| A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (NCT04978727) | Children's Oncology Group | 2022-07-01 |
| rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG (NCT04943848) | Ann & Robert H Lurie Children's Hospital of Chicago | 2022-01-10 |
| Combination Therapy for the Treatment of Diffuse Midline Gliomas (NCT05009992) | University of California, San Francisco | 2021-10-20 |
| PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy (NCT04837547) | University of Florida | 2021-09-20 |
| Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) (NCT04804709) | Columbia University | 2021-07-28 |
| A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) (NCT04771897) | Bexion Pharmaceuticals, Inc. | 2021-05-24 |
| A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion (NCT04655404) | Nationwide Children's Hospital | 2021-04-08 |
| Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children (NCT04532229) | Biotech Pharmaceutical Co., Ltd. | 2021-04-03 |
| Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma (NCT04749641) | Yang Zhang | 2021-03-08 |
| Phase I Study of Marizomib + Panobinostat for Children With DIPG (NCT04341311) | Dana-Farber Cancer Institute | 2020-08-10 |
| 9-ING-41 in Pediatric Patients With Refractory Malignancies. (NCT04239092) | Actuate Therapeutics Inc. | 2020-06-05 |
| CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas (NCT04264143) | Luca Szalontay | 2020-03-10 |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors (NCT04185038) | Seattle Children's Hospital | 2019-12-11 |
| Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG (NCT04049669) | Theodore S. Johnson | 2019-10-02 |
| A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas (NCT03632317) | University of Michigan Rogel Cancer Center | 2019-10-01 |
| Fimepinostat in Treating Brain Tumors in Children and Young Adults (NCT03893487) | Sabine Mueller, MD, PhD | 2019-08-07 |
| Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors (NCT03709680) | Pfizer | 2019-05-24 |
| REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma (NCT03690869) | Regeneron Pharmaceuticals | 2018-09-24 |
| A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma (NCT03605550) | Nationwide Children's Hospital | 2018-08-01 |
| International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (NCT03243461) | University of Göttingen | 2018-07-17 |
| ONC201 in Pediatric H3 K27M Gliomas (NCT03416530) | Jazz Pharmaceuticals | 2018-01-25 |
| A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) (NCT03355794) | Children's Hospital Medical Center, Cincinnati | 2017-11-14 |
| CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009) (NCT03086616) | Sabine Mueller, MD, PhD | 2017-10-31 |
| A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG (NCT03330197) | Alaunos Therapeutics | 2017-09-26 |
| Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG (NCT03033992) | Children's Oncology Group | 2017-04-04 |
| H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas (NCT02960230) | Sabine Mueller, MD, PhD | 2016-11-18 |
| Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma (NCT02992015) | University of Colorado, Denver | 2016-09-23 |
| Safety Study of DIPG Treatment With Autologous Dendritic Cells Pulsed With Lysated Allegenic Tumor Lines (NCT02840123) | Fundació Sant Joan de Déu | 2016-06-01 |
| A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG) (NCT02742883) | Burzynski Research Institute | 2016-04-13 |
| A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas (NCT02750891) | Sumitomo Pharma Co., Ltd. | 2016-04-01 |
| Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (NCT02644460) | Emory University | 2016-02-01 |
| Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma (NCT02420613) | M.D. Anderson Cancer Center | 2015-10-05 |
| Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors (NCT02502708) | NewLink Genetics Corporation | 2015-10-01 |
| Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors (NCT02444546) | Mayo Clinic | 2015-06-21 |
| Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication (NCT02233049) | Gustave Roussy, Cancer Campus, Grand Paris | 2014-10-01 |
| Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (NCT01922076) | National Cancer Institute (NCI) | 2013-09-03 |
| Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 (NCT01884740) | Weill Medical College of Cornell University | 2013-06-01 |
| Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG) (NCT01644773) | St. Jude Children's Research Hospital | 2012-11-27 |
| Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma (NCT01400672) | Masonic Cancer Center, University of Minnesota | 2012-07-17 |
| International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository (NCT03101813) | Children's Hospital Medical Center, Cincinnati | 2012-06-01 |
| Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) (NCT01182350) | Karen D. Wright MD | 2011-09-01 |
| PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma (NCT01393912) | St. Jude Children's Research Hospital | 2011-07-01 |
| Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas (NCT01222754) | National Cancer Institute (NCI) | 2010-11-23 |
| Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma (NCT01165333) | Centre Oscar Lambret | 2010-09-06 |
| Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (NCT01189266) | National Cancer Institute (NCI) | 2010-08-09 |
| Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma (NCT01106794) | Children's National Research Institute | 2010-04-01 |
| Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) (NCT00996723) | St. Jude Children's Research Hospital | 2009-10-01 |
| Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma (NCT00879437) | Baylor College of Medicine | 2009-09-01 |
| A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas (NCT00890786) | Children's Hospital Medical Center, Cincinnati | 2009-05-01 |
| Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors (NCT01445288) | National Cancer Institute (NCI) | 2006-12-05 |
| A Phase II Study of Pegylated Interferon Alfa 2b (PEG-Intron(Trademark)) in Children With Diffuse Pontine Gliomas (NCT00036569) | National Cancer Institute (NCI) | 2002-05-01 |
| Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered (NCT05518838) | Oblato, Inc. | |