| The Efficacy and Safety of Sintilimab Plus Chemotherapy in Surgical Conversion for Patients With Unresectable Stage IIIB-IIIC NSCLC: A Prospective, Single-Arm, Phase II Study (NCT06962189) | Zhejiang University | 2025-05-15 |
| Endoscopic Cryoablation Combined With PD-1 in Advanced Gastric Cancer (NCT06759233) | Zhongguang Luo, MD | 2025-05-15 |
| Research on the Application of 68Ga-PSMA-CYC PET Imaging in the Diagnosis, Staging, and Restaging of Prostate Cancer (NCT07056790) | First Affiliated Hospital of Fujian Medical University | 2025-05-15 |
| Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA) (NCT06640491) | The Methodist Hospital Research Institute | 2025-05-15 |
| Optimizing Reperfusion to Improve Outcomes and Neurologic Function (NCT06990867) | Corxel Pharmaceuticals | 2025-05-15 |
| Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer (NCT06949098) | Hebei Medical University Fourth Hospital | 2025-05-15 |
| Tislelizumab as Single-Agent Neoadjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma (NCT06692270) | Fujian Cancer Hospital | 2025-05-15 |
| Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU (NCT07391618) | Chinese PLA General Hospital | 2025-05-15 |
| A Single-Arm Exploratory Study of Enlansibumab Sequentially Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer (NCT06981858) | Chongqing University Cancer Hospital | 2025-05-15 |
| A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis (NCT07003425) | Apogee Therapeutics, Inc. | 2025-05-14 |
| A Safety and Efficacy Study of PDFE-2304 Topical Solution for the Treatment of Androgenic Alopecia. (NCT07011485) | PDFE Pharma Innovations FZCO | 2025-05-14 |
| A Multicenter, Open-label, Non-randomized Phase I/IIa Clinical Trial to Evaluate INR102 Injection in Patients With Prostate Cancer (NCT06970119) | Yunhe Pharmaceutical (Tianjin) Co., Ltd | 2025-05-14 |
| MAGIC Ruxolitinib for aGVHD (NCT06936566) | John Levine | 2025-05-14 |
| A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) (NCT06798012) | Takeda | 2025-05-14 |
| Beta Glucan 500 and Biological Age and Immune Age (NCT07104929) | OvationLab | 2025-05-14 |
| High Intensity Focused Ultrasound in Prostate Cancer (NCT06402357) | University of Florida | 2025-05-14 |
| The Phase 1b/IIa, Open-label, Dose Escalation and Dose Expansion to Evaluate Safety, Tolerability, and Preliminary Efficacy of the Combination of HCB101, Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in Advanced or Metastatic Colorectal Cancer (NCT07204574) | Chang Gung Memorial Hospital | 2025-05-14 |
| Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer (NCT06635980) | Mayo Clinic | 2025-05-14 |
| Evaluation of the Clinical Efficacy of Antrrix Probiotics in Improving Recurrent Respiratory Infections in Infants and Young Children (NCT07297966) | Min-Tze LIONG | 2025-05-14 |
| A Study of Andecaliximab in People With Spinal Cord Injury at Risk for Bone Growth Outside of the Normal Skeleton. (NCT07024407) | Ashibio Inc | 2025-05-14 |
| A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease (NCT06858397) | GC Biopharma Corp | 2025-05-14 |
| Towards Cure Via Only Ultra-short ICB in CSCC (NCT06823479) | The Netherlands Cancer Institute | 2025-05-14 |
| Study of Zatolmilast (BPN14770) in Participants With PPP2R5D Neurodevelopmental Disorder (Jordan's Syndrome [JS]) (NCT06717438) | Shionogi | 2025-05-13 |
| Probiotic Use for Recovery Enhancement From Long COVID-19 (NCT06643299) | Rush University Medical Center | 2025-05-13 |
| STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer (NCT06574880) | Angela Y. Jia, MD PhD | 2025-05-13 |
| Treatment of Charcot-Marie-Tooth Disease, Axonal, Type 2S (CMT2S) in an Individual Patient (NCT07223632) | Vanda Pharmaceuticals | 2025-05-13 |
| Investigation to Understand and Optimize Psilocybin (NCT06512194) | Charles Raison | 2025-05-13 |
| Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease (NCT06976853) | Washington University School of Medicine | 2025-05-13 |
| Clinical Trial for Safety and Effectiveness Evaluation of Tarlatamab (AMG757) With Etoposide, Carboplatin and Atezolizumab in Transformed Small Cell Lung Cancer Patients From Adenocarcinoma After EGFR TKI Treatment (NCT06830694) | Se-Hoon Lee | 2025-05-13 |
| A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma (NCT07105592) | Fudan University | 2025-05-13 |
| A Study of Reduced Radiation Therapy With Chemotherapy in People With HPV-Positive Throat Cancer (NCT06984861) | Memorial Sloan Kettering Cancer Center | 2025-05-13 |
| Pomalidomide as an Immune-enhancing Agent for the Control of HIV (NCT06660498) | University of Aarhus | 2025-05-13 |
| Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment (NCT07097051) | High Point University | 2025-05-13 |
