| A Study to Investigate the Exposure of Budesonide, Glycopyrronium, and Formoterol (BGF) Delivered by Hydrofluoroolefin (HFO) Propellant Metered Dose Inhaler (MDI) Compared to a Hydrofluoroalkane (HFA) Propellant MDI in Healthy Adults (NCT06723756) | AstraZeneca | 2025-01-23 |
| A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD) (NCT06721143) | AION Healthspan, Inc. | 2025-01-23 |
| ELVN-001 for the Treatment of Chronic Myeloid Leukemia With and Without T315I Mutation in Japanese Participants (NCT06787144) | Enliven Therapeutics | 2025-01-23 |
| A Study in Healthy Men to Test How Well Different Doses of BI 3776528 Are Tolerated (NCT06745297) | Boehringer Ingelheim | 2025-01-23 |
| Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants (NCT06180759) | University Hospital, Basel, Switzerland | 2025-01-23 |
| Clinical Study of Anti-FLT3 CAR-T Cells for the Treatment of Relapsed/Refractory AML (NCT06786533) | Hemogenyx Pharmaceuticals LLC | 2025-01-23 |
| A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer (NCT06609005) | Shenzhen Ionova Life Sciences Co., Ltd. | 2025-01-23 |
| A Study to Evaluate the Bioequivalence Between Immediate Release Tablets and Minitablets of Deucravacitinib (BMS-986165), and the Effect of Food and pH on the Drug Levels of the Minitablets in Healthy Adults (NCT06851871) | Bristol-Myers Squibb | 2025-01-23 |
| A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers. (NCT06697184) | BeOne Medicines | 2025-01-23 |
| Clinical Study of U01（ssCART-19） in Patients With B-Cell Lymphoma (NCT07093073) | Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd | 2025-01-23 |
| Study of HS135 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (NCT06581159) | 35Pharma Inc | 2025-01-23 |
| A Study of Interaction of Zasocitinib (TAK-279) With Other Medicines in Healthy Adults (NCT06793943) | Takeda | 2025-01-23 |
| A Clinical Trial to Evaluate Safety of Gusacitinib in Patients With Systemic Lupus Erythematosus (SLE) or Lupus (NCT06238531) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 2025-01-22 |
| Developing Microbial Therapy for MASLD: From Mechanism to Clinical Validation (NCT07488975) | Leeuwenhoek Laboratories Co. Ltd. | 2025-01-22 |
| A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors (NCT06777316) | Cogent Biosciences, Inc. | 2025-01-22 |
| Effect of Cannabis on Cigarette Use Behavior (NCT06609083) | Johns Hopkins University | 2025-01-22 |
| A Study of SHR-4394 Injection in Subjects With Prostate Cancer (NCT06783829) | Jiangsu HengRui Medicine Co., Ltd. | 2025-01-22 |
| A Study Evaluating the Safety and Immunogenicity of MVA Strain Monkeypox Attenuated Live Vaccine (NCT06771479) | Shanghai Institute Of Biological Products | 2025-01-22 |
| Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate Resection (NCT06320990) | University of Nebraska | 2025-01-22 |
| Mechanical Thrombectomy Blood Flow Reversal (NCT06721338) | MediSys Health Network | 2025-01-22 |
| A Study to Assess the Adverse Events and How Subcutaneous (SC) Injections and Intravenous (IV) Infusions of ABBV-142 Move Through the Body of Healthy Adult Participants (NCT06774313) | AbbVie | 2025-01-22 |
| Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma (NCT06478212) | Institut de Recherches Internationales Servier | 2025-01-22 |
| CTX-009 With Gemcitabine, Cisplatin, and Durvalumab as First-line Therapy in Patients With Unresectable or Metastatic Biliary Tract Cancers (NCT06548412) | M.D. Anderson Cancer Center | 2025-01-22 |
| A Phase 1 Study of CG001419 Administered Orally in Healthy Subjects (NCT06636500) | Cullgen Australia Pty Ltd | 2025-01-22 |
| A Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HRS-3802 Monotherapy in Patients With Malignant Solid Tumors (NCT06770569) | Shandong Suncadia Medicine Co., Ltd. | 2025-01-21 |
