| Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia (NCT05357482) | National Heart, Lung, and Blood Institute (NHLBI) | 2022-05-12 |
| A Low-Interventional Study of an Electronic Sickle Cell Disease Patient Reported Outcomes in Sickle Cell Participants (NCT06503458) | Sanguine Biosciences | 2022-01-19 |
| Management of Severe Acute Malnutrition in SCD, in Northern Nigeria (NCT03634488) | Vanderbilt University Medical Center | 2021-08-18 |
| A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD (NCT04201210) | University of Regensburg | 2021-06-30 |
| Stroke Prevention in Young Adults With Sickle Cell Anemia (NCT04808778) | Vanderbilt University Medical Center | 2021-05-17 |
| Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease (NCT04476277) | National Heart, Lung, and Blood Institute (NHLBI) | 2021-04-19 |
| A Long-term Follow-up Study in Participants Who Received CTX001 (NCT04208529) | Vertex Pharmaceuticals Incorporated | 2021-01-20 |
| Actigraphy Improvement With Voxelotor (ActIVe) Study (NCT04400487) | Pfizer | 2020-12-21 |
| Voxelotor Sickle Cell Exercise Study (NCT04581356) | Elizabeth Yang, MD, PhD | 2020-09-21 |
| ERN-EuroBloodNet Registry on Patients With Rare Red Blood Cell Defects and COVID-19 (NCT06831799) | Hospital Universitari Vall d'Hebron Research Institute | 2020-04-15 |
| The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria (NCT04800809) | Vanderbilt University Medical Center | 2020-04-01 |
| Physical Rehabilitation in Sickle Cell Anemia (NCT04705792) | Centro Universitário Augusto Motta | 2020-01-31 |
| Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation (NCT04093986) | Children's Hospital Medical Center, Cincinnati | 2019-12-22 |
| To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease (NCT04134299) | Axcella Health, Inc | 2019-09-25 |
| Hydroxyurea Optimization Through Precision Study (NCT03789591) | Lifespan | 2019-01-17 |
| T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias (NCT03653338) | Paul Szabolcs | 2018-08-02 |
| Shared-Decision Making for Hydroxyurea (NCT03442114) | Children's Hospital Medical Center, Cincinnati | 2018-07-12 |
| Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas (NCT03128515) | Indiana University | 2017-07-26 |
| Hydroxyurea Management in Kids: Intensive Versus Stable Dosage Strategies (NCT03020615) | St. Jude Children's Research Hospital | 2017-05-12 |
| Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia (NCT02961218) | Novartis Pharmaceuticals | 2017-04-05 |
| Hydoxyurea Exposure in Lactation A Pharmacokinetics Study (HELPS) (NCT02990598) | Children's Hospital Medical Center, Cincinnati | 2017-03-20 |
| Fetal Hemoglobin Induction Treatment Metformin (NCT02981329) | Baylor College of Medicine | 2017-03-02 |
| Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa (NCT02675790) | Vanderbilt University Medical Center | 2017-01-01 |
| The Influence of micro-and Macro Vascular Dysfunction on Clinical Severity in Adults With Sickle Cell Anemia (SS) and Sickle Cell Hemoglobin C Disease (SC) (NCT07277023) | Centre Hospitalier Universitaire de la Guadeloupe | 2016-04-29 |
| Measures of Respiratory Health (MRH) (NCT02657837) | The Hospital for Sick Children | 2016-01-01 |
| Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease (NCT02433158) | GlycoMimetics Incorporated | 2015-12-16 |
| Hematopoietic Stem Cell Transplant for Sickle Cell Disease (NCT02065596) | Case Comprehensive Cancer Center | 2015-10-19 |
| Carbon Monoxide Measurement to Screen for Sickle Cell Disease (NCT02530242) | UCSF Benioff Children's Hospital Oakland | 2015-07-01 |
| Evaluation of the AMICUS RBCx System in Sickle Cell Patients (NCT02372877) | Fenwal, Inc. | 2015-05-01 |
| Decision Aid for Therapeutic Options In Sickle Cell Disease (NCT02326597) | Emory University | 2015-01-01 |
| Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease (NCT02445144) | Albert Einstein College of Medicine | 2014-11-01 |
| Novel Use Of Hydroxyurea in an African Region With Malaria (NCT01976416) | Indiana University | 2014-09-01 |
| Study of Beet Juice for Patients With Sickle Cell Anemia (NCT02162225) | Wake Forest University Health Sciences | 2014-09-01 |
