| A Clinical Study of Efficacy, Safety, Tolerability and PK of ND0612H in Subjects With Advanced Parkinson's Disease (NCT02577523) | NeuroDerm Ltd. | 2015-12-29 |
| The BROADEN Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Partial Lipodystrophy (NCT02527343) | Akcea Therapeutics | 2015-12-28 |
| Study of Daratumumab in Combination With Dexamethasone in Resistant or Refractory Multiple Myeloma (NCT02626481) | University Hospital, Lille | 2015-12-28 |
| Combined Use of Raltitrexed and S-1 as Treatment for Patients With Metastasizing Colorectal Cancer (NCT02618356) | Fudan University | 2015-12-25 |
| Long-Term Treatment and Follow up of Subjects Completing 24 Months of Treatment With Tesevatinib on Study KD019-101 (NCT02616055) | Kadmon Corporation, LLC | 2015-12-25 |
| The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis (NCT03178526) | Islamic Azad University, Sanandaj | 2015-12-24 |
| Pomalidomide, Ixazomib Citrate, and Dexamethasone in Treating Patients With Previously Treated Multiple Myeloma or Plasma Cell Leukemia (NCT02547662) | Mayo Clinic | 2015-12-24 |
| A Clinical Trial to Evaluate the Safety and Efficacy of ALLO-ASC-DFU for Second Deep Degree Burn Injury Subjects (NCT02619851) | Anterogen Co., Ltd. | 2015-12-23 |
| Nivolumab and HPV-16 Vaccination in Patients With HPV-16 Positive Incurable Solid Tumors (NCT02426892) | M.D. Anderson Cancer Center | 2015-12-23 |
| Adrabetadex to Treat Niemann-Pick Type C1 (NPC1) Disease (NCT04958642) | Mandos LLC | 2015-12-23 |
| A Study of Idasanutlin in Combination With Obinutuzumab in Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and in Combination With Rituximab in R/R Diffuse Large B-Cell Lymphoma (DLBCL) Participants (NCT02624986) | Hoffmann-La Roche | 2015-12-23 |
| Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension (NCT02639286) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2015-12-23 |
| Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting (NCT02499627) | Fondazione Italiana Linfomi - ETS | 2015-12-23 |
| Trial of Radiotherapy With Leuprolide and Enzalutamide in High Risk Prostate Cancer (NCT02508636) | University of California, San Francisco | 2015-12-22 |
| A Study of Atezolizumab in Combination With Either Obinutuzumab Plus Bendamustine or Obinutuzumab Plus (+) Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Participants With Follicular Lymphoma (FL) or Rituximab + CHOP in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (NCT02596971) | Hoffmann-La Roche | 2015-12-22 |
| Prostvac in Patients With Biochemically Recurrent Prostate Cancer (NCT02649439) | National Cancer Institute (NCI) | 2015-12-22 |
| Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer (NCT02635009) | NRG Oncology | 2015-12-22 |
| Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN ) (NCT02633800) | Daiichi Sankyo | 2015-12-22 |
| A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma (NCT02601950) | Epizyme, Inc. | 2015-12-22 |
| HM2014-26 DT2219 for Relapsed or Refractory B-Lineage Leukemia or Lymphoma (NCT02370160) | Masonic Cancer Center, University of Minnesota | 2015-12-21 |
| Safety and Efficacy of Sirolimus for HIV Reservoir Reduction in Individuals on Suppressive Antiretroviral Therapy (ART) (NCT02440789) | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 2015-12-21 |
| A Study of A-101 Solution in Subjects With Common Warts. (NCT02669862) | Aclaris Therapeutics, Inc. | 2015-12-21 |
| IGF-1 Treatment for Individuals With Short Stature Due to PAPP-A2 Deficiency (NCT02636270) | Children's Hospital Medical Center, Cincinnati | 2015-12-21 |
| Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant (NCT02506933) | City of Hope Medical Center | 2015-12-21 |
| Docetaxel 2-weeks Regimen in the Treatment of HER2 Negative Metastatic Breast Cancer (NCT03147963) | Zhejiang Cancer Hospital | 2015-12-20 |
| Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency (NCT02004691) | Genzyme, a Sanofi Company | 2015-12-18 |
| Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma (NCT02395692) | National Cancer Institute (NCI) | 2015-12-18 |
| Evaluation of Gallium-68-HBED-CC-PSMA Imaging in Prostate Cancer Patients (NCT02611882) | Thomas Hope | 2015-12-18 |
| Pilot Study of the Effect of Liraglutide on Weight Loss and Gastric Functions in Obesity (NCT02647944) | Mayo Clinic | 2015-12-18 |
| Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) (NCT02628067) | Merck Sharp & Dohme LLC | 2015-12-18 |
| Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) (NCT02584634) | Pfizer | 2015-12-18 |
| Small Cell Lung Carcinoma Trial With Nivolumab and IpiliMUmab in LImited Disease (NCT02046733) | ETOP IBCSG Partners Foundation | 2015-12-18 |
| Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia (NCT02530515) | M.D. Anderson Cancer Center | 2015-12-18 |
| High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease (NCT02629120) | National Institute of Allergy and Infectious Diseases (NIAID) | 2015-12-17 |
| Ipilimumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma (NCT02403778) | University of Colorado, Denver | 2015-12-17 |
| An 8-Week Refractory Chronic Cough Study (MK-7264-021) (NCT02612623) | Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2015-12-17 |
| Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (NCT02623920) | University of Arizona | 2015-12-16 |
| Comparison of Single-Agent Carboplatin vs the Combination of Carboplatin and Everolimus for the Treatment of Advanced Triple-Negative Breast Cancer (NCT02531932) | Amy Tiersten | 2015-12-16 |
| A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease. (NCT02585596) | Yuhan Corporation | 2015-12-16 |
| A Study of Pertuzumab With High-Dose Trastuzumab for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) With Central Nervous System (CNS) Progression Post-Radiotherapy (NCT02536339) | Genentech, Inc. | 2015-12-16 |
| PF-06372865 in Subjects With Photosensitive Epilepsy (NCT02564029) | Pfizer | 2015-12-16 |
| A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children (NCT02637687) | Bayer | 2015-12-16 |
| Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation (NCT04687111) | Mark Ledwidge | 2015-12-16 |
| Safety and Dose Finding Study of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia B (NCT02618915) | Ultragenyx Pharmaceutical Inc | 2015-12-16 |
| Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant (NCT02668315) | Maisonneuve-Rosemont Hospital | 2015-12-16 |
| A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012) (NCT02612610) | Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2015-12-15 |
| An Ascending Multiple Dose Study of VTP-38543 in Adult Participants With Mild to Moderate Atopic Dermatitis (NCT02655679) | Vitae Pharmaceuticals, Inc. | 2015-12-15 |
| Safety and Efficacy of Modified Folfirinox Versus Gemcis in Bile Duct Tumours (NCT02591030) | Centre Hospitalier Universitaire de Saint Etienne | 2015-12-15 |
| The PRECISION Trial (Profiling Early Breast Cancer for Radiotherapy Omission): A Phase II Study of Breast-Conserving Surgery Without Adjuvant Radiotherapy for Favorable-Risk Breast Cancer (NCT02653755) | Dana-Farber Cancer Institute | 2015-12-15 |
| Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation (NCT02533180) | National Institute of Allergy and Infectious Diseases (NIAID) | 2015-12-15 |
| Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration (NCT02686658) | IVERIC bio, Inc. | 2015-12-15 |
| Efficacy and Safety Study in Pancreatic or Midgut Neuroendocrine Tumours Having Progressed Radiologically While Previously Treated With Lanreotide Autogel® 120 mg (NCT02651987) | Ipsen | 2015-12-15 |
| Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine (NCT02466750) | U.S. Army Medical Research and Development Command | 2015-12-15 |
| A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression (NCT02614547) | Supernus Pharmaceuticals, Inc. | 2015-12-15 |
| Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension (NCT02603809) | Idorsia Pharmaceuticals Ltd. | 2015-12-14 |
| An Efficacy and Safety Study of Mongersen (GED-0301) in Subjects With Active Ulcerative Colitis (NCT02601300) | Celgene | 2015-12-14 |
| AGN-151597 (Formerly RST-001) Phase I/II Trial for Advanced Retinitis Pigmentosa (NCT02556736) | AbbVie | 2015-12-14 |
| Sequential Chemotherapy and Lenalidomide Followed by Rituximab and Lenalidomide Maintenance for Untreated Mantle Cell Lymphoma (NCT02633137) | Memorial Sloan Kettering Cancer Center | 2015-12-14 |
| Study Examining PrEP-001 in Subjects With Asthma (NCT03296917) | Hvivo | 2015-12-11 |
| Cyclophosphamide, Paclitaxel, and Trastuzumab in Treating Stage I-II HER2/Neu Positive Breast Cancer After Surgery (NCT02654119) | University of Nebraska | 2015-12-11 |
| Fr1da Insulin Intervention (NCT02620072) | Technical University of Munich | 2015-12-11 |
| A Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of JNJ-63623872 in Combination With Oseltamivir in Adult, and Elderly Hospitalized Participants With Influenza A Infection (NCT02532283) | Janssen Research & Development, LLC | 2015-12-11 |
| Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo (NCT02598388) | Janssen Vaccines & Prevention B.V. | 2015-12-10 |
| The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis (NCT02403479) | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2015-12-10 |
| Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab (NCT01931098) | National Cancer Institute (NCI) | 2015-12-10 |
| Efficacy and Safety of Grazoprevir (+) Uprifosbuvir (+) Ruzasvir (MK-3682B) (MK-5172 + MK-3682 + MK-8408) Fixed Dose Combination in Chronic HCV Participants Failing Prior Antiviral Treatment (MK-3682-021) (NCT02613403) | Merck Sharp & Dohme LLC | 2015-12-10 |
| MR Guided Phase II Radiotherapy Dose Escalation in Unresectable Non-Metastatic Pancreatic Cancer (NCT01972919) | Medical College of Wisconsin | 2015-12-10 |
