| Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial (NCT07220733) | Wandercraft | 2025-10-01 |
| Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint (NCT04750252) | Akan Biosciences, LLC | 2025-10-01 |
| Precision Rifampin Trial for Personalized Dosing (NCT06318416) | University of Virginia | 2025-10-01 |
| A Study to Evaluate Adze1.C in Participants With Metastatic Melanoma (NCT07086105) | Adze Biotechnology Australia Pty Ltd | 2025-10-01 |
| Study of C6 Ceramide NanoLiposome (CNL) in Patients With Relapsed/Refractory Acute Myeloid Leukemia (NCT04716452) | Keystone Nano, Inc | 2025-10-01 |
| Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus (NCT07251608) | ChromaDex, Inc. | 2025-10-01 |
| Study of QLH12016 in Combination With Novel Hormonal Agent in Subjects With Advanced Prostate Cancer (NCT07104110) | Qilu Pharmaceutical Co., Ltd. | 2025-10-01 |
| A Trial to Evaluate Sacituzumab Govitecan in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Metastatic Breast Cancer Progressed on CDK4/6 Inhibitors (NCT07163481) | Hunan Cancer Hospital | 2025-10-01 |
| A Study of OL-CD19-GDT in Relapsed/ Refractory Autoimmune Diseases (NCT07167537) | Beijing GoBroad Hospital | 2025-10-01 |
| A Study of Single Dose of LP-003 in Adolescent Subjects (NCT07148557) | Longbio Pharma | 2025-10-01 |
| Evaluation of Long-term Safety in Parkinsonian Patients With Intracerebroventricular Administration of A-dopamine (Anaerobic Dopamine) (NCT07214285) | University Hospital, Lille | 2025-10-01 |
| Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization. (NCT07329686) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-10-01 |
| A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms (NCT07008118) | Incyte Corporation | 2025-10-01 |
| Combination Therapy With Tazemetostat in Relapsed and Refractory Peripheral T-cell Lymphoma (NCT07209163) | Ruijin Hospital | 2025-10-01 |
| Topical Imiquimod Treatment of Oral Dysplasia (NCT07210775) | University of Southern California | 2025-10-01 |
| ENgineered Tissue Repair of BronchopleUral FiSTula (NCT04435249) | Videregen Limited | 2025-10-01 |
| Dose Escalation and Dose Expansion Study of MDX2004 in Participants With Advanced Tumors (NCT07110584) | ModeX Therapeutics, An OPKO Health Company | 2025-10-01 |
| EDN Combined With TACE/HAIC and Second-Line Immune-Targeted Treatment Versus TACE/HAIC Alone in Locally Advanced HCC With Portal Vein Tumor Thrombosis After First-Line Therapy Failure: A Prospective, Multicenter, Randomized Controlled Trial (NCT07187284) | Zhongda Hospital | 2025-09-30 |
| Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors (NCT07055854) | Oregon State University | 2025-09-30 |
| Safety of Single and Repeat Dose of PYC-001 Eye Injections in People With Autosomal Dominant Optic Atrophy (Myrtle) (NCT06970106) | PYC Therapeutics | 2025-09-30 |
| A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity (NCT07137585) | Hoffmann-La Roche | 2025-09-30 |
| A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma (NCT07116616) | ModernaTX, Inc. | 2025-09-30 |
| A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants (NCT07216313) | Sagimet Biosciences Inc. | 2025-09-30 |
| A Study of SH3765 Tablets in Combination With Fulvestrant in Patients With HR+/HER2- Advanced Breast Cancer. (NCT07557004) | Nanjing Sanhome Pharmaceutical, Co., Ltd. | 2025-09-30 |
| A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases (NCT07177950) | Peking University Cancer Hospital & Institute | 2025-09-30 |
| Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Autoimmune Diseases (NCT07161193) | Hebei Senlang Biotechnology Inc., Ltd. | 2025-09-30 |
| A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of EDK060 in Adults With CMT1A. (NCT07140614) | Novartis Pharmaceuticals | 2025-09-30 |
| LDRT Combined With Pucotenlimab and Standard Therapy for Advanced Pancreatic Cancer: A Single-Arm Study (NCT07312422) | Zhejiang Provincial People's Hospital | 2025-09-30 |
| A Study of SJP-001 in Comparison With Fexofenadine and Naproxen Administered With Alcohol (NCT07487909) | Sen-Jam Pharmaceutical | 2025-09-30 |
| A Study to Evaluate the Tolerability, Safety and Efficacy of GNR-097 Gene Therapy in Pediatric Patients With Duchenne Muscular Dystrophy (NCT07673809) | AO GENERIUM | 2025-09-30 |
| Dopamine and Sensorimotor Function in Stuttering (NCT07215884) | University of California, San Francisco | 2025-09-30 |
| A Study of Mesenchymal Stem Cell in the Treatment of Autism Spectrum Disorder (NCT07177677) | Jiuzhitang Maker (Beijing) Cell Technology Co.,Ltd. | 2025-09-30 |
| A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (NCT07198867) | First Affiliated Hospital of Zhejiang University | 2025-09-30 |
