| Better Access to and Integration of Mental Health and Addiction Services Through Navigation: A Mixed-Methods Adaptive Pragmatic Clinical Trial (NCT07707492) | Sunnybrook Health Sciences Centre | 2026-10-01 |
| Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures (NCT07756047) | Sunnybrook Health Sciences Centre | 2026-08-01 |
| Ketogenic Diet and Neuromodulation in Treatment Resistant Depression (NCT07376018) | Sunnybrook Health Sciences Centre | 2026-08-01 |
| Safety and Feasibility of Next-Generation Dome Helmet (NGDH) for Focused Ultrasound Neuromodulation in Substance Use Disorder (SUD) (NCT07684976) | Sunnybrook Health Sciences Centre | 2026-07-01 |
| Neuromodulation and fMRI in Neurodegenerative Diseases Study (NCT06873750) | Sunnybrook Health Sciences Centre | 2026-06-01 |
| Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD) (NCT07434791) | Sunnybrook Health Sciences Centre | 2026-06-01 |
| InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression (NCT06781697) | Sunnybrook Health Sciences Centre | 2026-05-03 |
| Early Detection of Metastatic Recurrence Among Patients With Stage II or III Triple Negative Breast Cancer Using Liquid Biopsy and Imaging (NCT07478705) | Sunnybrook Health Sciences Centre | 2026-05-01 |
| Baseline Knowledge of Stress Urinary Incontinence Among Urogynecology Patients (NCT07553884) | Sunnybrook Health Sciences Centre | 2026-04-30 |
| Testing a New Treatment Strategy to Improve Secondary Stroke Prevention for Older Adults: The STROKE75+ Trial (NCT07454707) | Sunnybrook Health Sciences Centre | 2026-04-01 |
| Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares (NCT07245732) | Sunnybrook Health Sciences Centre | 2026-04-01 |
| A Phase II Trial Evaluating Radiation Boost to Painful Spinal Metastases (NCT07478289) | Sunnybrook Health Sciences Centre | 2026-04-01 |
| A Dose Optimization Study of Enzalutamide in Elderly Patients With Advanced Prostate Cancer (NCT07512076) | Sunnybrook Health Sciences Centre | 2026-04-01 |
| Dose-Escalated MR-Guided Radiotherapy for Localized Prostate Cancer (NCT07674225) | Sunnybrook Health Sciences Centre | 2026-03-22 |
| Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial (NCT07479836) | Sunnybrook Health Sciences Centre | 2026-03-01 |
| Fisetin in Mild Alzheimer's Disease (NCT07279714) | Sunnybrook Health Sciences Centre | 2026-01-27 |
| Evaluation of Intercostal Neuralgia in Patients With Chest Tube Insertion After Traumatic Rib Fracture (NCT07308587) | Sunnybrook Health Sciences Centre | 2026-01-19 |
| Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therapy Training: A Non-Inferiority Study (NCT07350278) | Sunnybrook Health Sciences Centre | 2026-01-18 |
| Study Of Ultrasound Windows For Measuring Inferior Vena Cava Changes Before Cardiac Surgery (NCT07305051) | Sunnybrook Health Sciences Centre | 2026-01-01 |
| Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia (NCT07279740) | Sunnybrook Health Sciences Centre | 2026-01-01 |
| Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants (NCT04608292) | Sunnybrook Health Sciences Centre | 2026-01-01 |
| Pilot Feasibility Trial of a Peer Support Program for Trauma Survivors (NCT07275892) | Sunnybrook Health Sciences Centre | 2026-01-01 |
| STUDIIO-Diabetes Pilot: STUdy of Drug Insurance to Improve Outcomes of Diabetes (NCT03804905) | Sunnybrook Health Sciences Centre | 2026-01-01 |
| The Use of Immersive 360-degree Video in Improving Spatial Orientation (NCT05894005) | Sunnybrook Health Sciences Centre | 2025-11-08 |
| Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma (NCT07476794) | Sunnybrook Health Sciences Centre | 2025-11-01 |
| Levetiracetam for Persons at Risk for Alzheimer's Disease (NCT07477431) | Sunnybrook Health Sciences Centre | 2025-10-23 |
| Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy in Symptomatic ICAD (NCT06714526) | Sunnybrook Health Sciences Centre | 2025-10-07 |
| Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor (NCT07212244) | Sunnybrook Health Sciences Centre | 2025-10-01 |
| Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD) (NCT07704632) | Sunnybrook Health Sciences Centre | 2025-09-23 |
| UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4 (NCT07459101) | Sunnybrook Health Sciences Centre | 2025-09-10 |
| Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for Refractory Anorexia Nervosa With Comorbid Obsessive Compulsive Disorder or Major Depressive Disorder (NCT07113665) | Sunnybrook Health Sciences Centre | 2025-08-01 |
| rTMS for Youth Inpatients With Depression (NCT07140575) | Sunnybrook Health Sciences Centre | 2025-08-01 |
