| Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial (NCT07267260) | King Edward Medical University | 2025-12-16 |
| Study of ENP-501 in Peanut-Allergic and Non-Allergic Participants (NCT07117669) | N-Fold, LLC | 2025-12-16 |
| A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M (NCT07183371) | University of Oxford | 2025-12-15 |
| A ctDNA-guided Phase II Trial of Osimertinib in Combination With Sacituzumab Tirumotecan in EGFR-mutated Advanced NSCLC Patients With Positive ctDNA After lead-in Osimertinib Monotherapy (NCT07375316) | Guangdong Association of Clinical Trials | 2025-12-15 |
| Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy (NCT07306286) | Ruijin Hospital | 2025-12-15 |
| Immunotherapy Before and After Surgery (NCT06765902) | ImmunityBio, Inc. | 2025-12-15 |
| IRE Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy (NCT07306273) | Ruijin Hospital | 2025-12-15 |
| Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (NCT07268170) | Gødstrup Hospital | 2025-12-15 |
| Safety and Immunogenicity of ID vs IM Rabies Vaccine (NCT07345208) | International Centre for Diarrhoeal Disease Research, Bangladesh | 2025-12-15 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension (NCT07221513) | Salubris Biotherapeutics Inc | 2025-12-15 |
| REVerse Intestinal Metaplasia in the Stomach (REVISE) (NCT06590454) | Katherine Garman | 2025-12-15 |
| BEBT-908 Plus Chemotherapy Treatment for CR MRD-Positive MEF2D-Rearranged and Pre-B Acute Lymphoblastic Leukemia Patients (NCT07301138) | Ruijin Hospital | 2025-12-15 |
| Menthol for Improving Movement and Sleep in Parkinson's Disease Patients (NCT07294469) | Taipei Medical University Hospital | 2025-12-15 |
| Safety and Efficacy of Lactobacillus Plantarum for Psoriasis: A Randomized Double-Blind Placebo-Controlled Trial (NCT07194200) | Shenzhen People's Hospital | 2025-12-15 |
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting (NCT04998058) | Pontificia Universidade Católica do Rio Grande do Sul | 2025-12-15 |
| Evaluation of Neoadjuvant Therapy With Trastuzumab, Pertuzumab, Docetaxel, and QL1706 in Early or Locally Advanced HER2+ Breast Cancer (NCT07246317) | Tianjin Medical University Cancer Institute and Hospital | 2025-12-15 |
| This is an Early-stage Clinical Trial to Determine a Safe and Effective Dose for Tivoxavir Marboxil in Patients With Mild to Moderate Influenza (NCT07371650) | Traws Pharma, Inc. | 2025-12-15 |
| Bovis Calculus Stativus Treat Acute Cerebral Ischemic Stroke With Impaired Consciousness (NCT07240467) | Xiang Luo | 2025-12-15 |
| Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators (NCT07052929) | Astellas Gene Therapies | 2025-12-15 |
| RESCUE Study (REcurrent Ovarian Cancer Secondary Cytoreduction Using Chemotherapy rEsponse) (NCT07295132) | Asan Medical Center | 2025-12-15 |
| Safety and Efficacy of the JAK1 Inhibitor Combined With Intensive Immunosuppressive Therapy in Severe Aplastic Anemia (NCT07297550) | Institute of Hematology & Blood Diseases Hospital, China | 2025-12-15 |
| A Phase II, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Neoadjuvant Therapy With Inavolisib Plus Pertuzumab and Trastuzumab as Subcutaneous (PH-FDC SC) and 3-week Cycle Nab-paclitaxel for PIK3CA-mutated, HER2+, eBC (NCT07245797) | Zhimin Shao | 2025-12-15 |
| Parcel-guided rTMS for Major Depressive Disorder (NCT07287839) | Soterix Medical | 2025-12-15 |
| A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH) (NCT07288138) | Eccogene | 2025-12-15 |
| Low-Dose Radiotherapy and Anti-PD-1 Immunotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma (NCT07371234) | Xiwei XU | 2025-12-15 |
| Phase II Study of LM-24C5 (NCT07387081) | LaNova Medicines Limited | 2025-12-15 |
| EPIC- Extracorporeal Photopheresis (ECP) for Immune-related Colitis (NCT06646016) | Therakos LLC | 2025-12-15 |
| A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures (NCT07219407) | Rapport Therapeutics Inc. | 2025-12-15 |
| Assessing Iparomlimab and Tuvonralimab in Recurrent or Metastatic MSI-H/dMMR Gastric Cancer (NCT07127822) | Peking University | 2025-12-15 |
| A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis (NCT07276581) | AstraZeneca | 2025-12-15 |
| TREND-02 - a Phase II Exploratory De-escalation Trial of Neoadjuvant Sacituzumab Govitecan Plus Tislelizumab (SG/I) in Early Triple-negative Breast Cancer (NCT07271992) | First Hospital of China Medical University | 2025-12-15 |
| Modified Conditioning Regimen for CML-BP (NCT07259161) | Institute of Hematology & Blood Diseases Hospital, China | 2025-12-15 |
| Normothermic Oxygenated Perfusion (NMP) Viability Testing Before Transplantation of Discarded Livers (NCT06950398) | Rennes University Hospital | 2025-12-15 |
