| Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01) (NCT06860477) | Fudan University | 2025-03-18 |
| The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease (NCT06853743) | Oslo University Hospital | 2025-03-18 |
| Personalized Antisense Oligonucleotide Therapy for A Single Participant With LMNB1 Mutation Associated Autosomal Dominant Leukodystrophy (ADLD) (NCT06816498) | n-Lorem Foundation | 2025-03-17 |
| Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery (NCT06357234) | IWK Health Centre | 2025-03-17 |
| A Clinical Study to Evaluate the Efficacy and Safety of TQC2938 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (NCT06789289) | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 2025-03-17 |
| Intralesional Injection of STS in Treatment of Calcinosis (NCT06672822) | Robyn T. Domsic, MD, MPH | 2025-03-17 |
| A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (NCT06356571) | Sanofi | 2025-03-17 |
| A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL (NCT06559345) | The First Affiliated Hospital of Zhengzhou University | 2025-03-17 |
| TOP 2301: Neoadjuvant Chemo for NSCLC (NCT06385262) | Duke University | 2025-03-17 |
| A Single-arm, Open-label Clinical Study to Evaluate the Efficacy and Safety of VRT106 in Combination With Chemotherapy for Resectable Pancreatic Cancer (NCT06758544) | Guangdong Provincial People's Hospital | 2025-03-17 |
| DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM) (NCT06805305) | Diakonos Oncology Corporation | 2025-03-17 |
| Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis (NCT06809530) | Guangzhou Medical University | 2025-03-17 |
| Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes (NCT06949982) | Sergey Orlov, MD | 2025-03-17 |
| Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS) (NCT06052618) | National Cancer Institute (NCI) | 2025-03-17 |
| Vitamin D to Improve Quadricep Muscle Strength (NCT05174611) | Chinese University of Hong Kong | 2025-03-17 |
| Extended LH Administration (NCT06883890) | Azienda Ospedaliero-Universitaria di Modena | 2025-03-17 |
| Iparomlimab and Tuvonralimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy for CC (NCT06878222) | Obstetrics & Gynecology Hospital of Fudan University | 2025-03-15 |
| Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025) (NCT07771049) | Hospital Universitario La Fe | 2025-03-15 |
| Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers (NCT06910579) | British University In Egypt | 2025-03-15 |
| The Efficacy and Safety of Ensartinib As Adjuvant Therapy in Stage I ALK-positive NSCLC Patients with High Risk Factors (NCT06772610) | Shanghai Pulmonary Hospital, Shanghai, China | 2025-03-15 |
| Randomized Controlled Trial of Berberine in Combination With Doxycycline in the Treatment of Chronic Endometritis (NCT07180563) | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 2025-03-15 |
| Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV (NCT06624839) | University of Maryland, Baltimore | 2025-03-15 |
| Nocardia Rubra Cell Wall Skeleton in Combination With Prior Second- or Third-line Regimens for the Treatment of Potentially Hazardous Colorectal Cancer SD Status (NCT06356714) | Sun Jing | 2025-03-15 |
| The Effect of Curcumin on Inflammatory Markers in Hemodialysis Patients (NCT06829186) | University of Guadalajara | 2025-03-15 |
| Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors (NCT06493552) | Vasgene Therapeutics, Inc | 2025-03-15 |
| Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical Carcinoma (NCT06831175) | West China Hospital | 2025-03-15 |
| A Study of Efficacy and Safety of AND017 in Patients With Myelodysplastic Syndrome (NCT06304103) | Kind Pharmaceuticals LLC | 2025-03-14 |
| A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM (NCT06897202) | Pfizer | 2025-03-14 |
| UBT251 Injection Phase II Study (Overweight or Obesity) (NCT07177469) | The United Bio-Technology (Hengqin) Co., Ltd. | 2025-03-14 |
| A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke (NCT06700824) | Organ, Tissue, Regeneration, Repair and Replacement | 2025-03-14 |
| Efficacy and Safety of Topical Clascoterone (WINLEVI) Cream 1% in Patients With Facial Acneiform Rosacea (NCT06952517) | Narrows Institute for Biomedical Research | 2025-03-14 |
| Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes (NCT06640283) | Instituto do Cancer do Estado de São Paulo | 2025-03-14 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of MT101-5 in Subjects with Early Parkinson's Disease (NCT06175767) | Mthera Pharma Co., Ltd. | 2025-03-14 |
| A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours (NCT06833008) | Ipsen | 2025-03-14 |