| A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL (NCT02514083) | National Heart, Lung, and Blood Institute (NHLBI) | 2015-12-09 |
| A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus (NCT02548585) | MedImmune LLC | 2015-12-09 |
| A Study of Mirikizumab (LY3074828) in Participants With Moderate to Severe Ulcerative Colitis (NCT02589665) | Eli Lilly and Company | 2015-12-09 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 (Alobresib) as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer (NCT02607228) | Gilead Sciences | 2015-12-08 |
| Dolutegravir Plus Lamivudine Dual Therapy in Treatment Naïve HIV-1 Patients (NCT02582684) | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 2015-12-08 |
| Ixazomib Citrate in Treating Patients With Chronic Graft-versus-Host Disease (NCT02513498) | Fred Hutchinson Cancer Center | 2015-12-08 |
| Phase I/II, Study of Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) + Sorafenib in Acute Myeloid Leukemia (NCT02530476) | M.D. Anderson Cancer Center | 2015-12-08 |
| Study to Evaluate the Safety of ALLO-ASC-DFU in the Subjects With Dystrophic Epidermolysis Bullosa (NCT02579369) | Anterogen Co., Ltd. | 2015-12-08 |
| A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol As a Treatment for Acutely Ill Schizophrenic Patients (NCT02088060) | Central Institute of Mental Health, Mannheim | 2015-12-08 |
| In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects (NCT02521792) | Clementia Pharmaceuticals Inc. | 2015-12-07 |
| A Phase I/II Study for the Safety and Efficacy of Panitumumab in Combination With TAS-102 for Patients With Colorectal Cancer (NCT02613221) | Takeda | 2015-12-07 |
| A Phase 2a to Evaluate the Safety of MEDI8852 in Adults With Uncomplicated Influenza (NCT02603952) | MedImmune LLC | 2015-12-07 |
| A Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension -AYAME Study- (NCT02623738) | Santen Pharmaceutical Co., Ltd. | 2015-12-06 |
| Treatment of Peri-calcification Edema in Neurocysticercosis (NCC) (NCT02945527) | Universidad Peruana Cayetano Heredia | 2015-12-04 |
| Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL) (NCT02633956) | Intercept Pharmaceuticals | 2015-12-04 |
| A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab (NCT02621021) | National Cancer Institute (NCI) | 2015-12-04 |
| A Study to Evaluate the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Participants With Geographic Atrophy (NCT02659098) | Janssen Research & Development, LLC | 2015-12-04 |
| A Study of GDC-0810 Versus Fulvestrant in Postmenopausal Women With Advanced or Metastatic Breast Cancer Resistant to Aromatase Inhibitor (AI) Therapy (NCT02569801) | Genentech, Inc. | 2015-12-04 |
| To Evaluate Safety, Pharmacokinetics and Pharmacodynamics of MEDI6012 in Subjects With Stable Coronary Artery Disease (NCT02601560) | MedImmune LLC | 2015-12-03 |
| Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM) (NCT02610140) | Bayer | 2015-12-03 |
| An Open-label Extension Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy (NCT02625090) | UCB Biopharma SRL | 2015-12-03 |
| MDCO-216 Infusions Leading to Changes in Atherosclerosis: A Novel Therapy in Development to Improve Cardiovascular Outcomes - Proof of Concept Intravascular Ultrasound (IVUS), Lipids, and Other Surrogate Biomarkers Trial (NCT02678923) | The Medicines Company | 2015-12-03 |
| Comparison of Two Concomitant Administration of RT With Cisplatin in Standard Infusion or Fractional Infusion (NCT03330249) | Groupe Oncologie Radiotherapie Tete et Cou | 2015-12-03 |
| A Dose Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Advanced Solid Tumors (NCT02605083) | Effector Therapeutics | 2015-12-03 |
| Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180) (NCT02559687) | Merck Sharp & Dohme LLC | 2015-12-02 |
| Efficacy and Tolerance of Sodium Thiosulfate Injection After Ultrasound-guided Percutaneous Irrigation of Calcific Tendinopathy of the Rotator Cuff (NCT02538939) | Nantes University Hospital | 2015-12-02 |
| Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD (NCT02515669) | Hoffmann-La Roche | 2015-12-02 |
| Phase 1/2 Study of Motolimod, Doxorubicin, and Durvalumab in Recurrent, Platinum-Resistant Ovarian Cancer (NCT02431559) | Ludwig Institute for Cancer Research | 2015-12-02 |
| Cardiometabolic Effects of Eplerenone in HIV Infection (NCT02629094) | National Institute of Allergy and Infectious Diseases (NIAID) | 2015-12-02 |
| CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies (NCT02965092) | Wuhan Sian Medical Technology Co., Ltd | 2015-12-02 |
| Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer (NCT03381352) | Chinese Academy of Medical Sciences | 2015-12-02 |
| Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myeloma (NCT02509052) | City of Hope Medical Center | 2015-12-02 |
| Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170) (NCT02576990) | Merck Sharp & Dohme LLC | 2015-12-02 |