| AK112 and Cadonilimab Combined With Chemotherapy for 1L Treatment of Metastatic Pancreatic Cancer (NCT06646055) | Akeso | 2025-01-21 |
| Intraglandular Treatment With Adipose-derived Mesenchymal Stem Cells in Patients With Xerostomia Due to Sjögren's Disease (NCT06805448) | Rigshospitalet, Denmark | 2025-01-21 |
| A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus (NCT06613360) | Cullinan Therapeutics Inc. | 2025-01-21 |
| The Safety and Antibody Response of the Nasal COV2 Vaccine Against the SARS-CoV-2 Virus (NCT06851611) | Rokote Laboratories Finland Oy | 2025-01-21 |
| To Assess the Bioavailability of TK-254RX in Comparison with Oral Flurbiprofen Tablets and the Adhesion of TK-254RX in Healthy Subjects (NCT06823284) | Teikoku Seiyaku Co., Ltd. | 2025-01-21 |
| A Single-center, Open-label, Study Evaluating Safety and Pharmacokinetics of Single Doses of Zidebactam-Cefepime and Metronidazole Alone or in Combination. (NCT06806995) | Wockhardt | 2025-01-21 |
| A Trial of HRS-2189 in Combination With Fluvastatin±HRS-6209, or HRS-8080±HRS-6209, or HRS-6209+HRS-1358 in Breast Cancer Patients (NCT06679036) | Shandong Suncadia Medicine Co., Ltd. | 2025-01-21 |
| A Phase I/II Clinical Study of SHR-1681 for Injection in Patients With Advanced Solid Tumors (NCT06737731) | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 2025-01-21 |
| Shigella Sonnei 53G Human Infection Study in Kenyan Adults (NCT05959616) | University of Oxford | 2025-01-21 |
| Ketamine for Combined Depression and Alcohol Use Disorder (NCT06090422) | University Hospital of North Norway | 2025-01-20 |
| A Study of AC-101 Tablets in Participants With Moderate to Severe Active Ulcerative Colitis (NCT07083193) | Accro Bioscience (Suzhou) Limited | 2025-01-20 |
| Efficacy and Safety of Adjunctive Use of Rifaximin In Preventing Radiotherapy-induced Diarrhea in Cancer Patients (NCT06783153) | Mansoura University | 2025-01-20 |
| A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Uterine Blood Mesenchymal Stem Cells Injection for the Treatment of Severe Pneumonia Caused by Viruses (NCT06693362) | Ruijin Hospital | 2025-01-20 |
| A Phase I Study OfLNF2007 Monotherapy in Patients with Advanced Solid Tumors (NCT06752447) | Shandong New Time Pharmaceutical Co., LTD | 2025-01-20 |
| CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma (NCT06834529) | Affiliated Hospital to Academy of Military Medical Sciences | 2025-01-20 |
| A Research Study to Evaluate the Safety and Preliminary Efficacy of SGC001 in Patients With Myocardial Infarction (NCT07091929) | Beijing Sungen Biomedical Technology Co., Ltd | 2025-01-20 |
| A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors (NCT06337630) | Institut Curie | 2025-01-20 |
| Evaluation of the Safety and Tolerability of Gemini in Subjects With Stage 3-4 Chronic Kidney Disease. (NCT06863467) | Revelation Biosciences, Inc | 2025-01-20 |
| A Phase I Clinical Study of VSA012 in Healthy Volunteers (NCT06766929) | Bisirna Therapeutics (Suzhou) Co., Ltd. | 2025-01-20 |
| Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury (NCT06836856) | Mansoura University | 2025-01-20 |
| Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 5 mg/850 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy® 5 mg/850 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany) (NCT06766500) | Gedeon Richter Plc. | 2025-01-20 |
| A Clinical Trial Evaluating IL-22BP/LNP Compound in Refractory Malignant Solid Tumors for Safety, Tolerability and Activity (NCT07100210) | Xingchen Peng | 2025-01-20 |
| Immune Reconstitution Monitoring and Pneumococcal Vaccination in Patients Treated With CAR-T Cells (NCT07071909) | UNC Lineberger Comprehensive Cancer Center | 2025-01-20 |
