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National Cancer Institute (NCI)

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RecordFirmDate
Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial (NCT07605416)National Cancer Institute (NCI)2027-04-20
Comparing Different Treatment Lengths for Venetoclax in Older People With Newly Diagnosed Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) (NCT07437950)National Cancer Institute (NCI)2027-04-18
Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment (NCT07463807)National Cancer Institute (NCI)2027-04-12
Testing the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma (NCT07332507)National Cancer Institute (NCI)2027-03-26
Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial (NCT07388524)National Cancer Institute (NCI)2027-03-02
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma (NCT07156227)National Cancer Institute (NCI)2027-02-13
Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma (NCT07689240)National Cancer Institute (NCI)2027-02-10
Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) (NCT06917911)National Cancer Institute (NCI)2027-02-02
Evaluating the Addition of Maintenance Immunotherapy Compared to the Usual Treatment of Chemotherapy and Autologous Stem Cell Transplant Alone for High-risk Patients With Relapsed or Refractory Hodgkin Lymphoma (NCT07572123)National Cancer Institute (NCI)2026-12-04
Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma (NCT07422363)National Cancer Institute (NCI)2026-12-04
Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma (NCT07281417)National Cancer Institute (NCI)2026-11-24
Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse (NCT07437963)National Cancer Institute (NCI)2026-10-28
AMC 120, Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma (The "Glofit-RCHOP Study") (NCT07649304)National Cancer Institute (NCI)2026-10-09
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer (NCT07137416)National Cancer Institute (NCI)2026-10-05
Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones (NCT06982222)National Cancer Institute (NCI)2026-10-01
Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers (NCT07686367)National Cancer Institute (NCI)2026-09-11
Sacituzumab Govitecan With Bevacizumab Compared to Usual Chemotherapy (Carboplatin, Pegylated Liposomal Doxorubicin and Bevacizumab) for Treating Recurrent Platinum-Sensitive Ovarian Cancer After PARP Inhibitor Maintenance Therapy (NCT07504588)National Cancer Institute (NCI)2026-09-10
Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a, for Advanced Pancreatic Ductal Adenocarcinoma (NCT07619521)National Cancer Institute (NCI)2026-09-08
Testing an Anti-cancer Radio-Active Immunotherapy Called Lintuzumab Ac225 in Patients With High-Risk Myelodysplastic Syndrome That Has Not Responded to Other Treatment (NCT06888323)National Cancer Institute (NCI)2026-09-03
Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse (NCT06948084)National Cancer Institute (NCI)2026-08-26
Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma (NCT06876142)National Cancer Institute (NCI)2026-08-23
IL-15 Superagonist With or Without Vaccine in Biochemically Recurrent Prostate Cancer After Previous Stereotactic Body Radiation Therapy (NCT07686380)National Cancer Institute (NCI)2026-08-23
Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL) (NCT07572136)National Cancer Institute (NCI)2026-08-23
Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP) (NCT07756840)National Cancer Institute (NCI)2026-08-23
Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms (NCT06303193)National Cancer Institute (NCI)2026-08-23
Multitargeted Recombinant Ad5 PSA/MUC-1/Brachyury-Based Immunotherapy (TriAdeno) Vaccine With IL-15 Superagonist N-803 in Participants With Clinically Localized Prostate Cancer Undergoing Active Surveillance (NCT07574541)National Cancer Institute (NCI)2026-08-23
Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy (NCT07715903)National Cancer Institute (NCI)2026-08-23
A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity (NCT06406465)National Cancer Institute (NCI)2026-08-23
NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors (NCT07489378)National Cancer Institute (NCI)2026-08-23
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases (NCT07619534)National Cancer Institute (NCI)2026-08-23
A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymph... (NCT05621291)National Cancer Institute (NCI)2026-08-23
Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC) (NCT06694454)National Cancer Institute (NCI)2026-08-23
