| Pembrolizumab Combination With Lenvatinib in Pts With Recurrent,Persistent,Metastatic or Locally Advanced Vulvar Cancer Not Amenable to Curative Surgery or Radiotherapy (NCT05903833) | AGO Research GmbH | 2025-06-24 |
| Efficacy of a Photosynthetic Dermal Matrix for the Treatment of Full-Thickness Skin Wounds (NCT07157657) | Pontificia Universidad Catolica de Chile | 2025-06-24 |
| Phase IIa Trial in Participants With Asthma to Evaluate Impact of Intranasal ETH47 on Development of Asthma-related Symptoms Following Rhinovirus Challenge (NCT07059767) | Ethris GmbH | 2025-06-24 |
| Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial (NCT07070479) | Ming-Yuan Chen | 2025-06-24 |
| Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study) (NCT05500326) | Murdoch Childrens Research Institute | 2025-06-24 |
| A Trial of SHR-2017 Injection in Patients With Bone Metastases From Solid Tumors (NCT07028268) | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 2025-06-24 |
| A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer (NCT06630325) | OHSU Knight Cancer Institute | 2025-06-24 |
| A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors (NCT07020221) | Verastem, Inc. | 2025-06-24 |
| A Single-arm, Open-label, Phase II Study to Evaluate Efficacy, Safety and Pharmacokinetics of HLX10 + Chemotherapy in Patients With ES-SCLC (NCT06812260) | Shanghai Henlius Biotech | 2025-06-24 |
| SHR-A2102 Combined With Adebrelimab as Neoadjuvant Therapy for Early Triple-Negative Breast Cancer (NCT06819319) | Henan Cancer Hospital | 2025-06-23 |
| Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause (NCT07118891) | AbCellera Biologics Inc. | 2025-06-23 |
| A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) (NCT07101939) | Actimed Therapeutics Ltd | 2025-06-23 |
| Entinostat Plus Pyrotinib and Endocrine Therapy in Advanced Triple-Positive Breast Cancer After Trastuzumab Failure (NCT07708194) | Tianjin Medical University Cancer Institute and Hospital | 2025-06-23 |
| [68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas (NCT06794372) | John O. Prior | 2025-06-23 |
| Phase I/II Study of SCTB39-1 in Advanced Solid Tumours (NCT07050641) | Sinocelltech Ltd. | 2025-06-23 |
| Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation (NCT06799195) | University of Nebraska | 2025-06-23 |
| Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer (NCT06532279) | NRG Oncology | 2025-06-23 |
| Simultaneous Integrated Boost FDOPA Positron Emission Tomography (PET) Guided in Patients With Partially- or Non-operated Glioblastoma (NCT05653622) | Centre Paul Strauss | 2025-06-23 |
| COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial (NCT07063290) | Zhejiang University | 2025-06-23 |
| A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio (NCT07215390) | Apellis Pharmaceuticals, Inc. | 2025-06-23 |
| Bioequivalence ANDA SNP Clinical Study - Raloxifene and Single Nucleotide Polymorphisms (NCT06062810) | Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair | 2025-06-21 |
| JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab (NCT06701682) | PPD Development, LP | 2025-06-21 |
| BCOR and ZC3H12 Genes Knock-out CD19-targeting CAR-T Cell Therapy in r/r B Cell Lymphoma (NCT07009002) | Chinese PLA General Hospital | 2025-06-20 |
| A Phase II Trial of 4 vs 6 Cycles of CHP Combined With Polatuzumab Vedotin-Rituximab in Untreated DLBCL Patients With IPI 0-1 (NCT07034508) | Institute of Hematology & Blood Diseases Hospital, China | 2025-06-20 |
| Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer (NCT07125391) | Bai-Rong Xia | 2025-06-20 |
| Autologous Serum Obtained by a Closed-Circuit Collection Device (NCT07014059) | GIANCARLO FATOBENE | 2025-06-20 |
| VAM in Secondary AML, AML With Extramedullary Involvement, and Myeloid Sarcoma (NCT07028086) | Ruijin Hospital | 2025-06-20 |
| Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery Syndrome (NCT06999993) | Misr University for Science and Technology | 2025-06-20 |
| Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer- (NCT06895577) | Sun Yat-sen University | 2025-06-20 |
| A Study of CM512 in Subjects With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (NCT06980142) | Keymed Biosciences Co.Ltd | 2025-06-20 |
| Safety of a Single, Intravitreal Injection of 6.0M jCell (Famzeretcel) in Retinitis Pigmentosa (RP) (NCT06912633) | jCyte, Inc | 2025-06-20 |
| Adebrelimab + Chemotherapy as Neoadjuvant Therapy for Resectable NSCLC (NCT07035392) | Zhangzhou Municipal Hospital | 2025-06-20 |
| An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II (NCT06232434) | Research Institute for Physical Chemical Problems of the Belarusian State University | 2025-06-20 |
