| Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/Navocaftor/ABBV-119 or Galicaftor/Navocaftor/ABBV-576 Combination Therapies in Adult Participants With Cystic Fibrosis (NCT04853368) | AbbVie | 2021-09-20 |
| Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors (NCT04056910) | Jason J. Luke, MD | 2021-09-20 |
| Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma (NCT05005429) | Fundación GECP | 2021-09-20 |
| Sildenafil for Early Pulmonary Vascular Disease in Scleroderma (NCT04797286) | Johns Hopkins University | 2021-09-20 |
| A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies (NCT05039177) | Erasca, Inc. | 2021-09-20 |
| A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL (NCT04594798) | University of Rochester | 2021-09-20 |
| Study of CAR-BCMA, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA in Subjects With Multiple Myeloma (NCT05243212) | Sheba Medical Center | 2021-09-19 |
| Comparative Study of Lobaplatin and Paclitaxel in Advanced Gastric Cancer Patients With D2 Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy (NCT04808466) | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2021-09-18 |
| To Evaluate the Efficacy and Safety of Tislelizumab in Combination With Lenvatinib in Participants With Selected Solid Tumors (NCT05014828) | BeiGene | 2021-09-18 |
| Safety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's Disease (NCT05068830) | Norwegian University of Science and Technology | 2021-09-17 |
| Study of the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of PA1010 in HBV Patients (NCT05019040) | Zhejiang Palo Alto Pharmaceuticals, Inc. | 2021-09-17 |
| Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (NCT04991974) | Friends Research Institute, Inc. | 2021-09-17 |
| Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007) (NCT05027074) | Merck Sharp & Dohme LLC | 2021-09-17 |
| A Pilot Trial of Nabilone for the Treatment of Obesity (NCT04801641) | Centre for Addiction and Mental Health | 2021-09-17 |
| Tislelizumab+Lenvatinib+Gemox Regiment for Potentially Resectable Locally Advanced Malignant Tumors of Biliary System. (NCT05036798) | Tianjin Medical University Cancer Institute and Hospital | 2021-09-17 |
| 9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma (NCT05010629) | Glenn J. Hanna | 2021-09-17 |
| Cabozantinib and Lanreotide as Treatment for Gastroenteropancreatic Neuroendocrine Tumors (NCT05048901) | National Health Research Institutes, Taiwan | 2021-09-17 |
| Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients (NCT04888312) | Alligator Bioscience AB | 2021-09-17 |
| A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis (NCT04179500) | Global Alliance for TB Drug Development | 2021-09-16 |
| Vortioxetine for Post-COVID-19 Condition (NCT05047952) | Brain and Cognition Discovery Foundation | 2021-09-16 |
| Ex-vivo Primed Memory Donor Lymphocyte Infusion to Boost Anti-viral Immunity After T-cell Depleted HSCT (NCT05066958) | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 2021-09-16 |
| MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) (NCT05007106) | Merck Sharp & Dohme LLC | 2021-09-16 |
| Repeated Neurocognitive Measurements in Depressed Patients (NCT04916548) | Rebecca Price | 2021-09-16 |
| Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002) (NCT05098119) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2021-09-16 |
| A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma (NCT04973605) | BeOne Medicines | 2021-09-16 |
| A Study Evaluating Safety, PK, and Efficacy of Tafasitamab and Parsaclisib in Participants With Relapsed/Refractory Non Hodgkin Lymphoma (R/R NHL) or Chronic Lymphocytic Leukemia (CLL) (NCT04809467) | Incyte Corporation | 2021-09-16 |
| Immune-Mediated Pathophysiology And Clinical Triage Program (NCT04354649) | AHS Cancer Control Alberta | 2021-09-16 |
| A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Max-40279-01 in Combination With Azacitidine (AZA) in Patients With Myelodysplastic Syndrome (MDS) or Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) (NCT05061147) | Maxinovel Pty., Ltd. | 2021-09-16 |
| An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (NCT05085964) | Laboratoires Thea | 2021-09-16 |
| A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of HSK21542 Injection in Liver Disease Subjects With Pruritus (NCT04999787) | Haisco Pharmaceutical Group Co., Ltd. | 2021-09-16 |
| A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease (NCT05063539) | Eli Lilly and Company | 2021-09-16 |
| A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease (NCT04881448) | Boehringer Ingelheim | 2021-09-16 |
| A Phase 2 Study of Intravenous AMB-05X in Tenosynovial Giant Cell Tumor Patients (NCT04938180) | AmMax Bio, Inc. | 2021-09-16 |
| Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases (NCT04899908) | Brigham and Women's Hospital | 2021-09-15 |
| Magnetic Particle-ICG Lymph Node Mapping in Colorectal Cancer (NCT05092750) | M.D. Anderson Cancer Center | 2021-09-15 |
| The Efficacy and Safety of Sintilimab Plus Anlotinib Combined With Chemotherapy as Neoadjuvant Therapy in TNBC (NCT04877821) | Guangdong Provincial People's Hospital | 2021-09-15 |
| To Evaluate the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects Caused by Neurotrophic Keratitis (NCT07120308) | Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. | 2021-09-15 |
| Pembrolizumab in Combination With Lenvatinib in Patients With Advanced Biliary Tract Carcinoma (NCT04550624) | Shanghai Jiahui International Hospital | 2021-09-15 |
| A Study of LY3502970 in Participants With Type 2 Diabetes Mellitus (NCT05048719) | Eli Lilly and Company | 2021-09-15 |
| Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients (NCT05078463) | Universiti Kebangsaan Malaysia Medical Centre | 2021-09-15 |
| Inhaled Interferon α2b for the Treatment of Coronavirus Disease 19 (COVID-19) (NCT04988217) | Pontificia Universidad Catolica de Chile | 2021-09-15 |
| A Study to Evaluate Safety and Tolerability of QLS-101 in NTG (NCT04857827) | Qlaris Bio, Inc. | 2021-09-15 |
| SHR-1210 Combined With Apatinib Mesylate in the Perioperative Therapy for Hepatocellular Carcinoma (NCT04930315) | Zhejiang University | 2021-09-15 |
| Anlotinib or Penpulimab in Combination With RAI for DTC (NCT04952493) | Peking Union Medical College Hospital | 2021-09-15 |
| A Study of Zanidatamab (ZW25) With Evorpacept (ALX148) in Patients With Advanced HER2-expressing Cancer (NCT05027139) | Jazz Pharmaceuticals | 2021-09-15 |
| Efficacy of Centanafadine SR as a Potential Smoking Cessation Treatment (NCT05066724) | Otsuka Pharmaceutical Development & Commercialization, Inc. | 2021-09-15 |
| Lurbinectedin With or Without Irinotecan in Treating Patients With Relapsed or High Risk Metastatic Ewing Sarcoma (NCT05042934) | M.D. Anderson Cancer Center | 2021-09-15 |
| The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors (NCT05124951) | Beijing Tiantan Hospital | 2021-09-15 |
| Novel mGluR5 Modulator Effects on Alcohol Drinking and MRI Outcomes (NCT04831684) | Medical University of South Carolina | 2021-09-15 |
| Safety, Tolerability and Efficacy Of S-1226 in Moderate Severity Covid-19 Bronchiolitis/Pneumonia (NCT04738136) | SolAeroMed Inc. | 2021-09-15 |
| ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2) (NCT04752358) | Adaptimmune | 2021-09-15 |
| Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome (NCT04842448) | Karolinska University Hospital | 2021-09-15 |
| A Study of KL590586 in Patients With Advanced Solid Tumors (NCT05265091) | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | 2021-09-15 |
| Study in Adults of AZD1222 and rAd26-S Administered as Heterologous Prime-Boost Regimen for the Prevention of COVID-19 (NCT04684446) | R-Pharm | 2021-09-15 |
| Non-inferiority of Clinical Trials in Comparison With the Length of Totally Implemented Porth-a-Cath Maintenance From 60 Versus 90 Days (NCT05084040) | AC Camargo Cancer Center | 2021-09-15 |
| Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades (NCT05038007) | Jannie Bisgaard Stæhr | 2021-09-15 |
| Immunogenicity of COVID-19 Vaccine on Heterologous Schedule (NCT05054621) | Chang Gung Memorial Hospital | 2021-09-15 |
| Low Dose ICG for Biliary Tract and Tumor Imaging (NCT04942665) | University of Florida | 2021-09-15 |
| Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome (NCT04845217) | University of Louisville | 2021-09-15 |
| Sabatolimab as a Treatment for Patients With Acute Myeloid Leukemia and Presence of Measurable Residual Disease After Allogeneic Stem Cell Transplantation. (NCT04623216) | Novartis Pharmaceuticals | 2021-09-14 |
| Effects of Edoxaban on Platelet Aggregation (NCT05122455) | University of Sao Paulo | 2021-09-14 |
| A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors (NCT04774718) | Hoffmann-La Roche | 2021-09-14 |
| Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma (NCT04305548) | Italian Sarcoma Group | 2021-09-14 |
| A Study of Mirdametinib on Its Own or in Combination With Fulvestrant in People With Solid Tumor Cancer (NCT05054374) | Memorial Sloan Kettering Cancer Center | 2021-09-14 |
| The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial (NCT05101798) | Icahn School of Medicine at Mount Sinai | 2021-09-14 |
| A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC (NCT04995523) | AstraZeneca | 2021-09-14 |
| A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer. (NCT05004350) | Pierre Fabre Medicament | 2021-09-14 |
