| A Study of HRS-5632 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events (NCT07185776) | Fujian Shengdi Pharmaceutical Co., Ltd. | 2025-10-21 |
| A Study to Evaluate the Immunogenicity and Safety of a Recombinant Respiratory Syncytial Virus Vaccine in Older Adults Aged 60 Years and Older (NCT07208461) | Guangzhou Patronus Biotech Co., Ltd. | 2025-10-21 |
| A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses (NCT06810934) | Kara Chew | 2025-10-21 |
| A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation (NCT07259590) | Genfleet Therapeutics (Shanghai) Inc. | 2025-10-21 |
| Prophylactic Intravenous Calcium Gluconate to Decrease Blood Loss at Time of Cesarean Delivery in Pregnant Patients at High Risk for Uterine Atony (NCT07217899) | University of Michigan | 2025-10-20 |
| A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP) (NCT07194850) | argenx | 2025-10-20 |
| Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study (NCT07334379) | Lorenzo delSorbo | 2025-10-20 |
| Vaginal Detection of Orally Delivered Probiotic Strains in Healthy Women (NCT07246161) | Lallemand Health Solutions | 2025-10-20 |
| An Open-label, Single-arm, Multicenter Exploratory Study of Adebrelimab Combined With Gemcitabine and Albumin-bound Paclitaxel as First-line Treatment for Biliary Tract Malignancies (NCT07668453) | The First Affiliated Hospital with Nanjing Medical University | 2025-10-20 |
| Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women (NCT07191353) | Odense University Hospital | 2025-10-20 |
| Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer. (NCT07407465) | Gruppo Oncologico del Nord-Ovest | 2025-10-20 |
| Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation (NCT07175428) | Regeneron Pharmaceuticals | 2025-10-20 |
| The Efficacy of Sequential Treatment With Bevacizumab Combined With Atezolizumab in Advanced Liver Cancer With MASLD (NCT07285850) | Eastern Hepatobiliary Surgery Hospital | 2025-10-20 |
| A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours[Substudy 02(BTC&HCC)] (NCT07111546) | Nanjing Leads Biolabs Co.,Ltd | 2025-10-20 |
| Proof of Concept Study to Assess the Pharmacokinetics/Pharmacodynamics of Nemolizumab in Adults With Chronic Pruritus of Unknown Origin (CPUO) (NCT07074977) | Galderma R&D | 2025-10-20 |
| NeoCARD: Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer Patients (NCT06845319) | Medical University of South Carolina | 2025-10-20 |
| A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors (NCT07213609) | GlaxoSmithKline | 2025-10-20 |
| Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Tislelizumab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement (NCT07104604) | Affiliated Cancer Hospital of Shantou University Medical College | 2025-10-20 |
| Evaluation of Different Types of HER2 Expression in Breast Cancer Using [99mTc]Tc -ZHER2:4107 (NCT07292571) | Tomsk National Research Medical Center of the Russian Academy of Sciences | 2025-10-20 |
| A Phase II Clinical Study to Evaluate the Efficacy and Safety of NS-136 in the Treatment of Schizophrenia (NCT07521683) | NeuShen Therapeutics | 2025-10-20 |
| A Dose-finding Study of JMKX003142 in Treatment of Renal Edema (NCT06670534) | Jemincare | 2025-10-17 |
| Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML (NCT06611839) | Institute of Hematology & Blood Diseases Hospital, China | 2025-10-17 |
| A Study to Determine the Optimal Dose and Frequency of ALDP001 Nasal Spray in Adults With Seasonal Allergic Rhinitis Under Allergen Exposure (NCT07219849) | Alixer Nexgen Therapeutics Limited | 2025-10-17 |
| A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC (NCT07206498) | Wayshine Biopharm, Inc. | 2025-10-17 |
