| Immune Dysregulation During Sepsis: A Natural History Cohort (NCT07735741) | National Heart, Lung, and Blood Institute (NHLBI) | 2027-01-01 |
| Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging (NCT07613099) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| EDEN Intracardiac Electrogram Recording and Classifying System (NCT07137455) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART) (NCT06280820) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms) Using Commercial Off-The-Shelf (COTS) Catheters (NCT06940752) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| NHLBI-Emory Advanced Cardiac CT Reconstruction (NCT05372627) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic Hyperlipidemia (NCT07715890) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| Syk Inhibition in MItigating Lung Allograft Rejection (SIMILAR): A Trial to Evaluate the Safety and Tolerability of Fostamatinib in Lung Transplant Patients With Donor-Specific Antibodies (NCT06948097) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-08-26 |
| Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease (NCT07566494) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-07-31 |
| Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors (NCT07599176) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-07-08 |
| GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation (NCT07516379) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-05-11 |
| Platelet Volunteers, Longitudinal and Multi-omic Study (NCT07137429) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-03-26 |
| Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib (NCT07428707) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-03-11 |
| Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement (NCT06923072) | National Heart, Lung, and Blood Institute (NHLBI) | 2026-02-18 |
| Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated Cytopenias (NCT05509582) | National Heart, Lung, and Blood Institute (NHLBI) | 2025-11-07 |
| Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study (NCT07102849) | National Heart, Lung, and Blood Institute (NHLBI) | 2025-09-09 |
| NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study (NCT06479824) | National Heart, Lung, and Blood Institute (NHLBI) | 2025-08-19 |
| Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome (NCT06676033) | National Heart, Lung, and Blood Institute (NHLBI) | 2025-07-18 |
| Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions (NCT06676046) | National Heart, Lung, and Blood Institute (NHLBI) | 2025-01-15 |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study (NCT06269640) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-12-18 |
| Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease (NCT05904093) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-12-18 |
| OurSleepKit To Support CPAP Adherence (NCT06621511) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-12-03 |
| Thrombosis and Inflammation in Vessels Initiative (TIVI) (NCT06552767) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-11-22 |
| Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis (NCT06615986) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-11-15 |
| Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling (NCT06313398) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-05-17 |
| Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease (NCT05675436) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-05-09 |
| Technical Development of Cardiovascular Magnetic Resonance Imaging (NCT04927429) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-04-08 |
| Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Transplantation (NCT06093867) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-04-08 |
| Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus (NCT06032923) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-03-13 |
| JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure (NCT05998408) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-02-20 |
| Healing Within: Mindfulness Smoking Cessation Intervention (NCT07013968) | National Heart, Lung, and Blood Institute (NHLBI) | 2024-01-25 |
| Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function (NCT06145282) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-12-28 |
| Study of Intravenous ZMA001 in Healthy Subjects (NCT05967299) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-11-27 |
| JAK/STAT Inhibition in CNS Kohlmeier-Degos Disease (NCT05998395) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-09-28 |
| Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia (NCT05828108) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-07-25 |
| Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias (NCT05502783) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-03-10 |
| Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax (NCT05724121) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-03-01 |
| NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial (NCT05666713) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-02-21 |
| Structural Heart and Valve Network PROSPECTIVE Registry (NCT03928639) | National Heart, Lung, and Blood Institute (NHLBI) | 2023-01-10 |
| Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD) (NCT05604547) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-11-28 |
| Vaccine Responses in Patients With B Cell Malignancies (NCT05170399) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-09-14 |
| Controls and Healthy Vasculature Initiative (NCT05403151) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-07-01 |
| The Effect of Inflammation in Heart Failure (NCT05330013) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-06-23 |
| Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia (NCT05357482) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-05-12 |
| Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung (NCT05027958) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-05-03 |
| Natural History Study of CADASIL (NCT05072483) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-04-18 |
| Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies (NCT05213572) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-03-24 |
| Natural History of Acquired and Inherited Bone Marrow Failure Syndromes (NCT05012111) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-10-25 |
| Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women (NCT04014348) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-10-20 |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers (NCT04216342) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-09-29 |
| Anti-Inflammatory Effects of Time-Restricted Feeding (NCT04728165) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-06-09 |
| Effect of Chronic Inflammation on Myocardial Perfusion and Function (NCT04870827) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-06-07 |
| Gene First Approach to Connective Tissue Disease (NCT04664478) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-04-22 |
| Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease (NCT04476277) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-04-19 |
| Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENE-FORECAST): Sodium Intervention Trial (SIT) (NCT04717336) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-01-22 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat (NCT04610866) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-12-09 |
| Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag (NCT04269889) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-12-01 |
| Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease (NCT04514510) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-11-02 |
| Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM) (NCT04603521) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-10-20 |
| Fostamatinib for Hospitalized Adults With COVID-19 (NCT04579393) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-10-08 |
| COV2Base-A Rare Disease by COVID Study (NCT04564274) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-10-04 |
| Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait (NCT04349189) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-09-01 |
| Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis (NCT04271735) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-08-26 |
| Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT04209621) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-07-31 |
| Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors (NCT04450927) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-06-16 |
| Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy (NCT04436367) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-06-15 |
| Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy (NCT04436380) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-06-15 |
| Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) (NCT04304820) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-05-07 |
| CHIP/CCUS Natural History Protocol (NCT04102423) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-03-03 |
| Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels (NCT04008368) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-10-24 |
| Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) (NCT03986034) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-06-26 |
| Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy (NCT03958643) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-05-24 |
| NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study (NCT03929913) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-05-07 |
| Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome (NCT03789175) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-03-25 |
| Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis (NCT03520647) | National Heart, Lung, and Blood Institute (NHLBI) | 2019-02-19 |
| HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I) (NCT03685708) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-12-07 |
| Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I) (NCT03702231) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-12-07 |
| Eltrombopag for People With Fanconi Anemia (NCT03206086) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-11-02 |
| Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease (NCT03685721) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-10-11 |
| The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects (NCT03565328) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-09-27 |
| Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults (NCT03372733) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-07-31 |
| Vascular Disease Discovery Protocol (NCT03538639) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-07-30 |
| HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma (NCT03354390) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-07-20 |
| Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging (NCT03581318) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-07-12 |
| Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments (NCT03288207) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-06-21 |
| Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension (NCT03572036) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-06-20 |
| Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant (NCT03511794) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-04-13 |
| Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest Imaging (NCT03478917) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-02-27 |
| Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation (NCT03381989) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-02-14 |
| Low-Dose Danazol for the Treatment of Telomere Related Diseases (NCT03312400) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-02-08 |
| Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement (NCT03432494) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-02-07 |
| Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System (NCT03331380) | National Heart, Lung, and Blood Institute (NHLBI) | 2018-01-05 |
| Discovery of Sirolimus Sensitive Biomarkers in Blood (NCT03304678) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-12-04 |
| dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC) (NCT03347214) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-10-20 |
| Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI) (NCT03253692) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-10-03 |
| Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT03204188) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-09-22 |
| Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires (NCT03152773) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-08-02 |
| Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients (NCT03226691) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-07-25 |
| Extracellular RNAs in Relation to Cardiometabolic Risk (NCT03225196) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-07-17 |
| RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2 (NCT03225183) | National Heart, Lung, and Blood Institute (NHLBI) | 2017-07-14 |