| A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia. (NCT06823752) | Woolcock Institute of Medical Research | 2025-05-13 |
| Effects of Ketone Supplement and Alcohol on Brain Metabolism (NCT06815237) | University of Pennsylvania | 2025-05-13 |
| A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01) (NCT06780085) | Merck Sharp & Dohme LLC | 2025-05-13 |
| TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer (NCT06589830) | Suzhou Teligene Ltd. | 2025-05-13 |
| Progesterone in Gender Affirming Hormone Therapy Study (NCT06807580) | Emory University | 2025-05-12 |
| A Study of ZL-1310 in Participants With Selected Solid Tumors (NCT06885281) | Zai Lab (Shanghai) Co., Ltd. | 2025-05-12 |
| Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer (NCT06445114) | Zachary Zumsteg | 2025-05-12 |
| A Study to Assess TTI-0102 vs Placebo in MELAS Patients (NCT06644534) | Thiogenesis Therapeutics, Inc. | 2025-05-12 |
| The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic Surgery (NCT06983886) | Ramathibodi Hospital | 2025-05-12 |
| CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D) (NCT06783309) | COUR Pharmaceutical Development Company, Inc. | 2025-05-12 |
| Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study (NCT06914908) | Sanofi | 2025-05-12 |
| A Study Evaluating the Efficacy of PD-1 Inhibitor Combined With Denosumab and Chemotherapy in Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Patients With Driver Gene-Negative Status (NCT07034391) | China Medical University, China | 2025-05-12 |
| Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt) (NCT06150898) | Jules Bordet Institute | 2025-05-12 |
| Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy (NCT07693387) | Taiwan Municipal An-Nan Hospital-China Medical University | 2025-05-12 |
| Ultralow Dose PET Imaging of 18F-FDOPA (NCT07542158) | Akiva Mintz | 2025-05-12 |
| A Safety, Tolerability and Pharmacokinetic Study of cP12 in Adults With Up To 10% Total Body Surface Area Burns (NCT06814717) | Neomatrix Therapeutics, Inc. | 2025-05-12 |
| Ultralow Dose PET Imaging for PSMA Expression (NCT06904313) | Akiva Mintz | 2025-05-12 |
| A Phase Ib/II Clinical Trial of Multiple Doses of STSA-1301 Subcutaneous Injection in Healthy Subjects and Patients With Immune Thrombocytopenia (ITP) (NCT06929299) | Jiangsu BioJeTay Biotechnology Co., Ltd. | 2025-05-12 |
| Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia (NCT06517641) | Medical College of Wisconsin | 2025-05-12 |
| Trabedersen (OT-101) With Pembrolizumab for Newly Diagnosed Advanced NSCLC and Positive PD-L1 (NCT06579196) | University of Nebraska | 2025-05-12 |
| Ultralow Dose PET Imaging of 18F-FDG Uptake (NCT06956391) | Akiva Mintz | 2025-05-12 |
| Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease (NCT07020026) | Michael J. Fox Foundation for Parkinson's Research | 2025-05-12 |
| Induction Chemotherapy Combined With Tislelizumab for Locally Advanced Squamous Cell Carcinoma of the External Auditory Canal (NCT07370337) | Eye & ENT Hospital of Fudan University | 2025-05-12 |
| A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION) (NCT06925750) | Merck Sharp & Dohme LLC | 2025-05-12 |
| Vaccination Against Human Papillomavirus (HPV) After Allogeneic Stem Cell Transplantation (NCT06793410) | Vastra Gotaland Region | 2025-05-12 |
| Study of MG-ZG122 Humanized Monoclonal Antibody in Asthma Subjects (NCT07054034) | Shanghai Mabgeek Biotech.Co.Ltd | 2025-05-11 |
| Adebrelimab Plus Apatinib Combined With SOX Regimen as Conversion Therapy for Gastric Cancer (NCT07353684) | Beijing Friendship Hospital | 2025-05-11 |
| PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC (NCT06977074) | Sun Yat-sen University | 2025-05-10 |
| Efficacy and Saftey Study of 99mTc-ECDG in the Evaluation of Coronary Artery Disease (CAD) (NCT01899833) | Cell>Point LLC | 2025-05-10 |
| Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With High-risk Myeloid Malignancies and a Partially Mismatched Donor (NCT07238712) | St. Petersburg State Pavlov Medical University | 2025-05-10 |
| Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease (NCT07001150) | Tanta University | 2025-05-10 |
| Effect of Theronomic Ova-All Care on Biomarkers of Ovarian Health in Adult Female With Polycystic Ovarian Syndrome (NCT06963840) | Wellizen Australia | 2025-05-09 |
| ICP-332 in Subjects With Non-segmental Vitiligo (NCT07047612) | Beijing InnoCare Pharma Tech Co., Ltd. | 2025-05-09 |
| Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation (NCT07256210) | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 2025-05-09 |
| Bispecific Antibody-Based Salvage Therapy Followed by CAR-T ± ASCT in R/R Aggressive B-Cell Lymphoma (NCT06996132) | Institute of Hematology & Blood Diseases Hospital, China | 2025-05-09 |