| EXTEND EXpanding Treatment for Existing Neurological Disease (NCT02556099) | Children's Hospital Medical Center, Cincinnati | 2014-08-01 |
| Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell Anemia (NCT02467257) | Al-Neelain University | 2014-04-01 |
| Hepcidin Levels in Sickle Cell Disease (SCD) (NCT02258997) | Kenneth Ataga, MD | 2014-03-01 |
| Risk-based Therapy for Sickle Cell Anemia: A Feasibility Study (NCT02090296) | Children's National Research Institute | 2014-02-01 |
| Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis (NCT01925001) | Sangart | 2013-10-01 |
| At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions (NCT01931644) | Sanguine Biosciences | 2013-07-01 |
| A Phase II Trial of Regadenoson in Sickle Cell Anemia (NCT01788631) | Dana-Farber Cancer Institute | 2013-07-01 |
| Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease (NCT01894594) | University Hospitals Cleveland Medical Center | 2013-06-01 |
| Effect of Exercise With and Without HMB on Body Composition and Muscle Strength in Sickle Cell Anaemia (NCT04001907) | The University of The West Indies | 2013-04-30 |
| Sickle Cell Disease - Stroke Prevention in Nigeria Trial (NCT01801423) | Vanderbilt University Medical Center | 2013-04-24 |
| A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease (NCT01800526) | Bloodworks | 2013-03-01 |
| Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia (NCT02565849) | Rio de Janeiro State University | 2013-02-01 |
| Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (NCT01758042) | Massachusetts General Hospital | 2012-11-01 |
| Carbon Monoxide Monitor for the Measurement of End-Tidal Carbon Monoxide Levels in Children With or Without Hemolysis (NCT01848691) | Ashutosh Lal | 2012-10-01 |
| Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II Protocol (NCT01783990) | National Heart, Lung, and Blood Institute (NHLBI) | 2012-10-01 |
| Microvascular Blood Flow in Sickle Cell Anemia (NCT01566890) | Versiti Blood Health | 2012-07-01 |
| Bi-Level Positive Airway Ventilation for Acute Chest Syndrome (NCT01589926) | Albert Einstein College of Medicine | 2012-07-01 |
| Effects of HQK-1001 in Patients With Sickle Cell Disease (NCT01601340) | HemaQuest Pharmaceuticals Inc. | 2012-07-01 |
| Sparing Conversion to Abnormal TCD (Transcranial Doppler) Elevation (SCATE) (NCT01531387) | Children's Hospital Medical Center, Cincinnati | 2012-05-01 |
| Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose (NCT03114137) | Cardiologie et Développement | 2012-03-01 |
| Losartan to Reverse Sickle Nephropathy (NCT01479439) | Children's Hospital Medical Center, Cincinnati | 2012-02-01 |
| Carbon Monoxide Levels and Sickle Cell Disease Severity (NCT01547793) | National Heart, Lung, and Blood Institute (NHLBI) | 2012-01-26 |
| Safety Study of MP4CO in Adult Sickle Cell Patients (NCT01356485) | Sangart | 2012-01-01 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia (NCT01703104) | Lagos State University | 2012-01-01 |
| Sickle Cell Anemia - A Comparative Study Between Three Ethnical Communities, a Multicenter Study (NCT01905787) | HaEmek Medical Center, Israel | 2012-01-01 |
| Pharmacokinetics (PK) of Liquid Hydroxyurea in Pediatric Patients With Sickle Cell Anemia (NCT01506544) | Children's Mercy Hospital Kansas City | 2011-12-01 |
| Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (NCT01425307) | Children's Hospital Medical Center, Cincinnati | 2011-08-01 |
| Sickle Cell Disease: A Retrospective Chart Review (NCT01441375) | Novartis Pharmaceuticals | 2011-07-01 |
| A Study of HQK-1001 in Patients With Sickle Cell Disease (NCT01322269) | HemaQuest Pharmaceuticals Inc. | 2011-04-01 |
| Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders (NCT01316796) | National Heart, Lung, and Blood Institute (NHLBI) | 2011-03-15 |
| Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy (NCT01340404) | Assistance Publique - Hôpitaux de Paris | 2010-12-01 |
| State Of The Art Functional Imaging In Sickle Cell Disease (NCT01137721) | St. Jude Children's Research Hospital | 2010-09-01 |
| Prasugrel Versus Placebo in Adult Sickle Cell Disease (NCT01167023) | Eli Lilly and Company | 2010-07-01 |