| Using Cannabis to Treat Restless Legs Syndrome (NCT06863740) | Sunnybrook Health Sciences Centre | 2025-07-25 |
| Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases (NCT07162246) | Sunnybrook Health Sciences Centre | 2025-07-14 |
| Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression (NCT07094789) | Sunnybrook Health Sciences Centre | 2025-07-11 |
| Wearable Cardiac Monitor to Enhance Detection of Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation (NCT06564012) | Sunnybrook Health Sciences Centre | 2025-07-01 |
| Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression (NCT07108257) | Sunnybrook Health Sciences Centre | 2025-06-25 |
| Evaluating the Impact of Virtual Reality on Mood in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Essential Tremor (NCT07287605) | Sunnybrook Health Sciences Centre | 2025-06-19 |
| Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy (NCT07179328) | Sunnybrook Health Sciences Centre | 2025-06-04 |
| A Randomized Neuroimaging Trial of Psilocybin in Depression (NCT06072898) | Sunnybrook Health Sciences Centre | 2025-05-28 |
| Life Following Excision of Neuroendocrine Tumors (NCT06981455) | Sunnybrook Health Sciences Centre | 2025-04-28 |
| Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) (NCT07193953) | Sunnybrook Health Sciences Centre | 2025-04-15 |
| The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain (NCT06579040) | Sunnybrook Health Sciences Centre | 2025-04-08 |
| OURA Ring Wearable Testing in MDS Patients: a Feasibility and Discovery Pilot Study (NCT06270771) | Sunnybrook Health Sciences Centre | 2025-03-20 |
| INTRAOCULAR PRESSURE MEASUREMENT AT the END of PARS PLANA VITRECTOMY (NCT06707168) | Sunnybrook Health Sciences Centre | 2025-03-01 |
| Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position (NCT06915857) | Sunnybrook Health Sciences Centre | 2025-02-26 |
| Priming CBT With rTMS for OCD (NCT06840951) | Sunnybrook Health Sciences Centre | 2025-02-05 |
| CPAP Randomized Controlled Trial (NCT06773416) | Sunnybrook Health Sciences Centre | 2025-02-01 |
| Comparing Cardiac Chamber Measurements: TTE vs. TEE Under Anesthesia (NCT06715371) | Sunnybrook Health Sciences Centre | 2025-01-27 |
| Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible (NCT06055257) | Sunnybrook Health Sciences Centre | 2025-01-16 |
| qEEG Brain Signature of Depression & Neuromodulation-induced Recovery (NCT06719427) | Sunnybrook Health Sciences Centre | 2025-01-06 |
| Patient Specific Virtual Reality for Simulation of Spine Procedures: an Intelligent Image Segmentation, Registration and 3-dimensional Visualization in a Unified Virtual Reality Workflow for Image Guided Therapy, and Education - Physician Testing (NCT06714539) | Sunnybrook Health Sciences Centre | 2024-12-02 |
| Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE) (NCT06423716) | Sunnybrook Health Sciences Centre | 2024-11-01 |
| Deep Brain Stimulation for Refractory PTSD (NCT06705296) | Sunnybrook Health Sciences Centre | 2024-11-01 |
| DBS for Cognitive Deficits After Traumatic Brain Injury (NCT06818864) | Sunnybrook Health Sciences Centre | 2024-11-01 |
| I-CARE: A Pilot Study of Cognitive Behavioural Therapy(CBT) for Mood and Anxiety Disorders (NCT06532500) | Sunnybrook Health Sciences Centre | 2024-10-24 |
| CAN3T - Canadian TAVI Triage Tool (NCT06551610) | Sunnybrook Health Sciences Centre | 2024-10-01 |
| Prospective Assessment of Acute Skin Toxicities in Breast Cancer Patients Undergoing Retreatment with 40 Gy in 15 Fractions Radiation Therapy (NCT06729814) | Sunnybrook Health Sciences Centre | 2024-08-07 |
| Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer (NCT06185972) | Sunnybrook Health Sciences Centre | 2024-07-25 |
| MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer (NCT06633601) | Sunnybrook Health Sciences Centre | 2024-07-01 |
| FET-PET/MRI Based Treatment Planning for Glioblastoma Multiforme in Post-Surgical Patients (FET-TREAT) (NCT06451042) | Sunnybrook Health Sciences Centre | 2024-07-01 |
| Cognitive Rehabilitation for People With Multiple Sclerosis (NCT06179134) | Sunnybrook Health Sciences Centre | 2024-06-03 |
| Immune Checkpoint Inhibitor Therapy for Cancer and Risk of Myocarditis or Cardiomyopathy (NCT06309862) | Sunnybrook Health Sciences Centre | 2024-06-01 |
| Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2 (NCT05983211) | Sunnybrook Health Sciences Centre | 2024-05-01 |
| A Platform Trial for Gram Negative Bloodstream Infections (NCT06537609) | Sunnybrook Health Sciences Centre | 2024-04-24 |
