| Tetra-modality Bladder Preservation Strategies in Muscle-invasive Bladder Cancer: TURBT+ Chemo/Immunotherapy+ Radiation Therapy+ Maintenance Immunotherapy vs. W&W (NCT06686381) | American University of Beirut Medical Center | 2025-04-15 |
| Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients (NCT06903559) | Mansoura University | 2025-04-15 |
| Phase II Study of Irinotecan Liposome (II) Combined With Temozolomide and Fluzoparib in Recurrent or Metastatic Ewing Sarcoma (NCT06827717) | Sun Yat-sen University | 2025-04-15 |
| A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003) (NCT06843447) | Merck Sharp & Dohme LLC | 2025-04-15 |
| Serplulimab Combined With Chemotherapy for Early-stage HR+/HER2- Breast Cancer (NCT06860529) | Henan Cancer Hospital | 2025-04-15 |
| Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System (NCT06080074) | Stanford University | 2025-04-15 |
| Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care. (NCT06810726) | Estar Medical dba Medical Technologies, LTD | 2025-04-15 |
| Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant (NCT06315309) | University of Alabama at Birmingham | 2025-04-15 |
| Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC) (NCT06923826) | National University Hospital, Singapore | 2025-04-15 |
| Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors (NCT06795412) | Pyxis Oncology, Inc | 2025-04-15 |
| A Study of Apabetalone in Subjects With Long -COVID (NCT06590324) | Resverlogix Corp | 2025-04-15 |
| Adebrelimab Combined With AG Regimen in Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer (NCT06916975) | Jin Xu | 2025-04-15 |
| EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC (NCT07647289) | Peking University Third Hospital | 2025-04-15 |
| Recurrent/Metastatic Olfactory Neuroblastoma: Evaluating the Efficacy and Safety of Nivolumab (NCT07100704) | National Cancer Center Hospital East | 2025-04-15 |
| Roxadustat for Bone and Neuropsychiatric Aspects in Hemodialysis Patients (NCT06917950) | Mansoura University | 2025-04-15 |
| A Study to Explore the Safety, Tolerability, Efficacy, and Pharmacokinetics of LT-002-158 Tablets in Chinese Adult Patients With Hidradenitis Suppurativa (NCT06932003) | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. | 2025-04-15 |
| Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer (NCT05840770) | City of Hope Medical Center | 2025-04-15 |
| Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation (NCT06905054) | Mayo Clinic | 2025-04-15 |
| A Study Comparing Immunotherapy Alone Versus Immunotherapy Combined With Radiotherapy in Patients With Hepatocellular Carcinoma (HCC) With Vascular Invasion (NCT06828380) | National Cancer Center, Korea | 2025-04-15 |
| Nivo40-AVD for Advanced Classic Hodgkin Lymphoma (NCT06984146) | National Medical Research Radiological Centre of the Ministry of Health of Russia | 2025-04-15 |
| SH-LPS System in Preoperative Planning for Liver Resection (NCT06911086) | Zhejiang Cancer Hospital | 2025-04-15 |
| Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF (NCT06884904) | National Engineering Center of Cell Products | 2025-04-15 |
| Pentoxifylline for Vascular Calcification in Kidney Disease (NCT06903689) | Mansoura University | 2025-04-15 |
| A Study to Explore the Safety, Tolerability, Efficacy, and Pharmacokinetics of LT-002-158 Tablets in Chinese Adult Subjects With Atopic Dermatitis (NCT06931990) | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. | 2025-04-15 |
| 9MW2821 Combined With Other Antitumor Drugs in Patients With Advanced Gynecological Tumors (NCT06926998) | Mabwell (Shanghai) Bioscience Co., Ltd. | 2025-04-15 |
| Randomized Phase II Trial Evaluating DFS in The Absence of an Adjuvant Component of Perioperative Chemotherapy in Patients With Gastric Cancer (NCT06942663) | Nizhny Novgorod Regional Clinical Oncology Center | 2025-04-15 |
| Iparomlimab and Tuvonralimab (QL1706) for Intermediate Trophoblastic Tumors (NCT06941766) | Peking Union Medical College Hospital | 2025-04-15 |
| Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma (NCT06914687) | Fudan University | 2025-04-15 |
| A Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral Vectored Marburg Virus Vaccine in Healthy Adults (NCT06620003) | Albert B. Sabin Vaccine Institute | 2025-04-14 |
| Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer (NCT06846268) | National University Hospital, Singapore | 2025-04-14 |
| Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial (NCT06835803) | Brigham and Women's Hospital | 2025-04-14 |
| Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk Younger Untreated Mantle Cell Lymphoma (NCT06846489) | Sun Yat-sen University | 2025-04-14 |
| Sedation vs No Sedation in Mechanically Ventilated COPD Patients (NCT07620912) | Al-Azhar University | 2025-04-14 |