| A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia (NCT01179217) | Emmaus Medical, Inc. | 2010-05-01 |
| Ranibizumab for Neovascularization in Sickle Cell Retinopathy (NCT00618644) | Kresge Eye Institute | 2010-01-01 |
| Haploidentical PBMC Transplant for Severe Congenital Anemias (NCT00977691) | National Heart, Lung, and Blood Institute (NHLBI) | 2009-12-14 |
| Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia (NCT01783093) | Namita Sood | 2009-12-01 |
| Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease (NCT01000155) | Dana-Farber Cancer Institute | 2009-10-01 |
| Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic Strategy (NCT00874172) | Assistance Publique - Hôpitaux de Paris | 2009-10-01 |
| Treatment of Sickle Cell Anemia With Stem Cell Transplant (NCT01350232) | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 2009-09-01 |
| Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil (NCT00937144) | The Baruch Padeh Medical Center, Poriya | 2009-09-01 |
| Exercise Capacity in Pediatric Sickle Cell Anemia (NCT01527799) | Ann & Robert H Lurie Children's Hospital of Chicago | 2009-06-01 |
| Blood Transfusions in Thalassemia Patients, Complications and Adverse Effects (NCT00971880) | HaEmek Medical Center, Israel | 2009-05-01 |
| The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia (NCT00971698) | HaEmek Medical Center, Israel | 2009-02-01 |
| Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia (NCT00512564) | HaEmek Medical Center, Israel | 2008-09-01 |
| Bone Marrow for Hemoglobinopathy Research (NCT00669305) | St. Jude Children's Research Hospital | 2008-05-15 |
| Sickle Cell Anemia Screening and Prevention in Northern Israel (NCT00735488) | HaEmek Medical Center, Israel | 2008-05-01 |
| Clinical Diagnosis of Teenagers Admitted to Pediatric Departments (NCT00735540) | HaEmek Medical Center, Israel | 2008-05-01 |
| Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With Fever (NCT00736060) | HaEmek Medical Center, Israel | 2008-05-01 |
| Adherence to Hydroxyurea in Children With Sickle Cell Anemia (NCT00672789) | Duke University | 2008-04-01 |
| Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia (NCT00011648) | National Heart, Lung, and Blood Institute (NHLBI) | 2008-02-19 |
| Blood Sampling for Research Related to Sickle Cell Disease (NCT00542230) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2007-11-07 |
| Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia (NCT00512226) | HaEmek Medical Center, Israel | 2007-09-01 |
| Pulmonary Hypertension, Hypoxia and Sickle Cell Disease (NCT00495638) | National Heart, Lung, and Blood Institute (NHLBI) | 2007-06-28 |
| Long Term Follow up in Sickle Cell Patients Treated by Hydroxyurea (NCT00480974) | HaEmek Medical Center, Israel | 2007-05-01 |
| Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia (NCT00538564) | Johns Hopkins University | 2006-11-01 |
| Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia (NCT00399074) | Makerere University | 2006-10-01 |
| Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain (NCT00236093) | Cephalon | 2006-10-01 |
| Exercise-induced Pulmonary Hypertension in Patients With Sickle-cell Anemia (NCT00948012) | Federal University of São Paulo | 2006-06-01 |
| A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study (NCT00360087) | Actelion | 2006-03-01 |
| A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy (NCT00294541) | Icagen | 2006-02-01 |
| Invasive Infections in Children With Hemoglobinopathies (NCT00456443) | HaEmek Medical Center, Israel | 2006-01-01 |
| Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial (NCT00072761) | Washington University School of Medicine | 2004-12-01 |
| Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease (NCT00095472) | National Heart, Lung, and Blood Institute (NHLBI) | 2004-11-01 |
| L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia (NCT00125788) | Emmaus Medical, Inc. | 2004-03-01 |
| L-Glutamine Therapy for Sickle Cell Anemia (NCT00586209) | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 2004-02-06 |
| Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia (NCT00056433) | National Institutes of Health Clinical Center (CC) | 2003-03-10 |