| A Study to Evaluate the Immune Response and Safety of an Influenza Vaccine in Adults 18 Years of Age and Above (NCT07204964) | GlaxoSmithKline | 2025-10-07 |
| Early Screening and Treatment of Heart Complication in Sickle Cell Disease (NCT07023666) | Inova Health Care Services | 2025-10-07 |
| Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer (NCT07065630) | University of Chicago | 2025-10-07 |
| Wellcome Leap Psilocybin for OUD (NCT06786325) | Anna Rose Childress, Ph.D. | 2025-10-07 |
| Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma (NCT06649812) | National Cancer Institute (NCI) | 2025-10-07 |
| A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer (NCT07100106) | Genentech, Inc. | 2025-10-07 |
| A Study of CTD402 in T-ALL/LBL Patients (NCT07070219) | Imviva Bio | 2025-10-07 |
| A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma (NCT06988488) | Celgene | 2025-10-07 |
| Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma (NCT07205731) | University Hospital, Clermont-Ferrand | 2025-10-07 |
| Tirzepatide for Alcohol Use Disorder (NCT06994338) | University of Southern California | 2025-10-06 |
| A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy (NCT07023614) | Imbria Pharmaceuticals, Inc. | 2025-10-06 |
| Deployment and Evaluation of Humanoid Robotics in Coalition-Aligned Clinical Care Settings (NCT07214896) | Truway Health, Inc. | 2025-10-06 |
| A Short-term Preoperative, Evaluating Activity and Safety of Elacestrant Monotherapy as Compared to Elacestrant + Ovarian Function Suppression (LHRH Agonist) in Premenopausal Patients With Stage I-II ER+/HER2- Breast Cancer (NCT07159451) | Gustave Roussy, Cancer Campus, Grand Paris | 2025-10-06 |
| A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease (NCT07132983) | Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA | 2025-10-06 |
| A Study Testing an Improved Dose of UM171 to Help Make Cord Blood Transplants More Effective and Safe. (NCT07301866) | Ciusss de L'Est de l'Île de Montréal | 2025-10-06 |
| A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS) (NCT07161258) | Hoffmann-La Roche | 2025-10-06 |
| Placebo-Controlled Study of Terpenes-Enriched Cannabis Oil T1/C28 for Children With Autism (NCT07199218) | Bazelet Nehushtan LtD. | 2025-10-05 |
| Safety, Tolerability and Efficacy of Adjunctive TBO-309 in Reperfusion for Stroke With Tandem Occlusion (NCT06813651) | ThromBio Pty. Ltd. | 2025-10-04 |
| Pemigatinib in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas (NCT06300528) | University of Utah | 2025-10-03 |
| The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes (NCT06976619) | Mayo Clinic | 2025-10-03 |
| Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors (NCT06731894) | City of Hope Medical Center | 2025-10-03 |
| A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease (NCT07196722) | Janssen Research & Development, LLC | 2025-10-03 |
| Guanfacine for Alcohol Use Disorder (AUD) (NCT06629259) | Indiana University | 2025-10-03 |
| Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis (NCT06441006) | University of California, San Francisco | 2025-10-03 |
| A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel (NCT07149857) | Janssen Research & Development, LLC | 2025-10-03 |
| A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue (NCT06989437) | Pfizer | 2025-10-03 |
| Eptacog Beta in Glanzmann's (HeT_LFB-Strength-Study_FID531) (NCT07136857) | Emory University | 2025-10-02 |
| BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001) (NCT07193511) | Avenzo Therapeutics, Inc. | 2025-10-02 |
| Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia (NCT07033481) | EIP Pharma Inc | 2025-10-02 |
| COMPASS - COpenhagen MenoPAuSe Study (NCT07254429) | Martin Blomberg Jensen | 2025-10-02 |
| CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients (NCT07096453) | University of Minnesota | 2025-10-02 |
| Phase II Decentralized Pragmatic Trial of Adjuvant Doxorubicin - Trabectedin Chemotherapy in uLMS (NCT07076186) | M.D. Anderson Cancer Center | 2025-10-02 |
| Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) (NCT07220629) | NodThera Limited | 2025-10-02 |
| Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy (NCT07076914) | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2025-10-02 |
| Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer (NCT06525766) | Mayo Clinic | 2025-10-01 |
| Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL (NCT07185373) | Huashan Hospital | 2025-10-01 |
| Effectiveness of Ashwagandha in Schizophrenia Patients on Risperidone (NCT07575516) | Hasanuddin University | 2025-10-01 |
