| A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury (NCT06870240) | Oragenics, Inc. | 2025-06-01 |
| A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment (NCT06748664) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-06-01 |
| EBV-AST Cell Injection for EBV-Associated Lymphoproliferative Disorders (NCT07450391) | Daihong Liu | 2025-06-01 |
| Trimodality Approach of Low Dose iOnizing Radiation With or Without Neoadjuvant Pembrolizumab and Prostatectomy for Men With Intermediate/High Risk Prostate Cancer (TALON) (NCT04569461) | Duke University | 2025-06-01 |
| MRD Guided De-intensification of Bendamustine/Rituximab for Indolent Non-Hodgkin Lymphoma (NCT06557330) | Fox Chase Cancer Center | 2025-06-01 |
| Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy (NCT06483659) | Brigham and Women's Hospital | 2025-06-01 |
| Standard Dose Versus High Dose Stereotactic Spine Radiosurgery for Metastatic Spinal Neoplasms (NCT07039968) | National Taiwan University Hospital | 2025-06-01 |
| Efficacy and Safety of Fruquintinib Combined With Sintilimab and Stereotactic Body Radiation Therapy (SBRT) for the Second-line and Higher-line Treatment of Gastric or Gastroesophageal Junction Adenocarcinoma With Oligometastatic Progression (NCT06977061) | Queling Liu | 2025-06-01 |
| MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment (NCT06177028) | St. Joseph's Hospital and Medical Center, Phoenix | 2025-06-01 |
| Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004) (NCT06991491) | West China Hospital | 2025-06-01 |
| Blinatumomab Combined With Venetoclax as Maintenance Therapy After Allo-HSCT in High-risk Ph Negative Acute B-cell Lymphoblastic Leukemia (NCT07199855) | Zhejiang University | 2025-06-01 |
| Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer (NCT07003815) | Tongji Hospital | 2025-06-01 |
| Study of SY-5933 Plus CT-707 in Advanced Solid Tumors With KRAS p.G12C Mutation (NCT06970132) | Shouyao Holdings (Beijing) Co. LTD | 2025-06-01 |
| Metformin as a Neuroprotective Therapy for Glaucoma (NCT05426044) | Christopher Kai Shun Leung | 2025-06-01 |
| SHR-A1811 and THPy in First or Second Line for HER2 Positive Advanced Breast Cancer Brain Metastases (NCT06975475) | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2025-06-01 |
| A Study of Linperlisib (YY-20394) in Combination With Rituximab in Patients With Relapsed/Refractory Indolent NHL (NCT06981988) | Jiangsu HengRui Medicine Co., Ltd. | 2025-06-01 |
| Evaluation of a Novel Nasal Conformer in Pediatric Patients (NCT06885801) | East Tennessee Children's Hospital | 2025-06-01 |
| Immune PET and Proteomics for the Assessment of Response to Spatially Fractionated or Palliative Radiotherapy With or Without Immunotherapy (NCT06976021) | Maria Sklodowska-Curie National Research Institute of Oncology | 2025-06-01 |
| Datopotamab Deruxtecan (Dato-DXd) for Non-Small Cell Lung Cancer (NSCLC) Patients With Active Brain Metastases (NCT06676917) | MedSIR | 2025-06-01 |
| Study on Optimizing the Treatment of Patients With Acute Myeloid Leukemia Based on Early Peripheral Blood Minimal Residual Disease (NCT07023588) | Yehui Tan | 2025-06-01 |
| LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This (NCT06978088) | Zulfa Omer | 2025-06-01 |
| Real-world Study of Darafenib or Trametinib and Clofarabine for High-risk/Recurrent/Refractory Langerhans Cell Histiocytosis in Children (NCT07022834) | West China Second University Hospital | 2025-06-01 |
| Exploratory Study of EBV-TCR-T Cell Injection for EBV DNAemia After Allogeneic Hematopoietic Stem Cell Transplantation (NCT07368634) | Daihong Liu | 2025-06-01 |
| Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI (NCT06564909) | Ain Shams University | 2025-06-01 |
| A Phase II Study of Adjuvant Durvalumab Combined With GEMOX/GC Chemotherapy Followed by Lenvatinib Versus Capecitabine in Biliary Tract Cancer. (NCT07679399) | Peking Union Medical College Hospital | 2025-06-01 |
| Acupuncture Versus Compound Diclofenac Sodium for Pain Relief in Non-Traumatic Acute Abdominal (NCT06982755) | The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine | 2025-06-01 |
| ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC (NCT07012954) | Sun Yat-sen University | 2025-06-01 |
| Adding IL-2 to Tebentafusp to Eradicate Cancer Progression (NCT07063875) | St Vincent's Hospital, Sydney | 2025-06-01 |
| Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus (NCT07374328) | Second Affiliated Hospital of Guangzhou Medical University | 2025-06-01 |
| A Clinical Study to Evaluate the Efficacy and Safety of Envafolimab Combined With Cetuxima-βand mFOLFOX6 in Patients With MSS, RAS/BRAF Wild-Type Metastatic Colorectal Cancer (mCRC) (NCT06959693) | Sun Yat-sen University | 2025-06-01 |
| Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients (NCT06922591) | Tango Therapeutics, Inc. | 2025-05-31 |
| Iparomlimab and Tuvonralimab Combined With Platinum-Based Chemotherapy for Neoadjuvant Treatment of Cervical Cancer (NCT06986057) | Shandong Tumor Hospital | 2025-05-31 |
| Node-Sparing Short-Course Radiotherapy Plus First-Line Therapy and PD-1 Inhibitor in Unresectable/Metastastic pMMR/MSS Gastric Cancer (MODIFI-GC) (NCT06980389) | Sixth Affiliated Hospital, Sun Yat-sen University | 2025-05-31 |
| Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension (NCT06964191) | PolyActiva Pty Ltd | 2025-05-31 |
| Bevacizumab and ICIs + hSRT in Symptomatic Melanoma Brain Metastases (NCT06163820) | Melanoma and Skin Cancer Trials Limited | 2025-05-31 |
| ATI-045 Versus Placebo in Patients With Moderate-to-Severe Atopic Dermatitis (NCT07011706) | Aclaris Therapeutics, Inc. | 2025-05-30 |
| Nitazoxanide in Patients With Ulcerative Colitis (NCT06993974) | Alexandria University | 2025-05-30 |
| A Phase II/III Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, in Healthy Infants as Primary Series (NCT06947499) | LG Chem | 2025-05-30 |
| A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) (NCT06124157) | National Cancer Institute (NCI) | 2025-05-30 |
| Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic Patients (NCT06995339) | Mostafa Bahaa | 2025-05-30 |
| Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty (NCT06955923) | David Grant U.S. Air Force Medical Center | 2025-05-30 |
| Clinical Study on the Treatment of MAFLD With Ganzhixiao Capsules (NCT06848907) | Dong Hui | 2025-05-30 |
| A Clinical Trial to Evaluate the Safety and Efficacy of Olanzapine Titration Schedule in Patients With Schizophrenia (NCT06821945) | Boryung Pharmaceutical Co., Ltd | 2025-05-30 |
| SK-NK Injection in Patients With Advanced Solid Tumors Accompanied by Malignant Ascites (NCT06991478) | Tianjin Medical University Cancer Institute and Hospital | 2025-05-30 |
| Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma (NCT06302569) | Giuseppe Procopio | 2025-05-30 |
| Administration of High Doses of Antiretroviral Drugs to Eliminate the Latent HIV-1 Reservoir (NCT06640192) | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 2025-05-30 |
| Infant Malaria Vaccine Schedule Optimization (NCT06879327) | PATH | 2025-05-30 |
| Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19) (NCT06533579) | Vironexis Biotherapeutics Inc. | 2025-05-30 |
| Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity (NCT06745063) | VA Office of Research and Development | 2025-05-30 |
| DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC (NCT06364917) | University of Alabama at Birmingham | 2025-05-30 |
| A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML) (NCT06969430) | Debiopharm International SA | 2025-05-30 |
| Recombinant Human IL-21-expressing Oncolytic Vaccinia Virus Injection (hV01) in Advanced Pancreatic Cancer (NCT07006077) | Hangzhou Converd Co., Ltd. | 2025-05-29 |
| Safety and Efficacy of Crofelemer in Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC) (NCT06904872) | Napo Therapeutics, S.p.A. | 2025-05-29 |
| Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases (NCT06887088) | Grupo Español Multidisciplinar de Melanoma | 2025-05-29 |
| A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation (NCT07023731) | Arvinas Inc. | 2025-05-29 |
| JS207 Combined With JS007 as First-line Treatment for Advanced Hepatocellular Carcinoma (NCT06954467) | Shanghai Junshi Bioscience Co., Ltd. | 2025-05-29 |
| Neoadjuvant Pembrolizumab and Carboplatin Plus Paclitaxel for Stage I Triple-negative Breast Cancer (NCT06604858) | MedSIR | 2025-05-29 |
| A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012) (NCT06961006) | Merck Sharp & Dohme LLC | 2025-05-29 |
| Glofitamab Plus Ibrutinib With Obinutuzumab for the Treatment of Patients With Mantle Cell Lymphoma, IGNITE MCL Trial (NCT06357676) | OHSU Knight Cancer Institute | 2025-05-29 |
| A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer (NCT06533644) | Syncromune, Inc. | 2025-05-29 |
| Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus (NCT06729996) | Mayo Clinic | 2025-05-29 |
| JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration (NCT06973564) | Jacobio Pharmaceuticals Co., Ltd. | 2025-05-29 |
| Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas (NCT07066982) | Essen Biotech | 2025-05-29 |
| Monthly Dosing of Atacicept in IgAN (NCT07020923) | Vera Therapeutics, Inc. | 2025-05-29 |
