| Pharmacokinetics, Safety, Tolerability and Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium Falciparum Malaria (NCT04300309) | Novartis Pharmaceuticals | 2020-12-21 |
| Study of Melflufen (Melphalan Flufenamide) in Combination With Daratumumab in Relapsed-Refractory Multiple Myeloma (NCT04649060) | Oncopeptides AB | 2020-12-21 |
| Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis (NCT04657666) | Jazz Pharmaceuticals | 2020-12-21 |
| Efficacy of Secukinumab Compared to Ustekinumab in Adults With Active Psoriatic Arthritis and Failure of TNFα-Inhibitor Treatment (NCT04632927) | Novartis Pharmaceuticals | 2020-12-21 |
| Characterization of Corneal Epithelial Changes in Participants Treated With Belantamab Mafodotin (NCT04549363) | GlaxoSmithKline | 2020-12-21 |
| Safety and Efficacy of [18F]PSMA-1007 Injection in Suspected Persistent or Recurrent Prostate Cancer. (NCT04644822) | Centre for Probe Development and Commercialization | 2020-12-21 |
| Contrast Enhanced Ultrasound in COVID-19 (NCT04640038) | Children's Hospital of Philadelphia | 2020-12-18 |
| HEALEY ALS Platform Trial - Regimen D Pridopidine (NCT04615923) | Merit E. Cudkowicz, MD | 2020-12-18 |
| A Study of Brexanolone for Acute Respiratory Distress Syndrome (ARDS) Due to Coronavirus Disease 2019 (COVID-19) (NCT04537806) | Sage Therapeutics | 2020-12-18 |
| Omecamtiv Mecarbil Post-trial Access Study (NCT04464525) | Cytokinetics | 2020-12-18 |
| Ravulizumab and COVID-19 (NCT04570397) | Brigham and Women's Hospital | 2020-12-18 |
| Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial (NCT04300920) | Fernando J Martinez | 2020-12-17 |
| A Phase II/III Study of Sargramostim (NCT04642950) | Nobelpharma | 2020-12-17 |
| HIPEC + FLOT vs. FLOT Alone in Patients With Gastric Cancer and GEJ (PREVENT) (NCT04447352) | Krankenhaus Nordwest | 2020-12-17 |
| Efficacy and Safety of ANX005 in Subjects With Guillain-Barré Syndrome (NCT04701164) | Annexon, Inc. | 2020-12-17 |
| COMPARATIVE ANALYSIS OF INNOVATIVE BONE HEALING TECHNIQUES (NCT05480631) | Dow University of Health Sciences | 2020-12-17 |
| COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial; (NCT04534725) | Peter MacCallum Cancer Centre, Australia | 2020-12-17 |
| A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxia (NCT04577352) | PTC Therapeutics | 2020-12-17 |
| Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough (NCT04429516) | Royal Brompton & Harefield NHS Foundation Trust | 2020-12-17 |
| Evaluation of the Efficacy of High Doses of Methylprednisolone in SARS-CoV2 ( COVID-19) Pneumonia Patients (NCT04673162) | Azienda USL Reggio Emilia - IRCCS | 2020-12-17 |
| A Phase Ⅲ Study to Evaluate Tildrakizumab in the Treatment of Chinese Subjects With Moderate to Severe Plaquetype Psoriasis (NCT05108766) | Shenzhen Kangzhe Pharmaceutical Co., Ltd. | 2020-12-17 |
| The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients With Depression Depending on Metabolic Syndrome Comorbidity (NCT04756544) | Medical University of Lodz | 2020-12-17 |
| VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) (NCT05780281) | National Institute of Allergy and Infectious Diseases (NIAID) | 2020-12-16 |
| A Trial of Enzastaurin Plus Temozolomide During and Following Radiation Therapy in Patients With Newly Diagnosed Glioblastoma With or Without the Novel Genomic Biomarker, DGM1 (NCT03776071) | Denovo Biopharma LLC | 2020-12-16 |
| BRII-196/BRII-198 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) (NCT05780424) | National Institute of Allergy and Infectious Diseases (NIAID) | 2020-12-16 |
| A Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia (NCT04687072) | argenx | 2020-12-16 |
| A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19 (NCT04646590) | Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. | 2020-12-16 |
| An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study (NCT04597632) | Novartis Pharmaceuticals | 2020-12-16 |
| EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) (NCT04509674) | Boehringer Ingelheim | 2020-12-16 |
| Durvalumab Plus Chemotherapy in Untreated Patients With Extensive-Stage Small Cell Lung Cancer (NCT04712903) | AstraZeneca | 2020-12-16 |
| Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD) (NCT04701983) | Sanofi | 2020-12-16 |
| Danicopan as Add-on Therapy to a C5 Inhibitor in Paroxysmal Nocturnal Hemoglobinuria (PNH) Participants Who Have Clinically Evident Extravascular Hemolysis (EVH)(ALPHA) (NCT04469465) | Alexion Pharmaceuticals, Inc. | 2020-12-16 |
| Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia (NCT04490915) | Neurocrine Biosciences | 2020-12-16 |
| A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19 (NCT04640194) | Boehringer Ingelheim | 2020-12-16 |
| A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2) (NCT04659161) | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 2020-12-16 |
| A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer (NCT04351555) | AstraZeneca | 2020-12-16 |
| Evaluation of Prognostic Modification in COVID-19 Patients in Early Intervention Treatment (NCT04673214) | Gilberto Cruz Arteaga | 2020-12-16 |
| A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer (NCT04619797) | Hoffmann-La Roche | 2020-12-15 |
| Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins (NCT04478721) | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 2020-12-15 |
| Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus (NCT04606576) | Oramed, Ltd. | 2020-12-15 |
| Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults (NCT04657172) | Eyenovia Inc. | 2020-12-15 |
| Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm (NCT04671082) | Neurana Pharmaceuticals, Inc. | 2020-12-15 |
| Sorafenib Maintenance for Prophylaxis of Leukemia Relapse in Allo-HSCT Recipients With FLT3 Negative Acute Leukemia (NCT04674345) | Nanfang Hospital, Southern Medical University | 2020-12-15 |
| Massive Pulmonary Embolism: Trial of Non-immunogenic Recombinant Staphylokinase VS Alteplase FORPE (NCT04688320) | Supergene, LLC | 2020-12-15 |
| An Efficacy, Immunogenicity and Safety Study Investigating an Adjuvanted SARS-CoV-2 Influenza Vaccine to Protect Against COVID-19 in Adults Over Aged 18 Years-old and Older (NCT04806529) | Seqirus | 2020-12-15 |
| D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II) (NCT04411199) | PolyPid Ltd. | 2020-12-15 |
| Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS) (NCT04609878) | AstraZeneca | 2020-12-15 |
| Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH) (NCT04681170) | Amryt Pharma | 2020-12-14 |
| Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP) (NCT04562766) | Principia Biopharma, a Sanofi Company | 2020-12-14 |
| Tislelizumab Monotherapy Versus Salvage Chemotherapy for Relapsed/Refractory Classical Hodgkin Lymphoma (NCT04486391) | BeiGene | 2020-12-14 |
| Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration (NCT04264819) | Novartis Pharmaceuticals | 2020-12-14 |
| The CASCADE HF Soft Launch and Calibration Phase I and II (NCT04738279) | Endeavor Health | 2020-12-14 |
| A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension (NCT03267108) | Bellerophon Pulse Technologies | 2020-12-14 |
| Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee (NCT04636229) | Organogenesis | 2020-12-14 |
| B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B (NCT04193189) | National Institute of Allergy and Infectious Diseases (NIAID) | 2020-12-14 |
| The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC (NCT04338399) | Adlai Nortye Biopharma Co., Ltd. | 2020-12-12 |
| School-Based Assessment of Micronutrient Interventions in Adolescents in Burkina Faso (NCT04657640) | Harvard School of Public Health (HSPH) | 2020-12-11 |
| Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE) (NCT04460560) | University of Pennsylvania | 2020-12-11 |
| Adolescent Type 1 Diabetes Treatment With SGLT2i for hyperglycEMia & hyPerfilTration Trial (NCT04333823) | The Hospital for Sick Children | 2020-12-11 |
| Study of the Safety and Efficacy of RPH-104 in Preventing Recurrences in Patients With Idiopathic Recurrent Pericarditis (NCT05673902) | R-Pharm International, LLC | 2020-12-11 |
| Opioid-Free Orthopaedics (NCT04659317) | Emory University | 2020-12-11 |
| A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older (NCT04652102) | CureVac | 2020-12-11 |
| A Study of Lurasidone Compared With Placebo for the Treatment of Bipolar I Depression (NCT04383691) | Marubeni Pharmaceuticals (Suzhou) Co., Ltd. | 2020-12-11 |
| Atrasentan in Patients With IgA Nephropathy (NCT04573478) | Novartis Pharmaceuticals | 2020-12-11 |
| Evaluate the Effect of Injectable Neucardin on the Cardiac Function of Subjects With Chronic Systolic Heart Failure (NCT04468529) | Zensun Sci. & Tech. Co., Ltd. | 2020-12-10 |
| Dupilumab for the Treatment of Chronic Inducible Cold Urticaria in Patients Who Remain Symptomatic Despite the Use of H1-antihistamine (LIBERTY-CINDU CUrIADS) (NCT04681729) | Sanofi | 2020-12-10 |