| A Study Evaluating Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade for Limited-stage Small Cell Lung Cancer (NCT07103408) | Sun Yat-sen University | 2025-10-01 |
| Study of Gecacitinib in the Treatment of Acute Graft-Versus-Host Disease After Failure of Ruxolitinib-containing Second-line Therapy (NCT07197112) | Ruijin Hospital | 2025-10-01 |
| HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies (NCT05751044) | Princess Maxima Center for Pediatric Oncology | 2025-10-01 |
| High-Dose Firmonertinib Plus Bevacizumab as Neoadjuvant Therapy for Resectable EGFRm Stage II-IIIB NSCLC (NCT07182708) | Peking University Cancer Hospital & Institute | 2025-10-01 |
| Anlotinib Hydrochloride Capsules in Maintenance Treatment for Intermediate-High Risk Rhabdomyosarcoma in Children (NCT07137884) | Sun Yat-sen University | 2025-10-01 |
| Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) (NCT06887777) | Assistance Publique - Hôpitaux de Paris | 2025-10-01 |
| Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia (NCT07298824) | Second Affiliated Hospital of Nanchang University | 2025-10-01 |
| Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy (NCT07214415) | Summit Hyperbarics and Wellness | 2025-10-01 |
| Propolis-Based Solution Application in Extraction Socket Healing (NCT07665814) | Saint-Joseph University | 2025-10-01 |
| A Clinical Study of BT02 in Patients With Relapsed or Refractory Hematologic Malignancies (NCT07107204) | Biotroy Therapeutics | 2025-10-01 |
| Intraoperative Lidocaine Infusion (NCT07150481) | Assiut University | 2025-10-01 |
| Investigator Initiated Study for the Safety and Efficacy in Frontotemporal Dementia (NCT07154485) | Hee-Jin Kim | 2025-10-01 |
| Efficacy and Safety of Xinglou Chengqi Granule for Acute Ischemic Stroke (NCT07163702) | Dongzhimen Hospital, Beijing | 2025-10-01 |
| Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study) (NCT07125664) | Fondazione IRCCS Policlinico San Matteo di Pavia | 2025-10-01 |
| Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study (NCT06496854) | University of Wisconsin, Madison | 2025-10-01 |
| Tislelizumab Combined With Chemotherapy for Different Cycles of Neoadjuvant Therapy for Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck (NeoTempo) (NCT07147426) | Tianjin Medical University Cancer Institute and Hospital | 2025-10-01 |
| Clinical Trial of Umbilical Cord Mesenchymal Stem Cells in Subacute Ischemic Stroke (NCT07197606) | Shanghai IxCell Biotechnology Co., LTD | 2025-10-01 |
| To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia (NCT07172100) | Ziauddin Hospital | 2025-10-01 |
| A Randomized Controlled Trial on the Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy in Subjects With Moderate to Severe Diabetic Peripheral Neuropathy (NCT07183761) | Min Long | 2025-10-01 |
| Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study (NCT07163611) | Radboud University Medical Center | 2025-10-01 |
| Study of LW231 in Participants With Chronic Hepatitis B (NCT07179575) | Shanghai Longwood Biopharmaceuticals Co., Ltd. | 2025-10-01 |
| A Pilot Trial of Preoperative Irradiation With the STRIDE (Single Dose of Tremelimumab With Ongoing Durvalumab) Regimen (PRISM) for Resectable/Advanced Hepatocellular Carcinoma (NCT06994299) | Weill Medical College of Cornell University | 2025-10-01 |
| An Open-label, Single-arm Clinical Study of Stapokibart Injection in Combination with Tislelizumab Injection in Patients with Non-Small Cell Lung Cancer (NCT06883552) | Sichuan University | 2025-10-01 |
| A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity (NCT07184632) | Novo Nordisk A/S | 2025-10-01 |
| Losartan to Improve Outcomes After Multi-ligament Knee Injury (NCT06933706) | Brigham and Women's Hospital | 2025-10-01 |
| Role of Estrogen on Skeletal Outcomes in FHA (NCT07010146) | University of Virginia | 2025-10-01 |
| A Randomized Study on Pemphigus Treatment With Humanized CD38 Antibody CM313. (NCT06663943) | Chao Ji | 2025-10-01 |
| Sacituzumab Tirumotecan (Sac-TMT) Plus Bevacizumab in 3rd Generation EGFR-TKI Treated Advanced EGFR-mutant Nonsquamous NSCLC With Brain Metastasis (NCT07197008) | Li-kun Chen | 2025-10-01 |
| QL1706 in Patients With Recurrent and Metastatic Cervical Cancer Resistant to Prior PD-1/PD-L1 Antibody Therapy (NCT07141186) | Tianjin Medical University Cancer Institute and Hospital | 2025-10-01 |
| Sintilimab in Combination With Surufatinib and Temozolomide in the Advanced Neuroendocrine Carcinoma (NCT07156019) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-10-01 |
| HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies (NCT05745714) | Princess Maxima Center for Pediatric Oncology | 2025-10-01 |
