| Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease (NCT05378945) | Corxel Pharmaceuticals | 2022-07-22 |
| Feasibility of IPL Combined With RF for Treatment of DED Due to MGD (NCT05487547) | Lumenis Be Ltd. | 2022-07-21 |
| Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3) (NCT05360966) | Aerie Pharmaceuticals | 2022-07-18 |
| A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dry Eye Disease (NCT05403827) | Kowa Research Institute, Inc. | 2022-07-03 |
| PMCF Study to Evaluate Performance and Safety of "Hyaluronic Acid (HA)-Based Eyedrops" Used to Relieve Dry Eye Symptoms (NCT05807360) | C.O.C. Farmaceutici S.r.l. | 2022-06-24 |
| A Study of AG-80308 in Dry Eye Patients (NCT05372107) | Allgenesis Biotherapeutics Inc. | 2022-06-13 |
| PMCF Study to Evaluate Performance and Safety of "CLHA-based Eyedrops" Used to Improve Lacrimal Abnormalities (NCT05823961) | C.O.C. Farmaceutici S.r.l. | 2022-06-10 |
| PMCF Study to Evaluate Performance and Safety of "Optrex Double Action Soothing and Lubricating Drops" (NCT05824000) | C.O.C. Farmaceutici S.r.l. | 2022-06-07 |
| Burden of Illness and Treatment Assessment of Patients With Dry Eye Disease: A Cross-Sectional Survey of Real-World Patients With Dry Eye Disease in the US (NCT06018571) | Novartis Pharmaceuticals | 2022-06-02 |
| Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye (NCT06323395) | Jadran Galenski laboratorij d.d. | 2022-06-01 |
| Study Evaluating the Safety and Efficacy of AR-15512 (NCT05285644) | Aerie Pharmaceuticals | 2022-05-09 |
| 2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD (NCT04946721) | University of Maryland, Baltimore | 2022-04-27 |
| Diamond Bur Microblepharoexfoliation, Intense Pulse Light and Meibomian Gland Expression for Evaporative Dry Eye (NCT05857579) | University of Seville | 2022-04-01 |
| Safety Study of Tivanisiran to Treat Dry Eye (NCT05310422) | Sylentis, S.A. | 2022-03-24 |
| PMCF Study to Evaluate Performance and Safety of "Ocular Drops Based Upon Carmellose" Used to Relieve Dry Eye Symptoms (NCT05825352) | C.O.C. Farmaceutici S.r.l. | 2022-03-24 |
| Comparison of Two Types of Artificial Tears (NCT05356728) | The Norwegian Dry Eye Clinic | 2022-03-11 |
| Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye Disease (NCT06122428) | University of Naples | 2022-02-08 |
| Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (NCT05136170) | Dompé Farmaceutici S.p.A | 2022-01-27 |
| A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease (NCT05238597) | Aramis Biosciences, Inc. | 2022-01-25 |
| Systane Hydration in Subjects Undergoing Cataract Surgery (NCT05056233) | Alcon Research | 2022-01-18 |
| Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness (NCT05187533) | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 2022-01-15 |
| Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease (NCT05119920) | Glaukos Corporation | 2022-01-03 |
| Safety of Tinted Soft Scleral Eye Shields When IPL is Applied on Eyelids (NCT05168670) | Lumenis Be Ltd. | 2021-12-21 |
| Study Evaluating Techniques for Measuring Tear Production (NCT05497479) | Aerie Pharmaceuticals | 2021-12-09 |
| Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease (NCT06221345) | Chang Gung Memorial Hospital | 2021-12-07 |
| IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL (NCT05136924) | Vance Thompson Vision - MT | 2021-12-01 |
| Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST) (NCT07469865) | University Hospital, Ghent | 2021-11-30 |
| Ditefossol Sodium 3% Eye Drops in Patients With Dry Eye (NCT06560580) | Tianjin Eye Hospital | 2021-11-15 |
| Systane Complete Multi-symptom Relief (NCT05056155) | Alcon Research | 2021-11-09 |
| Strip Meniscometry in Dry Eye Evaluation (NCT06120894) | University Hospital Olomouc | 2021-11-01 |
| Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK) (NCT05082974) | Vance Thompson Vision ND | 2021-10-20 |
| The Evaluation of the Transcutaneous Electrical Stimulation Medical Device's Safety and Effectiveness in Treating the Patients With Dry Eye Disease (NCT05203796) | Nu Eyne Co., Ltd. | 2021-08-23 |
| Corneal Thickness Changes in Patient Undergoing Dry Eye Managment (NCT04970329) | University of Faisalabad | 2021-07-01 |
| Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye (NCT06696625) | Beijing Tongren Hospital | 2021-07-01 |
| Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease (NCT04673643) | Beijing Tongren Hospital | 2021-07-01 |
| Efficacy of Blue Wavelength in Managing Dry Eye (NCT04965974) | University of Faisalabad | 2021-07-01 |
| Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome (NCT04819269) | Sylentis, S.A. | 2021-05-25 |
| Study of ST-100 as Treatment for Dry Eye Disease (NCT05241470) | Stuart Therapeutics, Inc. | 2021-05-17 |
| Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Disease (NCT04785261) | China Medical University Hospital | 2021-03-16 |
| Efficacy and Safety of SHR8028 Eye Drops for the Treatment of Dry Eye Disease (NCT05841043) | Jiangsu HengRui Medicine Co., Ltd. | 2021-03-04 |
| Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease (NCT05604651) | Peking University Third Hospital | 2021-03-01 |
| Safety and Efficacy of Two Different Concentrations (0.5% and 1%) of Progesterone Topical Gel Compared to Placebo in Patients Diagnosed With Moderate to Severe Dry Eye Syndrome (NCT04645446) | SIFI SpA | 2021-02-18 |
| Comparison of Efficacy Between 100% Platelet-rich Plasma and 100% Serum Eye Drops in Dry Eye Disease (NCT04683796) | Mahidol University | 2021-02-01 |
| Multimodal Screening of Dry Eye Disease (NCT04235400) | Assistance Publique - Hôpitaux de Paris | 2021-01-28 |
| A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease (NCT04735393) | Aldeyra Therapeutics, Inc. | 2021-01-26 |
| Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery (NCT04711642) | Fundación Oftalmológica Los Andes | 2021-01-15 |
| A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease (NCT04734197) | Surface Ophthalmics, Inc. | 2021-01-11 |
| Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease (NCT04734210) | Surface Ophthalmics, Inc. | 2021-01-07 |
| Pre-Surgical Ocular Surface Treatment With Intracanalicular Dexamethasone Insert And Effect On Intraocular Lens Measurement Accuracy (NCT04530864) | Prism Vision Group | 2021-01-01 |
| ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) (NCT04523129) | Novaliq GmbH | 2020-12-05 |
| A Phase 2b Study Evaluating the Safety and Efficacy of AR-15512 Ophthalmic Solution for the Treatment of Dry Eye Disease (NCT04498182) | Aerie Pharmaceuticals | 2020-10-26 |
| Study on Safety and Performance of an Artificial Tear in Dry Eye Treatment in Subjects With Ocular Surface Inflammation (NCT04633863) | MD Italy | 2020-10-12 |
| Ocular Microbiome and Immune System in Dry Eyes (NCT04658238) | Insel Gruppe AG, University Hospital Bern | 2020-10-01 |
| Study to Evaluate the Efficacy and Safety of CKD-352 (NCT04548427) | Chong Kun Dang Pharmaceutical | 2020-09-22 |
| Changes in Tear Lipid Layer Thickness After Short Exposure to Light Emitting Diode Displays (NCT05003128) | National Cheng-Kung University Hospital | 2020-07-01 |
| Effect of Cequa™ in Subjects With Dry Eye Disease (NCT04357795) | Sun Pharmaceutical Industries Limited | 2020-06-29 |
| Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI) (NCT04670263) | Adom Advanced Optical Technologies Ltd. | 2020-03-08 |
| A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease (NCT04030962) | AbbVie | 2020-03-04 |
| Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Scheduled for LASEK Surgery (NCT05271422) | Nu Eyne Co., Ltd. | 2020-02-28 |
| Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye (NCT04268069) | ORA, Inc. | 2020-02-14 |
| Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease (NCT04201574) | Allysta Pharmaceutical | 2019-12-16 |
| Refractory Meibomian Gland Dysfunction and Plasma Jet (NCT04608942) | Federal University of São Paulo | 2019-11-11 |
| Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease (NCT04139122) | Senju Pharmaceutical Co., Ltd. | 2019-10-05 |
| The Ocular Microbiome in Patients With Dry Eye Disease (NCT04656197) | Insel Gruppe AG, University Hospital Bern | 2019-09-30 |
| Concentration of Ofloxacin Into the Aqueous Humour of Patients With Dry Eye Disease (NCT05213156) | University Hospital of Patras | 2019-09-24 |