| Sleep Apnea and Cognition in Older Adults (NCT06423118) | Sunnybrook Health Sciences Centre | 2024-04-09 |
| Three-Dimensional Ultrasound Imaging and Spectroscopy for Characterizing Breast Masses (NCT06175078) | Sunnybrook Health Sciences Centre | 2024-04-01 |
| Three-Dimensional Ultrasound and Spectroscopy as Early Indicators of Breast Cancer Response to Neoadjuvant Treatment (NCT06193122) | Sunnybrook Health Sciences Centre | 2024-04-01 |
| Study to Actively Warm Trauma Patients-2 (NCT06322186) | Sunnybrook Health Sciences Centre | 2024-03-01 |
| Improving Sexual Quality of Life - Randomized Trial of Two vs Five MRI Guided SABR Treatments for Prostate Cancer (NCT05600400) | Sunnybrook Health Sciences Centre | 2024-03-01 |
| Usability of the Intracochlear Catheter INCAT - a Feasibility Study (NCT06218966) | Sunnybrook Health Sciences Centre | 2024-01-15 |
| Pilot Study of Dose Escalation in Prostate Radiotherapy Using the MR-Linac (DESTINATION-MRL) (NCT06177093) | Sunnybrook Health Sciences Centre | 2023-12-11 |
| MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer (NCT06247449) | Sunnybrook Health Sciences Centre | 2023-11-29 |
| Evaluating Simplified Layered Consent for Clinical Trials (NCT06168474) | Sunnybrook Health Sciences Centre | 2023-11-28 |
| Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study (NCT06016387) | Sunnybrook Health Sciences Centre | 2023-11-25 |
| Screening Using Portable Electronic Recorders for Sleep Apnea in Hypertensive At-Risk Populations (SUPER-SHARP Trial) (NCT05918120) | Sunnybrook Health Sciences Centre | 2023-11-13 |
| Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome (NCT06031662) | Sunnybrook Health Sciences Centre | 2023-10-31 |
| UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture (NCT05865327) | Sunnybrook Health Sciences Centre | 2023-10-23 |
| Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents (NCT05867472) | Sunnybrook Health Sciences Centre | 2023-10-10 |
| Passive Antibodies Against COVID-19 With EVUSHELD in Vaccine Non-responsive CLL (NCT05465876) | Sunnybrook Health Sciences Centre | 2023-10-01 |
| Lung Ultrasound Versus Chest Radiography for Detection of Pneumothorax (NCT06022081) | Sunnybrook Health Sciences Centre | 2023-09-27 |
| Interleaved TMS-fMRI in Ultra-treatment Resistant Depression (NCT05813093) | Sunnybrook Health Sciences Centre | 2023-09-27 |
| Cannabidiol Medication Intervention Trial (NCT06014424) | Sunnybrook Health Sciences Centre | 2023-09-27 |
| MRI Guided Closed-loop TMS-EEG (NCT06050603) | Sunnybrook Health Sciences Centre | 2023-09-07 |
| Magnetic Stimulation as a Treatment for Stress Urinary Incontinence (NCT05952258) | Sunnybrook Health Sciences Centre | 2023-09-01 |
| BALANCE+ Vanguard Phase (NCT05893147) | Sunnybrook Health Sciences Centre | 2023-08-26 |
| Alternative Dosing Of Niraparib To Decrease Dose Interruption In First Line Maintenance Treatment For Ovarian Cancer (NCT05961124) | Sunnybrook Health Sciences Centre | 2023-08-21 |
| Simulation for Operating Room Ergonomics (NCT05541354) | Sunnybrook Health Sciences Centre | 2023-08-18 |
| A Mindful Self-compassion Based Intervention for Specialist Rehabilitation Providers (NCT05997082) | Sunnybrook Health Sciences Centre | 2023-08-17 |
| Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661) | Sunnybrook Health Sciences Centre | 2023-08-02 |
| A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113) | Sunnybrook Health Sciences Centre | 2023-08-01 |
| CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NCT05828810) | Sunnybrook Health Sciences Centre | 2023-07-25 |
| Incidence of Adductor Canal Catheter Dislodgment (NCT05961085) | Sunnybrook Health Sciences Centre | 2023-07-10 |
| Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD) (NCT05931991) | Sunnybrook Health Sciences Centre | 2023-07-07 |
| Wadey RCT MSK Short Case Simulations With FMED (NCT05914922) | Sunnybrook Health Sciences Centre | 2023-07-02 |
| Psychosocial Transitional Group Pragmatic Trial (NCT05798091) | Sunnybrook Health Sciences Centre | 2023-06-28 |
| The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C) (NCT05427370) | Sunnybrook Health Sciences Centre | 2023-06-22 |
| Post-Hoc Enthusiasm and Wariness (NCT05686889) | Sunnybrook Health Sciences Centre | 2023-05-01 |
| Finding a Biomarker for Acute Neuromodulation Effects in Adolescent Depression (NCT05832294) | Sunnybrook Health Sciences Centre | 2023-04-20 |
| UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3) (NCT05720078) | Sunnybrook Health Sciences Centre | 2023-04-01 |