| Phase II Study of PD-1 Antibody Combined With Radiotherapy in Recurrent or Metastatic Adrenal Cortical Carcinoma (NCT06587802) | Sun Yat-sen University | 2025-03-14 |
| A Clinical Trial of TQB2102 for Injection in Gynecological Tumors With Recurrent/Metastatic Advanced (NCT06798207) | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 2025-03-13 |
| Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) (NCT06800651) | Jemincare | 2025-03-13 |
| Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder (NCT06446765) | Yale University | 2025-03-13 |
| An Exploratory Clinical Study on Neoadjuvant Treatment of Hepatocellular Carcinoma with QL1706 Combined with Lenvatinib (NCT06884982) | Northern Jiangsu People's Hospital | 2025-03-13 |
| Axicabtagene Ciloleucel CAR T-cells in Patients With Relapsed or Refractory Primary Mediastinal B-cell Lymphoma (NCT06912529) | Universität Münster | 2025-03-13 |
| Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA (NCT06868290) | Novartis Pharmaceuticals | 2025-03-13 |
| Safety and Efficacy of HCB101 in Combination With Multiple Agents in Patients With Advanced Solid Tumors (NCT06771622) | FBD Biologics Limited | 2025-03-13 |
| METR-NK Cells in Combination With Anti-angiogenic Neoadjuvant Therapy for Advanced Epithelial Ovarian Cancer (NCT06884345) | Anhui Provincial Cancer Hospital | 2025-03-13 |
| Efficacy of Guselkumab in Treating Hailey Hailey Disease (NCT06651489) | Yale University | 2025-03-13 |
| RT-310 Safety and Feasibility BPH Study (NCT07264205) | Resurge Therapeutics Inc. | 2025-03-13 |
| A Single-arm, Open-label Clinical Study to Evaluate the Efficacy and Safety of VRT106 in Combination With Chemotherapy for Advanced Pancreatic Cancer (NCT06866977) | Xiangya Hospital of Central South University | 2025-03-12 |
| A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers (NCT06852976) | Zhuhai Rui-Inno Pharmaceutical Technology Co., Ltd. | 2025-03-12 |
| Clinical Trial of TQB2825 Injection Combined With Chemotherapy in Subjects With Diffuse Large B-cell Lymphoma (NCT06854445) | Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. | 2025-03-12 |
| Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia (NCT05829460) | Washington University School of Medicine | 2025-03-12 |
| RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors (NCT05660408) | University of Florida | 2025-03-12 |
| A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer (NCT06792695) | AstraZeneca | 2025-03-12 |
| A Phase II Clinical Study to Evaluate the Efficacy and Safety of Technetium [99mtc]-H7ND Injection in the Diagnosis of Peritoneal Metastasis of Gastrointestinal Malignant Tumor. (NCT07107633) | Jiaxing Pharmadax Genesis Pharmaceutical Technology Co.,Ltd. | 2025-03-12 |
| Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody (NCT06688331) | PolTREG S.A. | 2025-03-12 |
| Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula (NCT06636032) | University Hospital, Toulouse | 2025-03-12 |
| A Single-Arm, Phase II Clinical Trail of Cadonilimab Combined With Chemoradiotherapy in Oligometastatic Stage IVB Cervical Cancer (NCT06998394) | Xiangbo Wan | 2025-03-12 |
| L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML (NCT06788756) | Moleculin Biotech, Inc. | 2025-03-12 |
| Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whitening and Anti-Aging (NCT07477288) | Hasanuddin University | 2025-03-12 |
| Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients (NCT06476132) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-03-12 |
| Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist (NCT06851858) | AstraZeneca | 2025-03-12 |
| Microbiota Modification for Immuno-oncology in Hepatocellular Carcinoma (NCT06551272) | Center Eugene Marquis | 2025-03-12 |
| A Study to Assess the Efficacy and Safety of PG-011 Nasal Spray in Adults With Moderate to Severe Seasonal Allergic Rhinitis (NCT06837233) | Prime Gene Therapeutics Co., Ltd. | 2025-03-12 |
| A Study to Evaluate Metabolism, Excretion, and Mass Balance of [14C]Vapendavir (NCT06834295) | Altesa Biosciences, Inc. | 2025-03-12 |
| Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer Progression (NCT06839144) | Tel-Aviv Sourasky Medical Center | 2025-03-12 |
| ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal Cancer (NCT06714357) | National Cancer Institute, Naples | 2025-03-12 |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. (NCT07097441) | Ziauddin University | 2025-03-12 |
| A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (NCT06453486) | University Health Network, Toronto | 2025-03-12 |
| A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma (NCT06915246) | VIVUS LLC | 2025-03-12 |
| Pathways 2 Success (NCT06831123) | University of Minnesota | 2025-03-12 |