| Phase 3 Study to Evaluate the Safety and Efficacy of Hydrocortisone Acetate Suppositories (NCT04469686) | Cristcot HCA LLC | 2020-12-10 |
| Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant (NCT04543591) | Alexion Pharmaceuticals, Inc. | 2020-12-10 |
| BCG + MMC: Adding Mitomycin C to BCG in High-risk, Non-muscle-invasive Bladder Cancer (NCT06462001) | Nottingham University Hospitals NHS Trust | 2020-12-10 |
| Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19 (NCT04655586) | ARCA Biopharma, Inc. | 2020-12-10 |
| A Study of Camrelizumab Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (NCT04613674) | Jiangsu HengRui Medicine Co., Ltd. | 2020-12-09 |
| 68Ga-PSMA PET/CT in Prostate Cancer (NCT04684628) | University of Saskatchewan | 2020-12-09 |
| The ALA, DHA and EPA Esters in the Prevention of Cardiovascular Diseases. (NCT04743050) | Wroclaw Medical University | 2020-12-09 |
| Randomized Therapy In Status Epilepticus (NCT04391569) | Marinus Pharmaceuticals | 2020-12-09 |
| Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients (NCT04608201) | Assistance Publique - Hôpitaux de Paris | 2020-12-09 |
| Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer (NCT04458909) | National Cancer Institute (NCI) | 2020-12-09 |
| A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100mcg/Blister Oral Inhalation Powder/GSK in Patients With Asthma (NCT04665895) | Respirent Pharmaceuticals Co Ltd. | 2020-12-09 |
| To Compare Efficacy and Safety of CT-P39 and EU-approved Xolair in Patients With Chronic Spontaneous Urticaria (NCT04426890) | Celltrion | 2020-12-09 |
| Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) (NCT04652882) | Vanda Pharmaceuticals | 2020-12-09 |
| A 2nd Generation E1/E2B/E3-Deleted Adenoviral COVID-19 Vaccine: The TCELL VACCINE TRIAL (NCT06022224) | ImmunityBio, Inc. | 2020-12-09 |
| A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19 (NCT04649151) | ModernaTX, Inc. | 2020-12-09 |
| A Study to Evaluate the Efficacy and the Safety of Single Pill Combination (SPC) Ezetimibe/Rosuvastatin in Chinese Adult Patients With Primary Hypercholesterolemia Not Adequately Controlled on Statin Therapy (NCT04669041) | Sanofi | 2020-12-08 |
| SAL-0951 Tablets in the Treatment of Renal Anemia in Non-dialysis Chronic Kidney Disease (NCT06016036) | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 2020-12-08 |
| Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A (NCT04323098) | BioMarin Pharmaceutical | 2020-12-08 |
| Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013) (NCT04624204) | Merck Sharp & Dohme LLC | 2020-12-08 |
| A Randomized Trial to Evaluate Sequential vs Simultaneous Patching (NCT04378790) | Jaeb Center for Health Research | 2020-12-08 |
| Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy (NCT04655976) | GlaxoSmithKline | 2020-12-08 |
| Efficacy of α-blocker or 5-ARI Withdrawal to Continued Combination Therapy on the Maintenance of LUTS in Men With BPH (NCT05023824) | Gangnam Severance Hospital | 2020-12-08 |
| A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation (NCT04620031) | Haisco Pharmaceutical Group Co., Ltd. | 2020-12-08 |
| Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis (NCT04670432) | Maastricht University Medical Center | 2020-12-08 |
| Study to Evaluate the Efficacy and Safety in Patients With Primary Hypercholesterolemia (NCT05206578) | Ahn-Gook Pharmaceuticals Co.,Ltd | 2020-12-08 |
| Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. (NCT04251156) | Novo Nordisk A/S | 2020-12-08 |
| Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus (NCT04460326) | Boston Medical Center | 2020-12-07 |
| A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder (NCT04658862) | Janssen Research & Development, LLC | 2020-12-07 |
| Durvalumab Plus Chemotherapy in ES-SCLC (Oriental) (NCT04449861) | AstraZeneca | 2020-12-07 |
| A Study of Dulaglutide (LY2189265) in Chinese Participants With Type 2 Diabetes (NCT04591626) | Eli Lilly and Company | 2020-12-07 |
| SHAPE Neoadjuvant Chemotherapy Response (NCT04715958) | Kibo Nam | 2020-12-07 |
| Tolerability, Safety and Immunogenicity Trial of the Flu-M® Inactivated Vaccine in Volunteers Aged 18 to 60 Years (NCT05312294) | St. Petersburg Research Institute of Vaccines and Sera | 2020-12-07 |
| BCG Vaccination to Prevent COVID-19 (NCT04632537) | Henry M. Jackson Foundation for the Advancement of Military Medicine | 2020-12-07 |
| Study of Ravulizumab in Pediatric Participants With HSCT-TMA (NCT04557735) | Alexion Pharmaceuticals, Inc. | 2020-12-07 |