| A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal Contraceptives (NCT06799884) | Idorsia Pharmaceuticals Ltd. | 2025-01-18 |
| HX009+ IN10018 With or Without Standard Chemotherapy for Advanced Solid Tumours (NCT06708663) | Hangzhou Hanx Biopharmaceuticals, Ltd. | 2025-01-17 |
| Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant (NCT06543381) | City of Hope Medical Center | 2025-01-17 |
| Clinical Study to Evaluate Debio0123 + Sacituzumab Govitecan Combination in TNBC or HR+/HER2- Advanced Breast Cancer (NCT06612203) | MedSIR | 2025-01-17 |
| Human ADME Study of [14C]-Ceralasertib (AZD6738) and Absolute Bioavailability of Ceralasertib (NCT06754761) | AstraZeneca | 2025-01-17 |
| Steroids Combined With Ruxolitinib as First-Line Therapy for Grade II Acute Graft-versus-Host Disease (NCT07576010) | Daihong Liu | 2025-01-17 |
| Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma (NCT06517888) | Akouos, Inc. | 2025-01-17 |
| Effects of Allogenic Umbilical Cord-Derived Mesenchymal Stem Cells on Patients With Rotator Cuff Disease (NCT06794294) | Seoul National University Hospital | 2025-01-17 |
| To Evaluate the Safety and PK Characteristics After Co-administration of JW0104 and C2402 and Administration of JW0105 (NCT06754943) | JW Pharmaceutical | 2025-01-17 |
| A Study of AK129 With or Without AK117 in PD(L)1-refractory Classic Hodgkin Lymphoma (NCT06642792) | Akeso | 2025-01-17 |
| A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Cabotegravir Ultra Long-acting (CAB ULA) Following Switch From Cabotegravir Long-acting (CAB LA) in Healthy Adults (NCT06786520) | ViiV Healthcare | 2025-01-17 |
| A Study to Assess the Effect of Ceftobiprole on the PK of Pitavastatin and on Plasma Levels of Coproporphyrin (NCT06808646) | Basilea Pharmaceutica | 2025-01-17 |
| HER-2 B Cell Peptide Vaccine (NCT06414733) | Pravin T.P Kaumaya | 2025-01-17 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-4729 Injection in Healthy Subjects (NCT06762600) | Fujian Shengdi Pharmaceutical Co., Ltd. | 2025-01-16 |
| A Study of YTS109 Cell Injection in Subjects With Relapsed/Refractory Autoimmune Hemolytic Anemia (NCT06770504) | Institute of Hematology & Blood Diseases Hospital, China | 2025-01-16 |
| Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma (NCT06667687) | AbbVie | 2025-01-16 |
| A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK) (NCT06555419) | Biogen | 2025-01-16 |
| Tolerability, Safety, and Immunogenicity of Tetravalent Inactivated Enterovirus Vaccine (Vero Cell). (NCT06754384) | Sinovac Biotech Co., Ltd | 2025-01-15 |
| Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD (NCT06841640) | AeroRx Therapeutics Inc. | 2025-01-15 |
| JSKN033 in Chinese Subjects with Advanced Malignant Tumors (NCT06770881) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 2025-01-15 |
| A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia (NCT06776510) | Institute of Hematology & Blood Diseases Hospital, China | 2025-01-15 |
| Natural Heart Health Supplement Trial (NCT06671769) | Efforia, Inc | 2025-01-15 |
| Safety and Efficacy of Fourth-Generation CAR-T in the Treatment of Hematologic Malignancies (NCT06758713) | The Third Affiliated Hospital of Southern Medical University | 2025-01-15 |
| Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer (NCT06336902) | University of Southern California | 2025-01-15 |
| A Study of YTS109 Cell in Subjects With Relapsed/Refractory Autoimmune Hemolytic Anemia (NCT07075484) | China Immunotech (Beijing) Biotechnology Co., Ltd. | 2025-01-15 |
| A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01) (NCT06395090) | Merck Sharp & Dohme LLC | 2025-01-15 |
| HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention) (NCT06513819) | Yale University | 2025-01-15 |
