| A Phase 2 Study to Evaluate the Safety and Efficacy of Pitolisant in Patients With Prader-Willi Syndrome, Followed by an Open Label Extension (NCT04257929) | Harmony Biosciences Management, Inc. | 2020-12-09 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1) (NCT04575467) | Caliway Biopharmaceuticals Co., Ltd. | 2020-12-09 |
| A 2nd Generation E1/E2B/E3-Deleted Adenoviral COVID-19 Vaccine: The TCELL VACCINE TRIAL (NCT06022224) | ImmunityBio, Inc. | 2020-12-09 |
| A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19 (NCT04649151) | ModernaTX, Inc. | 2020-12-09 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat (NCT04610866) | National Heart, Lung, and Blood Institute (NHLBI) | 2020-12-09 |
| Evaluation of PSMA Antagonist Produced by Two Different Methods (NCT04685811) | Weill Medical College of Cornell University | 2020-12-09 |
| Extension Study to Evaluate the Safety and Immunogenicity of a Revaccination Dose of the RSVPreF3 OA Investigational Vaccine in Adults 60 Years and Older Who Participated in the RSV OA=ADJ-002 Study (NCT04657198) | GlaxoSmithKline | 2020-12-09 |
| First-in-Human Study of the GDF-15 Neutralizing Antibody Visugromab (CTL-002) in Patients With Advanced Cancer (GDFATHER) (NCT04725474) | CatalYm GmbH | 2020-12-09 |
| ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma (NCT04480502) | Tracon Pharmaceuticals Inc. | 2020-12-09 |
| COVID-19 Prophylaxis South Africa (COVER HCW) (NCT04561063) | University of Witwatersrand, South Africa | 2020-12-08 |
| Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism (NCT04328337) | University of North Carolina, Chapel Hill | 2020-12-08 |
| A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab (NCT04590326) | Regeneron Pharmaceuticals | 2020-12-08 |
| A Trial to Evaluate the Safety and Efficacy of oNKord® in Subjects With Acute Myeloid Leukemia (NCT04632316) | Glycostem Therapeutics BV | 2020-12-08 |
| Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa (NCT04427826) | University Hospital, Grenoble | 2020-12-08 |
| Cabozantinib for Patients with Hepatocellular Carcinoma (HCC) Refractory to First Line Treatment (NCT04511455) | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 2020-12-08 |
| Use of a Nerve Regeneration Conduit (NerVFIX®) in the Treatment of Nerve Section of the Wrist (NCT05199155) | TBF Genie Tissulaire | 2020-12-08 |
| Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy (NCT04655976) | GlaxoSmithKline | 2020-12-08 |
| An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures (NCT04686786) | AbbVie | 2020-12-08 |
| A Study for AR100DP1 in Mild to Moderate Atopic Dermatitis (AD) (NCT04220411) | Arjil Pharmaceuticals LLC | 2020-12-08 |
| The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy. (NCT05069246) | Ishrat Rahman | 2020-12-08 |
| Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI (NCT04600089) | Sam Tyagi | 2020-12-08 |
| A Study to Evaluate the Efficacy and Safety of HR18042 Tablets in the Treatment of Postoperative Pain of Impacted Tooth. (NCT04812860) | Jiangsu HengRui Medicine Co., Ltd. | 2020-12-08 |
| SARS-CoV-2-Neutralizing Monoclonal COVID-19 Antibody DZIF-10c by Infusion (NCT04631666) | University of Cologne | 2020-12-08 |
| Oral Pyrophosphate Absorption in PXE Disease (NCT04441671) | Tampere University Hospital | 2020-12-08 |
| A Phase II Clinical Study to Assess the Efficacy and Safety of IBI310 or Placebo Combined With Sintilimab for Advanced Cervical Cancer Subjects Who Have Failed or Cannot Tolerate First-line or Above Platinum-based Chemotherapy (NCT04590599) | Innovent Biologics (Suzhou) Co. Ltd. | 2020-12-08 |
| Study of CG0070 Given in Combination With Pembrolizumab, in Non-Muscle Invasive Bladder Cancer, Unresponsive to Bacillus Calmette-Guerin (NCT04387461) | CG Oncology, Inc. | 2020-12-08 |
| Dacomitinib in Lung Cancer With Uncommon EGFR Mutations (NCT04504071) | Shanghai Chest Hospital | 2020-12-08 |
| Pyrotinib Combined With Pemetrexed Plus Carboplatin in the First-line Treatment (NCT04706949) | Fudan University | 2020-12-07 |
| A Phase 1/2 Study of TY101 for Locally Advanced /Metastatic Solid Tumors and Relapsed or Refractory Lymphomas (NCT04458389) | Tayu Huaxia Biotech Medical Group Co., Ltd. | 2020-12-07 |
| A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD) (NCT04602624) | Supernus Pharmaceuticals, Inc. | 2020-12-07 |
| BreastVAX: Radiation Boost to Enhance Immune Checkpoint Blockade Therapy (NCT04454528) | Abramson Cancer Center at Penn Medicine | 2020-12-07 |
| Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (NCT04678206) | Bellus Health Inc. - a GSK company | 2020-12-07 |
| Mechanisms for Activation of Beige Adipose Tissue in Humans (NCT04666636) | Philip Kern | 2020-12-07 |
| SHAPE Neoadjuvant Chemotherapy Response (NCT04715958) | Kibo Nam | 2020-12-07 |
| Interest of Medical Hypnosis in Anxious Patients Treated by Radiotherapy (NCT04513444) | Institut Claudius Regaud | 2020-12-07 |
| Study of KN026 Combined With KN046 in Patients With Locally Advanced HER2-positive Solid Tumors (NCT04521179) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 2020-12-07 |
| Ricolinostat in Patients With Painful Diabetic Peripheral Neuropathy (NCT03176472) | Regenacy Pharmaceuticals LLC | 2020-12-07 |
| Triac Trial II in MCT8 Deficiency Patients (NCT02396459) | Rare Thyroid Therapeutics International AB | 2020-12-07 |
| Central Nervous System(CNS) Efficacy of Dacomitinib (NCT04675008) | Samsung Medical Center | 2020-12-07 |
| Study to Evaluate the Effect on Parameters of Systemic Inflammation and Disease Outcomes and Safety of RPH-104 in Subjects With Acute ST-elevation Myocardial Infarction (NCT04463251) | R-Pharm Overseas, Inc. | 2020-12-07 |
| A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer (NCT04621370) | Liz-Anne Lewsley | 2020-12-07 |
| Efficacy and Safety Study of Combination of CPGJ602 and Chemotherapy, in First Line, With Wild KRAS/NRAS/BRAF in Metastatic Colorectal Cancer (NCT04466254) | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 2020-12-07 |
| Maintenance With Olaparib or Selumetinib + Durvaluma for m-PDAC Guided by BRCAness and KRAS Status. (NCT04348045) | GERCOR - Multidisciplinary Oncology Cooperative Group | 2020-12-07 |
| 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) (NCT05608395) | Masaryk Memorial Cancer Institute | 2020-12-04 |
| A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS (NCT04358393) | Ascentage Pharma Group Inc. | 2020-12-04 |
| Bictegravir/FTC/TAF for the Treatment of Primary HIV Infection (NCT04483674) | Anna Cruceta | 2020-12-04 |
| Durvalumab and Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer (NCT04607954) | Mayo Clinic | 2020-12-04 |
| Brentuximab Vedotin and Bendamustine for the Treatment of Relapsed or Refractory Follicular Lymphoma (NCT04587687) | University of California, Davis | 2020-12-04 |
| Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (BNT162b2) in Chinese Healthy Population (NCT04649021) | BioNTech SE | 2020-12-04 |
| Palbociclib, Trastuzumab,Pyrotinib and Fulvestrant Treatment in Patients With Brain Metastasis From ER/PR Positive, HER-2 Positive Breast Cancer: A Multi-center, Prospective Study in China (NCT04334330) | Sun Yat-sen University | 2020-12-04 |
| CBD Oil for Reducing Emotional Impact of COVID-19 (NCT04603781) | University of Texas at Austin | 2020-12-04 |
| COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction (NCT04420624) | University Hospital, Montpellier | 2020-12-04 |
| RCT Comparing ESPB Solutions in Breast Surgery (NCT04603911) | Tufts Medical Center | 2020-12-04 |
| 7-day Simvastatin and Emotional Processing (NCT04652089) | University of Oxford | 2020-12-03 |
| Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Melanoma (NCT04722575) | Fondazione Melanoma Onlus | 2020-12-03 |
| A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT. (NCT04688021) | Yi Luo | 2020-12-03 |
| The Combination of Venetoclax and Obinutuzumab in People With Chronic Lymphocytic Leukemia (CLL) (NCT04447768) | Memorial Sloan Kettering Cancer Center | 2020-12-03 |
| Study of VVN001 Ophthalmic Solution in Dry Eye Disease (NCT04556838) | VivaVision Biotech, Inc | 2020-12-03 |
| Methotrexate and Metformin in Rheumatoid Arthritis Patients (NCT04196868) | University Hospital, Bordeaux | 2020-12-03 |
| Cri Analog PG1 Effectiveness and Safety in Covid-19 (NCT04536363) | Alonso Vera Torres | 2020-12-03 |
| Pembrolizumab and Olaparib in Cervical Cancer Patients (NCT04483544) | Baptist Health South Florida | 2020-12-03 |
| Convalescent Plasma for Treatment of COVID-19 (NCT04649879) | Joakim Dillner | 2020-12-03 |
| Binimetinib and Nivolumab for the Treatment of Locally Advanced Unresectable or Metastatic BRAF V600 Wildtype Melanoma (NCT04375527) | Jonsson Comprehensive Cancer Center | 2020-12-03 |
| Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease (NCT04553406) | Spero Therapeutics | 2020-12-03 |
| CD19 CAR-T Therapy for Patients With Newly Diagnosed High-risk Large B-cell Lymphoma (NCT04661020) | Zhejiang University | 2020-12-03 |