| Modified Autologous Leukocyte Cells for the Treatment of Acute Kidney Injury After Cardiac Surgery (NCT07052513) | M2RLAB SL | 2025-12-14 |
| Efficacy and Safety of ZT006 in Overweight and Obese Participants (NCT07230132) | Beijing QL Biopharmaceutical Co.,Ltd | 2025-12-12 |
| Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty (NCT07138898) | NYU Langone Health | 2025-12-12 |
| BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma (NCT07226856) | Mayo Clinic | 2025-12-12 |
| Induction and Consolidation With Fludarabine, Cytarabine, Idarubicin, and Venetoclax for the Treatment of Acute Myeloid Leukemia (NCT07228273) | OHSU Knight Cancer Institute | 2025-12-12 |
| Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN) (NCT07062588) | Angitia Incorporated Limited | 2025-12-12 |
| KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer (NCT07481058) | Beijing Konruns Pharmaceutical Co., Ltd. | 2025-12-12 |
| An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors (NCT07293754) | Repertoire Immune Medicines | 2025-12-12 |
| A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013) (NCT07221474) | Merck Sharp & Dohme LLC | 2025-12-12 |
| Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) (NCT07072468) | VM Therapeutics LLC | 2025-12-12 |
| Alpha-Emitting Radionuclide or Beta-Emitting Radionuclide With Metastasis-Directed Stereotactic Body Radiotherapy for the Treatment of Recurrent, Oligometastatic Prostate Adenocarcinoma (NCT07150715) | Jonsson Comprehensive Cancer Center | 2025-12-12 |
| A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10 (NCT07304258) | Hebei Medical University | 2025-12-12 |
| Study for Frail Patients With Newly Diagnosed Multiple Myeloma Treated With Daratumumab With Teclistamab or Talquetamab. (NCT07107529) | European Myeloma Network B.V. | 2025-12-12 |
| Preventive Efficacy of Bergmann Enema for Acute Radiation-induced Rectal Injury in Rectal Cancer Patients Undergoing Short-course Radiotherapy (NCT07302126) | Sixth Affiliated Hospital, Sun Yat-sen University | 2025-12-11 |
| Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma (NCT06947928) | TuHURA Biosciences, Inc. | 2025-12-11 |
| Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer (NCT06962137) | Universitaire Ziekenhuizen KU Leuven | 2025-12-11 |
| Ultralow Dose PET Imaging of SSTR2 Radiotracer Uptake (NCT07284589) | Akiva Mintz | 2025-12-11 |
| Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm Patients (NCT07007052) | French Innovative Leukemia Organisation | 2025-12-11 |
| A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease (NCT07214571) | Shionogi | 2025-12-11 |
| DALY II Japan/MB-CART2019.1 for DLBCL (NCT07288879) | Miltenyi Biomedicine GmbH | 2025-12-11 |
| A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation (NCT07342205) | Shanghai University of Traditional Chinese Medicine | 2025-12-10 |
| Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis (NCT05910554) | University of Maryland, Baltimore | 2025-12-10 |
| Daunorubicin, Cytarabine Liposomes Plus Venetoclax vs Azacitidine Plus Venetoclax in AML Patients Unfit for Intensive Chemotherapy (NCT06770257) | Institute of Hematology & Blood Diseases Hospital, China | 2025-12-10 |
| A Phase II Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics/Pharmacodynamics of JSKN033 in Patients With Advanced Non-Small Cell Lung Cancer (NCT07283198) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 2025-12-10 |
| A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer (NCT07155187) | AbbVie | 2025-12-10 |
| Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody (NCT07285213) | AstraZeneca | 2025-12-10 |
| The Safety and Efficacy of Daratumumab in Patients With Refractory Aplastic Anemia (NCT07287228) | Institute of Hematology & Blood Diseases Hospital, China | 2025-12-10 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) (NCT07245264) | St. Olavs Hospital | 2025-12-10 |
| CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer (NCT07322094) | TORL Biotherapeutics, LLC | 2025-12-10 |
| The Effects of Vonoprazan Fumarate on DGF Incidence in DD Kidney Transplant Recipients (NCT07275632) | First Affiliated Hospital of Chongqing Medical University | 2025-12-10 |
| The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke (NCT07294391) | Tianjin Huanhu Hospital | 2025-12-10 |
| Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support (NCT06910943) | Protara Therapeutics | 2025-12-10 |
| Exploratory Evaluation of the Digital Therapeutic Device Zenicom for Subacute Stroke Aphasia (NCT07397923) | Seoul National University Bundang Hospital | 2025-12-10 |
| Nimotuzumab Combined With Nab-paclitaxel/Gemcitabine in the Perioperative Treatment of High-risk Resectable/Borderline Resectable Pancreatic Cancer (NCT07277452) | The First Affiliated Hospital with Nanjing Medical University | 2025-12-10 |
