| Efficacy and Safety of Tislelizumab and Nab-paclitaxel Combined With Low-dose Radiotherapy in Patients With Stage IVb Esophageal Squamous Cell Carcinoma (NCT05547828) | The First Affiliated Hospital of Xinxiang Medical College | 2022-12-20 |
| Perioperative TORIPALIMAB Plus LENVATINIB in Patients With Renal Cell Carcinoma Undergoing Nephrectomy (PLUTO) (NCT06114940) | Jinling Hospital, China | 2022-12-20 |
| Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) (NCT05536349) | M.D. Anderson Cancer Center | 2022-12-20 |
| Application of Al18F-octreotide PET/CT in Tumors With Positive SSTR Expression (NCT05749289) | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 2022-12-20 |
| Phase Ⅱ/Ⅲ Clinical Study of Tumor Treating Fields （EFE-P100）Combined With Docetaxel in the Treatment of Stage IV Non-small Cell Lung Cancer Patients With Disease Progression After Platinum-based Chemotherapy and Anti-programmed Death 1（PD-1)/Programmed Cell Death-Ligand 1(PD-L1) Antibody Treatment (NCT05661240) | Jiangsu Healthy Life Innovation Medical Technology Co., Ltd | 2022-12-20 |
| Efficacy and Safety of Nafamostat Mesylate for VV-ECMO Anticoagulation (NCT05555641) | Xiaobo Yang, MD | 2022-12-20 |
| JAB-2485 Activity in Adult Patients With Advanced Solid Tumors (NCT05490472) | Jacobio Pharmaceuticals Co., Ltd. | 2022-12-20 |
| Clinical Study to Evaluate the Possible Efficacy and Safety of Levocetirizine in Patients With Diabetic Kidney Disease (NCT05638880) | Mostafa Bahaa | 2022-12-20 |
| A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia (NCT05669950) | H. Lundbeck A/S | 2022-12-19 |
| Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction (NCT05964738) | Maimónides Biomedical Research Institute of Córdoba | 2022-12-19 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 in Pediatric Subjects With MMA (NCT05778877) | Selecta Biosciences, Inc. | 2022-12-19 |
| A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis (NCT05630547) | Sanofi | 2022-12-19 |
| Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER (NCT05640999) | Canadian Cancer Trials Group | 2022-12-19 |
| Acute Immunological Effects of Exercise in Cancer Patients (NCT05656651) | Universität Duisburg-Essen | 2022-12-19 |
| Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy (NCT05259527) | Virginia Commonwealth University | 2022-12-19 |
| Study of GST-HG171/Ritonavir Compared With Placebo in Patients With Mild to Moderate COVID-19 (NCT05656443) | Fujian Akeylink Biotechnology Co., Ltd. | 2022-12-19 |
| A Study Called ARAMON to Learn to What Extent Does Study Treatment With Darolutamide Affects Testosterone Levels in Men With Prostate Cancer That Had Not Been Treated With Hormonal Therapy Compared to Treatment With Enzalutamide (NCT05526248) | Bayer | 2022-12-19 |
| Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible Pulpitis (NCT06862570) | 28 Military Dental Centre Lahore | 2022-12-19 |
| Efficacy and Safety in Transfusion Independent Non-severe Aplastic Anemia (NCT05399732) | Bing Han | 2022-12-19 |
| Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer (NCT04348747) | Roswell Park Cancer Institute | 2022-12-19 |
| Study of EQ101 in Adult Subjects With Moderate to Severe Alopecia Areata (NCT05589610) | Equillium | 2022-12-19 |
| A Study to Investigate DSA Rebound in Patients Treated With Imlifidase Prior to Transplantation (NCT05049850) | Hansa Biopharma AB | 2022-12-16 |
| Parent Study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA Sub-study) (NCT05648110) | AstraZeneca | 2022-12-16 |
| A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis (NCT05287126) | Pfizer | 2022-12-16 |
| A Study of ANV419 Alone or in Combination With Approved Treatment in Patients With Cutaneous Melanoma (OMNIA-1). (NCT05578872) | Anaveon AG | 2022-12-16 |
| A Study to Evaluate the Safety and Efficacy of Basmisanil Treatment in Children Aged 2-14 Years With Dup15q Syndrome (NCT05307679) | Hoffmann-La Roche | 2022-12-16 |
| ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma (NCT05233397) | Nationwide Children's Hospital | 2022-12-16 |
| Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT) (NCT05337618) | University of Cincinnati | 2022-12-16 |
| The Application of Ursodeoxycholic Acid for the Prevention of SARS-CoV-2 Infection (COVID-19) (NCT05659654) | Institute of Hematology & Blood Diseases Hospital, China | 2022-12-16 |
| Iberdomide-dexamethasone Alone or in Combination With Standard MM Treatment Regimens in Transplant Ineligible Newly Diagnosed Patients. (NCT05527340) | PETHEMA Foundation | 2022-12-15 |
| Immunogenicity and Safety Study of the 3rd Booster Dose Using the High or Medium Dose of Inactivated (CoronaVac®) Vaccine in Healthy Adults in Turkey (NCT05150496) | Sinovac Research and Development Co., Ltd. | 2022-12-15 |
| Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome (NCT05748405) | Aelis Farma | 2022-12-15 |
| Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (NCT05638698) | University of Kansas Medical Center | 2022-12-15 |
| Ezurpimtrostat Autophagy Inhibitor in Association With Atezolizumab-Bevacizumab in First Line Treatment of Unresectable Hepatocellular Carcinoma (NCT05448677) | University Hospital, Grenoble | 2022-12-15 |
| To Assess Efficacy and Safety of Batoclimab in Adult Participants With Active CIDP (NCT05581199) | Immunovant Sciences GmbH | 2022-12-15 |
| Ori-C101Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of HCC (NCT05652920) | OriCell Therapeutics Co., Ltd. | 2022-12-15 |
| FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study (NCT05639543) | Intercept Pharmaceuticals | 2022-12-15 |
| Study of AK119 Combined With AK104 in Patients With Advanced Solid Tumors (NCT05559541) | Akeso | 2022-12-15 |
| A Clinical Study to Evaluate Safety, Tolerance, Pharmacokinetics and Efficacy of Sc610 Injection for Treating Advanced Urinary System Tumors (NCT05633589) | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2022-12-15 |
| Evaluation of the Safety and Efficacy of Esperanza Extract (PA001) (NCT05587088) | Hospital Universitario San Ignacio | 2022-12-15 |
| TT-4 As a Single Agent in Subjects with Advanced Selected Solid Tumors (NCT04976660) | Tarus Therapeutics, Inc. | 2022-12-15 |
| The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction (NCT05499702) | Adrian Vella | 2022-12-15 |
| Hydroxychloroquine Combined With Gemcitabine in the Treatment of Advanced Non-small Cell Lung Cancer (NCT05647330) | Henan Cancer Hospital | 2022-12-15 |
| Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation (NCT05519293) | RedCloud Bio | 2022-12-15 |
| Restoring Sensitivity To Immunotherapy In Advanced Triple Negative Breast Cancer Exploiting Ceralasertib Priming Followed By Combined Durvalumab/Nab-Paclitaxel (NCT05582538) | IFOM ETS - The AIRC Institute of Molecular Oncology | 2022-12-15 |
| Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer (NCT05198830) | National Cancer Institute (NCI) | 2022-12-15 |
| Restoring Tissue and Evaluating Novel Treatments for Efficacy in Wounds (NCT05607979) | Lavior Pharma Inc. | 2022-12-15 |
| Near-infrared Imaging With Indocyanine Green for Detection of Peritoneal Metastases for Gastric Adenocarcinoma. (NCT05687617) | Laval University | 2022-12-15 |
| Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction (NCT05637398) | I.M. Sechenov First Moscow State Medical University | 2022-12-15 |
| Ritlecitinib for Cicatricial Alopecia (NCT05549934) | Emma Guttman | 2022-12-15 |
| Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors (NCT05599048) | Robert Bok, MD, PhD | 2022-12-15 |
| The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning (NCT05647707) | Alexandria University | 2022-12-15 |
| Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects (NCT05906563) | Amira ragab | 2022-12-14 |
| A Study on the Immune Response and Safety of a Combined Measles, Mumps, Rubella, Chickenpox Vaccine Compared to a Marketed Combined Vaccine, Given to Healthy Children 4 to 6 Years of Age (NCT05630846) | GlaxoSmithKline | 2022-12-14 |
| A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease (NCT05496374) | Spero Therapeutics | 2022-12-14 |
| CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL). (NCT05260957) | Lazaros Lekakis | 2022-12-14 |
| A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE) (NCT04803058) | ITB-Med LLC | 2022-12-14 |
| Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients (NCT05691361) | ADARx Pharmaceuticals, Inc. | 2022-12-14 |
| A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS) (NCT05469737) | Bristol-Myers Squibb | 2022-12-14 |
| A Study of VGL101 in Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia (NCT05677659) | Vigil Neuroscience, Inc. | 2022-12-14 |
| Topical SGX302 for Mild-to-Moderate Psoriasis (NCT05442190) | Soligenix | 2022-12-14 |
| Durvalumab and Lenvatinib With or Without Chemotherapy in First-Line Treatment of Advanced Biliary Tract Cancer (NCT05935579) | Peking Union Medical College Hospital | 2022-12-14 |
| Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) (NCT05683860) | Wave Life Sciences USA, Inc. | 2022-12-14 |
| The Synergistic Effect of Portal Venous Supply Control and Immunotherapy in Hepatocellular Carcinoma (NCT05760430) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2022-12-14 |
| Phase II Clinical Study to Compare the Efficacy and Safety of HLX07 + Serplulimab +Chemotherapy Versus Placebo + Serplulimab + Chemotherapy in First-Line Treatment of Patients With Recurrent or Metastatic NPC (NCT05513573) | Shanghai Henlius Biotech | 2022-12-14 |
| A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (NCT05545319) | Pfizer | 2022-12-13 |
| Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events (NCT05537571) | Silence Therapeutics plc | 2022-12-13 |
| A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer (NCT05488314) | Janssen Research & Development, LLC | 2022-12-13 |
| Sotorasib in Previously Treated Locally Advanced or Metastatic NSCLC Subjects With Mutated KRAS p.G12C (NCT05631249) | Gustave Roussy, Cancer Campus, Grand Paris | 2022-12-13 |
| A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Function and Other Systemic Sclerosis Symptoms (NCT05559580) | Boehringer Ingelheim | 2022-12-13 |
| Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease (NCT05650229) | Pharming Technologies B.V. | 2022-12-13 |
| Evaluation of Sonelokimab for the Treatment of Patients With Active Psoriatic Arthritis (NCT05640245) | MoonLake Immunotherapeutics AG | 2022-12-13 |
| A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia (NCT06211634) | Hemab ApS | 2022-12-13 |
| Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation (NCT05659576) | Memorial Sloan Kettering Cancer Center | 2022-12-13 |
| Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION) (NCT05475171) | M.D. Anderson Cancer Center | 2022-12-13 |
| Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder (NCT05512377) | Boehringer Ingelheim | 2022-12-13 |
| A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (NCT05271604) | BioAtla, Inc. | 2022-12-13 |
| UNITy-BasED MR-Linac Adaptive Simultaneous Integrated Hypofractionated Boost Trial for High Grade Glioma in the Elderly (NCT05565521) | Sunnybrook Health Sciences Centre | 2022-12-13 |
| Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5413 in Adult Participants18 Years of Age and Older (NCT05650554) | Sanofi Pasteur, a Sanofi Company | 2022-12-12 |
| A Human Tick Kill Study to Investigate the Safety, Tolerability, and Whole Blood Concentration of TP-05 (NCT05387083) | Tarsus Pharmaceuticals, Inc. | 2022-12-12 |
| A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma (NCT05529316) | Agenus Inc. | 2022-12-12 |
| Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants (NCT05340582) | Mount Sinai Hospital, Canada | 2022-12-12 |
| The Combination of Immunotherapy and Neoadjuvant Short-course Radiotherapy in Early Rectal Cancer (NCT05555888) | Fudan University | 2022-12-12 |
| CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 (NCT04378244) | Aveni Foundation | 2022-12-12 |
| Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer (NCT06417476) | Pei-Rong Ding | 2022-12-12 |
| A Study to Assess the Safety of TPM502 in Adults With Celiac Disease (NCT05660109) | Topas Therapeutics GmbH | 2022-12-12 |
| Dose Finding Study to Evaluate Safety and Efficacy of 3 Dosages of SAP 001. (NCT05690204) | Shanton Pharma Pte. Ltd. | 2022-12-12 |
| Surufatinib Combined With Sintilimab and AG in First-line Therapy of Patients With Locally Advanced or Metastatic Pancreatic Cancer (NCT05481476) | Sun Yat-sen University | 2022-12-12 |
| Allogenic CD19-targeting CAR-γδT Cell Therapy in R/R NHL (NCT05554939) | Chinese PLA General Hospital | 2022-12-11 |
| Sintilimab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for ctDNA-level-relapse and Clinical-relapse Glioblastoma (NCT05502991) | Henan Provincial People's Hospital | 2022-12-11 |
| Anti-PD-1 Immunotherapy Combined With SBRT for Patients With Oligometastatic ESCC (NCT05626569) | Sun Yat-sen University | 2022-12-10 |
| Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma (NCT05102721) | Vaccinex Inc. | 2022-12-10 |
| Yttrium Y 90 Glass Microspheres, Atezolizumab, and Cabozantinib for the Treatment of Unresectable or Locally Advanced Hepatocellular Carcinoma (NCT05327738) | OHSU Knight Cancer Institute | 2022-12-10 |
| Safety and Efficacy of Sequential CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma (NCT05651100) | Kecellitics Biotech Company Ltd | 2022-12-10 |
| Melatonin for Post Operative Delirium Prevention in Elderly Patients (NCT05640934) | Menoufia University | 2022-12-10 |
| A Clinical Trial to Assess Safety and Efficacy of Daratumumab in the Treatment of Primary Immune Thrombocytopenia (NCT05562882) | Institute of Hematology & Blood Diseases Hospital, China | 2022-12-10 |
| A Study to Evaluate Inetetamab + Pyrotinib + Chemotherapy in Previously Untreated HER2-Positive Metastatic Breast Cancer (NCT05621434) | Fujian Medical University | 2022-12-10 |
| A Study of Intraperitoneally Administered AVB-001 in Patients With Serous Adenocarcinoma of the Ovary (NCT05538624) | Avenge Bio, Inc | 2022-12-09 |
| A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia (NCT05664737) | Bristol-Myers Squibb | 2022-12-09 |
| Sepantronium Bromide for the Treatment of High-grade B-cell Lymphoma (NCT05263583) | Cothera Bioscience, Inc | 2022-12-09 |