| A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (NCT04978727) | Children's Oncology Group | 2022-07-01 |
| Study of Pembrolizumab and M032 (NSC 733972) (NCT05084430) | University of Alabama at Birmingham | 2022-02-25 |
| Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection (NCT04608812) | OncoSynergy, Inc. | 2021-03-02 |
| Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms (NCT04541082) | Jazz Pharmaceuticals | 2020-10-26 |
| INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas (NCT04295759) | Pediatric Brain Tumor Consortium | 2020-07-27 |
| Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma (NCT03919071) | National Cancer Institute (NCI) | 2020-02-20 |
| Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma (NCT04105374) | NRG Oncology | 2020-01-31 |
| Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas (NCT03971734) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2019-12-06 |
| Pediatric Long-Term Follow-up and Rollover Study (NCT03975829) | Novartis Pharmaceuticals | 2019-11-04 |
| Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG (NCT03973918) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2019-07-29 |
| Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations (NCT03581292) | National Cancer Institute (NCI) | 2018-11-06 |
| 3D Prediction of Patient-Specific Response (NCT03561207) | KIYATEC | 2018-06-11 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors (NCT03434262) | St. Jude Children's Research Hospital | 2018-03-05 |
| HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM (NCT03603405) | The Methodist Hospital Research Institute | 2018-02-28 |
| Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma (NCT03180502) | NRG Oncology | 2018-01-23 |
| Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors (NCT02684058) | Novartis Pharmaceuticals | 2017-12-28 |
| Loupe-Based Intraoperative Fluorescence Imaging (NCT04780009) | Guoqiang Yu | 2017-11-17 |
| A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) (NCT03355794) | Children's Hospital Medical Center, Cincinnati | 2017-11-14 |
| Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children (NCT03043391) | Istari Oncology, Inc. | 2017-11-07 |
| Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 (NCT03332355) | Vanquish Oncology, Inc. | 2017-10-01 |
| Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children (NCT02885324) | Indiana University | 2017-05-18 |
| Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma (NCT03072134) | Northwestern University | 2017-04-24 |
| Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma (NCT02101905) | National Cancer Institute (NCI) | 2016-11-07 |
| FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy (NCT03370926) | University Hospital, Brest | 2016-10-31 |
| Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients (NCT02796261) | Orbus Therapeutics, Inc. | 2016-07-01 |
| HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors (NCT02457845) | Gregory K. Friedman, MD | 2016-05-01 |
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors (NCT02644291) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2016-05-01 |
| Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma (NCT02758366) | Meyer Children's Hospital IRCCS | 2016-02-01 |
| The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma (NCT02414165) | Tocagen Inc. | 2015-11-30 |
| Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors (NCT02372409) | Washington University School of Medicine | 2015-08-14 |
| A Safety Study of Fingolimod With Radiation and Temozolomide in Newly Diagnosed High Grade Glioma (NCT02490930) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2015-07-01 |
| Fluorescein vs. iMRI in Resection of Malignant High Grade Glioma (NCT02540135) | University of Colorado, Denver | 2015-03-01 |
| Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas (NCT02238496) | Andrew B Lassman, MD | 2014-12-08 |
| Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma (NCT02168270) | University of Nebraska | 2014-06-16 |
| Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor (NCT01985256) | Tocagen Inc. | 2014-02-01 |
| Phase I Study of Safety and Immunogenicity of ADU-623 (NCT01967758) | Providence Health & Services | 2014-01-08 |
| Immunophenotyping From Blood of Patients With Malignant Gliomas (NCT02022384) | University of Erlangen-Nürnberg Medical School | 2013-12-01 |
| Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma (NCT02039778) | Beth Israel Medical Center | 2013-12-01 |
| Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas (NCT01849952) | Dartmouth-Hitchcock Medical Center | 2013-10-09 |
| Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (NCT01922076) | National Cancer Institute (NCI) | 2013-09-03 |
| Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma (NCT01808820) | Macarena De La Fuente, MD | 2013-08-21 |
| p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors (NCT01975116) | Pediatric Brain Tumor Consortium | 2013-08-01 |
| Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 (NCT01884740) | Weill Medical College of Cornell University | 2013-06-01 |
| Valproic Acid in Childhood Progressive Brain Tumors (NCT01861990) | Medical University of South Carolina | 2013-05-01 |
| Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors (NCT01836549) | Pediatric Brain Tumor Consortium | 2013-03-01 |
| Re-irradiation of High Grade Gliomas: a Quality of Life Study (NCT01711580) | Maastricht Radiation Oncology | 2013-03-01 |
| Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas (NCT01721577) | Rush University Medical Center | 2012-12-01 |
| Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma (NCT01250470) | Roswell Park Cancer Institute | 2012-09-05 |
| A Phase III Trial on Adjuvant Temozolomide With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas (NCT01765088) | Sun Yat-sen University | 2012-09-01 |
| Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma (NCT01656980) | Shandong Lanjin Pharmaceuticals Co.,Ltd | 2012-08-01 |
| Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma (NCT01637753) | Shandong Lanjin Pharmaceuticals Co.,Ltd | 2012-06-01 |
| Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors (NCT01522820) | Roswell Park Cancer Institute | 2012-03-01 |
| Quality of Life and Patient Needs in Advanced High Grade Gliomas (NCT05039346) | Henry Ford Health System | 2012-02-11 |
| Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas (NCT01514201) | National Cancer Institute (NCI) | 2012-02-01 |
| Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor (NCT01470794) | Tocagen Inc. | 2012-02-01 |
| Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma (NCT01386710) | Northwell Health | 2011-09-01 |
| AZD8055 for Adults With Recurrent Gliomas (NCT01316809) | National Cancer Institute (NCI) | 2011-03-04 |
| (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas (NCT01281982) | National Cancer Institute (NCI) | 2011-01-13 |
| Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas (NCT01222754) | National Cancer Institute (NCI) | 2010-11-23 |
| Dendritic Cell Vaccine for Patients With Brain Tumors (NCT01204684) | Jonsson Comprehensive Cancer Center | 2010-10-08 |
| Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA (NCT01269853) | Northwell Health | 2010-10-01 |
| A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma (NCT01227434) | University of California, San Francisco | 2010-09-01 |
| Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor (NCT01171469) | Masonic Cancer Center, University of Minnesota | 2010-09-01 |
| Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (NCT01189266) | National Cancer Institute (NCI) | 2010-08-09 |
| Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors (NCT01151670) | Wake Forest University Health Sciences | 2010-08-01 |
| Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed GBM And AA (NCT01180816) | Northwell Health | 2010-08-01 |
| A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma (NCT01156584) | Tocagen Inc. | 2010-07-01 |
| Cellular Immunotherapy Study for Brain Cancer (NCT01144247) | Jonsson Comprehensive Cancer Center | 2010-07-01 |
| Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 (NCT01082926) | City of Hope Medical Center | 2010-05-01 |
| Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA (NCT01238237) | Northwell Health | 2009-12-01 |
| Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma (NCT00879437) | Baylor College of Medicine | 2009-09-01 |
| A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas (NCT00995007) | National Cancer Institute (NCI) | 2009-09-01 |
| Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) (NCT00968240) | Northwell Health | 2009-07-01 |
| Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma (NCT00734864) | Annick Desjardins | 2009-06-01 |
| Sorafenib in Newly Diagnosed High Grade Glioma (NCT00884416) | University Hospital, Geneva | 2009-03-01 |
| Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma (NCT01095094) | Case Comprehensive Cancer Center | 2009-01-01 |
| Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma (NCT00761280) | Isarna Therapeutics GmbH | 2008-12-01 |
| Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors (NCT00667394) | National Cancer Institute (NCI) | 2008-04-01 |
| Examination of Changes on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Patients Who Receive Gliadel Wafers During Initial Surgery for Glioblastoma Multiforme. Response or Failure to Gliadel Wafers for Subjects With Glioblastoma Multiforme. (NCT00645385) | Weill Medical College of Cornell University | 2007-06-01 |
| The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas (NCT00473408) | Haukeland University Hospital | 2007-03-01 |
| Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma (NCT00589875) | Candel Therapeutics, Inc. | 2007-03-01 |
| A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma (NCT00606008) | H. Lee Moffitt Cancer Center and Research Institute | 2007-03-01 |
| Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma (NCT00409214) | Light Sciences Oncology | 2006-11-01 |
| Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme (NCT00390299) | Mayo Clinic | 2006-10-23 |
| Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma (NCT00301418) | Northwell Health | 2006-03-01 |
| Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas (NCT00751270) | Candel Therapeutics, Inc. | 2005-11-01 |
| PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas (NCT00612651) | Duke University | 2005-10-01 |
| Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas (NCT00100802) | Children's Oncology Group | 2005-03-21 |
| Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly (NCT01502241) | Heidelberg University | 2005-01-01 |
| 131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma (NCT00114309) | TransMolecular | 2004-11-01 |
| IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma (NCT00089427) | INSYS Therapeutics Inc | 2004-07-01 |
| Phase 2 Trial Using Talampanel in Patients With Recurrent High Grade Gliomas (NCT00062504) | Teva Branded Pharmaceutical Products R&D, Inc. | 2003-07-01 |
| Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma (NCT00064779) | INSYS Therapeutics Inc | 2003-07-01 |
| Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma (NCT00431561) | Isarna Therapeutics GmbH | 2003-04-01 |
| Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols (NCT00035373) | National Cancer Institute (NCI) | 2002-04-19 |
| Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas (NCT00031083) | Biogen | 2002-04-02 |
| Genetic Analysis of Brain Tumors (NCT00031538) | National Cancer Institute (NCI) | 2002-03-01 |
| Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients (NCT00024557) | INSYS Therapeutics Inc | 2001-06-01 |
| BNCT to Treat Glioma That Has Progressed Following Radiotherapy (NCT00115440) | Boneca Corporation | 2001-03-01 |
| Radiotherapy for Malignant Astrocytomas in the Elderly (NCT00430911) | Assistance Publique - Hôpitaux de Paris | 2001-02-01 |