| An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment (NCT04165135) | Hoffmann-La Roche | 2020-02-24 |
| A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin America (NCT04158258) | Hoffmann-La Roche | 2020-02-21 |
| A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function (NCT04226833) | Hoffmann-La Roche | 2020-02-11 |
| A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants With Mild or Moderate Hemophilia A Without FVIII Inhibitors (NCT04158648) | Hoffmann-La Roche | 2020-02-10 |
| A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (NCT04182204) | Hoffmann-La Roche | 2020-02-07 |
| A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer (NCT04256421) | Hoffmann-La Roche | 2020-02-04 |
| A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (NCT04191499) | Hoffmann-La Roche | 2020-01-29 |
| A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors (NCT04029688) | Hoffmann-La Roche | 2020-01-27 |
| A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (NCT04075266) | Hoffmann-La Roche | 2020-01-09 |
| A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation (NCT04102098) | Hoffmann-La Roche | 2019-12-31 |
| A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis (NCT04090411) | Hoffmann-La Roche | 2019-12-19 |
| A Study of Atezolizumab Plus Nab-Paclitaxel in the Treatment of Unresectable Locally Advanced or Metastatic PD-L1-Positive Triple-Negative Breast Cancer (NCT04148911) | Hoffmann-La Roche | 2019-12-10 |
| A Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors (NCT04158583) | Hoffmann-La Roche | 2019-12-09 |
| A Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer (NCT04177108) | Hoffmann-La Roche | 2019-11-25 |
| Atezolizumab in Combination With Bevacizumab in Patients With Unresectable Locally Advanced or Metastatic Mucosal Melanoma (NCT04091217) | Hoffmann-La Roche | 2019-11-25 |
| A Study of Ipatasertib Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Hormone Receptor Positive and HER2 Negative Locally Advanced Unresectable or Metastatic Breast Cancer (NCT04060862) | Hoffmann-La Roche | 2019-11-21 |
| A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy Volunteers (NCT04156646) | Hoffmann-La Roche | 2019-11-19 |
| Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households (NCT03969212) | Hoffmann-La Roche | 2019-10-10 |
| A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 to Patients With Relapsed and/or Refractory Acute Myeloid Leukemia (NCT03922477) | Hoffmann-La Roche | 2019-10-08 |
| A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME (NCT04108156) | Hoffmann-La Roche | 2019-09-30 |
| Untreated FolliculaR Lymphoma Treated With OBinituzumAb in a Non-interventional Study (URBAN) (NCT04034056) | Hoffmann-La Roche | 2019-09-02 |
| A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease (NCT04000594) | Hoffmann-La Roche | 2019-09-02 |
| A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NCT04077723) | Hoffmann-La Roche | 2019-08-13 |
| A Study of Atezolizumab in Combination With Carboplatin Plus Etoposide to Investigate Safety and Efficacy in Patients With Untreated Extensive-Stage Small Cell Lung Cancer (NCT04028050) | Hoffmann-La Roche | 2019-08-12 |
| A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (NCT04035005) | Hoffmann-La Roche | 2019-08-12 |
| A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Participants With Multiple Sclerosis (NCT03972306) | Hoffmann-La Roche | 2019-08-12 |
| A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy (NCT03779334) | Hoffmann-La Roche | 2019-08-07 |
| A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA). (NCT03923738) | Hoffmann-La Roche | 2019-08-05 |
| A Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Intravenously Administered RO7126209 in Healthy Participants (NCT04023994) | Hoffmann-La Roche | 2019-08-03 |
| A Study to Investigate RO7200220 as Monotherapy and in Combination With Ranibizumab in Participants With Diabetic and Uveitic Macular Edema (NCT06771271) | Hoffmann-La Roche | 2019-07-22 |
| A Study to Investigate the Safety and Efficacy of Atezolizumab in Previously-Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NCT03922997) | Hoffmann-La Roche | 2019-07-03 |
| A Study to Evaluate Safety and Therapeutic Activity of RO6874281 in Combination with Pembrolizumab, in Participants with Advanced or Metastatic Melanoma (NCT03875079) | Hoffmann-La Roche | 2019-06-24 |
| Study to Assess the Pharmacokinetics, Safety and Tolerability of Baloxavir Marboxil in Healthy Chinese Participants (NCT03959332) | Hoffmann-La Roche | 2019-06-19 |