IL-12 Genetically Engineered Myeloid Cells in Participants With Relapsed, Refractory Solid Tumors (NCT07672483)National Cancer Institute (NCI)2026-08-23
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer (NCT07667400)National Cancer Institute (NCI)2026-08-23
Autologous B7-H3 Chimeric Antigen Receptor T Cells in Previously Treated Extensive-Stage Small Cell Lung Cancer With Recurrent or Refractory Disease (NCT07509034)National Cancer Institute (NCI)2026-08-23
Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical Carcinoma (NCT06487481)National Cancer Institute (NCI)2026-08-23
Clinical Genetics Branch Eligibility Screening Survey (NCT07005297)National Cancer Institute (NCI)2026-08-23
Natural History Study of Early Life Exposures in Agriculture (ELEA) (NCT07328516)National Cancer Institute (NCI)2026-08-23
Experience and Management of Cancer Screening-Related Anxiety in Fanconi Anemia (NCT06744283)National Cancer Institute (NCI)2026-08-23
Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers (NCT07524530)National Cancer Institute (NCI)2026-08-23
Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies (NCT06904066)National Cancer Institute (NCI)2026-08-23
Testing the Safety and Feasibility of Immunotherapy Drugs, Botensilimab and Balstilimab, Before Surgery for Clear Cell Renal Cell Carcinoma, NEO RoBOT Trial (NCT07516366)National Cancer Institute (NCI)2026-08-21
Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma (NCT07444710)National Cancer Institute (NCI)2026-08-20
Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit Lymphoma (NCT07724457)National Cancer Institute (NCI)2026-08-14
Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial (NCT07551596)National Cancer Institute (NCI)2026-08-14
Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer (NCT07147231)National Cancer Institute (NCI)2026-08-10
A Scientific Evaluation of One or Two Doses of a Vaccine Against Human Papillomavirus: Long Term Follow Up of Gardasil9 Recipients in the ESCUDDO Study ("Estudio de Comparación de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano [VPH]") (NCT07706673)National Cancer Institute (NCI)2026-08-03
Venetoclax or Placebo in Combination With Reduced-Intensity Conditioning Hematopoietic Cell (Bone Marrow/Blood Stem Cell) Transplant and as Maintenance Therapy After Transplant in Patients With Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) (NCT06954987)National Cancer Institute (NCI)2026-07-17
An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis (NCT06557733)National Cancer Institute (NCI)2026-07-13
Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy (NCT07003295)National Cancer Institute (NCI)2026-07-08
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer (NCT07349641)National Cancer Institute (NCI)2026-07-06
Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial) (NCT05554419)National Cancer Institute (NCI)2026-07-01
Testing the SurVaxM Vaccine for Lung Cancer Prevention (NCT07169617)National Cancer Institute (NCI)2026-07-01
Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus (NCT06732388)National Cancer Institute (NCI)2026-06-23
A Trial Comparing Three Different Treatment Options for Adults With Low-Risk Myelodysplasia and Anemia (A MyeloMATCH Treatment Trial) (NCT07463820)National Cancer Institute (NCI)2026-06-19
Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation (NCT07012031)National Cancer Institute (NCI)2026-06-17
A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia (NCT07012044)National Cancer Institute (NCI)2026-06-09
Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia (NCT06965114)National Cancer Institute (NCI)2026-05-29
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event (NCT07499128)National Cancer Institute (NCI)2026-05-27
Testing the Use of an IDH1 Inhibitor, Olutasidenib, in Acute Myeloid Leukemia Added to ASTX727 and Venetoclax; in High-Risk MDS Added to ASTX727; and Alone in Low Risk MDS (A MyeloMATCH Treatment Substudy) (NCT07153497)National Cancer Institute (NCI)2026-05-27
Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia (NCT07061951)National Cancer Institute (NCI)2026-05-27
Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer (NCT06980038)National Cancer Institute (NCI)2026-05-27
Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer (NCT07328490)National Cancer Institute (NCI)2026-04-25
Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer (NCT07195734)National Cancer Institute (NCI)2026-04-24
