| A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes (NCT04786262) | Vertex Pharmaceuticals Incorporated | 2021-03-29 |
| A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program (NCT04657016) | Eli Lilly and Company | 2021-03-29 |
| A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight (NCT04657003) | Eli Lilly and Company | 2021-03-29 |
| To Evaluate SCTA01 Treatment of High-risk Outpatients With COVID-19 (NCT04709328) | Sinocelltech Ltd. | 2021-03-28 |
| Efficacy of Mefloquine as Prophylaxis Against COVID-19: A Placebo-control, Randomized Clinical Trial (NCT04847661) | Helwan University | 2021-03-28 |
| The Efficacy and Safety of SCTA01 in Hospitalized Patients With Severe COVID-19 (NCT04644185) | Sinocelltech Ltd. | 2021-03-27 |
| Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty. (NCT04736602) | Ipsen | 2021-03-27 |
| A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention (NCT04804033) | Pfizer | 2021-03-26 |
| Study to Assess the Safety, Tolerability and Efficacy of Bilastine Ophthalmic Solution 0.6% in Children (NCT04810390) | Faes Farma, S.A. | 2021-03-26 |
| Pre-Exposure Prophylaxis for Transgender Women in the US and South America (NCT04742491) | HIV Prevention Trials Network | 2021-03-26 |
| Efficacy and Safety Assessment of T4030 Eye Drops Versus Ganfort® UD in Ocular Hypertensive or Glaucomatous Patients. (NCT04898387) | Laboratoires Thea | 2021-03-26 |
| Camrelizumab Combined With Apatinib Mesylate for Perioperative Treatment of Resectable Hepatocellular Carcinoma (NCT04521153) | Shanghai Zhongshan Hospital | 2021-03-25 |
| Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome (NCT04681417) | Institut Curie | 2021-03-25 |
| Diagnostic Role of the "White Test" With Lipidic Solution in the Early Intraoperative Identification of Open Bile Ducts for the Prevention of Bile Leakage After Liver Resection (BiLe -Trial) (NCT04523701) | Giulia Manzini | 2021-03-25 |
| Novaferon for COVID-19 Treatment Trial (NCTT-005) (NCT04708158) | Genova Inc. | 2021-03-25 |
| Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects (NCT04629703) | Rigel Pharmaceuticals | 2021-03-25 |
| A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 (NCT04672395) | Clover Biopharmaceuticals AUS Pty | 2021-03-24 |
| Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) (NCT04586023) | Hoffmann-La Roche | 2021-03-24 |
| Paracetamol UNIFLASH for Buccal Use Phase III Trial in Acute Pain Due to a Tooth Extraction (NCT04640376) | Unither Pharmaceuticals, France | 2021-03-24 |
| A Clinical Study to Evaluate Efficacy and Safety of HSK21542 for Postoperative Analgesia of Subjects Undergoing Elective Laparoscopic Surgery Under General Anesthesia (NCT04738357) | Haisco Pharmaceutical Group Co., Ltd. | 2021-03-24 |
| A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression (NCT04714190) | RemeGen Co., Ltd. | 2021-03-24 |
| A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 3) (NCT04795531) | Novo Nordisk A/S | 2021-03-24 |
| A Study to Investigate Interchangeability of ABP 654 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (NCT04761627) | Amgen | 2021-03-24 |
| A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated (NCT04716114) | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 2021-03-24 |
| Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children (NCT04816643) | BioNTech SE | 2021-03-24 |
| A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vaccine (NCT04811664) | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-03-24 |
| Prephase Treatment With Prednisone +/- Vitamin D Supplementation Followed by Immunochemotherapy (NCT04442412) | Fondazione Italiana Linfomi - ETS | 2021-03-23 |
| 8- Versus 12-week of Sofosbuvir-ravidasvir Treatment of Chronic Hepatitis C (NCT04885855) | Muhammad Radzi Abu Hassan | 2021-03-23 |
| A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis (NCT04772079) | Bristol-Myers Squibb | 2021-03-23 |
| Clinical Trial to Investigate Safety and Efficacy of Edoxaban in Patients With CTEPH (KABUKI) (NCT04730037) | Kyushu University | 2021-03-23 |
| Study of VB4-845 Injection for Treating Patients With Non-muscle Invasive Bladder Cancer (NCT04859751) | Qilu Pharmaceutical Co., Ltd. | 2021-03-23 |
| An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. (NCT04855045) | ProQR Therapeutics | 2021-03-23 |
| The Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Caesarean Section (NCT04733157) | University of Zimbabwe | 2021-03-23 |