| A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease (NCT04084483) | Kowa Research Institute, Inc. | 2019-08-04 |
| Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC Study) (NCT03873246) | Oyster Point Pharma, Inc. | 2019-02-18 |
| Self-care Management Program for Dry Eye Disease Patients Using the heiQ (NCT03467490) | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2018-11-24 |
| Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation (NCT03688802) | Oyster Point Pharma, Inc. | 2018-09-25 |
| Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects (NCT04762355) | Clementia Pharmaceuticals Inc. | 2018-08-30 |
| Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (NCT03636061) | Oyster Point Pharma, Inc. | 2018-08-15 |
| Evaluation of the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (the RAINIER Study) (NCT03633461) | Oyster Point Pharma, Inc. | 2018-08-14 |
| Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects (NCT03660475) | Sassani, Joseph S., MD, MHA | 2018-07-31 |
| Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease (NCT03492541) | Alcon Research | 2018-07-18 |
| Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease (NCT03287635) | Toyos Clinic | 2018-07-01 |
| Investigating the Effect of At Home Thermal Therapy on Dry Eye Patients With Meibomian Gland Dysfunction (NCT03291704) | UMay Care Inc. | 2018-03-01 |
| Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study) (NCT03452397) | Oyster Point Pharma, Inc. | 2018-02-27 |
| A Dose-Finding Study Comparing InSite Vision, Inc. 101 to Vehicle and DuraSite Alone for Dry Eye Disease (NCT01478555) | Sun Pharmaceutical Industries Limited | 2018-01-01 |
| CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) (NCT03292809) | Novaliq GmbH | 2017-10-19 |
| Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease (NCT03216096) | Santen Pharmaceutical Co., Ltd. | 2017-09-08 |
| HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED) (NCT03108664) | Sylentis, S.A. | 2017-05-18 |
| Femtosecond Small Incision Lenticular Extraction in Comparison to Femtosecond Laser Insitu Keratomileusis Regarding Dry Eye Disease (NCT04477421) | Al-Rasheed University College | 2017-03-01 |
| Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease (NCT03048526) | Novaliq GmbH | 2016-12-15 |
| Fingerprick Autologous Blood (FAB) in Mebomian Gland Dysfunction (MGD) (NCT02943382) | Bedford Hospital NHS Trust | 2016-11-01 |
| Evaluation of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease (NCT02831387) | Parion Sciences | 2016-07-01 |
| Study of the Pharmacodynamic Activity of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease (NCT02824913) | Parion Sciences | 2016-07-01 |
| In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye (NCT02764814) | BioTissue Holdings, Inc | 2015-07-01 |
| A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) (NCT02284516) | Shire | 2014-11-06 |
| Optical Coherence Tomography of Tear Film Dynamics In-Vivo (NCT02554084) | University of Rochester | 2014-11-01 |
| Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca (NCT02254265) | Sun Pharmaceutical Industries Limited | 2014-09-01 |
| Study of the Safety and Tolerability of P 321 Ophthalmic Solution in Subjects With Dry Eye Disease (NCT02242032) | Parion Sciences | 2014-07-01 |
| The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease (NCT02260960) | Physician Recommended Nutriceuticals | 2014-03-01 |
| Ocular Surface Immune Response in Dry Eye Disease (NCT02042820) | Tufts Medical Center | 2014-01-01 |
| A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis® (NCT02028312) | Edward Holland, MD | 2014-01-01 |
| NovaTears® Eye Drops Observational Study (NCT02111928) | Novaliq GmbH | 2013-12-01 |
| A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye Disease (NCT01664949) | Allergan | 2013-01-01 |
| A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye (NCT01743729) | Shire | 2012-12-07 |
| Safety Study of Lifitegrast to Treat Dry Eye (NCT01636206) | Shire | 2012-10-16 |
| Systane Ultra Versus Maxidex Versus Saline (NCT01775540) | Icahn School of Medicine at Mount Sinai | 2012-05-01 |
| A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients (NCT01468168) | Santen Inc. | 2011-10-01 |