| Orelabrutinib Combined With Rituximab as First-line Systemic Treatment for Marginal Zone Lymphoma (NCT07022223) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-03-11 |
| Clinical Study of HRS-2129 for Postoperative Analgesia in Orthopaedics (NCT06780267) | Shandong Suncadia Medicine Co., Ltd. | 2025-03-11 |
| Epcoritamab and Tazemetostat for the Treatment of Relapsed or Refractory Grade I-IIIa Follicular Lymphoma (NCT06575686) | City of Hope Medical Center | 2025-03-11 |
| A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011) (NCT06833073) | Merck Sharp & Dohme LLC | 2025-03-11 |
| BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS) (NCT06773910) | SCRI Development Innovations, LLC | 2025-03-11 |
| A Study of SRSD107 in Participants With Chronic Coronary and/or Peripheral Arterial Disease (NCT07318155) | Sirius Therapeutics Co., Ltd. | 2025-03-11 |
| NT-101 Topical Ophthalmic Solution in Patients With Wet AMD (NCT06704009) | NexThera Co., Ltd. | 2025-03-11 |
| CD8 PET Imaging in Metastatic Solid Tumours (NCT06534190) | University Medical Center Groningen | 2025-03-11 |
| Newly-diagnosed Pediatric T-cell ALL Protocol (NCT06855810) | Institute of Hematology & Blood Diseases Hospital, China | 2025-03-11 |
| Preoperative Planning With PSMA-PET in Melanoma Surgery Trial (NCT06560905) | Royal Marsden NHS Foundation Trust | 2025-03-11 |
| Building Evidence for Ablative Internal Radiation Therapy in Localized HCC Beyond the Up-To-7 Criteria (NCT06773845) | Seoul National University Hospital | 2025-03-11 |
| Pembrolizumab/Lenvatinib With and Without Healthy Donor FMT (hdFMT) in Relapsed/ Refractory (R/R) Melanoma (NCT06030037) | Diwakar Davar | 2025-03-11 |
| Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (NCT06192160) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-03-11 |
| A Study Evaluating NPT 2042 Versus Placebo in Subjects Aged 16-75 Years With Genetic Generalized Epilepsy (GGE) and Absence Seizures (NCT06769659) | NeuroPro Therapeutics, Inc. | 2025-03-11 |
| A Multicenter Randomized Controlled Phase II Trial of Iparomlimab and Tuvonralimab (QL1706) Combined With SOX Chemotherapy Versus Chemotherapy Alone in the Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (NCT06829797) | Shandong Provincial Hospital | 2025-03-11 |
| Capecitabine Plus Pembrolizumab in Patients With Triple Negative Breast Cancer After Chemo-immunotherapy and Surgery (NCT05973864) | UNICANCER | 2025-03-11 |
| A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel (NCT06940739) | Iovance Biotherapeutics, Inc. | 2025-03-11 |
| AD1208 in Subjects With Any Progressive, Locally Advanced or Metastatic Solid Tumors (NCT06911333) | Avelos Therapeutics Inc. | 2025-03-11 |
| A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA (NCT06698822) | M.D. Anderson Cancer Center | 2025-03-10 |
| Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines (NCT07061847) | Northwell Health | 2025-03-10 |
| A Phase 2 Trial in Healthy Adult Participants of the Recombinant MVA-BN-WEV Vaccine (NCT06899802) | Bavarian Nordic | 2025-03-10 |
| A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Chinese Women Going Through Menopause (NCT06812754) | Astellas Pharma Global Development, Inc. | 2025-03-10 |
| Oral Deucrictibant for Prophylactic and Acute Treatment in Hereditary Angioedema Patients (NCT07046806) | Institute for Asthma and Allergy | 2025-03-10 |
| Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors (NCT06578624) | Lamassu Bio Inc | 2025-03-10 |
| Clinical Trial of TQH2722 Injection in Patients With Seasonal Allergic Rhinitis (NCT06760182) | Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. | 2025-03-10 |
| Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1) (NCT06822049) | State University of New York at Buffalo | 2025-03-10 |
| Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients (NCT06730126) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-03-10 |
| Hypofractionated Radiotherapy Plus Immunotherapy Versus Conventional Radiotherapy in Locally Recurrent Rectal Cancer (NCT06928584) | Fudan University | 2025-03-10 |
| A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO) (NCT06789445) | BlueRock Therapeutics | 2025-03-10 |
| Personalized Ultrasonic Brain Stimulation for Depression (R61) (NCT06902298) | Brian Mickey | 2025-03-10 |
| A Phase II Single-Arm Clinical Study to Evaluate the Efficacy and Safety of Carbon Ion Radiotherapy With Atezolizumab and Bevacizumab Combination Therapy in Patients With Advanced Hepatocellular Carcinoma (NCT07246668) | Yonsei University | 2025-03-10 |
| Chemo-immunotherapy for Cervical Cancer Stage IIICp Trial (NCT07167160) | Women's Hospital School Of Medicine Zhejiang University | 2025-03-10 |