| A First-in-Human Safety and Pharmacokinetic Trial of GenSci142 Administered as Single Ascending Doses in Healthy Chinese Women (NCT07302035) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-12-01 |
| Drug-Drug Interaction Between THC and AEF0117 (NCT06395688) | Aelis Farma | 2025-12-01 |
| A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies (NCT07197554) | SEED Therapeutics, Inc. | 2025-12-01 |
| Temporal Interference for Thalamocortical Activity and Network Modulation (NCT07219719) | University of Wisconsin, Madison | 2025-12-01 |
| Evaluation of Safety and Tolerability of ATB-320 in Participants With Progressive or Metastatic Solid Tumors (NCT06933524) | Autotelicbio | 2025-12-01 |
| A Phase I Study Investigating the Local Tolerability and Pharmacokinetics of Isoniazid (INH) Inhalation by Wet Nebulization in Patients With Tuberculosis (NCT07708779) | University Medical Center Groningen | 2025-12-01 |
| Clostridium Butyricum in Stenosing Crohn's Desease (NCT07263880) | San Giovanni Addolorata Hospital | 2025-12-01 |
| A Multiple Tumor Species, Open and Multi-center Clinical Study of Alpaloritovorelli Antibodies (QL-1706) Combined with Pulsed Low Dose Rate External Irradiation (PLDR) for Disease Progression After Previous Anti-tumor Therapy (NCT06760676) | Anhui Provincial Hospital | 2025-12-01 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Skin Ulcer (NCT05158127) | The Foundation for Orthopaedics and Regenerative Medicine | 2025-12-01 |
| Safety of Cultured Autologous Adult Adipose Derived Mesenchymal Stem Cell Intravenous Infusion for CP (NCT05018871) | The Foundation for Orthopaedics and Regenerative Medicine | 2025-12-01 |
| Evaluation of Piezocision Versus Injectable Platelet-rich Fibrin During Orthodontic Canine Retraction Orthodontic Canine Retraction: A Comparative Clinical Study (NCT07239024) | Al-Azhar University | 2025-12-01 |
| A Study to Access the Efficacy in Type 2 Diabetes Mellitus on Stable Metformin (NCT04662164) | Shanghai HEP Pharmaceutical Co., Ltd. | 2025-12-01 |
| Study of CHO-A04 in Advanced Solid Tumors (NCT07049458) | Cho Pharma Inc. | 2025-12-01 |
| Nebulized Nasal Steroids (NCT07270302) | Washington University School of Medicine | 2025-12-01 |
| Personalized KXV01 Lentinvivo (TCR) Injection as the Therapy for Advanced Solid Tumors (NCT07275853) | TCRx Therapeutics Co.Ltd | 2025-12-01 |
| Intervention of Ovarian Cancer With Antigen-specific Engineered Immune Effectors (NCT03393962) | Shenzhen Geno-Immune Medical Institute | 2025-12-01 |
| CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease (NCT07305116) | The Children's Hospital of Zhejiang University School of Medicine | 2025-12-01 |
| MCRcI® Stem Cell Treatment for Diffuse Coronary Artery Disease (NCT04052191) | Honya Medical Inc | 2025-12-01 |
| A Study (Phase 1b/2) of GS3-007a Oral Treatment in Children With Growth Hormone Deficiency (PGHD) (NCT07264595) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-12-01 |
| An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia (NCT06281847) | Advesya SAS | 2025-12-01 |
| Exploratory Study of Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Treatment of Ischemic Stroke (NCT07232563) | Zhujiang Hospital | 2025-12-01 |
| Reverse Transcriptase Inhibitors in Aicardi Goutières Syndrome (NCT03304717) | Children's Hospital of Philadelphia | 2025-12-01 |
| A First-in-Human Phase I Study of ESG206 in Subjects With B-cell Lymphoid Malignancies (NCT05263739) | Shanghai Escugen Biotechnology Co., Ltd | 2025-12-01 |
| Helpline Pilot Factorial Trial (NCT06591026) | The National Center on Addiction and Substance Abuse at Columbia University | 2025-12-01 |