| Ivarmacitinib in Advanced Solid Tumors: A Prospective, Two-Cohort, Two-Phase Exploratory Study in Patients Discontinued Due to Immune Intolerance (NCT07313202) | Fujian Cancer Hospital | 2025-12-10 |
| A Phase II Study of Toripalimab Plus RC48-ADC With Radiotherapy for Bladder Preservation in HER2-Positive Muscle-Invasive Bladder Cancer (NCT07279597) | Tongji Hospital | 2025-12-10 |
| Study Evaluating ISM5411 Administered Orally to Subjects With Active Ulcerative Colitis (BETHESDA) (NCT07265570) | InSilico Medicine Hong Kong Limited | 2025-12-10 |
| Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression (NCT06591091) | University of Illinois at Chicago | 2025-12-10 |
| Alternating HAIC and Systemic Chemotherapy With or Without Adebrelimab and Apatinib for Unresectable Biliary Tract Cancer (NCT07569679) | Air Force Military Medical University, China | 2025-12-10 |
| A Study of ABSK061 to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy in Children With Achondroplasia (NCT07297875) | Abbisko Therapeutics Co, Ltd | 2025-12-10 |
| Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation (NCT05450328) | Montreal Heart Institute | 2025-12-10 |
| ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer (NCT07007559) | ALX Oncology Inc. | 2025-12-10 |
| EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES (NCT07305350) | University of Child Health Sciences and Children's Hospital, Lahore | 2025-12-10 |
| Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL) (NCT07247370) | South West Sydney Local Health District | 2025-12-10 |
| Definitive Hypofractionated Intensity-modulated Radiation Theraphy With Concurrent Chemotherapy in Cervical Cancer (NCT07439497) | Samsung Medical Center | 2025-12-09 |
| SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin (NCT07560566) | National Taiwan University Hospital | 2025-12-09 |
| A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Uncontrolled Hypertension (NCT07654140) | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 2025-12-09 |
| Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome (NCT07216443) | Orca Biosystems, Inc. | 2025-12-09 |
| Nimotuzumab Combined With Chemoradiotherapy in the Treatment of Unresectable Locally Advanced or Oligometastatic Pancreatic Cancer (NCT07386704) | Peking University First Hospital | 2025-12-09 |
| Zanzalintinib Maintenance in Patients With High Grade Neuroendocrine Neoplasms (HG-NENs) (NCT06926634) | Washington University School of Medicine | 2025-12-09 |
| A Study of NTX-1472 in Social Anxiety Disorder (NCT07323784) | Newleos Therapeutics, Inc. | 2025-12-09 |
| HC010 in First-line PD-L1 Positive Advanced NSCLC Patients (NCT07169552) | HC Biopharma Inc. | 2025-12-09 |
| Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms (NCT07316088) | Oui Therapeutics, Inc. | 2025-12-09 |
| A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003) (NCT07222488) | Merck Sharp & Dohme LLC | 2025-12-09 |
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea (NCT07224438) | Stephanie B. Seminara, MD | 2025-12-09 |
| Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer (NCT07226999) | Pfizer | 2025-12-09 |
| A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia (NCT07269210) | Eli Lilly and Company | 2025-12-08 |
| Risk-adapted Adjuvant Chemotherapy Guided by the Tumour Stage for Operated Pancreatic Adenocarcinoma Following Neoadjuvant Chemotherapy With mFOLFIRINOX (NCT07044453) | University Hospital, Rouen | 2025-12-08 |
| Study Testing the Efficacy, Safety, and Tolerability of EDI048 in Cryptosporidium Infection Model in Healthy Adults (NCT07249463) | Novartis Pharmaceuticals | 2025-12-08 |
| NWRD06 DNA Plasmid for HCC After Curative Resection. (NCT07324304) | Newish Technology (Beijing) Co., Ltd. | 2025-12-08 |
| Trilaciclib in Patients Receiving Sacituzumab Tirumotecan for EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC) (NCT06992739) | The First Affiliated Hospital of Xiamen University | 2025-12-08 |
| The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment (NCT07340463) | Nanjing University School of Medicine | 2025-12-08 |
| Radioembolization Versus External Radiation Therapy (NCT07530172) | Henry Ford Health System | 2025-12-08 |
| Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer (NCT07276789) | Integro Theranostics | 2025-12-08 |
| Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients (NCT07287189) | Satellos Bioscience, Inc. | 2025-12-08 |
| Toripalimab Combined With BCG Perfusion for the Treatment of HR-NMIBC After TURBT Surgery Exploration (NCT07307456) | Changhai Hospital | 2025-12-08 |
| EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer (NCT05467748) | VA Office of Research and Development | 2025-12-08 |