| Digital Therapeutic for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) (NCT05016050) | Happify Inc. | 2021-08-09 |
| EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT (NCT05006365) | The Hong Kong Polytechnic University | 2021-08-02 |
| Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression (NCT06331572) | First Affiliated Hospital of Chongqing Medical University | 2021-08-01 |
| IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL) (NCT04629599) | Michigan State University | 2021-08-01 |
| Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder (NCT04985942) | Intra-Cellular Therapies, Inc. | 2021-07-30 |
| ECT vs. Esketamine (NCT04924257) | Medical University Innsbruck | 2021-07-28 |
| Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression (NCT04935619) | Centre for Addiction and Mental Health | 2021-07-21 |
| GW117 ODT （Orally Disintegrating Tablets） Safety and Pharmacokinetics Study in Healthy Subjects (NCT06964711) | Beijing Greatway Pharmaceutical Technology Co.,Ltd. | 2021-07-12 |
| D-serine Supplementation for Depression (NCT04721249) | André Schmidt | 2021-07-01 |
| Antidepressant Effects of Nitrous Oxide (NCT05357040) | University of Chicago | 2021-06-30 |
| A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder (NCT04969510) | Praxis Precision Medicines | 2021-06-24 |
| Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression (NCT04953208) | Mor Nahum | 2021-06-22 |
| Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders (NCT04939818) | Novoic Limited | 2021-06-14 |
| Treatment Response Biomarkers in MDD (NCT05585047) | Zhang Yan | 2021-06-10 |
| Mechanism of Action of tACS for the Treatment of MDD (NCT03994081) | University of North Carolina, Chapel Hill | 2021-06-09 |
| A Study to Assess the Efficacy and Safety of REL-1017 as Monotherapy for Major Depressive Disorder (MDD) (NCT05081167) | Relmada Therapeutics, Inc. | 2021-06-02 |
| Tracking Response to Antidepressants in Advance of Investigational Trials, Relapse Study (NCT04933630) | Adams Clinical | 2021-06-01 |
| Sumor as Adjuvant Therapy in Treatment-resistant Major Depression (NCT04832178) | Azienda Ospedaliero-Universitaria Careggi | 2021-06-01 |
| Reward Processing and Depressive Subtypes: Identifying Neural Biotypes (NCT06080646) | San Francisco Veterans Affairs Medical Center | 2021-06-01 |
| Closed-loop Optimized rTMS for Depression (NCT04142320) | Stanford University | 2021-06-01 |
| Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study (NCT05054699) | University of Sao Paulo | 2021-05-31 |
| Can the Affects Conveyed by Baroque Music Reduce Anxiety in Patients With Major Depressive Disorder ? (NCT04903522) | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | 2021-05-28 |
| Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study (NCT04889976) | University of Sao Paulo | 2021-05-22 |
| Neural Response to Inflammatory Challenge in Major Depressive Disorder (NCT04751331) | Laureate Institute for Brain Research, Inc. | 2021-05-15 |
| Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep (NCT04832750) | University of Oldenburg | 2021-05-03 |
| Naturalistic Study of Ketamine in the Treatment of Depression (NCT05249309) | Hospital de Clinicas de Porto Alegre | 2021-05-01 |
| Boosting Psychotherapy Effects by Means of Transcranial Direct Current Stimulation (NCT05866042) | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 2021-05-01 |
| Stress and the Sympathetic Nervous System in Adults With Depression (NCT04838262) | University of Delaware | 2021-05-01 |
| Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive Disorder (NCT04847245) | Peking University | 2021-05-01 |
| Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts (NCT04225624) | Massachusetts General Hospital | 2021-04-30 |
| Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray (NCT04843462) | Lukas Pezawas | 2021-04-29 |
| Clonidine to Prevent Delirium After Electroconvulsive Therapy. (NCT04828226) | Insel Gruppe AG, University Hospital Bern | 2021-04-27 |
| Neural Correlates of Stress and Perceived Control in Adolescent Depression (NCT04788524) | Mclean Hospital | 2021-04-23 |
