| A Phase II Trial of the Safety and Efficacy of RSS0309 Ointment in Adults With Atopic Dermatitis (NCT07158151) | Reistone Biopharma Company Limited | 2025-09-25 |
| Safety and Tolerability of Subretinally Injected OPGx-BEST1 in Patients With Best Vitelliform Macular Dystrophy (BVMD) or Autosomal-Recessive Bestrophinopathy (ARB) (NCT07185256) | Opus Genetics, Inc | 2025-09-25 |
| FOLFOX Combined With Durvalumab (MEDI4736), Bevacizumab, and Stereotactic Body Radiotherapy in Sequential Treatment of Potentially Resectable Locally Advanced Hepatocellular Carcinoma (NCT07012798) | Tianjin Medical University Cancer Institute and Hospital | 2025-09-25 |
| An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy (NCT07117630) | Fudan University | 2025-09-25 |
| A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy) (NCT06561074) | M.D. Anderson Cancer Center | 2025-09-25 |
| Dose-dense Capecitabine Schedule [7days on _7 Days Off] in Colorectal Cancer in Comparison With Standered Regimen (NCT07215936) | Sohag University | 2025-09-25 |
| Oral Semaglutide in Patients With Alzheimer's Disease (NCT07200622) | Imperial College London | 2025-09-25 |
| PA3-17 Injection in Adult Patients With CD7-positive Relapsed/Refractory T-lymphoblastic Leukemia/Lymphoma (NCT07188610) | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 2025-09-25 |
| Iparomlimab and Tuvonralimab (QL1706) in Patients With HR-positive, HER2-negative Advanced Breast Cancer (NCT07180160) | Wenjin Yin | 2025-09-25 |
| SSTR2 Imaging With [68Ga]Ga-DOTA-TOC PET/CT in NPC (NCT06982300) | University Medical Center Groningen | 2025-09-25 |
| Chinese Medicine in Treating Insomnia (NCT06511011) | Chinese University of Hong Kong | 2025-09-25 |
| QL1706 Plus XELOX as Neoadjuvant Therapy for MSS/pMMR Clinical Stage III Colon Cancer (NCT07156682) | Qilu Hospital of Shandong University | 2025-09-25 |
| Neoadjuvant Chemotherapy Combined With Sintilimab and Bevacizumab for TNBC (NEOTORCH-BREAST07) (NCT07351487) | First Affiliated Hospital of Zhejiang University | 2025-09-25 |
| TAS-102 Plus Radiotherapy in Elderly ESCC (NCT07196345) | Qianfoshan Hospital | 2025-09-25 |
| Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia (NCT06752694) | Fred Hutchinson Cancer Center | 2025-09-25 |
| Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS) (NCT06463743) | State University of New York at Buffalo | 2025-09-24 |
| Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy (NCT05953766) | Mount Sinai Hospital, Canada | 2025-09-24 |
| The Purpose of This Study is to Evaluate the Efficacy and Safety of 626 in the Treatment of SLE (NCT07185269) | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 2025-09-24 |
| Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma (NCT06161545) | National Cancer Institute (NCI) | 2025-09-24 |
| A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (NCT07123454) | AstraZeneca | 2025-09-24 |
| G-Pola-ZLP in Diffuse Large B-Cell Lymphoma (NCT06665217) | Navy General Hospital, Beijing | 2025-09-24 |
| A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer (NCT07102381) | Jazz Pharmaceuticals | 2025-09-24 |
| Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil (NCT07189208) | University of California, Los Angeles | 2025-09-24 |
| ZG006 and ZG005 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma (NCT07038096) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2025-09-23 |
| Patients With High-grade Pancreatic Neuroendocrine Tumors (NCT07121478) | National Cancer Center, Korea | 2025-09-23 |
| Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse (NCT06928662) | Fred Hutchinson Cancer Center | 2025-09-23 |
| Study of ZG005 in Combination With Gecacitinib in Participants With Advanced Cervical Cancer (NCT07080216) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2025-09-23 |
| Carbon Ion Radiotherapy in Frail Patients With Pancreatic Cancer (NCT07257523) | Yonsei University | 2025-09-23 |
| HCL001 Cell Injection for Decompensated Cirrhosis: A Phase I/II Trial (NCT07488546) | Shanghai Huicun Medical Technology Co., Ltd. | 2025-09-23 |
| Phase I/II Open Label Study Evaluating the Safety and Efficacy of Combining STAT3 Inhibition (TTI-101) With Anti-PD-1 Therapy (Pembrolizumab) in Patients With Recurrent or Metastatic (RM) Head and Neck Squamous Cell Carcinoma (HNSCC) (NCT05668949) | M.D. Anderson Cancer Center | 2025-09-23 |
| A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations (NCT07109726) | Terremoto Biosciences Inc. | 2025-09-23 |
| Pyrotinib Maleate Tablets in Combination With Dalpiciclib Isethionate Tablets and Standard Endocrine Therapy (NCT07189884) | The First Affiliated Hospital of Xiamen University | 2025-09-23 |
| A Pilot Study Testing the Safety and Feasibility of Restorative Microbiota Therapy (RMT) in Patients With Refractory Immune-checkpoint Inhibitor-related Colitis (NCT05726396) | University of Minnesota | 2025-09-23 |
