2021-12-23 |
| Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL) (NCT05218668) | Woolsey Pharmaceuticals | 2021-12-22 |
| Online Self-Compassion Course for pALS (Compassion pALS) (NCT05202743) | Washington University School of Medicine | 2021-12-17 |
| 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS) (NCT05039268) | Macquarie University, Australia | 2021-11-25 |
| Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients (NCT04654689) | Fundación Universidad Católica de Valencia San Vicente Mártir | 2021-11-20 |
| An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS (NCT05299658) | Clene Nanomedicine | 2021-11-13 |
| Study in ALS With Abatacept & IL-2 (NCT06307301) | The Methodist Hospital Research Institute | 2021-10-28 |
| Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment (NCT05021536) | Amylyx Pharmaceuticals Inc. | 2021-10-28 |
| Open Label Extension of TUDCA-ALS Study (NCT05753852) | Humanitas Mirasole SpA | 2021-10-25 |
| Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis (NCT05178810) | Ferrer Internacional S.A. | 2021-10-18 |
| A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study (NCT05095571) | Haukeland University Hospital | 2021-10-07 |
| A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD (NCT04993755) | Transposon Therapeutics, Inc. | 2021-10-01 |
| Telehealth Implementation of Brain-Computer Interface (NCT05951556) | Shirley Ryan AbilityLab | 2021-09-30 |
| Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments (NCT04816227) | Institut National de la Santé Et de la Recherche Médicale, France | 2021-09-29 |
| A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic Lateral Sclerosis (NCT04948645) | AbbVie | 2021-09-22 |
| Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis (NCT04953286) | University Hospital, Tours | 2021-09-17 |
| Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS (NCT05204017) | University of Alberta | 2021-09-12 |
| A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS (NCT05053035) | Alector Inc. | 2021-09-02 |
| A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS) (NCT05039099) | AL-S Pharma | 2021-09-02 |
| Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS (NCT04749433) | Johns Hopkins University | 2021-09-01 |
| A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT04944784) | Cytokinetics | 2021-08-16 |
| Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) (NCT06008249) | Stichting TRICALS Foundation | 2021-08-09 |
| Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis (NCT04953494) | Peking University Third Hospital | 2021-08-01 |
| Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) (NCT04788745) | The University of Queensland | 2021-06-29 |
| Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China (NCT04961450) | Peking University Third Hospital | 2021-06-24 |
| New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis (NCT04691011) | Assistance Publique Hopitaux De Marseille | 2021-06-16 |
| Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders (NCT04939818) | Novoic Limited | 2021-06-14 |
| FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS) (NCT04768972) | Ionis Pharmaceuticals, Inc. | 2021-06-14 |
| A Longitudinal Analysis of Biomarkers in Patients With ALS (NCT05309408) | Holy Cross Hospital, Florida | 2021-06-11 |
| Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures (NCT05137665) | Target ALS Foundation, Inc. | 2021-06-01 |
| EMERALD TRIAL Open Label Extension Study (NCT04997954) | Gold Coast Hospital and Health Service | 2021-05-17 |
| Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS (NCT05747937) | Istituti Clinici Scientifici Maugeri SpA | 2021-05-15 |
| Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and Caregivers (NCT04719403) | Dartmouth-Hitchcock Medical Center | 2021-05-12 |
| Telespirometry in Amyotrophic Lateral Sclerosis (ALS) (NCT05106569) | State University of New York - Upstate Medical University | 2021-04-28 |
| HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial (NCT07656714) | Hospital Universitario Virgen Macarena | 2021-04-15 |
| Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home. (NCT04797845) | University Hospital, Toulouse | 2021-04-12 |
| Intermuscular Coherence as a Biomarker for ALS (NCT05104710) | University of Chicago | 2021-03-31 |
| Counterfactual Thinking in Amyotrophic Lateral Sclerosis (NCT05768646) | Istituto Auxologico Italiano | 2021-03-31 |
| Enoxacin for Amyotrophic Lateral Sclerosis (ALS) (NCT04840823) | McGill University | 2021-03-26 |
| RT001 in Amyotrophic Lateral Sclerosis (NCT04762589) | Biojiva LLC | 2021-03-10 |
| Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis (NCT04632225) | Helixmith Co., Ltd. | 2021-03-09 |
| China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine (NCT04885374) | Dongzhimen Hospital, Beijing | 2021-03-01 |
| Geometrical Facial Deformation According to Posture in Amyotrophic Lateral Sclerosis (NCT04798183) | Pusan National University Yangsan Hospital | 2021-03-01 |
| Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALS (NCT04745299) | Corestemchemon, Inc. | 2021-02-24 |
| Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA (NCT04686110) | University Hospital, Angers | 2021-02-12 |
| Fatigue in Patients With Amyotrophic Lateral Sclerosis (NCT04468191) | Cara Donohue | 2021-02-10 |
| Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients (NCT03127267) | AB Science | 2021-02-02 |
| To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers (NCT03651349) | Everfront Biotech Co., Ltd. | 2021-02-01 |
| Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS) (NCT04569435) | Annexon, Inc. | 2021-01-15 |
| Phenotype, Genotype and Biomarkers 2 (NCT04875416) | University of Miami | 2021-01-08 |
| Exploratory Evaluation of [11C]MPC6827 (NCT04575727) | Columbia University | 2021-01-08 |
| Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral Sclerosis (NCT04953481) | Peking University Third Hospital | 2021-01-01 |
| Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS (NCT05003167) | Purdue University | 2021-01-01 |
| Food Supplement for the Treatment of Patients With Amyotrophic Lateral Sclerosis (NCT02588807) | Herb Spirit | 2021-01-01 |
| HEALEY ALS Platform Trial - Regimen D Pridopidine (NCT04615923) | Merit E. Cudkowicz, MD | 2020-12-18 |
| The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS (NCT04651855) | Polski Bank Komorek Macierzystych JSC (PBKM) | 2020-12-02 |
| A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT04516096) | Amylyx Pharmaceuticals Inc. | 2020-11-22 |
| Neurofilament Light Chain in Amyotrophic Lateral Sclerosis (NCT06201650) | Charite University, Berlin, Germany | 2020-11-11 |
| The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS (NCT04391361) | Ruijin Hospital | 2020-11-01 |
| Multiple Doses of AT-1501-A201 in Adults With ALS (NCT04322149) | Anelixis Therapeutics, LLC | 2020-10-16 |
| COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry (NCT04559009) | Wake Forest University Health Sciences | 2020-10-15 |
| Evaluation of Palliative Care for Patients With ALS and Their Caregivers (NCT04257760) | Ottawa Hospital Research Institute | 2020-10-08 |
| The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS. (NCT04562831) | Haukeland University Hospital | 2020-10-07 |
| MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) (NCT04579666) | Apellis Pharmaceuticals, Inc. | 2020-09-30 |
| A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic Mutation (NCT04494256) | Biogen | 2020-09-28 |
| Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part. (NCT04882904) | Centre Hospitalier Universitaire de Liege | 2020-09-25 |
| Open Label Study: Treatment of ALS Fatigue With PolyMVA (NCT04557410) | University of Missouri-Columbia | 2020-09-23 |
| A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease (NCT04428775) | AZTherapies, Inc. | 2020-09-08 |
| Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis (NCT04518540) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2020-09-01 |
| The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)" (NCT04305639) | Istanbul Medeniyet University | 2020-09-01 |
| Investigation on Home Care Needs of ALS Patients and Their Caregivers (NCT04950231) | Peking University Third Hospital | 2020-09-01 |
| Analysis of Human ALS Tissues and Registry of ALS Patients (NCT05067179) | University of Illinois at Chicago | 2020-09-01 |
| AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis (NCT04721717) | University of Alabama at Birmingham | 2020-09-01 |
| Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT04499963) | Richard Bedlack, M.D., Ph.D. | 2020-08-28 |
| Appetite and Related Factors in Patients With ALS (NCT04953624) | Peking University Third Hospital | 2020-08-01 |
| Sleep Disorders and the Onset and Progression of ALS (NCT04952038) | Peking University Third Hospital | 2020-08-01 |
| HEALEY ALS Platform Trial - Regimen C CNM-Au8 (NCT04414345) | Merit E. Cudkowicz, MD | 2020-07-30 |
| HEALEY ALS Platform Trial - Regimen A Zilucoplan (NCT04436497) | Merit E. Cudkowicz, MD | 2020-07-29 |
| HEALEY ALS Platform Trial - Regimen B Verdiperstat (NCT04436510) | Merit E. Cudkowicz, MD | 2020-07-28 |