| Study of NM8074 in Adult PNH Patients With Inadequate Response to Soliris (NCT05646563) | NovelMed Therapeutics | 2027-01-01 |
| Relaxin Therapy for Atrial Fibrillation (NCT07359872) | Deeptankar DeMazumder | 2027-01-01 |
| Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform (NCT01777919) | Olympion Medical Center | 2027-01-01 |
| Group PACBT for Depression (NCT07566104) | University of California, Los Angeles | 2027-01-01 |
| Evaluation of the Safety and Efficacy of XoGlo Pro, a Placental Mesenchymal Stem Cell-derived Extracellular Vesicles in Treating COVID-19 Symptoms (NCT07664696) | Kimera Labs Inc. | 2027-01-01 |
| A Safety, Immunogenicity and Efficacy Study of PvRII/Matrix-M in Healthy Thai Adults Living in Thailand ( MIST3 ) (NCT05380388) | University of Oxford | 2027-01-01 |
| Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC (NCT07765836) | Massachusetts General Hospital | 2027-01-01 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial (NCT07131306) | Institute of Liver and Biliary Sciences, India | 2027-01-01 |
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia (NCT06488794) | University Hospital Fattouma Bourguiba | 2027-01-01 |
| rSIFN-co in Combination With Total Neo-adjuvant Therapy in Subjects With Mid-low Locally Advanced Rectal Cancer (NCT07662278) | Sichuan Huiyang Life Science and Technology Corporation | 2027-01-01 |
| Trial of Oral Community SVMP INhibitors for Snakebite (NCT07500233) | Liverpool School of Tropical Medicine | 2027-01-01 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor (NCT07743554) | Girish Dhall, MD | 2027-01-01 |
| Oral Fosamprenavir + Sodium Alginate for GERD (NCT06704100) | Medical College of Wisconsin | 2027-01-01 |
| Daridorexant for Alcohol Use Disorder (NCT07532252) | Johns Hopkins University | 2027-01-01 |
| SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. (NCT07614412) | Ministry of Health, Saudi Arabia | 2027-01-01 |
| Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety. (NCT07679269) | Novartis Pharmaceuticals | 2027-01-01 |
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) (NCT05559801) | Emory University | 2027-01-01 |
| GRACE: A Phase 1/2a Study of VTRU200 in Relapsed/Refractory AML, High-risk MDS, DLBCL Post CART Failure and Advanced Solid Tumors (NCT07749976) | Vitruviae | 2027-01-01 |
| Clinical Trial Evaluating the Effects of Ganaxolone in Children With Autism (NCT07635862) | Stanford University | 2027-01-01 |
| AVTX-801 D-galactose Supplementation in SLC35A2-CDG (NCT05402384) | Eva Morava-Kozicz | 2027-01-01 |
| Nebulized Ketamine for Severe Asthma Attacks in Children (NCT07728851) | Sultan Qaboos University | 2027-01-01 |
| Ketamine HCl Prolonged Release Oral Tablets for CRPS (NCT06419985) | University of Southern California | 2027-01-01 |
| Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage (NCT07662174) | Massachusetts General Hospital | 2027-01-01 |
| Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 (NCT07450183) | Henry Ford Health System | 2027-01-01 |
| Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery (NCT07037004) | City of Hope Medical Center | 2027-01-01 |
| RCT for the Chinese Medicine in Treating Hypercholesterolemia (NCT06700408) | Chinese University of Hong Kong | 2027-01-01 |
| Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study (NCT06435299) | University Hospital, Brest | 2027-01-01 |
| Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO (NCT07499037) | University Hospital Ostrava | 2027-01-01 |
| Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA) (NCT07567768) | University of Calgary | 2027-01-01 |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial (NCT07625930) | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2027-01-01 |
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes (NCT07201987) | Ganesh M. Shankar | 2027-01-01 |
| Safety of F14 Following Total Knee Replacement (NCT04860635) | Arthritis Innovation Corporation | 2027-01-01 |
| An Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia Nervosa (NCT06518941) | New York State Psychiatric Institute | 2027-01-01 |
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) (NCT03180463) | Sclnow Biotechnology Co., Ltd. | 2026-12-31 |
| Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa (NCT05539989) | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 2026-12-31 |
| A Phase 2 Trial Of The Combination Of Zanubrutinib, Sonrotoclax, And Obinutuzumab For Patients With Treatment-Naïve Chronic Lymphocytic Leukemia (NCT07674810) | M.D. Anderson Cancer Center | 2026-12-31 |
| Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. (NCT03176498) | Sclnow Biotechnology Co., Ltd. | 2026-12-31 |
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia (NCT03378414) | Sclnow Biotechnology Co., Ltd. | 2026-12-31 |
| Research for Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-MDS) in the Treatment of Myelodysplastic Syndrome (MDS) (NCT03184935) | Sclnow Biotechnology Co., Ltd. | 2026-12-31 |
| Epcoritamab Plus Venetoclax Plus Ibrutinib in Patients With Chronic Lymphocytic Leukemia With TP53 Alterations (NCT07738887) | The Lymphoma Academic Research Organisation | 2026-12-31 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders (NCT05974293) | Michael, Levy M.D.,Ph.D. | 2026-12-31 |
| Antibody-based PET Imaging and Treatment Response in Breast Cancer Treated With an Antibody-drug Conjugate. (NCT07294430) | UNICANCER | 2026-12-31 |
| Phase 2 Trial of CD70.CAR NK Cells for Patients With Primary Refractory or Early Relapsed Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma (NCT07164469) | M.D. Anderson Cancer Center | 2026-12-28 |
| Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3 (NCT07595874) | City of Hope Medical Center | 2026-12-27 |
| Golcadomide in Combination With Rituximab for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma (NCT07578077) | City of Hope Medical Center | 2026-12-21 |
| Tafasitamab With Acalabrutinib and Venetoclax for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT07582159) | City of Hope Medical Center | 2026-12-19 |
| Elacestrant With Everolimus for the Treatment of Recurrent Advanced or Metastatic ER-Positive Endometrial Cancer (NCT07634601) | Jonsson Comprehensive Cancer Center | 2026-12-18 |
| Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone Lymphoma (NCT07583810) | City of Hope Medical Center | 2026-12-16 |
| Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss (NCT06437054) | Seoul National University Hospital | 2026-12-15 |
| ENA-001 for Post Operative Respiratory Depression (PORD) (NCT06137638) | Enalare Therapeutics Inc. | 2026-12-15 |
| Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy (NCT07354100) | University of Chicago | 2026-12-15 |
| A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer (NCT07603856) | University of Chicago | 2026-12-12 |
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients (NCT03686657) | ARKAY Therapeutics | 2026-12-10 |
| Evaluating the Addition of Maintenance Immunotherapy Compared to the Usual Treatment of Chemotherapy and Autologous Stem Cell Transplant Alone for High-risk Patients With Relapsed or Refractory Hodgkin Lymphoma (NCT07572123) | National Cancer Institute (NCI) | 2026-12-04 |
| Geriatric Assessment-Guided Treatment Selection in Older Adults With Acute Myeloid Leukemia (NCT07735208) | University of Rochester | 2026-12-01 |
| XVIE to Treat Androgenetic Alopecia (AGA) (NCT07482423) | Restore Biologics Holdings, Inc. dba Xtressé | 2026-12-01 |
| Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS (NCT07703462) | n-Lorem Foundation | 2026-12-01 |
| A Study to Evaluate the Efficacy and Safety of ENERGI-F705 Tablets for Parkinson's Disease (NCT07647614) | Energenesis Biomedical Co., Ltd. | 2026-12-01 |
| Electrophysiologic Mechanisms of Ketamine Antidepressant Response (NCT07768618) | Emory University | 2026-12-01 |
| Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma (NCT07125183) | University of Colorado, Denver | 2026-12-01 |
| Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple Myeloma (NCT07600151) | Universitätsklinikum Hamburg-Eppendorf | 2026-12-01 |
| 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain (NCT05265052) | 3D Medicines | 2026-12-01 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response (NCT07767110) | NanOlogy, LLC | 2026-12-01 |
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway (NCT06320951) | University of Alabama at Birmingham | 2026-12-01 |
| The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD (NCT04231760) | University of Alberta | 2026-12-01 |
| Revumenib in Patients With Myelofibrosis (NCT07734077) | John Mascarenhas | 2026-12-01 |
| Menin-Inhibitor Targeted Maintenance in AML (NCT07563010) | Center for International Blood and Marrow Transplant Research | 2026-12-01 |
| A Sequential Phase 2/3 Study of APL2 in Patients With Focal Segmental Glomerulosclerosis (NCT07213960) | Apellis Pharmaceuticals, Inc. | 2026-12-01 |
| A Phase 1b/2a Study of Velinotamig in Adults With Relapsed/Refractory ITP and wAIHA (NCT07738822) | Cullinan Therapeutics Inc. | 2026-12-01 |