| Using Voice Biomarkers to Predict the Likelihood of Major Depressive Disorder (NCT04874077) | Kintsugi Mindful Wellness, Inc. | 2021-04-21 |
| MAO-B Occupancy in Depressed Patients (NCT04841798) | Centre for Addiction and Mental Health | 2021-04-15 |
| Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder (NCT04620759) | Johns Hopkins University | 2021-04-14 |
| An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients (NCT04971291) | Axsome Therapeutics, Inc. | 2021-04-14 |
| Incorporating Stepped Care Approach Into e-CBT for Depression (NCT04747873) | Dr. Nazanin Alavi | 2021-04-07 |
| Exploring Engagement With Remote Symptom Tracking for Depression (RADAR: Engage) (NCT04972474) | King's College London | 2021-04-07 |
| Safety of REL-1017 for Major Depressive Disorder (NCT04855760) | Relmada Therapeutics, Inc. | 2021-04-01 |
| The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression (NCT04602715) | NuBiyota | 2021-04-01 |
| Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder (NCT04830215) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2021-04-01 |
| A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) (NCT04855747) | Levomecor Inc. | 2021-03-30 |
| A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder (NCT04832425) | Praxis Precision Medicines | 2021-03-30 |
| The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant Depression (NCT04530942) | Ruijin Hospital | 2021-03-29 |
| iCBT With TMS in Patients With MDD (NCT05988619) | University of California, Los Angeles | 2021-03-21 |
| Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans (NCT04711915) | Yale University | 2021-03-17 |
| Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders (NCT04675593) | Case Western Reserve University | 2021-03-15 |
| OMT as an Adjunctive Treatment in MDD (NCT05065580) | Corewell Health South | 2021-03-12 |
| Internet-delivered Cognitive Behavioral Treatment of Depression and Anxiety in Latin American College Students (NCT04780542) | Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente | 2021-03-01 |
| 5-HTP and Creatine for Depression (NCT04395183) | University of Utah | 2021-03-01 |
| Optimisation of ECT Based on ASTI vs Narcotrend (NCT04657575) | Medical University Innsbruck | 2021-03-01 |
| Electroconvulsive Therapy Amplitude Titration (NCT04621786) | University of New Mexico | 2021-03-01 |
| Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder in Viet Nam (NCT04826614) | University of Medicine and Pharmacy at Ho Chi Minh City | 2021-03-01 |
| MicroRNA Correlates of Childhood Maltreatment and Suicidality (NCT04923685) | University of Alabama at Birmingham | 2021-02-26 |
| Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive Disorder (NCT04770285) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2021-02-25 |
| Use of a Digitally Enabled App With Clinical Team Interface in the Management of Depression (NCT04891224) | Wake Forest University Health Sciences | 2021-02-19 |
| Cognitive Behavioral Therapy Group for Older Adults Delivered by Telethealth (NCT04714164) | Nova Scotia Health Authority | 2021-02-18 |
| SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients (NCT04673383) | Small Pharma Ltd | 2021-02-04 |
| Symptom-specific TMS Targets for Depression and Anxiety (NCT04604210) | Brigham and Women's Hospital | 2021-02-03 |
| Comparing Group Therapies for Veterans With Depression and PTSD (NCT03979040) | VA Office of Research and Development | 2021-02-03 |
| Maternal Mental Health Trial (NCT04685148) | Vibe G Frøkjær, MD, PhD | 2021-02-03 |
| Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis (NCT04423471) | Germans Trias i Pujol Hospital | 2021-02-01 |
| The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients (NCT04751071) | Sadat City University | 2021-02-01 |
| Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression (NCT04448327) | Massachusetts General Hospital | 2021-01-29 |
| A Study of HS-10353 in Chinese Participants. (NCT05195203) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2021-01-27 |
| ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators (NCT01590862) | Massachusetts General Hospital | 2021-01-23 |