| Iparomlimab and Tuvonralimab Combined With Nimotuzumab in Recurrent or Metastatic NPC After First-line Treatment Failure: A Single-arm Phase IIa Clinical Trial (NCT07101744) | Sun Yat-sen University | 2025-10-17 |
| Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients (NCT07071038) | Dartmouth-Hitchcock Medical Center | 2025-10-17 |
| A Phase 2 Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HRS-7085 Tablets in Patients With Inflammatory Bowel Disease (NCT07229950) | Shandong Suncadia Medicine Co., Ltd. | 2025-10-17 |
| The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road (NCT07182500) | Universiti Sains Malaysia | 2025-10-16 |
| A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes (NCT07215559) | Eli Lilly and Company | 2025-10-16 |
| Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories (NCT07041281) | Massachusetts General Hospital | 2025-10-16 |
| Mozobil for Autologous Hematopoietic Stem Cell Transplantation (NCT07188090) | Thomas Jefferson University | 2025-10-16 |
| Evaluating the Safety and Preliminary Efficacy of EXG202 Gene Therapy for Neovascular AMD (NCT07178249) | Guangzhou Jiayin Biotech Ltd | 2025-10-16 |
| STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer (NCT07213570) | National Cancer Institute, Naples | 2025-10-16 |
| Iparomlimab and Tuvonralimab Combined With GC in Advanced ICC (NCT07152769) | Fudan University | 2025-10-15 |
| A Study of IMM2510 + IMM01 Combination Therapy in Patients With Advanced Solid Tumors (NCT07170787) | ImmuneOnco Biopharmaceuticals (Shanghai) Inc. | 2025-10-15 |
| A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis (NCT07260669) | Gesynta Pharma AB | 2025-10-15 |
| One-Year Study of S1B-509 vs Placebo for Weight Loss (NCT06517797) | S1 Biopharma, Inc. | 2025-10-15 |
| The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series (NCT06048263) | Washington University School of Medicine | 2025-10-15 |
| AssociatiNG Bevacizumab bEmarituzumab for GynecoLogIcal CAncer (NCT07146919) | Centre Leon Berard | 2025-10-15 |
| Fruquintinib Combined With Standard Chemotherapy Versus Standard Chemotherapy as First-line Treatment for Advanced pMMR Endometrial Cancer (NCT07170982) | Sun Yat-sen University | 2025-10-15 |
| ResQ133A-NMIBC: Intravesical Recombinant Mycobacterium (rMBCG) in Participants With NMIBC Eligible to Receive Intravesical Tice BCG (NCT06800963) | ImmunityBio, Inc. | 2025-10-15 |
| Immunogenicity and Safety of Meningococcal Conjugate Vaccine (EG-MCV4) in Healthy Adults Aged 19 to 55 Years Old (NCT07204457) | EyeGene Inc. | 2025-10-15 |
| Study on the Safety and Efficacy of PA9159 Inhalation Aerosol for the Treatment of Adult Bronchial Asthma (NCT07324707) | Anhui Palo Alto Pharmaceuticals, Inc. | 2025-10-15 |
| Biotin-Acridine Red Cell Exchange Kinetics (NCT07155031) | Cerus Corporation | 2025-10-15 |
| Tebentafusp-tebn With LDT in Metastatic UM (NCT06626516) | Thomas Jefferson University | 2025-10-15 |
| Phase II Study of Resistant Potato Starch Plus Deferasirox to Improve Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation (NCT06784336) | University of Michigan Rogel Cancer Center | 2025-10-15 |
| A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors (NCT07160725) | Bristol-Myers Squibb | 2025-10-15 |
| An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01) (NCT07206056) | Novartis Pharmaceuticals | 2025-10-15 |
| Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC (NCT07447570) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-10-15 |
| A Prospective, Single-Arm, Single-Center Phase II Study Evaluating the Efficacy and Safety of Chidamide Combined With PD-L1 Inhibitor, Carboplatin, and Etoposide as First-Line Treatment in Patients With Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) (NCT07373964) | China Medical University, China | 2025-10-15 |