| To Establish Whether Dapagliflozin and Spironolactone in Patients With Severe Aortic Stenosis Undergoing Aortic Valve Replacement, Result in Better Left Ventricular Mass Regression, Myocardial Health and Patient Reported Outcomes (NCT07539259) | University College, London | 2026-12-01 |
| Erlotinib for Hepatocellular Carcinoma Chemoprevention (NCT04172779) | University of Texas Southwestern Medical Center | 2026-12-01 |
| Retreat-Based Program for Violence-Exposed Women Veterans (NCT07738445) | VA Office of Research and Development | 2026-12-01 |
| Augmentation Cystoplasty Using an Autologous Neo-Bladder Construct (NCT05054790) | Wake Forest University Health Sciences | 2026-12-01 |
| NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI (NCT05635851) | Simon Fraser University | 2026-12-01 |
| Enfortumab Vedotin, Pembrolizumab and Quemliclustat for the Treatment of Unresectable Locally Advanced and Metastatic Urothelial Cancer (NCT07667335) | Fred Hutchinson Cancer Center | 2026-12-01 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation (NCT07752875) | LG Chem | 2026-12-01 |
| Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) (NCT07739459) | The Lymphoma Academic Research Organisation | 2026-12-01 |
| LVT DURATION: Pilot Study of Anticoagulation Duration for Left Ventricular Thrombus (NCT07246005) | Queen Mary University of London | 2026-12-01 |
| Nivolumab Plus Relatlimab and Gemcitabine/Cisplatin as First-Line Treatment in Advanced Biliary Tract Cancer. (NCT07369791) | National Health Research Institutes, Taiwan | 2026-12-01 |
| Measuring Circulating Tumor Deoxyribonucleic Acid Tumor Fraction to Guide Early 177Lu-PSMA-617 Treatment Discontinuation in Patients With Metastatic Castration-Resistant Prostate Cancer, DYNAMO Trial (NCT07698535) | University of Washington | 2026-12-01 |
| A Phase II Randomized Study to Evaluate Measures for Endpoint Derivation in Patients With Progressive or Refractory Disseminated Coccidioidomycosis (DCM ) Treated With Olorofim Plus Baseline SOC or Placebo Plus Baseline SOC (NCT07712484) | F2G Ltd | 2026-12-01 |
| Comparing UDCA and Corticosteroids in Immunotherapy Induced Cholestatic Hepatitis (NCT07378761) | University Hospital, Montpellier | 2026-12-01 |
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide (NCT07760948) | Vanderbilt University Medical Center | 2026-12-01 |
| Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of PLX-200 in Pediatric Patients (Master Protocol) (NCT07740512) | Polaryx Therapeutics, Inc. | 2026-12-01 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder (NCT03787290) | Massachusetts General Hospital | 2026-12-01 |
| Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer (NCT06196671) | Fudan University | 2026-12-01 |
| SPI-1005 in Adults Receiving Cochlear Implant (NCT06340633) | Sound Pharmaceuticals, Incorporated | 2026-12-01 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients (NCT07724834) | Charite University, Berlin, Germany | 2026-12-01 |
| Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma (NCT07575724) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2026-12-01 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease (NCT07671222) | Instituto de Oftalmología Fundación Conde de Valenciana | 2026-12-01 |
| Oxfendazole in Mild Parenchymal Brain Cysticercosis (NCT06565507) | Universidad Peruana Cayetano Heredia | 2026-12-01 |
| Efficacy and Safety of 3D185 Monotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Cholangiocarcinoma (NCT05039892) | 3D Medicines (Beijing) Co., Ltd. | 2026-12-01 |
| CD30 CAR T-cells Post AutoHSCT for Poor-risk Hodgkin Lymphoma (NCT06617286) | New York Medical College | 2026-12-01 |
| HEME-25: Open-Label Feasibility Study of Elranatamab Utilized in Newly Diagnosed Plasmablastic Lymphoma With or Without HIV (NCT07647432) | University of Illinois at Chicago | 2026-12-01 |
| Faricimab for Chronic Central Serous Chorioretinopathy: A Randomized Sham-Controlled Trial (NCT07681167) | Singapore National Eye Centre | 2026-12-01 |
| Study of CU06-1004 in Patients With Daibetic Macular Edema (NCT07459829) | Curacle Co., Ltd. | 2026-12-01 |
| COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer (NCT06790589) | AHS Cancer Control Alberta | 2026-12-01 |
| 3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial (NCT06638125) | St. Joseph's Healthcare Hamilton | 2026-12-01 |
| Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and Pembrolizumab (NCT07720180) | Medical University of South Carolina | 2026-12-01 |
| A Study of ONC201 for Refractory Meningioma (NCT06012929) | University of Nebraska | 2026-12-01 |