Testing the Combination of Targeted Radiotherapy With Anti-Cancer Drugs, Venetoclax and ASTX-727, to Improve Outcomes for Adults With Newly Diagnosed Acute Myeloid Leukemia (NCT06802523)National Cancer Institute (NCI)2026-04-21
Recombinant Glycosylated Human Interleukin-7 (CYT107) for the Treatment of Kaposi Sarcoma in Participants With HIV and Immune Non-Response (REGIMENKS HIV) (NCT07308886)National Cancer Institute (NCI)2026-04-08
Quality of Care for Adolescent and Young Adult (AYA) Patients Living With Serious or Advanced Cancer (NCT07484282)National Cancer Institute (NCI)2026-04-07
Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma (NCT07388563)National Cancer Institute (NCI)2026-03-26
Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System (NCT07042295)National Cancer Institute (NCI)2026-03-23
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma (NCT06498648)National Cancer Institute (NCI)2026-03-18
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma (NCT06654050)National Cancer Institute (NCI)2026-03-16
Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (NCT06856226)National Cancer Institute (NCI)2026-03-04
A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast) (NCT07067138)National Cancer Institute (NCI)2026-02-23
Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer (NCT06900595)National Cancer Institute (NCI)2026-02-22
A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1) (NCT06507748)National Cancer Institute (NCI)2026-02-18
CBX-12 for the Treatment of Metastatic Chemotherapy-Refractory Microsatellite Stable Colorectal Cancer (NCT06730100)National Cancer Institute (NCI)2026-02-17
Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors (NCT07374692)National Cancer Institute (NCI)2026-02-04
Testing RG1-VLP Vaccine to Prevent HPV-related Cancers (NCT05985681)National Cancer Institute (NCI)2026-01-27
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer (NCT07198074)National Cancer Institute (NCI)2026-01-27
Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE) (NCT06041503)National Cancer Institute (NCI)2026-01-20
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer (NCT06524544)National Cancer Institute (NCI)2025-12-02
Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial (NCT07061964)National Cancer Institute (NCI)2025-11-25
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04) (NCT07281430)National Cancer Institute (NCI)2025-11-24
Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial (NCT06811116)National Cancer Institute (NCI)2025-11-17
Phase I Trial Integrating HLA-Haploidentical Anti-CD19 CAR-T Cells With Post-Transplantation Cyclophosphamide-Based HLA-Haploidentical Hematopoietic Cell Transplantation (NCT07162038)National Cancer Institute (NCI)2025-11-14
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer (NCT07061977)National Cancer Institute (NCI)2025-11-05
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing (NCT06066138)National Cancer Institute (NCI)2025-11-04
Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 (NCT05630794)National Cancer Institute (NCI)2025-10-06
A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) (NCT07055477)National Cancer Institute (NCI)2025-09-29
FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma (NCT06865664)National Cancer Institute (NCI)2025-09-22
A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer (NCT06410534)National Cancer Institute (NCI)2025-09-09
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection (NCT06503146)National Cancer Institute (NCI)2025-09-09
A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies (NCT06690281)National Cancer Institute (NCI)2025-09-09
[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers (NCT06479811)National Cancer Institute (NCI)2025-08-19
Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC) (NCT06603818)National Cancer Institute (NCI)2025-08-15
Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes (NCT06484062)National Cancer Institute (NCI)2025-08-15
A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) (NCT06661915)National Cancer Institute (NCI)2025-08-14
Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients With Non-Small Cell Lung Cancer (NCT06732401)National Cancer Institute (NCI)2025-08-07
Testing the Addition of an Investigational Anti-Cancer Drug, ASTX660 (Tolinapant), to a Usual Chemotherapy Treatment (Eribulin) for Treatment of Advanced Triple Negative Breast Cancer (NCT06590558)National Cancer Institute (NCI)2025-08-04
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma (NCT06860594)National Cancer Institute (NCI)2025-07-30
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