| A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants (NCT03988907) | Hoffmann-La Roche | 2019-06-18 |
| A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer. (NCT03840200) | Hoffmann-La Roche | 2019-06-12 |
| Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease (NCT03977584) | Hoffmann-La Roche | 2019-06-10 |
| Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC) (NCT03869190) | Hoffmann-La Roche | 2019-06-01 |
| Trial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma Following First-Line Immunochemotherapy and as Monotherapy or in Combination With Polatuzumab Vedotin in Elderly/Unfit Participants With Previously Untreated Diffuse Large B-Cell Lymphoma (NCT03677154) | Hoffmann-La Roche | 2019-05-23 |
| A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function (NCT03920865) | Hoffmann-La Roche | 2019-05-16 |
| A Phase Ib Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Cibisatamab in Combination With Atezolizumab After Pretreatment With Obinutuzumab in Participants With Previously Treated Metastatic Colorectal Adenocarcinoma (NCT03866239) | Hoffmann-La Roche | 2019-05-07 |
| An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Participants Who Participated in Prior Roche and Genentech Sponsored Studies (NCT03842969) | Hoffmann-La Roche | 2019-04-23 |
| A Study Evaluating the Safety and Efficacy of Idasanutlin in Combination With Cytarabine and Daunorubicin in Patients Newly Diagnosed With Acute Myeloid Leukemia (AML) and the Safety and Efficacy of Idasanutlin in the Maintenance of First AML Complete Remission (NCT03850535) | Hoffmann-La Roche | 2019-03-25 |
| A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants (NCT03847987) | Hoffmann-La Roche | 2019-03-12 |
| A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE) (NCT03823300) | Hoffmann-La Roche | 2019-03-11 |
| A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma (NCT03677141) | Hoffmann-La Roche | 2019-03-08 |
| A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (NCT03768063) | Hoffmann-La Roche | 2019-02-28 |
| An Open-Label, Single Arm Study of Obinutuzumab Short Duration Infusion in Patients With Previously Untreated Advanced Follicular Lymphoma (NCT03817853) | Hoffmann-La Roche | 2019-02-26 |
| A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA) (NCT03823287) | Hoffmann-La Roche | 2019-02-19 |
| A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice (NCT03782207) | Hoffmann-La Roche | 2019-02-07 |
| Study to Investigate the Effect of Balovaptan on the QTC Interval in Healthy Subjects (NCT03808298) | Hoffmann-La Roche | 2019-02-07 |
| Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants From Birth to < 1 Year With Influenza-Like Symptoms (NCT03653364) | Hoffmann-La Roche | 2019-01-23 |
| A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease (NCT03761849) | Hoffmann-La Roche | 2019-01-23 |
| A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer (NCT03726879) | Hoffmann-La Roche | 2019-01-11 |
| A Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell or Non-Clear Cell Renal Cell Carcinoma (NCT03693573) | Hoffmann-La Roche | 2019-01-11 |
| A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers (NCT03764449) | Hoffmann-La Roche | 2019-01-10 |
| A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer (NCT03695380) | Hoffmann-La Roche | 2019-01-09 |
| Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza (NCT03684044) | Hoffmann-La Roche | 2019-01-08 |
| A Study to Investigate Atezolizumab Subcutaneous in Patients With Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NCT03735121) | Hoffmann-La Roche | 2018-12-27 |
| A Study to Evaluate Patient Preference and Satisfaction of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Participants With HER2-Positive Early Breast Cancer (NCT03674112) | Hoffmann-La Roche | 2018-12-19 |
| A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants (NCT03774576) | Hoffmann-La Roche | 2018-12-17 |
| A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection (NCT03762681) | Hoffmann-La Roche | 2018-12-14 |
| A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases (NCT03625141) | Hoffmann-La Roche | 2018-12-13 |
| An Interventional Study of Avastin (Bevacizumab) in Patients With Advanced/Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer (NCT01932125) | Hoffmann-La Roche | 2018-12-05 |
| Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease (NCT03664804) | Hoffmann-La Roche | 2018-12-05 |
