| A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma (NCT07099391) | Memorial Sloan Kettering Cancer Center | 2025-07-24 |
| An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma (NCT07018570) | National Cancer Center Hospital East | 2025-07-24 |
| Efficacy of Immediate Allogeneic Hematopoietic Stem Cell Transplantation Versus Bridging Therapy Followed by Transplantation in Higher-Risk Myelodysplastic Syndrome Patients (NCT06918834) | Institute of Hematology & Blood Diseases Hospital, China | 2025-07-24 |
| Phase I/II Clinical Study of SHR-1501 Combined With Adbelizumab in Patients With Malignant Tumors (NCT07073534) | Shanghai Hengrui Pharmaceutical Co., Ltd. | 2025-07-24 |
| Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma (NCT07120503) | Windward Bio | 2025-07-24 |
| Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma. (NCT07044635) | University of Utah | 2025-07-23 |
| Neoadjuvant Radiotherapy Plus Tegafur, Oxaliplatin and Iparomlimab and Tuvonralimab in Resectable Gastric and GE-junction Cancer : A Randomized, Two-arm, Prospective Trial (TRIUNITE-05) (NCT07165847) | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 2025-07-23 |
| A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression (NCT06597695) | Juliana Zambrano, MD, MPH | 2025-07-23 |
| A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM) (NCT06953960) | AbbVie | 2025-07-23 |
| Fluorescence Lymph Node Mapping for Colon Cancer Surgery (NCT07060443) | Pusan National University Yangsan Hospital | 2025-07-23 |
| A Study to Investigate the Safety, Tolerability, and Efficacy of SAR446268, an Adeno-associated Viral Vector-mediated Gene Therapy in Participants Aged 10 to 55 Years of Age With Non-congenital Myotonic Dystrophy Type 1 (NCT06844214) | Sanofi | 2025-07-23 |
| Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. (NCT06940388) | brenner baruch | 2025-07-23 |
| "Sexual Health Assessment of TinidaZole Against M. Genitalium (SHAZAM)" (NCT07088419) | University of Washington | 2025-07-23 |
| Neoadjuvant Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Advanced Esophageal Squamous Cell Carcinoma (NCT06764355) | National Taiwan University Hospital | 2025-07-23 |
| Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Upper Tract Urothelial Cancer (NCT06356155) | University of Michigan Rogel Cancer Center | 2025-07-22 |
| Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer (NCT06627270) | Case Comprehensive Cancer Center | 2025-07-22 |
| A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol Dependence (NCT06845124) | Central Institute of Mental Health, Mannheim | 2025-07-22 |
| Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease (NCT06638944) | University of Illinois at Urbana-Champaign | 2025-07-22 |
| NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility Study (NCT07121374) | University Hospital, Antwerp | 2025-07-22 |
| Safety and Efficacy of JKN2304 Inhalation Solution in Patients With Moderate to Severe COPD (NCT07450482) | Joincare Pharmaceutical Group Industry Co., Ltd | 2025-07-22 |
| Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery (NCT06959511) | M.D. Anderson Cancer Center | 2025-07-22 |
| MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes (NCT06930638) | Medical College of Wisconsin | 2025-07-22 |
| L9LS in Women of Childbearing Potential in Mali (NCT07060508) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-07-22 |
| Early Intervention in Plaque Psoriasis: is Bimekizumab Able to Delay Chronic Inflammation? (NCT06742333) | Centre Hospitalier Universitaire de Nice | 2025-07-22 |
| A Randomized Study to Compare Post-transplant Cyclophosphamide, Sirolimus, Ruxolitinib and Post-transplant Cyclophosphamide, Sirolimus, Mycophenolate Mofetil to Prevent Graft Versus Host Disease (NCT06973668) | M.D. Anderson Cancer Center | 2025-07-22 |
| A Phase I/II Study of HY05350 in Mesothelin(MSLN)-Positive Advanced Solid Tumors (NCT07083323) | Sichuan Huiyu Pharmaceutical Co., Ltd | 2025-07-22 |
| A Phase II Study of SHR-8068 Injection in Combination With Anti-tumor Therapies in Colorectal Cancer (NCT07071714) | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 2025-07-22 |
| A Study of LY3549492 in Healthy Weight Adult Participants (NCT07085468) | Eli Lilly and Company | 2025-07-21 |
| A Phase I/Ⅱ Human Study of HY0001a for Injection in Adult Participants With Advanced Solid Tumors (NCT07069062) | Sichuan Huiyu Pharmaceutical Co., Ltd | 2025-07-21 |
| A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer (NCT06888921) | Compugen Ltd | 2025-07-21 |
| Transcranial Pulse Stimulation for Alzheimer's Disease (NCT07143734) | Chinese University of Hong Kong | 2025-07-21 |
| Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder (NCT06577636) | Stanford University | 2025-07-21 |
| Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC） (NCT06910072) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-07-21 |
| Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors (NCT06943755) | Exelixis | 2025-07-21 |
| Efficacy and Safety of AK112 Combined Chemotherapy as Neoadjuvant Treatment for Signet Ring Cell-containing G/GEJ Adenocarcinoma (NCT07091227) | Peking Union Medical College Hospital | 2025-07-20 |
| Combination of Concurrent Chemoradiotherapy With Surufatinib and Tislelizumab in Patients With Locally Advanced Non-Small Cell Lung Cancer (NCT07086456) | Sun Yat-sen University | 2025-07-20 |
| Efficacy and Safety of Disitamab Vedotin Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer：a Phase II Study (NCT07093866) | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2025-07-20 |
| Surufatinib in Combination With Neoadjuvant Chemo-immunotherapy and Concurrent Chemoradiotherapy for Patients With Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma (NCT07086469) | Sun Yat-sen University | 2025-07-20 |
| The Efficacy of TROP2-ADC in Advanced Extrapulmonary High-Grade Neuroendocrine Neoplasms Failure of Standard Therapy (NCT07077564) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-07-20 |
| A Prospective, Single-arm, Phase II Clinical Study of Tislelizumab Combined With Anlotinib and Platinum-based Doublet Perioperative Therapy for Resectable Stage II-IIIB Driver Gene-negative NSCLC (NCT06977828) | The First Affiliated Hospital with Nanjing Medical University | 2025-07-20 |
| Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03) (NCT07049926) | Merck Sharp & Dohme LLC | 2025-07-20 |
| Efficacy and Safety of UCBT With TMI -Based Conditioning Regimen for Adults With Refractory/Relapsed Aplastic Anemia (NCT07078721) | Institute of Hematology & Blood Diseases Hospital, China | 2025-07-20 |
| CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study (NCT07072494) | Zhujiang Hospital | 2025-07-19 |
| A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease (NCT06926660) | Boehringer Ingelheim | 2025-07-18 |
| Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease. (NCT06831500) | Julien Bally | 2025-07-18 |
| Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder (NCT06788587) | Centre hospitalier de l'Université de Montréal (CHUM) | 2025-07-18 |
| DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors (NCT06953089) | DualityBio Inc. | 2025-07-18 |
| A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC. (NCT07052253) | Akeso | 2025-07-18 |
| CANnabinoids in Pediatric ONCology (NCT05754840) | University of Manitoba | 2025-07-18 |
| Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma (NCT07057596) | Grupo Español Multidisciplinar de Melanoma | 2025-07-18 |
| A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer (NCT07079631) | BioNTech SE | 2025-07-18 |
| ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis (NCT07090330) | Oruka Therapeutics, Inc. | 2025-07-18 |
| Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission (NCT06824168) | Daiichi Sankyo | 2025-07-18 |
| Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer (NCT06933329) | BicycleTx Limited | 2025-07-18 |
| Merck IIT: RRP Pembro and Lenvatinib (NCT04645602) | Yale University | 2025-07-18 |
| Safety and Performance, and Dose, of OsteoAdapt DE in Localized Alveolar Ridge Augmentations (NCT07078331) | Theradaptive, Inc | 2025-07-17 |
| EMERALD: Endocrine Therapy oMission With Radiation in ER+ Breast Cancer: Assessing Quality of Life and Disease Control: a Prospective Phase II Trial (NCT06897488) | M.D. Anderson Cancer Center | 2025-07-17 |
| A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma (NCT07069712) | AstraZeneca | 2025-07-17 |
| A Study of MHB046C Injection in Patients With Advanced Solid Tumors (NCT06985355) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-07-17 |
| Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial (NCT07121595) | University of Michigan Rogel Cancer Center | 2025-07-17 |
| A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases (NCT06932458) | Western University, Canada | 2025-07-17 |
| A Study to Assess Safety and Efficacy of Surgical Implant of RNDP-001 in Patients With Idiopathic Parkinson's Disease (NCT07106021) | Kenai Therapeutics | 2025-07-17 |
| Phase I/II Clinical Trial of 26-valent Pneumococcal Conjugate Vaccine (NCT06703203) | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 2025-07-17 |
| Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia (NCT07658508) | Alexandria University | 2025-07-16 |
| NEODOXy: Targeting Breast Cancer Stem Cells With Doxycycline (NCT06452394) | Swiss Cancer Institute | 2025-07-16 |
| Pharmacogenomics ANDA SNP Clinical Study - Etoposide and Single Nucleotide Polymorphisms (NCT01064466) | Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair | 2025-07-16 |
