| Intraperitoneal Injection of Liposomal Irinotecan as Monotherapy or in Combination With Recombinant Mutant Human Tumor Necrosis Factor or Bevacizumab for the Treatment of Malignant Ascites Following Failure of Prior Standard Therapy (NCT07397819) | Dong sheng Zhang | 2025-11-28 |
| Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab (NCT06816927) | Duke University | 2025-11-28 |
| HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial (NCT06719947) | Universidade Federal do Rio Grande do Norte | 2025-11-28 |
| A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib (NCT07362940) | Henan Genuine Biotech Co., Ltd. | 2025-11-27 |
| A Study of Dostarlimab in Combination With Carboplatin-paclitaxel in Chinese Participants With Primary Advanced or Recurrent Endometrial Cancer (EC) (NCT07108270) | GlaxoSmithKline | 2025-11-27 |
| Study of the Efficacy and Safety of ICP-332 in Participants With Prurigo Nodularis (NCT07236099) | Beijing InnoCare Pharma Tech Co., Ltd. | 2025-11-27 |
| A Study of MHB042C in Patients With Advanced Solid Tumors (NCT07192107) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-11-27 |
| Study of CM512 Injection in Subjects With Chronic Spontaneous Urticaria(CSU) (NCT07166211) | Keymed Biosciences Co.Ltd | 2025-11-27 |
| Dupilumab Therapy in Nephrotic Syndrome in Children (NCT07091175) | National University Hospital, Singapore | 2025-11-27 |
| A Study of Rocbrutinib in Participants With Relapse or Refractory Non-GCB Diffuse Large B-Cell Lymphoma (NCT07189065) | Guangzhou Lupeng Pharmaceutical Company LTD. | 2025-11-27 |
| Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R) (NCT07210086) | City of Hope Medical Center | 2025-11-26 |
| Consolidative Local Therapy (CLT) in Oligo-metastatic Urothelial Carcinoma (NCT07048457) | Yale University | 2025-11-26 |
| A Phase II Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of SR604 Injection in Patients With Von Willebrand Disease (NCT07640893) | Shanghai RAAS Blood Products Co., Ltd. | 2025-11-26 |
| A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors (NCT07129252) | Crinetics Pharmaceuticals Inc. | 2025-11-26 |
| Toripalimab Combined With Anthracycline-free or Anthracycline-containing Chemotherapy as Neoadjuvant Chemotherapy for Early Triple Negative Breast Cancer (NCT07256964) | Henan Cancer Hospital | 2025-11-26 |
| Safety and Efficacy of Tarperprumig in Adult Participants With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (NCT07160608) | Alexion Pharmaceuticals, Inc. | 2025-11-26 |
| Study of Healthy Aging and Physical Function With Elamipretide (NCT07275424) | David Marcinek | 2025-11-26 |
| Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus (NCT04370795) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-11-26 |
| Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial (NCT07279077) | Sixth Affiliated Hospital, Sun Yat-sen University | 2025-11-26 |
| PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS (NCT07142291) | PhenoNet, Inc. | 2025-11-25 |
| Targeted Induction Therapy for Stage III Unresectable EGFR Mutant Positive NSCLC (NCT07742332) | Peng Zhang | 2025-11-25 |
| Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer (NCT07199764) | University of Pennsylvania | 2025-11-25 |
| Clinical Trial of PCV24 in Infants and Children Aged 2 Months to 5 Years (NCT07300644) | Sinovac Life Sciences Co., Ltd. | 2025-11-25 |
| The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder (NCT07239778) | Oslo University Hospital | 2025-11-25 |
| SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes (NCT07187531) | SAb Biotherapeutics, Inc. | 2025-11-25 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) (NCT07414212) | Biogipuzkoa Health Research Institute | 2025-11-25 |
| Momelotinib in VEXAS Syndrome (NCT07098936) | Groupe Francophone des Myelodysplasies | 2025-11-25 |
| A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer (NCT07155174) | AbbVie | 2025-11-25 |
| Nephron-sparing Treatment of Tislelizumab + Nab-Paclitaxel for Renal Pelvic Cancer (NCT07233252) | Tianjin Medical University Second Hospital | 2025-11-25 |
| A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies (NCT07223047) | Bristol-Myers Squibb | 2025-11-25 |
| A Phase II Study To Evaluate the Efficacy And Safety Of HRS-1301 In Participants With Dyslipidemia (NCT07229937) | Shandong Suncadia Medicine Co., Ltd. | 2025-11-25 |
| Auricular Point Stimulation Plus Dexamethasone for Nausea and Vomiting Caused by Trastuzumab Deruxtecan (NCT07537673) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-11-25 |
| Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial (NCT07061964) | National Cancer Institute (NCI) | 2025-11-25 |
| A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (NCT07281937) | Verdiva Bio Dev Limited | 2025-11-25 |