| A Study to Learn About the Long-Term Health of Adult Participants From a Previous Study of a New Melanoma Treatment (NCT06848088) | Regeneron Pharmaceuticals | 2025-04-14 |
| Pharmacogenomics for Better Treatment of Fungal Infections Clinical Trial (NCT06510699) | The University of Queensland | 2025-04-14 |
| Study of BLU-808 in Allergic Rhinoconjunctivitis (NCT06922448) | Blueprint Medicines Corporation | 2025-04-14 |
| A Study of Islatravir (ISL) and Ulonivirine (ULO) Once Weekly (QW) in Virologically Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8591B-060) (NCT06891066) | Merck Sharp & Dohme LLC | 2025-04-14 |
| ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia (NCT06364774) | Children's Hospital of Philadelphia | 2025-04-14 |
| Defining ctDNA Metrics in Posttransplant Lymphoproliferative Disorder (PTLD) (NCT06954805) | Jennifer Amengual | 2025-04-14 |
| Efgartigimod for the Treatment of Guillain-Barré Syndrome (NCT06885762) | Zhongming Qiu | 2025-04-13 |
| A Study to Investigate Efficacy and Safety of Tozorakimab Injections Compared With Placebo in Adult Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations and Elevated Eosinophils (NCT06897748) | AstraZeneca | 2025-04-12 |
| IVIG Trial for the Treatment of Bronchopulmonary Dysplasia (NCT06925360) | International Peace Maternity and Child Health Hospital | 2025-04-12 |
| Efficacy and Safety of Low-Dose Cytarabine Combined With Thalidomide in Adult Patients With Untreated LCH (NCT07187193) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-04-12 |
| Efficacy and Safety of the RD Regimen(Lenalidomide, Dexamethasone) for Rosai-Dorfman Disease (NCT07187167) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-04-12 |
| A Phase I/II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Initial Efficacy of JS212 in Subjects With Advanced Malignant Solid Tumour (NCT06888830) | Shanghai Junshi Bioscience Co., Ltd. | 2025-04-11 |
| A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of Dual Immune Checkpoint Inhibition With Anti-PD-L1 (Atezolizumab) and Anti-TIGIT (Tiragolumab) in Cancer of Unknown Primary (NCT06754501) | M.D. Anderson Cancer Center | 2025-04-11 |
| Study of Re-treatment With [177Lu]Lu-PSMA in Men With Metastatic Castration Resistance Prostate Cancer (NCT06866938) | Hospices Civils de Lyon | 2025-04-11 |
| Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease (NCT04339751) | National Institute of Neurological Disorders and Stroke (NINDS) | 2025-04-11 |
| A Study of PARG Inhibitor XNW29016 in Patients With Advanced Solid Tumors Who Failed Standard Treatment (NCT06987500) | Evopoint Biosciences Inc. | 2025-04-11 |
| Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis (NCT06865105) | AbbVie | 2025-04-11 |
| Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking (NCT06235567) | Maanasa Indaram, MD | 2025-04-11 |
| Clinical Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of LM-108 ± Penpulimab+Chemotherapy in Advanced Solid Tumors - Cohort C (NCT06821503) | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2025-04-11 |
| A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011) (NCT06890884) | Merck Sharp & Dohme LLC | 2025-04-11 |
| First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors (NCT06877650) | Shanghai JMT-Bio Inc. | 2025-04-11 |
| Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers (NCT06906341) | Corcept Therapeutics | 2025-04-11 |
| Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial (NCT06901102) | Mansoura University | 2025-04-10 |
| Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU (NCT06547892) | Hospital do Coracao | 2025-04-10 |
| The Minimalist Trial-2 (NCT06702033) | Washington University School of Medicine | 2025-04-10 |
| A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL) (NCT06864104) | Kardigan, Inc. | 2025-04-10 |
| Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity (NCT06820099) | Shandong Suncadia Medicine Co., Ltd. | 2025-04-10 |
| Circulating Tumor DNA Guided Boost Therapy in Early Triple Negative Breast Patients With Residual Disease After Neoadjuvant Therapy (NCT06992336) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-04-10 |
| Naltrexone for Overdose Prevention (NCT06633900) | University of California, San Francisco | 2025-04-10 |
| A Clinical Study of Arfolitixorin in Patients With mCRC (NCT06922383) | Isofol Medical AB | 2025-04-10 |
| A Randomized Clinical Trial Evaluating the Efficacy of Clinical Pharmacist Assistance Along With Pharmaceutical and Non-pharmaceutical Therapy in the Early Rheumatoid Arthritis (NCT07726355) | Deraya University | 2025-04-10 |
| The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines. (NCT06930118) | Shanghai Changzheng Hospital | 2025-04-10 |
| Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +] (NCT06713382) | Beth Israel Deaconess Medical Center | 2025-04-10 |
| Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (NCT06887621) | Instituto do Cancer do Estado de São Paulo | 2025-04-10 |
| Safety and Efficacy of BAFF-R CART for Refractory Neuroimmune Diseases (NCT07022197) | Tianjin Medical University General Hospital | 2025-04-10 |
| Using CICS-1 and SPM-011 and ［18F］FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMA (NCT06603987) | Stella Pharma Corporation | 2025-04-10 |
| Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease (NCT06355310) | Justin Ryder | 2025-04-10 |
| A Study to Evaluate Efficacy and Safety of HS-10374 for Mild-to-moderate Plaque Psoriasis (NCT06926582) | Hansoh BioMedical R&D Company | 2025-04-09 |
| Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy (NCT06731270) | Emory University | 2025-04-09 |
| Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma (NCT06956716) | Zhejiang University | 2025-04-09 |
| Maralixibat in Patients With Cystic Fibrosis and Constipation (NCT06413368) | Children's Hospital Los Angeles | 2025-04-09 |
| Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance (NCT06396247) | Milton S. Hershey Medical Center | 2025-04-09 |
| Personalized Tumor Neoantigen mRNA Therapy for Advanced Hepatocellular Carcinoma (NCT06995105) | Zhejiang University | 2025-04-09 |
| To Evaluate the Efficacy and Safety of TRD205 Tablets in the Treatment of Chronic Postoperative Neuralgia (NCT07123402) | Beijing Tide Pharmaceutical Co., Ltd | 2025-04-09 |
| A Phase 2/3 Study of Brepocitinib in Adults With Cutaneous Sarcoidosis (NCT06978725) | Priovant Therapeutics, Inc. | 2025-04-09 |
| Study of the Efficacy and Safety for Rituximab in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (NCT06952413) | National Center of Neurology and Psychiatry, Japan | 2025-04-09 |
| Chidamide in Combination With PD-1 Inhibitor, Bevacizumab, and XELOX for Metastatic Colorectal Cancer (NCT06858969) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-04-09 |
| A Trial of "APL-9796'' in Adults With Pulmonary Hypertension (NCT06846554) | Apollo Therapeutics Ltd | 2025-04-09 |
| Suramin for the Treatment of Autism Trial: KZ101 in a Male Pediatric Population With Autism Spectrum Disorder (ASD) (NCT06866275) | Children's Hospital of Orange County | 2025-04-09 |
| A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL) (NCT06835530) | Fondazione Italiana Linfomi - ETS | 2025-04-09 |
| Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease (NCT06679374) | Vikas Kotagal | 2025-04-09 |
| A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH (NCT06920043) | GlaxoSmithKline | 2025-04-09 |
| Clinical Studies for the Treatment of Advanced Solid Tumors (NCT06825494) | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 2025-04-08 |
| TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation (NCT06802081) | The Cleveland Clinic | 2025-04-08 |
| Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection (NCT06621251) | Trellis Bioscience LLC | 2025-04-08 |
| Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure (NCT07087223) | Peking University Cancer Hospital & Institute | 2025-04-08 |
| Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant (NCT06265584) | University of Alabama at Birmingham | 2025-04-08 |
| Understanding and Treating Suicidal Ideation With Ketamine (NCT06891300) | The Royal's Institute of Mental Health Research | 2025-04-08 |
| Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer (NCT06287775) | National Cancer Institute (NCI) | 2025-04-08 |
| DFMO Maintenance for Patients With Relapsed/Refractory Ewing Sarcoma or Osteosarcoma (NCT06892678) | Montefiore Medical Center | 2025-04-07 |
| Y-90, Capecitabine, and Atezolizumab for Oligometastatic CRC (NCT06555133) | Brown University | 2025-04-07 |
| Using Tumor Models to Determine Treatments (NCT06813079) | University Health Network, Toronto | 2025-04-07 |
| Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis (NCT06871904) | Ziauddin University | 2025-04-07 |
| Use of a Product Containing the Cannabinoids CBD and THC as a Treatment Strategy for Alzheimer's Disease - Alzheimer's Disease and Cannabis Clinical Trial (DAZACANN) Open-Label Phase (NCT07091747) | Federal University of Latin American Integration | 2025-04-07 |
| Carboplatin/Cisplatin + Etoposide + Benmelstobart Sequential Benmelstobart Combined With Anlotinib Versus Carboplatin/Cisplatin + Etoposide + Tislelizumab Sequential Tislelizumab in the Treatment of Extensive Stage Small Cell Lung Cancer (NCT06897579) | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2025-04-07 |
| A Study of SRSD216 in Patients With Elevated Lipoprotein (a) (NCT07172646) | Sirius Therapeutics Co., Ltd. | 2025-04-07 |
| Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer (NCT06809140) | Matthew Galsky | 2025-04-07 |