| Study of ESG401 in Adults With Solid Tumors (NCT04892342) | Shanghai Escugen Biotechnology Co., Ltd | 2021-09-14 |
| Denosumab and Screw Fixation for Osteoporotic Compression Fracture (NCT05065164) | Shenzhen People's Hospital | 2021-09-14 |
| A Study to Evaluate Safety, Tolerability, Dosimetry, and Preliminary Efficacy of the HER2 Directed Radioligand CAM-H2 in Patients With Advanced/Metastatic HER2-Positive Breast, Gastric, and Gastro-Esophageal Junction (GEJ) Cancer (NCT04467515) | Precirix | 2021-09-14 |
| Ipatasertib and Docetaxel in Metastatic NSCLC Patients Who Have Failed 1st Line Immunotherapy (NCT04467801) | Jun Zhang, MD, PhD | 2021-09-14 |
| PD-1 Blockade With JS001 Plus Neoadjuvant Chemotherapy for Gastric/Gastroesophageal Junction Cancer (NCT05033392) | Wan He | 2021-09-14 |
| A Prospective Phase II Efficacy and Safety Study of Anlotinib in Metastatic or Locally Advanced Pheochromocytoma/ Paraganglioma : Open-label Single-arm, Exploratory Trial (NCT05133349) | Nanjing First Hospital, Nanjing Medical University | 2021-09-14 |
| PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN (NCT04983901) | M.D. Anderson Cancer Center | 2021-09-14 |
| SNIFF - Combo INI+EMPA Trial (NCT05081219) | Wake Forest University Health Sciences | 2021-09-14 |
| Comparison of Tc 99m Tilmanocept Imaging With IHC Analysis of CD206 Expression in Synovial Tissue of Subjects With RA (NCT04078191) | Navidea Biopharmaceuticals | 2021-09-14 |
| A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes (NCT04747431) | Passage Bio, Inc. | 2021-09-14 |
| COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age (NCT04992273) | Regeneron Pharmaceuticals | 2021-09-13 |
| Complement Regulation to Undo Systemic Harm in Preeclampsia (NCT04725812) | Cedars-Sinai Medical Center | 2021-09-13 |
| Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP-II) (NCT04847739) | Avobis Bio, LLC | 2021-09-13 |
| Combined Antihistaminics Therapy in COVID 19 Patients (NCT05043350) | Ain Shams University | 2021-09-13 |
| A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies (NCT05006716) | BeOne Medicines | 2021-09-13 |
| Thrombolysis Combined With Edaravone Dexborneol on Hemorrhagic Transformation for Acute Ischemic Stroke (NCT05035953) | Huashan Hospital | 2021-09-13 |
| Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors (NCT04896697) | Xilio Development, Inc. | 2021-09-13 |
| Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy (NCT04923594) | NLS Pharmaceutics | 2021-09-13 |
| A Study of GFH925 in Patients With Advanced Solid Tumors With KRAS G12C Mutations (NCT05005234) | Innovent Biologics (Suzhou) Co. Ltd. | 2021-09-13 |
| Add-on Intravenous Immunoglobulins in Early Myositis (NCT05832034) | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 2021-09-13 |
| A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα) (NCT05001282) | Elucida Oncology | 2021-09-13 |
| NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial (NCT04750616) | Kaiser Permanente | 2021-09-13 |
| Study Evaluating the Efficacy and Safety of Miconazole Nitrate + Domiphen Bromide Vaginal Cream in the Treatment of Subjects With Acute Vulvovaginal Candidiasis (NCT04813822) | Aesculape CRO Belgium BV | 2021-09-13 |
| Telotristat With Lutathera in Neuroendocrine Tumors (NCT04543955) | Lowell Anthony, MD | 2021-09-13 |
| A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Modified RNA Vaccine Against Influenza (NCT05052697) | Pfizer | 2021-09-13 |
| Evaluation of Bone Regeneration After Apical Surgery Using Advanced Platelet-rich Fibrin: Utilization of Ultrasound for the Assessment of Periapical Lesions (NCT06734962) | Riga Stradins University | 2021-09-12 |
| Safety and Efficiency of γδ T Cell Against Hematological Malignancies After Allo-HSCT (NCT04764513) | Chinese PLA General Hospital | 2021-09-12 |
| Clinical Trial on Sequential Immunization of Recombinant COVID-19 Vaccine (CHO Cells) and Inactivated COVID-19 Vaccine (Vero Cells) in Population Aged 18 Years and Above (NCT05033847) | National Vaccine and Serum Institute, China | 2021-09-12 |
| Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia (NCT05327088) | Ain Shams University | 2021-09-12 |
| Innovative SonoCloud-9 Device for Blood Brain Barrier Opening in First Line Temozolomide Glioblastoma Patients. (NCT04614493) | Assistance Publique - Hôpitaux de Paris | 2021-09-11 |
| Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block (NCT05083663) | Sohag University | 2021-09-10 |
| Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee (NCT04120402) | Eupraxia Pharmaceuticals Inc. | 2021-09-10 |
| Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma (NCT04911621) | University Hospital, Antwerp | 2021-09-10 |