| First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies (NCT07136779) | VelaVigo Bio Inc | 2025-09-23 |
| An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera (NCT07148999) | Urmila DIwekar | 2025-09-23 |
| Phase IIa Study of Flonoltinib Maleate Tablets in the Treatment of Patients With Polycythemia Vera (NCT07232290) | Chengdu Zenitar Biomedical Technology Co., Ltd | 2025-09-23 |
| A Study of Osimertinib-based Adaptive Treatment Guided by ctDNA EGFRm+ Monitoring in NSCLC (NCT07058519) | Shanghai Chest Hospital | 2025-09-23 |
| Clinical Study to Evaluate XS411 in Treatment of Early-onset Parkinson's Disease (NCT07166757) | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | 2025-09-22 |
| Study of Epcoritamab in R/R Primary Diffuse Large B-cell Lymphoma of the CNS Treated With Lenalidomide and Rituximab (NCT06931652) | The Lymphoma Academic Research Organisation | 2025-09-22 |
| A Study of YL242 in Subjects With Advanced Solid Tumors (NCT07197827) | MediLink Therapeutics (Suzhou) Co., Ltd. | 2025-09-22 |
| A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors (NCT07198321) | Genfleet Therapeutics (Shanghai) Inc. | 2025-09-22 |
| Sacituzumab Tirumotecan in Combination With Tagitanlimab in the Treatment of Aggressive Variant Prostate Cancer (AVPC) and Neuroendocrine Prostate Cancer (NEPC) (NCT07179783) | Tianjin Medical University Second Hospital | 2025-09-22 |
| Warrior CARE: Cannabis Behavioral Health (NCT06381180) | Wayne State University | 2025-09-22 |
| A Study of DZD8586 Combination in CLL/SLL (TAI-SHAN10) (NCT07154264) | Dizal Pharmaceuticals | 2025-09-22 |
| A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC) (NCT07111520) | BioNTech SE | 2025-09-22 |
| Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor (IMPROVE TRIAL) (NCT06919003) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-09-22 |
| Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke (NCT06781385) | Wake Forest University Health Sciences | 2025-09-22 |
| A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Glecirasib (NCT07164170) | Abbisko Therapeutics Co, Ltd | 2025-09-22 |
| Surufatinib Combined With Chemo Versus Surufatinib in the Treatment of Pulmonary Neuroendocrine Tumors (NCT07357623) | Shanghai Chest Hospital | 2025-09-22 |
| Safety and Impact of Baricitinib on Cell Surivival Pathways, HIV-1 Reservoir and Inflamation in People With HIV-1 (NCT07028385) | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 2025-09-22 |
| Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian (NCT07399626) | Babes-Bolyai University | 2025-09-22 |
| A Study on the Treatment of Androgenetic Alopecia in Young Men With Umbilical Cord Mesenchymal Stem Cell Exosomes (NCT07203599) | Shenzhen People's Hospital | 2025-09-20 |
| Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome (NCT07182526) | Al-Mustansiriyah University | 2025-09-20 |
| Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base (NCT07145931) | Sun Yat-sen University | 2025-09-20 |
| RK-4 Intracalvariosseous Injection in Treatment of Acute Large Hemispheric Infarction (NCT07166380) | Neurodawn Pharmaceutical Co., Ltd. | 2025-09-20 |
| Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap (NCT06915662) | Massachusetts General Hospital | 2025-09-20 |
| Bozitinib Combined With Chemotherapy as Radical Treatment for Stage IIA-IIIC MET-Altered Non-Small Cell Lung Cancer (NCT07153770) | Shanghai Pulmonary Hospital, Shanghai, China | 2025-09-20 |
| SC-101 in Subjects With Advanced NECTIN4-Amplified Cancers (NCT07080619) | Tianjin ConjuStar Biologics Co., Ltd. | 2025-09-20 |
| Immunotherapy Combined With Anti-angiogenic Therapy and Chemotherapy for Gastric/Gastroesophageal Junction Adenocarcinoma (NCT07148427) | The First Affiliated Hospital with Nanjing Medical University | 2025-09-20 |
| A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole (NCT07199504) | Yunfeng Xia | 2025-09-20 |
| QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer (NCT07175636) | Sun Yat-sen University | 2025-09-20 |
| A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC) (NCT06946797) | Bristol-Myers Squibb | 2025-09-19 |
| A Recovery and Lifespan Study Using INTERCEPT Red Blood Cells Prepared Using the INTERCEPT Blood System for RBCs With AS-1 (NCT07015437) | Cerus Corporation | 2025-09-19 |
| Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer (NCT07140679) | Emory University | 2025-09-19 |
| Study of 5-fluorouracil (5-FU) in Patients With Metastatic Colorectal Cancer (NCT06501989) | Inova Health Care Services | 2025-09-19 |
| A Study of AK130 in Combination With AK112 for the Treatment of Advanced Pancreatic Cancer (NCT07114315) | Akeso | 2025-09-19 |
| A Phase 2b Clinical Study of JDB0131 Benzenesulfonate Tablets (NCT07170800) | WestVac Biopharma Co., Ltd. | 2025-09-19 |