| A Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALE1 in Healthy Adults and Adults With Hypophosphatasia in Order to Identify Suitable Doses of ALE1 (NCT07179640) | Alesta Therapeutics | 2025-09-30 |
| A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer (NCT07192614) | AstraZeneca | 2025-09-30 |
| A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) (NCT07055477) | National Cancer Institute (NCI) | 2025-09-29 |
| Nucleoside Therapy in Patients With Telomere Biology Disorders (NCT06817590) | Suneet Agarwal | 2025-09-29 |
| A Clinical Study to See How the Body Handles and How Safe a Combination Tablet of Gemigliptin, Dapagliflozin, and Metformin 50/10/1000mg is Compared to Taking Gemigliptin 50mg Separately With Dapagliflozin/Metformin 10/1000mg in Healthy Adults After a Meal (NCT07333742) | LG Chem | 2025-09-29 |
| Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC (NCT06912087) | University of Chicago | 2025-09-29 |
| A Study of AAVB-039 in Participants With Stargardt Disease (STGD1) (NCT07161544) | AAVantgarde Bio Srl | 2025-09-29 |
| A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin (NCT07118215) | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 2025-09-29 |
| Clinical Study on the Mass Balance of Clifutinib (NCT07211165) | Sunshine Lake Pharma Co., Ltd. | 2025-09-29 |
| Evaluation of the Efficacy and Safety of Megestrol Acetate in Preventing Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy (NCT07130617) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-09-29 |
| Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042 (NCT07222878) | NeuroPro Therapeutics, Inc. | 2025-09-29 |
| T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients. (NCT06474676) | M.D. Anderson Cancer Center | 2025-09-29 |
| Evaluating Bioequivalence of a Fixed Dose Combination Versus Individual Tablets of Bempedoic Acid, Ezetimibe, and Rosuvastatin (NCT07182383) | Daiichi Sankyo | 2025-09-29 |
| TLN-372 in Advanced KRAS Mutant Solid Tumors (NCT07204340) | Treeline Biosciences, Inc. | 2025-09-29 |
| Bioequivalence Study to Compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg in Fast Condition (NCT07372118) | Humanis Saglık Anonim Sirketi | 2025-09-27 |
| A Study of Doravirine/Islatravir in Healthy Lactating Females (MK-8591A-061) (NCT07086079) | Merck Sharp & Dohme LLC | 2025-09-26 |
| Evaluation of Circulating Immune Response After Histosonics in Colorectal Cancer (ECHO-CRC) (NCT07361107) | Northwell Health | 2025-09-26 |
| A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors (NCT07160335) | Shanghai Henlius Biotech | 2025-09-26 |
| A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet (NCT07184086) | Novo Nordisk A/S | 2025-09-26 |
| Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors (NCT06441331) | ITM Solucin GmbH | 2025-09-26 |
| B7H3/IL13Ra2 Bispecific Armored Chimeric Antigen Receptor T-Cell Therapy Study for Recurrent/Refractory Glioblastoma (NCT07193628) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-09-26 |
| EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease (NCT07168603) | ASTEROGENE Biomedical Co. Ltd. | 2025-09-26 |
| A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease (NCT07168356) | GlaxoSmithKline | 2025-09-26 |
| Safety and Tolerability of Subretinally Injected OPGx-BEST1 in Patients With Best Vitelliform Macular Dystrophy (BVMD) or Autosomal-Recessive Bestrophinopathy (ARB) (NCT07185256) | Opus Genetics, Inc | 2025-09-25 |
| MethaLoad Dose-Finding Study (NCT06877858) | University of Pennsylvania | 2025-09-25 |
| Phase I Study of Allogeneic Transforming Growth Factor-beta Receptor Type 2 Knockout CD70 CAR NK Cells in Treatment Refractory Clear Cell Renal Cell Carcinoma (NCT07072234) | M.D. Anderson Cancer Center | 2025-09-25 |
| SSTR2 Imaging With [68Ga]Ga-DOTA-TOC PET/CT in NPC (NCT06982300) | University Medical Center Groningen | 2025-09-25 |
| TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies (NCT07052370) | St. Jude Children's Research Hospital | 2025-09-25 |
| TAS-102 Plus Radiotherapy in Elderly ESCC (NCT07196345) | Qianfoshan Hospital | 2025-09-25 |
| A Study of IBI3032 in Chinese Participants With Overweight or Obesity (NCT07170319) | Innovent Biologics Technology Limited (Shanghai R&D Center) | 2025-09-25 |
| JMT106 Injection in the Treatment of Advanced Solid Tumors (NCT07275073) | Shanghai JMT-Bio Inc. | 2025-09-25 |
| A Single Ascending Dose of HRS-2162 in Healthy Subjects (NCT07195604) | Fujian Shengdi Pharmaceutical Co., Ltd. | 2025-09-25 |