| A Phase 2 Study of JNT-517 in Adolescent Participants With Phenylketonuria (NCT06637514) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2025-07-16 |
| Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) (NCT05690048) | Michael Dill | 2025-07-16 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced Cancer (NCT07048743) | University Health Network, Toronto | 2025-07-16 |
| A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases (NCT06570798) | Amgen | 2025-07-16 |
| A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004) (NCT07033494) | Merck Sharp & Dohme LLC | 2025-07-16 |
| DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7) (NCT07070440) | Dizal Pharmaceuticals | 2025-07-16 |
| Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin (NCT06886464) | Matthew James | 2025-07-16 |
| Suvorexant for Treatment of AUD and PTSD (NCT06679062) | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance | 2025-07-16 |
| Safety, Pharmacokinetics, and Antiviral Activity of Remdesivir (VEKLURY®) in Hospitalized Children With RSV (NCT06873633) | PENTA Foundation | 2025-07-16 |
| Immune-checkpoint Blockade After Partial Breast Irradiation by Pembrolizumab in Early TNBC (NCT07011823) | Gangnam Severance Hospital | 2025-07-16 |
| A Study Comparing SHR-3167 and Insulin Degludec in Type 2 Diabetic Subjects Treated With Basal Insulin With or Without Oral Antidiabetic Drugs (NCT07018453) | Jiangsu HengRui Medicine Co., Ltd. | 2025-07-16 |
| Base Editing Hematopoietic Stem Cell and T Cell Gene Therapy for CD40L-HyperIgM Syndrome: Single Patient Study (NCT06959771) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-07-16 |
| Evaluating the Preliminary Efficacy and Safety of JS207 in NSCLC After Progression Following Platinum-based Chemotherapy and Immunotherapy (NCT06924606) | Shanghai Junshi Bioscience Co., Ltd. | 2025-07-15 |
| Feasibility Trial for a Right Ventricular Failure Platform Trial (NCT06570473) | University of Alberta | 2025-07-15 |
| Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes (NCT06923488) | West Virginia University | 2025-07-15 |
| Phase II Study of Combined Pirtobrutinib, Venetoclax and Obinutuzumab (PVO) Time-limited Treatment for Patients With Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). (NCT06967610) | M.D. Anderson Cancer Center | 2025-07-15 |
| Rupatadine in Patients With Ulcerative Colitis (NCT07064707) | Alexandria University | 2025-07-15 |
| Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke (NCT06440707) | University of California, Los Angeles | 2025-07-15 |
| Patient Preference Study: Standard of Care Versus Once-daily Trientine Tetrahydrochloride (NCT07010575) | Orphalan | 2025-07-15 |
| Trastuzumab in Combination With Serplulimab and Chemotherapy for the Treatment of HER2-overexpressing Unresectable Locally Advanced or Metastatic Biliary Tract Cancer or Urothelial Carcinoma After Failure of Standard Therapy (NCT07506057) | Xiujuan Qu | 2025-07-15 |
| A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB) (NCT06993480) | Ausper Biopharma Co., Ltd. | 2025-07-15 |
| A Study Evaluating BFB759 in Moderate to Severe Atopic Dermatitis (NCT07105488) | Bluefin Biomedicine, Inc. | 2025-07-15 |
| Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators. (NCT06576583) | University Hospital, Basel, Switzerland | 2025-07-15 |
| BrECADD Therapy in Stage 2 B-IV Hodgkin Lymphoma (NCT07002216) | University of Miami | 2025-07-15 |
| Study to Evaluate Efficacy and Safety of Ropanicant in MDD Patients (NCT06836063) | Suven Life Sciences Limited | 2025-07-15 |
| Golidocitinib With Azacitidine and Chidamide in Patients With Peripheral T-cell Lymphoma. (NCT07081607) | Ruijin Hospital | 2025-07-15 |
| VEN+DAC+Bu2Flu4 vs Bu2Flu5 Conditioning Regimen for Elderly Myeloid Malignancies Undergoing Allo-HSCT (NCT07052422) | Nanfang Hospital, Southern Medical University | 2025-07-15 |
| CAR-T vs. Auto-SCT: Which Works Better for New Myeloma Patients? (NCT07070934) | Xuzhou Medical University | 2025-07-15 |
| A Study to Evaluate 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD) (NCT07292714) | Mabwell (Shanghai) Bioscience Co., Ltd. | 2025-07-15 |
| Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial (NCT06841705) | Shilpa Grover, MD, MPH | 2025-07-15 |
| CAR-T Immunotherapy Targeting CD19- ALL (NCT04016129) | Shenzhen Geno-Immune Medical Institute | 2025-07-15 |
| Ivonescimab for the Treatment of Thymic Cancer (NCT06980077) | Jonsson Comprehensive Cancer Center | 2025-07-15 |
| Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique (NCT07595757) | Cairo University | 2025-07-15 |
| Multi-CAR T Cell Therapy for Acute Myeloid Leukemia (NCT03222674) | Shenzhen Geno-Immune Medical Institute | 2025-07-15 |