| A Study to Evaluate the Safety and Effectiveness of Magnetic Resonance-Guided Ultrasound Ablation of the Anterior Nucleus of Thalamus for the Treatment of Drug-resistant Epilepsy. (NCT07249190) | Chinese PLA General Hospital | 2025-12-01 |
| A Clinical Study to Explore CT1195E in Patients With Relapsed/Refractory B-Cell Neoplasms (NCT07234045) | Institute of Hematology & Blood Diseases Hospital, China | 2025-11-30 |
| The Safety and Efficacy of NouvSoma001 in Ischemic Stroke (NCT06612710) | Wei Wang | 2025-11-30 |
| IL-5 CAR-T Cell Therapy for Refractory/Relapsed Eosinophilic Leukemia (NCT07257640) | Zhejiang University | 2025-11-30 |
| Clofutriben Pharmacokinetics in Patients With Impaired Renal Function (NCT07227922) | Sparrow Pharmaceuticals | 2025-11-30 |
| Safety Trial of 68Ga/177Lu-NRT6020 in FAP-Positive Advanced Solid Tumor Patients (NCT06911489) | Chengdu New Radiomedicine Technology Co. LTD. | 2025-11-29 |
| Multicenter, Single-Arm Exploratory Phase I Clinical Study (Assessment of Safety and Efficacy) of Fully Human BAFF-R Chimeric Antigen Receptor T-Cell Injection in Relapsed/Refractory BAFF-R-Positive B-Cell Lymphoma (NCT07259070) | Institute of Hematology & Blood Diseases Hospital, China | 2025-11-29 |
| Intraperitoneal Injection of Liposomal Irinotecan as Monotherapy or in Combination With Recombinant Mutant Human Tumor Necrosis Factor or Bevacizumab for the Treatment of Malignant Ascites Following Failure of Prior Standard Therapy (NCT07397819) | Dong sheng Zhang | 2025-11-28 |
| Study of Food Effects of VV119 Capsules in Chinese Healthy Volunteers (NCT07240636) | Vigonvita Life Sciences | 2025-11-28 |
| A Study to Evaluate COR-1004 in Adult Volunteers. (NCT07229118) | Corsera Health | 2025-11-28 |
| A Study to Assess Adverse Events, Change in Disease Activity and How Intravenous (IV) ABBV901 Moves Through the Body Alone or in Combination With Bevacizumab in Adult Participants With Ovarian Cancer (NCT07278336) | AbbVie | 2025-11-27 |
| A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib (NCT07362940) | Henan Genuine Biotech Co., Ltd. | 2025-11-27 |
| A Study of MHB042C in Patients With Advanced Solid Tumors (NCT07192107) | Minghui Pharmaceutical (Hangzhou) Ltd | 2025-11-27 |
| A Mass Balance Study of [14C] MT1013 in Hemodialysis Subjects With Secondary Hyperparathyroidism (NCT07284043) | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 2025-11-27 |
| A Trial of Itraconazole Effect on HRS-8080 Pharmacokinetics in Healthy Participants (NCT07229560) | Shandong Suncadia Medicine Co., Ltd. | 2025-11-26 |
| A Phase I Study of JSB462 (Luxdegalutamide) in Japanese Patients With Metastatic Prostate Cancer (NCT07174063) | Novartis Pharmaceuticals | 2025-11-26 |
| A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors (NCT07129252) | Crinetics Pharmaceuticals Inc. | 2025-11-26 |
| Pharmacokinetic, Safety, Tolerability, and Immunogenicity Comparison of CKD-704 (Risankizumab Biosimilar), With EU-approved Skyrizi®, and US-licensed Skyrizi® in Healthy Adult Participants (NCT07258745) | Chong Kun Dang Pharmaceutical | 2025-11-26 |
| Safety and Challenge Study of BCG TICE(R) Vaccination to Test Tuberculosis Immunity in Heathy Humans (NCT06845358) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-11-26 |
| A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures (NCT07233239) | Jazz Pharmaceuticals | 2025-11-26 |
| Single-dose,First-in-human of KLA478 (NCT07240675) | Hunan Kelun Pharmaceutical Co., Ltd. | 2025-11-26 |
| Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus (NCT04370795) | National Institute of Allergy and Infectious Diseases (NIAID) | 2025-11-26 |