| Extension Study of Participants From SPG302-ALS-001 (NCT06903286) | Spinogenix | 2025-05-29 |
| A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease (NCT06976268) | Biohaven Therapeutics Ltd. | 2025-05-28 |
| Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer (NCT06787612) | Regeneron Pharmaceuticals | 2025-05-28 |
| A Randomized Neuroimaging Trial of Psilocybin in Depression (NCT06072898) | Sunnybrook Health Sciences Centre | 2025-05-28 |
| Therapy of Niacin for Rheumatoid Arthritis (NCT07004725) | Peking University People's Hospital | 2025-05-28 |
| A Study to Evaluate KRIYA-825 (VV-14295) in Adults With Geographic Atrophy Secondary to Age-related Macular Degeneration (NCT06765980) | Kriya Therapeutics, Inc. | 2025-05-28 |
| Investigating a Marijuana-based Compound as a Treatment for Anxiety in Autistic Adults (NCT06526208) | Southwest Autism Research & Resource Center | 2025-05-28 |
| Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I) (NCT06780098) | Merck Sharp & Dohme LLC | 2025-05-28 |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) (NCT06666322) | David Boulware | 2025-05-28 |
| Clinical Assessment of Injectable Composite Versus Packable Composite in Treatment of Carious Primary Anterior Teeth (NCT06991582) | Cairo University | 2025-05-28 |
| A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine (NCT06682988) | AbbVie | 2025-05-28 |
| A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD) (NCT06764615) | Takeda | 2025-05-28 |
| Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC (NCT06819566) | Asan Medical Center | 2025-05-28 |
| Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU) (NCT06931405) | Blueprint Medicines Corporation | 2025-05-28 |
| A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS) (NCT06782373) | Swedish Orphan Biovitrum | 2025-05-28 |
| A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis (NCT07012395) | Spyre Therapeutics, Inc. | 2025-05-27 |
| Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury (NCT06937307) | Giuseppe Cullaro, MD | 2025-05-27 |
| Phase II Trial of Tunlametinib in NRAS-Mutant Advanced Thyroid Cancer (NCT06970353) | Fudan University | 2025-05-27 |
| A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or Behavior (NCT07193901) | Sichuan Purity Pharmaceutical Technology Co., Ltd. | 2025-05-27 |
| Elranatamab Post Cilta-cel in Patients With Clinical High Risk Relapsed Myeloma (NCT06947083) | H. Lee Moffitt Cancer Center and Research Institute | 2025-05-27 |
| Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects (NCT06981195) | Virginia Commonwealth University | 2025-05-27 |
| Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) (NCT07047209) | Massachusetts General Hospital | 2025-05-27 |
| Ruxolitinib Treatment in Inclusion Body Myositis (NCT06536166) | Assistance Publique - Hôpitaux de Paris | 2025-05-27 |
| Zanubrutinib in Patients With DLBCL and MYD88 or NOTCH1 Mutation or CD5+ (NCT06846463) | Virginia Commonwealth University | 2025-05-27 |
| Acalabrutinib for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT06757647) | Seema Bhat | 2025-05-27 |
| Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease (NCT06873334) | Skyhawk Therapeutics, Inc. | 2025-05-27 |
| Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer (NCT06782932) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2025-05-27 |
| Adjuvant Quisinostat in High-Risk Uveal Melanoma (NCT06932757) | University of Miami | 2025-05-27 |
| Treatment of UC With Novel Therapeutics (NCT06420375) | Brigham and Women's Hospital | 2025-05-27 |
| A First-in-Human Study Using BDC-4182 as a Single Agent in Advanced Gastric and Gastroesophageal Cancer (NCT06921837) | Bolt Biotherapeutics, Inc. | 2025-05-26 |
| Study to Evaluate Safety and Efficacy of SYHX1901 Tablets in Severe Alopecia Areata Patients (NCT06562894) | CSPC Ouyi Pharmaceutical Co., Ltd. | 2025-05-26 |
| A Phase Ib/II Clinical Study of Regorafenib Combined With Toripalimab and Albumin-bound Paclitaxel for the Third-line Treatment of Advanced Pancreatic Cancer (NCT07040228) | Junjie Hang | 2025-05-26 |
| A Phase IIa Clinical Study to Assess the Efficacy and Safety of GenSci048 in Patients With Moderate to Severe Endometriosis-Associated Pain (NCT06963177) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-05-26 |
| Efficacy and Safety Study of Isuzinaxib in Subjects With DKD (NCT06962098) | Aptabio Therapeutics, Inc. | 2025-05-26 |
| A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL (NCT06966154) | Fudan University | 2025-05-26 |
| LAttice Radiation Therapy for Large Lesions: Reggio Emilia Single-arm Phase II Trial (NCT07000162) | Azienda USL Reggio Emilia - IRCCS | 2025-05-26 |