| A Study to Investigate the Relative Bioavailability and Food Effect of a Fixed-Dose Combination Tablet Containing Zanubrutinib and Sonrotoclax (BG-71332) in Healthy Adults (NCT07141511) | BeOne Medicines | 2025-09-24 |
| The Purpose of This Study is to Evaluate the Efficacy and Safety of 626 in the Treatment of SLE (NCT07185269) | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 2025-09-24 |
| A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer (NCT06396091) | Astellas Pharma Global Development, Inc. | 2025-09-24 |
| A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (NCT07123454) | AstraZeneca | 2025-09-24 |
| Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA). (NCT06751238) | Novartis Pharmaceuticals | 2025-09-24 |
| A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin (NCT07331389) | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 2025-09-24 |
| Robot-Assisted Prostate Biopsy With a Novel Ultrasound Probe (NCT07271017) | Johns Hopkins University | 2025-09-23 |
| ZG006 and ZG005 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma (NCT07038096) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2025-09-23 |
| Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse (NCT06928662) | Fred Hutchinson Cancer Center | 2025-09-23 |
| A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors (NCT07141706) | DualityBio Inc. | 2025-09-23 |
| Evaluation of the Effect of Itraconazole on the Pharmacokinetics of HS-20093 in Patients With Advanced Solid Tumors (NCT07186452) | Hansoh BioMedical R&D Company | 2025-09-23 |
| Study of ZG005 in Combination With Gecacitinib in Participants With Advanced Cervical Cancer (NCT07080216) | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 2025-09-23 |
| HCL001 Cell Injection for Decompensated Cirrhosis: A Phase I/II Trial (NCT07488546) | Shanghai Huicun Medical Technology Co., Ltd. | 2025-09-23 |
| Phase I/II Open Label Study Evaluating the Safety and Efficacy of Combining STAT3 Inhibition (TTI-101) With Anti-PD-1 Therapy (Pembrolizumab) in Patients With Recurrent or Metastatic (RM) Head and Neck Squamous Cell Carcinoma (HNSCC) (NCT05668949) | M.D. Anderson Cancer Center | 2025-09-23 |
| A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations (NCT07109726) | Terremoto Biosciences Inc. | 2025-09-23 |
| Pyrotinib Maleate Tablets in Combination With Dalpiciclib Isethionate Tablets and Standard Endocrine Therapy (NCT07189884) | The First Affiliated Hospital of Xiamen University | 2025-09-23 |
| A Study of PHN-012 in Patients With Advanced Solid Tumors (NCT07127874) | Pheon Therapeutics | 2025-09-23 |
| First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies (NCT07136779) | VelaVigo Bio Inc | 2025-09-23 |
| A Study of Inhaled Fentanyl Aerosol in Chinese Patients With Malignant Tumors (NCT06953453) | Lee's Pharmaceutical Limited | 2025-09-23 |
| An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera (NCT07148999) | Urmila DIwekar | 2025-09-23 |
| Clinical Study to Evaluate XS411 in Treatment of Early-onset Parkinson's Disease (NCT07166757) | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | 2025-09-22 |
| FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma (NCT06865664) | National Cancer Institute (NCI) | 2025-09-22 |
| A Study of YL242 in Subjects With Advanced Solid Tumors (NCT07197827) | MediLink Therapeutics (Suzhou) Co., Ltd. | 2025-09-22 |
| Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003) (NCT07089784) | Merck Sharp & Dohme LLC | 2025-09-22 |
| A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors (NCT07198321) | Genfleet Therapeutics (Shanghai) Inc. | 2025-09-22 |
| VSV-02 Compassionate Use in Advanced Solid Tumors (NCT07260591) | The First Affiliated Hospital of Xinxiang Medical College | 2025-09-22 |
| A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC) (NCT07140016) | Astellas Pharma Global Development, Inc. | 2025-09-22 |
| Warrior CARE: Cannabis Behavioral Health (NCT06381180) | Wayne State University | 2025-09-22 |
| Pharmacokinetic Study of a Novel Cannabidiol (CBD) Formulation in Healthy Volunteers (NCT07186283) | NW PharmaTech Ltd | 2025-09-22 |
| A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC) (NCT07111520) | BioNTech SE | 2025-09-22 |
| A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 (NCT07160738) | Pfizer | 2025-09-22 |
| I.V. Selonabant in Healthy Adult Subjects (NCT07211607) | Anebulo Pharmaceuticals | 2025-09-22 |
| DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer (NCT06964009) | Elizabeth Stover, MD, PhD | 2025-09-22 |
| A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers. (NCT07176728) | Bayer | 2025-09-22 |
| Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian (NCT07399626) | Babes-Bolyai University | 2025-09-22 |