| Phase I Clinical Study To Evaluate Pharmacokinetic Profile, Safety, Efficacy and Immunogenicity Of Ipilimumab Biosimilar HLX13 Vs. YERVOY® (US-Sourced YERVOY®) As A First-Line Treatment For Patients With Unresectable Hepatocellular Carcinoma (NCT07176650) | Shanghai Henlius Biotech | 2025-11-25 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) (NCT07414212) | Biogipuzkoa Health Research Institute | 2025-11-25 |
| Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease (NCT07226219) | St. Jude Children's Research Hospital | 2025-11-25 |
| A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 Diabetes (NCT07270731) | Novo Nordisk A/S | 2025-11-25 |
| A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TQC3302 Inhalation Spray in Healthy Adult Subjects (NCT07267130) | Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd. | 2025-11-25 |
| A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies (NCT07223047) | Bristol-Myers Squibb | 2025-11-25 |
| A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy (NCT07161414) | AstraZeneca | 2025-11-25 |
| Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes (NCT07263945) | University of Colorado, Denver | 2025-11-25 |
| Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MT-304 in Adults With Advanced HER2-Expressing Solid Tumors (NCT07334119) | Myeloid Therapeutics | 2025-11-25 |
| SA1211 Injection Phase 1 Study (NCT07275918) | Suzhou Siran Biotechnology Co.,Ltd. | 2025-11-25 |
| A Phase I Study of WTX212A Monotherapy or in Combination With Radiotherapy in Patients With Advanced Solid Tumors (NCT07269899) | Sun Yat-sen University | 2025-11-25 |
| Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors (NCT07261631) | Novartis Pharmaceuticals | 2025-11-24 |
| A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy (NCT07227857) | Institut de Recherches Internationales Servier | 2025-11-24 |
| A Study to Evaluate How the Study Drug Moves Through the Body, Adverse Events, and How the Body Tolerates ABBV-547 Injections (NCT07232004) | AbbVie | 2025-11-24 |
| An Exploratory Clinical Study of YTS109 Cell for R/R Autoimmune Diseases (NCT07236762) | China Immunotech (Beijing) Biotechnology Co., Ltd. | 2025-11-24 |
| A Study to Compare Blood Levels of Different Dosage Formulations of the Study Medicine That Is a CGRP Receptor Antagonist in Healthy Adults (NCT07261371) | Pfizer | 2025-11-24 |
| A Platform Study in Non-Small Cell Lung Cancer (NSCLC) (NCT06996782) | AstraZeneca | 2025-11-24 |
| The Effect of an Oral Nutritional Supplement on the Nutritional and Health Outcomes of the Elderly (NCT06773975) | University of Ghana | 2025-11-24 |
| Mosunetuzumab for CLL MRD Clearance (NCT07052695) | Inhye Ahn | 2025-11-24 |
| An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin (NCT07269327) | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 2025-11-24 |
| A Phase Ia Clinical Trial of HW241045 (NCT07448194) | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. | 2025-11-24 |
| Establishing a Controlled Human Infection Model of Pertactin-deficient Bordetella Pertussis (NCT06827470) | Dalhousie University | 2025-11-24 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Preliminary Efficacy of BC2027 in Patients With Advanced Solid Malignancies (NCT07368478) | Biocity Biopharmaceutics Co., Ltd. | 2025-11-24 |
| Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat. (NCT07256834) | Jinnah Postgraduate Medical Centre | 2025-11-22 |
| Phase I Study of PollenVax in Patients With Mugwort Pollen-Induced Allergic Rhinitis (NCT07317960) | Kazakh National Agrarian University | 2025-11-22 |
| Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS (NCT07532824) | Institute of Hematology and Blood Transfusion, Czech Republic | 2025-11-21 |
| IASO208 Injection in the Treatment of Relapsed/Refractory B-cell Malignancies (NCT07309900) | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2025-11-21 |
| A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors (NCT07300150) | PAQ Therapeutics, Inc. | 2025-11-21 |
| A Study of GensSci098 in Subjects With Graves' Disease (NCT07286656) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-11-21 |
| A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants (NCT07329972) | Genentech, Inc. | 2025-11-21 |
| A Trial to Investigate Safety and Pharmacokinetics of GRT6019, Including Food Effect, in Healthy Male Participants (NCT07317063) | Grünenthal GmbH | 2025-11-21 |
| A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001) (NCT07103018) | K36 Therapeutics, Inc. | 2025-11-21 |
| Acute Effects of Oral Nicotine Pouches (NCT07128329) | Johns Hopkins University | 2025-11-21 |
| A Study in Healthy Men to Find Out How Different Doses of BI 3009947 Are Tolerated and How Different Formulations or Food Influence How BI 3009947 is Taken up Into the Blood (NCT07250048) | Boehringer Ingelheim | 2025-11-21 |
| A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults (NCT07444294) | Scholar Rock, Inc. | 2025-11-21 |
| Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma (NCT07136181) | Novelwise Pharmaceutical Corporation | 2025-11-20 |
| Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2) (NCT07158411) | Deciphera Pharmaceuticals, LLC | 2025-11-20 |
| A Phase I/II Clinical Study of WJ22096 Tablets in Patients With Advanced Tumors (NCT07253116) | Nanjing Jingao biomidical technology Co. Ltd. | 2025-11-20 |
| A Study of SHR-4610 Injection in Patients With Advanced Solid Tumors (NCT07231211) | Shanghai Shengdi Pharmaceutical Co., Ltd | 2025-11-20 |
| Erdosteine in the Treatment of Nonalcoholic Fatty Liver Disease (NCT07242222) | Tanta University | 2025-11-20 |
| Celecoxib in Parkinson Disease as Adjuvant Therapy (NCT07246278) | Tanta University | 2025-11-20 |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease (NCT07235059) | Novartis Pharmaceuticals | 2025-11-20 |
| A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors (NCT07241039) | AbbVie | 2025-11-20 |
| A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016) (NCT07222098) | Merck Sharp & Dohme LLC | 2025-11-19 |
| A Study of BPR-6023021 in Advanced Solid Tumors With Bone Metastases (NCT07249892) | Chengdu Syncor Pharmaceutical Co., Ltd. | 2025-11-19 |
| GenSci139 in Patients With Advanced Solid Tumors (NCT07230977) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2025-11-19 |
| A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma (NCT07076550) | Alpha-9 Oncology USA Inc. | 2025-11-19 |
| GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma (NCT06921317) | IVIEW Therapeutics Inc. | 2025-11-19 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease (NCT07246941) | Hoffmann-La Roche | 2025-11-19 |
| A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors (NCT07205718) | Takeda | 2025-11-19 |
| A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity (NCT07291232) | AbbVie | 2025-11-19 |
| Study to Assess Safety, Tolerability, PK, and PD of Multiple Doses of ZE63-0302 Administrated Orally in T2DM Patients. (NCT07234864) | Eilean Therapeutics | 2025-11-19 |
| [68Ga]Ga DOTA-5G as a Diagnostic Imaging Agent for Metastatic/Advanced Invasive Lobular Breast Cancer (LBC) (NCT07020806) | University of California, Davis | 2025-11-18 |
| A Study to Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function (NCT07231991) | Pfizer | 2025-11-18 |