| An Open-label, Single Center, Single Participant Study of an Experimental Antisense Oligonucleotide Treatment for TUBB4A-related Leukodystrophy (NCT07222371) | University of California, San Diego | 2025-09-19 |
| Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer (NCT07161115) | Longhao Li | 2025-09-19 |
| Study of Naxitamab and Sacituzumab Govitecan in Patients With Metastatic Triple-negative Breast Cancer (TNBC) (NCT07011654) | M.D. Anderson Cancer Center | 2025-09-19 |
| Orelabrutinib Plus Low-Dose Radiotherapy Or Rituximab For Ocular Adnexal MALT Lymphoma (NCT07247383) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-09-19 |
| Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN) (NCT07157787) | Alexion Pharmaceuticals, Inc. | 2025-09-19 |
| A Study of MHB088C Combined With MHB039A in Patients With Advanced Malignant Solid Tumors (NCT07126665) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-09-18 |
| Dasatinib and Quercetin With CAR-T Therapy for the Treatment of Patients With Relapsed or Refractory Multiple Myeloma (NCT06940297) | Mayo Clinic | 2025-09-18 |
| Contrast-enhanced Ultrasound for Sentinel Node Detection (NCT07310758) | The Netherlands Cancer Institute | 2025-09-18 |
| A Phase 2 Trial of Fruquintinib and Tislelizumab in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant Chemotherapy (NCT07136077) | M.D. Anderson Cancer Center | 2025-09-18 |
| Cemiplimab as Maintenance Treatment for Advanced Adrenocortical Cancer (NCT07085572) | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 2025-09-18 |
| Perioperative Therapy for HER2-negative Hepatoid Adenocarcinoma of Stomach (NCT07178340) | Peking University Cancer Hospital & Institute | 2025-09-18 |
| A Single-arm Phase 2 Prospective Clinical Study of Enatumab in the Treatment of Relapsed/Refractory Warm Antibody Autoimmune Hemolytic Anemia (NCT07190261) | Bing Han | 2025-09-18 |
| Ivonescimab Plus Chemotherapy in Patients With Initially Unresectable Colorectal Cancer Liver Metastases (NCT06848842) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-09-18 |
| High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater) (NCT07192458) | Vanderbilt University Medical Center | 2025-09-17 |
| A Phase I/II Study of LM-2417 in Subjects With Advanced Solid Tumours (NCT06682780) | LaNova Medicines Limited | 2025-09-17 |
| A Study of Surgery and Radiotherapy in People With Breast Cancer (NCT07053085) | Memorial Sloan Kettering Cancer Center | 2025-09-17 |
| JS207 Combination Therapy in Triple-negative Breast Cancer (NCT07045311) | Shanghai Junshi Bioscience Co., Ltd. | 2025-09-17 |
| Systemic Chemotherapy With FOLFOX Plus Atezolizumab & Bevacizumab for Patients With Advanced HCC Who Previously Received Atezolizumab & Bevacizumab (NCT07192185) | Sun Yat-sen University | 2025-09-17 |
| Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis (NCT07023835) | Zydus Therapeutics Inc. | 2025-09-17 |
| Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder (NCT06847399) | Johns Hopkins University | 2025-09-17 |
| Proof of Concept Study on BP1.4979 Effect on Essential Tremor (NCT07074002) | Bioprojet | 2025-09-17 |
| Repurposing Tilmanocept for Cardiac Sarcoidosis (NCT07159074) | Duke University | 2025-09-17 |
| A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CONTROLLED STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 µG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF SJÖGREN'S RELATED DRY EYE DISEASE (NCT07118241) | Lubris Bio Pty Ltd | 2025-09-17 |
| A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CROSSOVER STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 μG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE (OGVHD) (NCT07118254) | Lubris Bio Pty Ltd | 2025-09-17 |
| The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA. (NCT07535554) | Universitaire Ziekenhuizen KU Leuven | 2025-09-17 |
| Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease (NCT06489548) | Brigham and Women's Hospital | 2025-09-16 |
| A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA (NCT07140523) | Sirius Therapeutics Co., Ltd. | 2025-09-16 |
| Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19 (NCT07157007) | Traws Pharma, Inc. | 2025-09-16 |
| Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow (NCT07281781) | University of California, Irvine | 2025-09-16 |
| Adding Urea to the Final Dialysis Fluid (NCT06366230) | University of California, San Francisco | 2025-09-16 |
| Alternating Regimen of VA and Low-dose CHA in the Treatment of Unfit Newly Diagnosed AML (NCT07172204) | First Affiliated Hospital of Zhejiang University | 2025-09-16 |
| Cisplatin-Based Chemotherapy Followed by Maintenance Avelumab in UTUC (NCT07225374) | Samsung Medical Center | 2025-09-16 |
| ERd Combination Treatment in Newly Diagnosed Multiple Myeloma (NCT06997081) | University of Miami | 2025-09-16 |