| A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201) (NCT07221500) | Nurix Therapeutics, Inc. | 2025-10-15 |
| TTFields and Chemotherapy in Metastatic Pancreatic Adenocarcinoma (mPDAC) (NCT07284277) | Clinica Universidad de Navarra, Universidad de Navarra | 2025-10-14 |
| Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects With MCI or Alzheimer's Disease (AD) (NCT07741526) | Arctic Therapeutics | 2025-10-14 |
| Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure (NCT07131475) | Massachusetts General Hospital | 2025-10-14 |
| Lenvatinib 24 mg/Day Versus 10 mg/Day to Treat Symptomatic or Progressive Radioactive Iodine Resistant (RAIR) Differentiated Thyroid Cancer (DTC) (NCT07092514) | Washington University School of Medicine | 2025-10-14 |
| A Study to Investigate the Efficacy and Safety of SAR444336 in Adults With Microscopic Colitis in Clinical Remission (NCT07156175) | Sanofi | 2025-10-14 |
| A Trial of Varenicline for E-cigarette Cessation (NCT07040566) | Yale University | 2025-10-14 |
| A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer (NCT07174583) | IDEAYA Biosciences | 2025-10-14 |
| Daridorexant to Prevent Post-cardiotomy Delirium (NCT07217912) | University of Rochester | 2025-10-14 |
| Efficacy and Safety of QD202 in Participants With Acute Ischemic Stroke Undergoing Thrombolysis Excluding Endovascular Thrombectomy (NCT07581210) | Shanghai QuietD Biotechnology Co., Ltd. | 2025-10-14 |
| Daridorexant for Alzheimer Disease Prevention (NCT07213349) | Douglas Mental Health University Institute | 2025-10-14 |
| To Evaluate the Safety and Efficacy of RNK08954 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma. (NCT07303465) | Ranok Therapeutics (Hangzhou) Co., Ltd. | 2025-10-14 |
| Clinical Trial Comparing Induction Treatment With EGFR-ADC MRG003 Alone or in Combination With the Anti PD1 Pucotenlimab, Followed by Radiochemotherapy in Locally Advanced Squamous Cell Cancers of the Head and Neck (NCT06959108) | Groupe Oncologie Radiotherapie Tete et Cou | 2025-10-13 |
| NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals (NCT06971224) | Haukeland University Hospital | 2025-10-13 |
| Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL) (NCT06796998) | Izidore Lossos, MD | 2025-10-13 |
| Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of RESP30TB in Tuberculosis (NCT07073638) | Thirty Respiratory Limited | 2025-10-13 |
| Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (NCT06817720) | M.D. Anderson Cancer Center | 2025-10-13 |
| Mirdametinib in Patients With Advanced NF1-mutant Melanoma (NCT07237100) | Kevin Kim, MD | 2025-10-13 |
| A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS) (NCT07157254) | Ultragenyx Pharmaceutical Inc | 2025-10-13 |
| Herombopag Treated T-DM1 Induced Platelet Reduction (NCT07257809) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2025-10-13 |
| A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin (NCT07215312) | Eli Lilly and Company | 2025-10-13 |
| A Phase II Trial of SHR-A1811 in HER2-Expressing Recurrent/Metastatic Cervical Cancer (NCT07051486) | Jiangsu HengRui Medicine Co., Ltd. | 2025-10-11 |
| A Trial to Evaluate the Efficacy, Safety, PK, and PD of HP515 in Non - Alcoholic Fatty Liver Disease ( NASH/MASH ) (NCT07308548) | Hinova Pharmaceuticals Inc. | 2025-10-11 |
| A Study of PRL3-zumab in Neovascular Age-related Macular Degeneration (nAMD) (NCT07547228) | Intra-IMMUSG Pte Ltd | 2025-10-11 |
| Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA (NCT07070466) | Massachusetts General Hospital | 2025-10-10 |
| Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma (NCT06918431) | City of Hope Medical Center | 2025-10-10 |
| A Phase II Exploratory Study of Iparomlimab and Tuvonralimab Combined With Chemotherapy in Neoadjuvant Treatment of HR+/HER2- Breast Cancer Patients (NCT07197697) | Anhui Provincial Cancer Hospital | 2025-10-10 |
| Induction High-Low Dose Radiotherapy Plus Anti-PD-1 Followed by Definitive Radiotherapy in Recurrent Nasopharyngeal Carcinoma (Single-Arm Phase II) (NCT07277764) | Jiangxi Provincial Cancer Hospital | 2025-10-10 |
| Combination Therapy of Senaparib and Bevacizumab for First-line Maintenance Therapy in Newly Diagnosed Advanced Homologous Recombination Proficient Ovarian Cancer Based on Exosome Protein Marker (NCT07120451) | Fudan University | 2025-10-10 |
| AG Followed by FOLFIRINOX Both Combined With PD-L1 Antibodies as a Conversion Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer. (NCT07208539) | Shanghai Zhongshan Hospital | 2025-10-10 |
| A Multicenter, Randomized, Double-blind, Placebo-controlled Trial on the Treatment of Hypertensive Intracerebral Hemorrhage With Naoxuekang Dropping Pills (NCT07200921) | Beijing Tiantan Hospital | 2025-10-10 |
| Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer (NCT07218601) | Memorial Sloan Kettering Cancer Center | 2025-10-10 |
| Tislelizumab Combined With Chemotherapy Followed by Thoracic Consolidation Radiotherapy in the First-line Treatment of Extensive Stage Small Cell Lung Cancer (NCT07425795) | Chongqing University Cancer Hospital | 2025-10-10 |
| Prospective Clinical Trial of Crisugabalin Capsules in the Treatment of Generalized Anxiety Disorder (NCT07330648) | Anhui Medical University | 2025-10-10 |
| Nano-crystalline Megestrol Acetate for Anorexia-Cachexia Syndrome in Advanced Lung Cancer (NCT07092137) | Guangzhou Institute of Respiratory Disease | 2025-10-10 |
| Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization (NCT07323329) | Beni-Suef University | 2025-10-10 |
| Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial (NCT07407920) | M.D. Anderson Cancer Center | 2025-10-09 |
| A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration (NCT07215234) | Sanofi | 2025-10-09 |
| Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma (NCT06517017) | University of Utah | 2025-10-09 |
| An Investigational Scan (Flotufolastat F 18 PET/CT) for Detecting Residual or Recurrent Disease in Patients Who Completed Focal Therapy for Prostate Cancer. (NCT07185165) | Jonsson Comprehensive Cancer Center | 2025-10-09 |
| Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer (NCT07068763) | Sir Run Run Shaw Hospital | 2025-10-09 |
| Phase II Clinical Study of SHR2554 Tablets Combined With Other Anti-tumor Treatments in Non-small Cell Lung Cancer Subjects (NCT07175220) | Jiangsu HengRui Medicine Co., Ltd. | 2025-10-09 |
| EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS) (NCT06997588) | Novartis Pharmaceuticals | 2025-10-09 |
| Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients (NCT06529718) | UNICANCER | 2025-10-09 |
| Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma (NCT07213934) | University of Cincinnati | 2025-10-08 |
| HEARTS Trial for Thoracic Cancers (NCT07132918) | University of Wisconsin, Madison | 2025-10-08 |
| A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014) (NCT07176390) | Merck Sharp & Dohme LLC | 2025-10-08 |
| Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ) (NCT07210112) | Centre Hospitalier St Anne | 2025-10-08 |
| Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors (NCT07001241) | University of Colorado, Denver | 2025-10-08 |
| Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC (NCT07246863) | CatalYm GmbH | 2025-10-07 |