| Auricular Point Stimulation Plus Dexamethasone for Nausea and Vomiting Caused by Gemcitabine Plus Paclitaxel (NCT07537660) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-11-25 |
| Auricular Point Stimulation Plus Dexamethasone for Nausea and Vomiting Caused by Docetaxel Plus Cyclophosphamide (NCT07537699) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-11-25 |
| Safety and Efficacy of Anricfen for Postoperative Analgesia and Rehabilitation Promotion After Pancreaticoduodenectomy.Intervention Measures: For Normal Adults, Administer Ariceptin Injection Intravenously Post-operation at a Dose of 1 μg/Kgevery 8 Hours for Three Consecutive Days After Surgery. (NCT07514637) | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2025-11-25 |
| A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy (NCT07227857) | Institut de Recherches Internationales Servier | 2025-11-24 |
| Taurine's Therapeutic Effect on Acute Radiation-induced Oral Mucositis and Dermatitis (NCT07029178) | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 2025-11-24 |
| A Study of KT-621 Administered Orally to Participants With Moderate to Severe Atopic Dermatitis (NCT07217015) | Kymera Therapeutics, Inc. | 2025-11-24 |
| Restoring Iron Deficiency in POTS (NCT07197905) | Vanderbilt University Medical Center | 2025-11-24 |
| A Phase II Clinical Study Evaluating Entinostat With or Without Anlotinib + Fulvestrant for the Treatment of Hormone Receptor (HR) -Positive, Human Epidermal Growth Factor Receptor-2 (HER-2) -Negative Advanced Breast Cancer That Relapsed or Progressed After Endocrine Therapy (NCT07330544) | Zhejiang Cancer Hospital | 2025-11-24 |
| A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma (NCT07123090) | Stephanie Berg | 2025-11-24 |
| A Platform Study in Non-Small Cell Lung Cancer (NSCLC) (NCT06996782) | AstraZeneca | 2025-11-24 |
| A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1) (NCT07286175) | Eli Lilly and Company | 2025-11-24 |
| Mosunetuzumab for CLL MRD Clearance (NCT07052695) | Inhye Ahn | 2025-11-24 |
| A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer (NCT07229729) | Shanghai Hengrui Pharmaceutical Co., Ltd. | 2025-11-24 |
| Taldefgrobep Alfa in Adults With Overweight and Obesity (NCT07281495) | Biohaven Therapeutics Ltd. | 2025-11-24 |
| A Phase II Clinical Study on the Efficacy and Safety of SHR-2173 Injection in the Treatment of Patients With Active Lupus Nephritis (NCT07229742) | Guangdong Hengrui Pharmaceutical Co., Ltd | 2025-11-22 |
| Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat. (NCT07256834) | Jinnah Postgraduate Medical Centre | 2025-11-22 |
| Efficacy and Safety of the KPCXM18 Injection in Patients With Acute Ischemic Stroke (NCT07279493) | Kunming Pharmaceuticals, Inc. | 2025-11-22 |
| Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM) (NCT07209462) | Mirum Pharmaceuticals, Inc. | 2025-11-22 |
| A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia (NCT06986174) | Shayna Sarosiek, MD | 2025-11-21 |
| Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder (NCT07523048) | Roger McIntyre | 2025-11-21 |
| Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS (NCT07532824) | Institute of Hematology and Blood Transfusion, Czech Republic | 2025-11-21 |
| Exploratory Clinical Study of Camrelizumab Combined With Concurrent Chemoradiotherapy as an Organ-preserving Strategy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma (NCT07622797) | The First Affiliated Hospital of Henan University of Science and Technology | 2025-11-21 |
| Maxigesic for Postoperative Pain Control After Laparoscopic or Robotic Gastrectomy (NCT07768514) | Seoul National University Bundang Hospital | 2025-11-21 |
| A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer. (NCT06890338) | AbbVie | 2025-11-21 |
| Iparomlimab and Tuvonralimab (QL1706) Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC (NCT07389629) | Sun Yat-sen University | 2025-11-21 |
| Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS (NCT07328425) | Italian Sarcoma Group | 2025-11-21 |
| IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study (NCT07217873) | Columbia University | 2025-11-21 |
| Study of Deucravacitinib for Refractory Adults With Dermatomyositis/Juvenile Dermatomyositis (NCT07012057) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 2025-11-21 |
| Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma (NCT07136181) | Novelwise Pharmaceutical Corporation | 2025-11-20 |
| Phase II Study of Trastuzumab Rezetecan or in Combination With Adebrelimab in HER2-Expressing Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) (NCT07241793) | Sun Yat-sen University | 2025-11-20 |
| Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma (NCT06846346) | UNICANCER | 2025-11-20 |