| Venetoclax-containing Therapy Combined With Microtransplant for Newly Diagnosed AML (NCT07078591) | Beijing 302 Hospital | 2025-06-20 |
| Venetoclax-containing Therapy Combined With Microtransplant for Intermediate-risk and Higher MDS (NCT07238686) | Beijing 302 Hospital | 2025-06-20 |
| BCOR and ZC3H12 Genes Knock-out CD19-targeting CAR-T Cell Therapy in r/r B-ALL (NCT07008885) | Chinese PLA General Hospital | 2025-06-20 |
| Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer (NCT07108127) | Peking Union Medical College Hospital | 2025-06-20 |
| Wide-Awake Local Anesthesia No Tourniquet (WALANT) With Versus Without Hyaluronidase for Hand Surgery (NCT07000058) | Misr University for Science and Technology | 2025-06-20 |
| Pembrolizumab for Advanced Cutaneous Sarcomas Not Including Angiosarcoma (NCT07007273) | H. Lee Moffitt Cancer Center and Research Institute | 2025-06-20 |
| Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery. (NCT07016373) | Nancy Mouradian | 2025-06-20 |
| PRP Exosomes Therapy for Erectile Dysfunction (NCT07124871) | Institute for the Study of Urological Diseases, Greece | 2025-06-20 |
| A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis (NCT06736990) | Calluna Pharma AS | 2025-06-20 |
| SFRT+Sequential Hypofractionated/Conventional Fractionated RT+Iparomlimab and Tuvonralimab for Relapsed/Refractory Solid Tumors (NCT06936748) | Second Affiliated Hospital of Nanchang University | 2025-06-20 |
| A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's Disease (NCT07048197) | Novartis Pharmaceuticals | 2025-06-20 |
| Monthly Alternating NALIRIFOX and GnP in the First-Line Setting for Metastatic Pancreatic Ductal Adenocarcinoma (NCT07163273) | Northwell Health | 2025-06-20 |
| A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis (NCT06972446) | AbbVie | 2025-06-20 |
| MSC303 Subcutaneous Injection for the Treatment of Immunologic Glomerular Disease. (NCT07000292) | Shanghai Changzheng Hospital | 2025-06-20 |
| Trial of Trastuzumab Deruxtecan in Previously Treated HER2 (NCT06750484) | Yale University | 2025-06-20 |
| A PHASE II TRIAL AIMING TO INVESTIGATE THE SAFETY AND CLINICAL ACTIVITY OF BELANTAMAB MAFODOTIN IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA PREVIOUSLY TREATED WITH A THROMBOPOIETIN RECEPTOR AGONIST AND/OR RITUXIMAB AFTER CORTICOSTEROID FIRST-LINE THERAPY (NCT07019545) | Hellenic Society of Hematology | 2025-06-20 |
| A Clinical Study to Investigate the Effect of Oral Neflamapimod on Motor Recovery After Acute Ischaemic Stroke (NCT06987643) | EIP Pharma Inc | 2025-06-20 |
| Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder (NCT07116694) | BioXcel Therapeutics Inc | 2025-06-19 |
| Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age (NCT05956821) | University of Miami | 2025-06-19 |
| Neoadjuvant Sugemalimab + Chemotherapy Followed by Adjuvant Sugemalimab for Patients With Resectable Stage II-IIIA Non-small-cell Lung Cancer Patients (NCT06987734) | Shanghai Pulmonary Hospital, Shanghai, China | 2025-06-19 |
| JS207Combined With Chemotherapy in First-line Treatment of Advanced NSCLC (NCT06969027) | Shanghai Junshi Bioscience Co., Ltd. | 2025-06-19 |
| Trial for Local Ablative Treatment (LAT) Optimization in Patients With Advanced Non-Small Cells Lung Cancer (NSCLC) Presenting an Anaplastic Lymphoma Kinase (ALK) Rearrangement Treated by Brigatinib (NCT06620835) | Groupe Francais De Pneumo-Cancerologie | 2025-06-19 |
| A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study) (NCT07065240) | Seaport Therapeutics | 2025-06-19 |
| Study of CM512 in Patients With Moderate-to-Severe Atopic Dermatitis (NCT06947980) | Keymed Biosciences Co.Ltd | 2025-06-19 |
| A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease (NCT07018323) | Immunovant Sciences GmbH | 2025-06-19 |
| Neoadjuvant Low-Dose Radiotherapy Combined With Adebrelimab and Single-Agent Albumin-Bound Paclitaxel Chemotherapy for Early-Stage Oral Squamous Cell Carcinoma: A Prospective, Single-Arm Clinical Trial (NCT07007364) | Jun Jia | 2025-06-19 |
| A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) (NCT06991257) | Pfizer | 2025-06-19 |
| Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer (NCT06850623) | EXACT Therapeutics AS | 2025-06-19 |
| A Study of LY3549492 in Adults With Obesity or Overweight With Type 2 Diabetes (NCT07030868) | Eli Lilly and Company | 2025-06-19 |
| Safety and Immunogenicity Study of SCB-1022 and SCB-1033 in Healthy Older Adults (NCT06984094) | Clover Biopharmaceuticals AUS Pty | 2025-06-18 |
| Study of Cetuximab Plus/Minus Weekly Paclitaxel After Progression To First-Line Pembrolizumab Plus Platinum-5FU in Subjects With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck. (NCT06856213) | Grupo Español de Tratamiento de Tumores de Cabeza y Cuello | 2025-06-18 |