| Natural Killer-cell Therapy for Acute Myeloid Leukemia (NCT04347616) | Radboud University Medical Center | 2020-12-03 |
| A Study of the Efficacy and Safety of MEDI7352 in Participants With Painful Osteoarthritis of the Knee (NCT04675034) | AstraZeneca | 2020-12-02 |
| Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19) (NCT04551898) | BeiGene | 2020-12-02 |
| Study of LP002 in Combination With Chemotherapy for Patients With Extensive Stage Small Cell Lung Cancer (NCT04740021) | Taizhou HoudeAoke Biomedical Co., Ltd. | 2020-12-02 |
| LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer (NCT04616183) | M.D. Anderson Cancer Center | 2020-12-02 |
| Neo-DIANA: Neoadjuvant Treatment for EGFR Mutated Patients (NCT04512430) | Fundación GECP | 2020-12-02 |
| RAPA-201 T Cell Therapy for Relapsed, Refractory Multiple Myeloma (NCT04176380) | Rapa Therapeutics LLC | 2020-12-02 |
| Feasibility of Using Bortezomib With or Without Chemotherapy in Patients With Atypical Teratoid/Rhabdoid Tumors (NCT06853080) | Taipei Medical University | 2020-12-02 |
| A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia (NCT04638153) | Pfizer | 2020-12-02 |
| Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840 (NCT04422431) | Alexion Pharmaceuticals, Inc. | 2020-12-02 |
| Clinical Study of Jaktinib in the Treatment of Patients With Moderate and Severe Atopic Dermatitis (NCT04539639) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2020-12-02 |
| Acalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphoma (NCT04257578) | University of Washington | 2020-12-02 |
| Dupilumab in CRSsNP (NCT04678856) | Sanofi | 2020-12-02 |
| KN046 (a Humanized PD-L1/CTLA4 Bispecific Single Domain Fc Fusion Protein Antibody) in Subjects With Thymic Carcinoma (NCT04469725) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 2020-12-02 |
| A Triple Combination Antiviral Coronavirus Therapy (TriACT) for COVID-19 (NCT04605588) | Rutgers, The State University of New Jersey | 2020-12-02 |
| A Study of SHR3680 in Combination With Docetaxel in the Treatment of mCRPC (NCT04603833) | Jiangsu HengRui Medicine Co., Ltd. | 2020-12-02 |
| Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 (NCT04613596) | Mirati Therapeutics Inc. | 2020-12-02 |
| Eltrombopag for Treatment of Fanconi Anemia (NCT06045052) | Julian Sevilla | 2020-12-02 |
| Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing (NCT04611750) | Brigham and Women's Hospital | 2020-12-02 |
| The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS (NCT04651855) | Polski Bank Komorek Macierzystych JSC (PBKM) | 2020-12-02 |
| MT1002 Phase II Study in ACS Patients With PCI (NCT04723186) | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 2020-12-02 |
| To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain (NCT04647773) | Haisco Pharmaceutical Group Co., Ltd. | 2020-12-02 |
| Antibiotics Against Amyloid Angiopathy (NCT05680389) | Leiden University Medical Center | 2020-12-02 |
| Corticosteroids in Community Acquired Pneumonia (NCT04652414) | Vanderbilt University Medical Center | 2020-12-01 |
| Isoquercetin in Sickle Cell Anemia (NCT04474626) | Jeffrey Zwicker, MD | 2020-12-01 |
| Cannabis Oil for Pain in Parkinson's Disease (NCT03639064) | University Health Network, Toronto | 2020-12-01 |
| Dose Finding Study of STR-324 (NCT04582786) | Alaxia SAS | 2020-12-01 |
| Abscopal Effect of SBRT in Combination With rhGM-CSF and INF-α 2b for Metastatic Thymic Epithelial Tumors (NCT04517539) | Shanghai Cancer Hospital, China | 2020-12-01 |
| A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease (NCT05574543) | Angitia Biopharmaceuticals | 2020-12-01 |
| Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation. (NCT04646135) | Bambino Gesù Hospital and Research Institute | 2020-12-01 |
| Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial) (NCT05246020) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2020-12-01 |
| Study of M4344 in Combination With Niraparib (NCT04655183) | EMD Serono Research & Development Institute, Inc. | 2020-12-01 |
| Toripalimab as Maintenance Therapy in Patients With Driver-gene Negative Advanced NSCLC After First-line Chemotherapy (NCT04613804) | Fujian Cancer Hospital | 2020-12-01 |
| Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer (NCT02811809) | The University of Texas Health Science Center, Houston | 2020-12-01 |
| Neoadjuvant PD-1 Monoclonal Antibody in Cisplatin-ineligible High Risk Upper Tract Urothelial Carcinoma (NCT04672330) | RenJi Hospital | 2020-12-01 |