| A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems (NCT06692322) | Boehringer Ingelheim | 2025-01-15 |
| Intramuscular ACM-CpG Monotherapy in Patients With Advanced/Metastatic Solid Tumors With Prior Response to Immunotherapy Alone or in Combination With Chemotherapy (NCT06587295) | National Cancer Centre, Singapore | 2025-01-15 |
| Study Evaluating Safety Pharmacokinetics and Pharmacodynamics of AUR112 in Patients With Relapsed Advanced Lymphoma (NCT06755450) | Aurigene Discovery Technologies Limited | 2025-01-15 |
| Optimal Dose of Anti-lymphocyte Globulin in Kidney Transplant Recipients With Low Immunological Risk (NCT06744400) | Centre Hospitalier Universitaire de Besancon | 2025-01-15 |
| Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy (NCT06595329) | University Hospital of Split | 2025-01-15 |
| Safety, Tolerability and PK of ATTO-1310 in Healthy Volunteers and Patients With Atopic Dermatitis and Patients With Chronic Pruritus (NCT06787586) | Attovia Therapeutics Inc | 2025-01-14 |
| Safety and Efficacy of LPM3770164 Sustained-release Tablets in Patients With Tardive Dyskinesia (NCT06731868) | Luye Pharma Group Ltd. | 2025-01-14 |
| A Study of XS-04 in Patients with Relapsed or Refractory Hematologic Malignancies (NCT06820268) | NovaOnco Therapeutics Co., Ltd. | 2025-01-14 |
| A Study of JNJ-89853413 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms (NCT06618001) | Janssen Research & Development, LLC | 2025-01-14 |
| A Phase I/II Study of Golidocitinib Combined with Pomalidomide in R/R PTCL (NCT06855823) | Sun Yat-sen University | 2025-01-14 |
| Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal Detachment (NCT06033703) | Massachusetts Eye and Ear Infirmary | 2025-01-14 |
| QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations (NCT06715124) | Quanta Therapeutics | 2025-01-14 |
| GT719 Injection for Recurrent/Refractory Antibody-mediated Neurological Immune Diseases (NCT07021209) | Grit Biotechnology | 2025-01-14 |
| A Study to Assess the Safety of ARGX-109 in Healthy Volunteers (NCT06799416) | argenx | 2025-01-14 |
| A Study to Evaluate a Single-Dose Subcutaneous Axatilimab Compared With Intravenous Axatilimab in Healthy Participants (NCT06713590) | Incyte Corporation | 2025-01-14 |
| Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus (NCT06994949) | Eva Sevick | 2025-01-14 |
| Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab (NCT06447376) | Taylor Brooks | 2025-01-14 |
| A Study of Different Forms of BGB-43395 and Food Effect in Healthy Participants (NCT06761898) | BeiGene | 2025-01-14 |
| Psilocybin-Assisted Therapy for Physician Well-Being and Burnout (NCT06814522) | University of California, San Diego | 2025-01-13 |
| Study of the Safety, Tolerability, and Pharmacokinetic Profile of Ascending Doses of Ingavirin Forte, Capsules, Folliwing Single and Subsequent Multiple Oral Administration in Healthy Volunteers (NCT06859333) | Valenta Pharm JSC | 2025-01-13 |
| A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF10073 After Single and Multiple Doses in Healthy Volunteers and the Effect of Itraconazole on CHF10073 Exposure (NCT06746064) | Chiesi Farmaceutici S.p.A. | 2025-01-13 |
| A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function (NCT06568861) | Aligos Therapeutics | 2025-01-13 |
| Comparative Bioavailability Study Between Ticagrelor and ASA Administered Individually or in Combination. (NCT07444164) | Laboratorios Silanes S.A. de C.V. | 2025-01-13 |
| A Phase 1/2a, Single- and Multiple-dose Escalation Study of KRRO-110 (NCT06677307) | Korro Bio, Inc. | 2025-01-13 |
| A Study to Compare Eutropin Formulations in Healthy Volunteers for Bioavailability, Safety, and Tolerability (NCT06743997) | LG Chem | 2025-01-13 |