| A Phase 2 Study to Assess STP938 (Dencatistat) as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial (NCT06786234) | Step Pharma, SAS | 2025-06-18 |
| Dose Escalation Trial of CD40.Pan.CoV Vaccine, Adjuvanted or Not, as a Booster in Adult Healthy Volunteers (NCT07113106) | ANRS, Emerging Infectious Diseases | 2025-06-18 |
| An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis (NCT07013110) | Prof Salvatore Albani | 2025-06-18 |
| Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage (NCT07026994) | Huashan Hospital | 2025-06-18 |
| The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation (NCT06843551) | Benjamin Spieler | 2025-06-18 |
| Clinical Trial of PCV24 in Adults Aged ≥18 Years (NCT07543198) | Sinovac Life Sciences Co., Ltd. | 2025-06-18 |
| A Study to Evaluate the Efficacy and Safety of CX11 Tablets in Overweight/Obese Participants (NCT07011797) | Corxel Pharmaceuticals | 2025-06-17 |
| Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation (NCT06717958) | Technische Universität Dresden | 2025-06-17 |
| A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis (NCT07037901) | Inmagene LLC | 2025-06-17 |
| First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer (NCT06934538) | Brenus Pharma | 2025-06-17 |
| Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository (NCT06789601) | Brigham and Women's Hospital | 2025-06-17 |
| Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity (NCT07000955) | Innovent Biologics (Suzhou) Co. Ltd. | 2025-06-17 |
| Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations (NCT06630221) | Abhay Singh, MD MPH | 2025-06-17 |
| PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer (NCT06906887) | Medical College of Wisconsin | 2025-06-17 |
| Toripalimab With Chemotherapy for Sinus Cancer (NCT06940180) | Glenn J. Hanna | 2025-06-17 |
| A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis (NCT07225829) | 4Moving Biotech | 2025-06-17 |
| Effect of Cilostazol in Promoting Hematoma Clearance After Intracerebral Hemorrhage (NCT06504576) | National Taiwan University Hospital | 2025-06-16 |
| Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy (NCT05567406) | Kadmon, a Sanofi Company | 2025-06-16 |
| Study on the Effectiveness and Comfort of Innovative Solutions for the Internal Transport of Patients in Wheelchairs in a Hospital Setting (NCT06902883) | Gustave Roussy, Cancer Campus, Grand Paris | 2025-06-16 |
| SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID) (NCT07021794) | Nancy Klimas | 2025-06-16 |
| Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine) (NCT06839235) | Arbor Biotechnologies | 2025-06-16 |
| Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 (NCT06006143) | Yale University | 2025-06-16 |
| The Phase-2 CCR5-targeting Leronlimab With Oral Chemotherapy and VEGF-inhibitor Enriched Regimen Trial (CLOVER) (NCT06699836) | CytoDyn, Inc. | 2025-06-16 |
| RESTORE TRIAL: Study of the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD) (NCT07009860) | Altimmune, Inc. | 2025-06-16 |
| Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI (NCT05630235) | University of Miami | 2025-06-16 |
| A Phase II Trial of Neoadjuvant PD-1 Vaccine PD1-Vaxx in Operable MSI High Colorectal Cancer (NCT06692959) | University of Southampton | 2025-06-16 |
| Phase II Clinical Trial of KJ101in the Treatment of Deep II Degree Burns (NCT07025408) | Shanghai Bao Pharmaceuticals Co., Ltd. | 2025-06-16 |
| Immune Modulation With PRaG-1 Treatment (NCT07002502) | Second Affiliated Hospital of Soochow University | 2025-06-15 |
| Phase II Trial of Zanubrutinib, Obinutuzumab, Bendamustine (ZGB) as First-Line Therapy for Chronic Lymphocytic Leukemia: A Single-Center Study (NCT07003464) | The First Hospital of Jilin University | 2025-06-15 |
| Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER (NCT05870800) | Baylor College of Medicine | 2025-06-15 |
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis (NCT06993337) | Cairo University | 2025-06-15 |
| A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers. (NCT06283979) | Biocomposites Ltd | 2025-06-15 |
| Prostate Cancer Vaccines (NCT07068555) | Shenzhen Geno-Immune Medical Institute | 2025-06-15 |
| PD1/TGFβ In Combination With SHR2554 or Apatinib And Chemotherapy For First - Line Treatment Of Gastric Cancer (NCT07294664) | The First Affiliated Hospital of Zhengzhou University | 2025-06-15 |
| A Study on Using SFRT With Standard Treatment for Oligoprogressive NSCLC (NCT07193641) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2025-06-15 |
| JSKN003 Combined Treatment of HER2-positive Gastric Cancer (NCT06998771) | Shanghai JMT-Bio Inc. | 2025-06-15 |