| A Prospective, Single-arm, Multicenter Exploratory Clinical Study of Anlotinib Combined With Bempegaldesleukin and Conventional Chemoradiotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Soft Tissue Sarcoma. (NCT07156643) | The First Affiliated Hospital with Nanjing Medical University | 2025-10-01 |
| Phase I/II Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of GC310 Injection in Patients With Wilson's Disease (WD) (NCT07173933) | GeneCradle Inc | 2025-10-01 |
| Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer (NCT07181161) | AstraZeneca | 2025-10-01 |
| A Clinical Trial of MT200605 for the Treatment of Acute Ischemic Stroke (NCT07205328) | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 2025-10-01 |
| Effect of RECK in Posterior Spinal Fusion (NCT06447194) | University of Maryland, Baltimore | 2025-10-01 |
| PSMA Therapy and Immunotherapy in Kidney Cancer (NCT06361810) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2025-10-01 |
| Luspatercept for the Treatment of Anemia Following Allogeneic Hematopoietic Stem Cell Transplantation(Allo-HSCT) (NCT07362095) | Zhujiang Hospital | 2025-10-01 |
| Safety and Efficacy of CBP-0276 to Improve Severity and Quality of Life on Moderate to Severe Psoriasis in Subjects (NCT07204639) | Clarent Biopharma, Inc. | 2025-10-01 |
| IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers (NCT06790706) | Hospices Civils de Lyon | 2025-10-01 |
| Tranexamic Acid Therapy For The Treatment of Subdural Hematomas (NCT06718751) | Baylor College of Medicine | 2025-10-01 |
| The Efficacy and Safety RC48 Plus QL1706 in Second-Line Treatment of HER2-Expressing Recurrent CC (NCT07172217) | Qilu Hospital of Shandong University | 2025-10-01 |
| Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder (NCT07072728) | Psyence Australia Pty Ltd | 2025-10-01 |
| Simultaneous Boost in Neoadjuvant Radiotherapy for Rectal Cancer (NCT07200141) | Peking Union Medical College Hospital | 2025-10-01 |
| A Probiotic Based Intervention in Pregnancies Complicated by GDM (NCT06794723) | Queen's University | 2025-10-01 |
| FHND1002 for ALS Treatment: Phase 2 (NCT07138014) | Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. | 2025-10-01 |
| An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye (NCT07179055) | Vanda Pharmaceuticals | 2025-10-01 |
| Efficacy of Gemcitabine Submucosal Injection for Preventing Recurrence in Intermediate- and High-Risk Non-Muscle-Invasive Bladder Cancer: A Randomized Trial (NCT07198451) | Shanghai University of Traditional Chinese Medicine | 2025-10-01 |
| Repurposing Empagliflozin for DMD-associated Cardiomyopathy in Children 6-18 Years of Age (NCT06643442) | Sebastiano Lava | 2025-10-01 |
| Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression (NCT06866236) | Ebima Clifford Okundaye | 2025-10-01 |
| Clinical Study of mTOR Inhibitor as a Treatment for Grey Hair (Canities) (NCT07166354) | Applied Biology, Inc. | 2025-10-01 |
| Study of Gecacitinib-corticosteroid as First-line Therapy for Grade II-IV Acute Graft Versus Host Disease (NCT07185633) | Bin Gu | 2025-10-01 |
| SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety (NCT07174947) | First Affiliated Hospital of Wenzhou Medical University | 2025-10-01 |
| Stereotactic Body Radiotherapy and NALIRIFOX for Locally Advanced Pancreatic Cancer (NCT07173387) | Shandong Cancer Hospital and Institute | 2025-10-01 |
| Serplulimab Combined With Cryoablation for Early-Stage Non-Small Cell Lung Cancer (NCT07064876) | Xi Junjie | 2025-10-01 |
| A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (NCT06520098) | VA Office of Research and Development | 2025-10-01 |
| Treatment of Orelabrutinib+Hi-CVP Regimen for Previously Untreated MZL (NCT07480863) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2025-10-01 |
| Ribociclib for HR-positive HER2-negative Metastatic Breast Cancer (NCT07164976) | Nagoya City University | 2025-10-01 |
| Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor (NCT07078357) | University of Sao Paulo General Hospital | 2025-10-01 |
| INTERACT Stomach-II (NCT07133490) | Erasmus Medical Center | 2025-10-01 |
| Total Neoadjuvant Therapy With PD-1 for Locally Advcancer Rectal Cancer (NCT07214142) | The First Affiliated Hospital of University of Science and Technology of China | 2025-10-01 |
| Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer (NCT07134218) | Changhai Hospital | 2025-10-01 |
| Chemotherapy Combined With Targeted Therapy as First-line Treatment for Mantle Cell Lymphoma Based on MRD and PET-CT Assessment (NCT07206264) | Tianjin Medical University Cancer Institute and Hospital | 2025-10-01 |