| rTMS for Depression in Young Adults With Autism (NCT04972136) | Centre for Addiction and Mental Health | 2021-01-14 |
| The Efficacy of Automated Feedback After Internet-based Depression Screening (NCT04633096) | Universitätsklinikum Hamburg-Eppendorf | 2021-01-12 |
| Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine (NCT04711005) | National Institute of Mental Health (NIMH) | 2021-01-11 |
| Appalachian Mind Health Initiative (NCT04120285) | University of South Florida | 2021-01-09 |
| A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) (NCT04688164) | Relmada Therapeutics, Inc. | 2021-01-08 |
| Model-based Defining of Subtypes of Depression and Optimal Treatment: an Integrated Techniques Module. (NCT04518592) | Shanghai Mental Health Center | 2020-12-22 |
| Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive Disorder (NCT04619121) | China Medical University Hospital | 2020-12-21 |
| Non-Inferiority RCT Comparing Online and On-Site CBT in MDDi (NCT04825535) | Centre for Addiction and Mental Health | 2020-12-15 |
| Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression (NCT04507243) | University of California, Los Angeles | 2020-12-01 |
| Supportive-Expressive and Emotion-Focused Treatment for Depression (NCT04576182) | University of Haifa | 2020-11-29 |
| Psychophysiological Study of Pain Perception in Depressed Patients With Suicidal Risk (NCT04461327) | University Hospital, Montpellier | 2020-11-25 |
| Mechanisms of Emotion Regulation Underlying Successful CBT in Depression (NCT04328103) | New York State Psychiatric Institute | 2020-11-25 |
| Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders (NCT05840861) | Central South University | 2020-11-05 |
| Interactive Voice-Based Administration of the PHQ-9 (NCT04609267) | Oklahoma State University Center for Health Sciences | 2020-11-03 |
| University of Iowa Interventional Psychiatry Service Patient Registry (NCT04480918) | Mark Niciu | 2020-11-02 |
| Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1) (NCT04607226) | Massachusetts General Hospital | 2020-11-02 |
| Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy Subjects (NCT04598607) | Zhejiang Huahai Pharmaceutical Co., Ltd. | 2020-10-30 |
| Bear Bile Pill as add-on the Treatment of MDD (NCT04509882) | Shanghai Mental Health Center | 2020-10-30 |
| Assessment of Transcultural Psychotherapy in Child Major Depressive Disorder (NCT04206969) | Assistance Publique - Hôpitaux de Paris | 2020-10-28 |
| Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human Volunteers (NCT04618263) | Syndeio Biosciences, Inc | 2020-10-26 |
| Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses (NCT04276259) | Marta Peciña, MD PhD | 2020-10-19 |
| Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression (NCT04487730) | Weill Medical College of Cornell University | 2020-10-15 |
| Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion (NCT04388189) | Alto Neuroscience | 2020-10-15 |
| Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram (NCT04388202) | Alto Neuroscience | 2020-10-15 |
| eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk (NCT04437485) | Indiana University | 2020-10-14 |
| Ketamine Treatment Effects on Synaptic Plasticity in Depression (NCT04091971) | New York State Psychiatric Institute | 2020-10-09 |
| A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatine (NCT04589143) | Central South University | 2020-10-01 |
| Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment Classification (NCT04528628) | Shanghai Mental Health Center | 2020-10-01 |
| Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder (NCT04293341) | VA Office of Research and Development | 2020-10-01 |
| PKC as Serum Biomarkers for Depression (NCT04531423) | Shanghai Mental Health Center | 2020-10-01 |
| A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder (NCT04479852) | Sirtsei Pharmaceuticals, Inc. | 2020-09-30 |
| Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation (NCT04392947) | University Hospital Tuebingen | 2020-09-29 |
| Home-based tDCS in Major Depressive Disorder (NCT04799405) | Hebrew SeniorLife | 2020-09-24 |