| Clinical Study to Evaluate the Efficacy of Febuxostat in the Treatment of Conservatively Managed Intracranial Hemorrhage Patients (NCT07701512) | Tanta University | 2025-11-20 |
| Application of Zanubrutinib-based Combination Regimens in the Treatment of Newly-diagnosed Diffuse Large B-cell Lymphoma (NCT07371923) | Beijing Tongren Hospital | 2025-11-20 |
| A Phase I/II Clinical Study of WJ22096 Tablets in Patients With Advanced Tumors (NCT07253116) | Nanjing Jingao biomidical technology Co. Ltd. | 2025-11-20 |
| A Study of SHR-4610 Injection in Patients With Advanced Solid Tumors (NCT07231211) | Shanghai Shengdi Pharmaceutical Co., Ltd | 2025-11-20 |
| The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients (NCT07519863) | Ain Shams University | 2025-11-20 |
| Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes (NCT07252778) | Krzysztof Durkalec-Michalski | 2025-11-20 |
| Erdosteine in the Treatment of Nonalcoholic Fatty Liver Disease (NCT07242222) | Tanta University | 2025-11-20 |
| Celecoxib in Parkinson Disease as Adjuvant Therapy (NCT07246278) | Tanta University | 2025-11-20 |
| A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema (NCT07216027) | Pfizer | 2025-11-20 |
| Efficacy and Safety of Ginkgo Biloba Extract EGb761® in Patients With Diabetic Retinopathy (NCT07236645) | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 2025-11-20 |
| Evaluation of Efficacy and Safety of Oral Roflumilast for Treatment of Moderate to Severe Atopic Dermatitis in Patients Aged 12 Years and Older: A Pilot Study (NCT07297602) | Nora Mohamed Abdelrazik | 2025-11-20 |
| Development of FAPI PET as a Non-invasive Biomarker of Pulmonary Fibrogenesis (NCT06940427) | University of Wisconsin, Madison | 2025-11-19 |
| Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW) (NCT07161037) | Vertex Pharmaceuticals Incorporated | 2025-11-19 |
| A Study of BPR-6023021 in Advanced Solid Tumors With Bone Metastases (NCT07249892) | Chengdu Syncor Pharmaceutical Co., Ltd. | 2025-11-19 |
| Interventional Study of Infigratinib in Children < 3 Years Old With Achondroplasia (ACH) (NCT07169279) | QED Therapeutics, a BridgeBio company | 2025-11-19 |
| GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma (NCT06921317) | IVIEW Therapeutics Inc. | 2025-11-19 |
| A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors (NCT07205718) | Takeda | 2025-11-19 |
| A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome (NCT07211685) | Bayer | 2025-11-19 |
| ONO-4538 Study in Patients With Richter's Transformation (NCT06936943) | Ono Pharmaceutical Co., Ltd. | 2025-11-19 |
| Gene Therapy for HER-Positive Cancer (SENTRY-HER2) (NCT07192432) | Vironexis Biotherapeutics Inc. | 2025-11-18 |
| Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma (NCT07260175) | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 2025-11-18 |
| A Phase Ib/IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral Ecnoglutide Tablets in Chinese Participants With Overweight or Obesity (NCT07243171) | Hangzhou Sciwind Biosciences Co., Ltd. | 2025-11-18 |
| A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9 (NCT07186842) | BioNTech SE | 2025-11-18 |
| Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer (NCT07094685) | University of Michigan Rogel Cancer Center | 2025-11-18 |
| B-FREE Chronic Babesiosis Study (NCT06656351) | 60 Degrees Pharmaceuticals LLC | 2025-11-18 |
| Subcutaneous Talquetamab in Elderly Patients With Multiple Myeloma in Early Relapse (NCT06827860) | Larysa Sanchez | 2025-11-18 |
| A Pilot Study to Correlate 4-18F- Fluoro-1-naphthol 18F-4FN PET/CT Imaging With Chronic Graft Versus Host Disease Manifestations (NCT07325253) | M.D. Anderson Cancer Center | 2025-11-18 |
| A Study of CM336 in Patients With Relapsed or Refractory Autoimmune Cytopenia (NCT07175493) | Keymed Biosciences Co.Ltd | 2025-11-18 |
| Study to Assess Efficacy and Safety of HSK39297 Tablets in Patients With LN (NCT07363460) | Haisco Pharmaceutical Group Co., Ltd. | 2025-11-18 |
| Taurine Supplementation in Long COVID (NCT06721949) | University of Alberta | 2025-11-18 |
| Hypofractionated Radiotherapy Plus Immunochemotherapy for Neoadjuvant Treatment of Gastroesophageal Junction Adenocarcinoma (NCT07182565) | West China Hospital | 2025-11-18 |
| Study of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease (NCT07221344) | Arrowhead Pharmaceuticals | 2025-11-18 |
| A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer (NCT06948448) | Ono Pharmaceutical Co., Ltd. | 2025-11-18 |
| Oral Pooled Fecal Microbiotherapy (MaaT033) Concomitant to Cemiplimab Versus Best Investigator's Choice in Patients With Resistance to Treatment Due to Antibiotics Uptake With Advanced Non-small Cell Lung Cancer (NCT07001618) | Gustave Roussy, Cancer Campus, Grand Paris | 2025-11-17 |
| A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer (NCT07112053) | University of Washington | 2025-11-17 |