| Early DOlutegravir/LAmivudine Switching After Virological Suppression (EDOLAS Study) (NCT04979468) | Societa' Italiana Di Malattie Infettive E Tropicali | 2021-03-23 |
| the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia (NCT04252209) | Cairo University | 2021-03-22 |
| Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer (NCT04499924) | Seagen Inc. | 2021-03-22 |
| Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19 (NCT04858633) | Post Graduate Institute of Medical Education and Research, Chandigarh | 2021-03-22 |
| Impact of the Immune System on Response to Anti-Coronavirus Disease 19 (COVID-19) Vaccine in Allogeneic Stem Cell Recipients (Covid Vaccin Allo) (NCT04951323) | University of Liege | 2021-03-22 |
| A Study to Test if TVB-009P is Effective in Relieving Postmenopausal Osteoporosis (NCT04729621) | Teva Pharmaceuticals USA | 2021-03-22 |
| Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease (NCT04727528) | AstraZeneca | 2021-03-22 |
| Metformin in Alzheimer's Dementia Prevention (NCT04098666) | Columbia University | 2021-03-22 |
| CATCH-R: A Rollover Study to Provide Continued Access to Rucaparib (NCT04676334) | pharmaand GmbH | 2021-03-22 |
| Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder (NCT04819776) | Vanda Pharmaceuticals | 2021-03-22 |
| ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study (NCT04620239) | Steba Biotech S.A. | 2021-03-22 |
| The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells (NCT04802616) | Medical University of Lublin | 2021-03-22 |
| Clinical Benefit, Safety, PK and PD Study of AT-007 in Pediatric Subjects With Classic Galactosemia (NCT04902781) | Applied Therapeutics, Inc. | 2021-03-20 |
| Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia (NCT04683237) | Xiaojun Chen | 2021-03-20 |
| To Compare the Efficacy and Tolerability of A. Paniculata/A. Chilensis in Individuals With URTI (NCT04955327) | Vedic Lifesciences Pvt. Ltd. | 2021-03-20 |
| Vitamin D and COVID-19 Management (NCT04385940) | University of Alberta | 2021-03-19 |
| Surfactant Nebulization for the Early Aeration of the Preterm Lung (NCT04315636) | University of Zurich | 2021-03-19 |
| Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome (NCT04674761) | Albireo | 2021-03-19 |
| Randomized Open Investigation Determining Steroid Dose (NCT04834375) | Northwell Health | 2021-03-19 |
| A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis (NCT04552899) | Hoffmann-La Roche | 2021-03-19 |
| Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discectomy (NCT04574778) | Rothman Institute Orthopaedics | 2021-03-18 |
| A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer (NCT04691804) | Jiangsu HengRui Medicine Co., Ltd. | 2021-03-18 |
| Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis (NCT04356664) | Hopital Foch | 2021-03-18 |
| Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine Fibroids or Endometriosis Who Are at Risk for Pregnancy (NCT04756037) | Sumitomo Pharma Switzerland GmbH | 2021-03-18 |
| A Phase III Study to Assess the Effects of Almonertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer (NCT04951635) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2021-03-18 |
| Study to Evaluate Viralym-M (ALVR105) for the Treatment of Virus-Associated Hemorrhagic Cystitis (HC) (NCT04390113) | AlloVir | 2021-03-18 |
| Placebo-controlled Efficacy and Safety Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype (NCT04719832) | GlaxoSmithKline | 2021-03-17 |
| Acetazolamide Efficacy in Ataxia in PMM2-CDG (NCT04679389) | Mayo Clinic | 2021-03-17 |
| A Study of Ustekinumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (UC) (NCT04630028) | Janssen Research & Development, LLC | 2021-03-17 |
| Multimodal Analgesia for Cholecystectomy (NCT04788654) | Gangnam Severance Hospital | 2021-03-17 |
| A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition (NCT04654468) | Hoffmann-La Roche | 2021-03-17 |
| A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) (NCT04586010) | Hoffmann-La Roche | 2021-03-17 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus (NCT04754334) | Oramed, Ltd. | 2021-03-16 |
| Isavuconazole for the Prevention of COVID-19-associated Pulmonary Aspergillosis (NCT04707703) | Jeffrey Jenks, MD, MPH | 2021-03-16 |
| Study on a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Compared to a Meningococcal Reference Vaccine, and When Given Alone or With Two Other Vaccines in Healthy Adolescents (NCT04490018) | Sanofi Pasteur, a Sanofi Company | 2021-03-16 |
| Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery Including a Corneal Endothelial Cell Sub-study (NCT04810962) | Formosa Pharmaceuticals, Inc. | 2021-03-16 |
| Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity (NCT04788511) | Novo Nordisk A/S | 2021-03-16 |
| Improving Care Through Azithromycin Research for Infants in Africa (NCT04235816) | Barcelona Institute for Global Health | 2021-03-15 |
| A Study to Evaluate Mirabegron in Pediatric Participants From 5 to Less Than 18 Years of Age With Overactive Bladder (OAB) (NCT04641975) | Astellas Pharma Global Development, Inc. | 2021-03-15 |
| HC-1119 Versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC) (NCT03850795) | Hinova Pharmaceuticals USA, Inc. | 2021-03-15 |
| Phase 3 Trial of a Bivalent Human Papilloma Virus (HPV) Vaccine (Cecolin®) in Young Girls (NCT04508309) | PATH | 2021-03-15 |
| The Use of Amantadine in the Prevention of Progression and Treatment of COVID-19 Symptoms (NCT04854759) | Independent Public Clinical Hospital No. 4 in Lublin | 2021-03-15 |
| Postoperative Pain Difference for 'IV Paracetamol' and TAP Block' in Acute Cholecystitis (NCT04767542) | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 2021-03-15 |
| A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age (NCT04796896) | ModernaTX, Inc. | 2021-03-15 |
| Comparison of Efficacy of Double Dose Oral Terbinafine Vs Itraconazole in Treatment of Dermatophyte Infections of Skin. (NCT04880980) | Pak Emirates Military Hospital | 2021-03-15 |
| Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024) (NCT04652700) | Merck Sharp & Dohme LLC | 2021-03-15 |
| Phosphate Binder Switch Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis (NCT04771780) | Kyowa Kirin Co., Ltd. | 2021-03-15 |
| Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069) (NCT04708041) | Merck Sharp & Dohme LLC | 2021-03-15 |
| Study of GRAd-COV2 for the Prevention of COVID-19 in Adults (NCT04791423) | ReiThera Srl | 2021-03-15 |
| Phosphate Binder-combination Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis (NCT04766398) | Kyowa Kirin Co., Ltd. | 2021-03-15 |
| Efficacy and Safety of Tanzânia Association in the Treatment of Erectile Dysfunction Associated With Benign Prostatic Hyperplasia (NCT04185441) | EMS | 2021-03-14 |
| Immunogenicity of a Recombinant Human Papillomavirus Nonavalent (Types 6,11,16,18,31,33,45,52,58)Vaccine(E.Coli) Versus Gardasil®9 in Healthy Females 18-26 Years of Age (NCT04782895) | Xiamen University | 2021-03-14 |
| OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD) (NCT04757610) | Opthea Limited | 2021-03-12 |
| Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures (NCT04320940) | NEMA Research, Inc. | 2021-03-12 |
| OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD) (NCT04757636) | Opthea Limited | 2021-03-12 |
| A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma (NCT04712643) | Hoffmann-La Roche | 2021-03-12 |
| Study of Anlotinib Combined With Icotinib as the First-line Treatment in Patients With EGFR Concomitant Mutation NSCLC (NCT04797806) | Tianjin Medical University Cancer Institute and Hospital | 2021-03-12 |
| Topotecan and Melphalan for Retinoblastoma (NCT04799002) | Sun Yat-sen University | 2021-03-11 |
| Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis (NCT04562389) | Karyopharm Therapeutics Inc | 2021-03-11 |
| A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures (NCT04715646) | UCB Biopharma SRL | 2021-03-11 |
| COVID-19 Vaccine in Immunosuppressed Adults With Autoimmune Diseases (NCT04806113) | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2021-03-11 |
| Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy (NCT04610398) | Balgrist University Hospital | 2021-03-11 |
| Possible Role of Roflumilast in Diabetic Nephropathy (NCT04755946) | Tanta University | 2021-03-10 |
| A Study of Lebrikizumab (LY3650150) in Combination With Topical Corticosteroids in Japanese Participants With Moderate-to-Severe Atopic Dermatitis (NCT04760314) | Eli Lilly and Company | 2021-03-10 |
| A Clinical Study to Evaluate Efficacy and Safety of Serplulimab（HLX10） Combined With Bevacizumab（HLX04) and Chemotherapy (XELOX) in Patients With Metastatic Colorectal Cancer (mCRC) (NCT04547166) | Shanghai Henlius Biotech | 2021-03-10 |
| The Effects of Prucalopride in Patients With Constipation Predominant Irritable Bowel Syndrome (NCT04757493) | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 2021-03-10 |
| A Study of Sintilimab Plus Ramucirumab as First-line Treatment for G/EGJ Adenocarcinoma (ORIENT-106) (NCT04675983) | Innovent Biologics (Suzhou) Co. Ltd. | 2021-03-10 |