| A Study to Assess the Effects of RO6889450 (Ralmitaront) in Participants With Schizophrenia or Schizoaffective Disorder and Negative Symptoms (NCT03669640) | Hoffmann-La Roche | 2018-12-04 |
| Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms (NCT03629184) | Hoffmann-La Roche | 2018-11-20 |
| Non-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Sclerosis (NCT03593590) | Hoffmann-La Roche | 2018-11-12 |
| A Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy Volunteers (NCT03717064) | Hoffmann-La Roche | 2018-11-07 |
| 18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capacity in the Whole Striatum After 2 Weeks of Treatment With Ralmitaront or Placebo in Participants With Schizophrenia (NCT06880328) | Hoffmann-La Roche | 2018-11-07 |
| A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors (NCT03708328) | Hoffmann-La Roche | 2018-10-15 |
| A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC) (NCT03555149) | Hoffmann-La Roche | 2018-09-27 |
| A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma (NCT03671018) | Hoffmann-La Roche | 2018-09-25 |
| Extension Study for the Port Delivery System With Ranibizumab (Portal) (NCT03683251) | Hoffmann-La Roche | 2018-09-20 |
| A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration (NCT03677934) | Hoffmann-La Roche | 2018-09-12 |
| A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy (NCT03584009) | Hoffmann-La Roche | 2018-09-06 |
| A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE) (NCT03622580) | Hoffmann-La Roche | 2018-09-05 |
| A Double-Blind Single-Ascending Dose (SAD) and Multiple-Ascending Dose (MAD) Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7049389 in Healthy Chinese Participants (NCT03570658) | Hoffmann-La Roche | 2018-08-24 |
| Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD) (NCT03443973) | Hoffmann-La Roche | 2018-08-22 |
| A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer (NCT03456076) | Hoffmann-La Roche | 2018-08-16 |
| A Study of the Efficacy and Safety of Bevacizumab in Chinese Women With Newly Diagnosed, Previously Untreated Stage III or Stage IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (NCT03635489) | Hoffmann-La Roche | 2018-08-15 |
| A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD) (NCT03611075) | Hoffmann-La Roche | 2018-08-13 |
| A Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension (NCT03504917) | Hoffmann-La Roche | 2018-08-08 |
| A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting (NCT03589105) | Hoffmann-La Roche | 2018-08-06 |
| Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis. (NCT03552393) | Hoffmann-La Roche | 2018-08-03 |
| A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (NCT03498716) | Hoffmann-La Roche | 2018-08-02 |
| Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers (NCT03596632) | Hoffmann-La Roche | 2018-07-27 |
| This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS) (NCT03599245) | Hoffmann-La Roche | 2018-07-12 |
| A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers (NCT03579719) | Hoffmann-La Roche | 2018-07-10 |
| A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors (NCT03539484) | Hoffmann-La Roche | 2018-07-04 |
| A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Participants With HER2-Positive Early Breast Cancer (NCT03493854) | Hoffmann-La Roche | 2018-06-14 |
| A Study to Assess the Feasibility of an E-Health System (ZEMY) Designed to Manage Symptoms in Participants With Breast Cancer Under Anti-Cancer Treatment (NCT03558490) | Hoffmann-La Roche | 2018-06-12 |
| Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD) (NCT03444870) | Hoffmann-La Roche | 2018-06-06 |
| The Effectiveness Of Atezolizumab In Patients With Locally-Advanced Or Metastatic Non-Small Cell Lung Cancer After Prior Chemotherapy (NCT03559647) | Hoffmann-La Roche | 2018-05-30 |
| A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis (NCT03523858) | Hoffmann-La Roche | 2018-05-28 |
| Participant-Reported Outcomes With the Accu-Chek® Solo Micropump System (NCT03478969) | Hoffmann-La Roche | 2018-05-17 |
| A Study to Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chinese Healthy Participants. (NCT03530917) | Hoffmann-La Roche | 2018-05-15 |
| An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps (NCT03478930) | Hoffmann-La Roche | 2018-05-09 |
| An Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NCT03533283) | Hoffmann-La Roche | 2018-05-08 |
| A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers. (NCT03505190) | Hoffmann-La Roche | 2018-05-03 |
| A Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA) (NCT03301883) | Hoffmann-La Roche | 2018-04-26 |