| A Study of QLP2117 in Combination With QL2107 in Advanced Solid Tumor Patients (NCT06911827) | Qilu Pharmaceutical Co., Ltd. | 2025-05-09 |
| Base-Edited Hematopoietic Stem/Progenitor Cell X-Linked Severe Combined Immunodeficiency Gene Therapy (NCT06851767) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-05-09 |
| Trilaciclib in Combination With Docetaxel for Second-Line and Beyond Treatment of Locally Advanced or Metastatic NSCLC (NCT06929936) | The First Affiliated Hospital of Xiamen University | 2025-05-09 |
| Study Comparing Safety and Immunogenicity of Intranasal COVID-19 Vaccine and mRNA Booster in Healthy Adults (NCT06821126) | ANRS, Emerging Infectious Diseases | 2025-05-09 |
| A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus (NCT06937203) | Arrowhead Pharmaceuticals | 2025-05-09 |
| 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee (NCT06865079) | OrthoTrophix, Inc | 2025-05-09 |
| A Study of MHB036C Combined With Anti-tumor Therapies in Patients With Advanced Lung Cancer (NCT07229599) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-05-09 |
| Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia (NCT06976476) | Memorial Sloan Kettering Cancer Center | 2025-05-08 |
| Lipomas Treated With Subcutaneous Injections of Cooled or Warmed Sodium Chloride (NCT06820164) | West Virginia University | 2025-05-08 |
| A Phase 1/2 Study of ESG206 in Patients With Primary Immune Thrombocytopenia (NCT06853444) | Shanghai Escugen Biotechnology Co., Ltd | 2025-05-08 |
| Clinical Trials of Quadrivalent Influenza Vaccine (NCT06824519) | Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. | 2025-05-08 |
| A First-in-human Study of EPI-321 in Facioscapulohumeral Muscular Dystrophy (NCT06907875) | Epicrispr Biotechnologies, Inc. | 2025-05-08 |
| Effect of YAP1-inhibition in Surgical Wounds. (NCT06944249) | Jöri Pünchera | 2025-05-08 |
| Exploratory Safety and Efficacy of EMP-01 in Social Anxiety Disorder (NCT06693609) | atai Therapeutics, Inc. | 2025-05-08 |
| Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) Therapy, a Phase 2 Randomized Study (NCT06811233) | M.D. Anderson Cancer Center | 2025-05-08 |
| Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use (NCT06379984) | University of Pennsylvania | 2025-05-08 |
| A Prospective, Multicenter, Multicohort Phase II Study: Evaluating the Efficacy and Safety of Preoperative Neoadjuvant Treatment With a PD-1 Inhibitor in Combination With Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma (NCT06894459) | Beijing Tongren Hospital | 2025-05-08 |
| Evaluate the Efficacy and Safety of NT-0796 in Participants With Obesity With or Without Type 2 Diabetes Mellitus (NCT07055516) | NodThera Limited | 2025-05-08 |
| 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer (NCT06887218) | The Methodist Hospital Research Institute | 2025-05-08 |
| Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY) (NCT07029009) | Mansa | 2025-05-08 |
| Exploratory Clinical Study on Memory NK Cell Therapy for Advanced Metastatic Solid Tumors (NCT07274449) | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2025-05-08 |
| Evaluation of the Efficacy and Safety of Polatuzumab Vedotin Combined With Rituximab, Gemcitabine, and Oxaliplatin (Pola-R-GemOx) as Salvage Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients Ineligible for Autologous Transplantation (NCT07001540) | Fudan University | 2025-05-08 |
| SN514-066b Enzyme in Deep Partial Thickness Burns (NCT06628037) | SERDA bv | 2025-05-08 |
| Evaluating the Safety, Tolerability, and Preliminary Anti-tumor Activity of MB0151 in Adult Subjects With Advanced Solid Tumors Expressing Somatostatin Receptors (NCT06840821) | Mainline Biosciences (Shanghai) Co., Ltd | 2025-05-08 |
| Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial (NCT06903416) | University of Alberta | 2025-05-07 |
| A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Lymphoma (NCT06939283) | Werewolf Therapeutics, Inc. | 2025-05-07 |
| Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig) (NCT07202078) | Monash University | 2025-05-07 |
| Safety and Efficacy of AGN-INM176 in Prostate Patients With Rising PSA (NCT06600698) | Milton S. Hershey Medical Center | 2025-05-07 |
| Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy (NCT06747845) | Abramson Cancer Center at Penn Medicine | 2025-05-07 |
| Crisugabalin for Radiotherapy-Related Neuropathic Pain (NCT06766916) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-05-07 |
| Protecting the Kidney's Proximal Tubules From Platinum-Based Chemotherapy Toxicity (NCT07018622) | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 2025-05-07 |
| A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High Proteinuria (NCT06942910) | AstraZeneca | 2025-05-07 |