| First in Human Study of ANXV (Recombinant Human Annexin A5) in Healthy Volunteers (NCT04850339) | Annexin Pharmaceuticals AB | 2020-12-21 |
| A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers (NCT04626635) | Regeneron Pharmaceuticals | 2020-12-21 |
| A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors (NCT04672460) | Pfizer | 2020-12-21 |
| An Open Label, Multi-center, Phase I Clinical Study to Evaluate the Safety, Effectiveness and Pharmacokinetic Characteristics of SIM1803-1A in Patients With Locally Advanced/Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion Mutations. (NCT04671849) | Jiangsu Simcere Pharmaceutical Co., Ltd. | 2020-12-21 |
| First-in-Human Evaluation of GRN-300 in Subjects With Recurrent Ovarian, Primary Peritoneal, and Fallopian Tube Cancers. (NCT04711161) | Green3Bio, Inc. | 2020-12-21 |
| Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia (NCT04250051) | Northwestern University | 2020-12-21 |
| A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the Blood (NCT04679948) | Boehringer Ingelheim | 2020-12-21 |
| Absolute Bioavailability and ADME Study of [14C]AZD9977 in Healthy Male Subjects (NCT04686591) | AstraZeneca | 2020-12-21 |
| Study of GSK3845097 in Previously Treated Participants With Advanced Synovial Sarcoma and Myxoid/Round Cell Liposarcoma (NCT05943990) | Adaptimmune | 2020-12-21 |
| A Safety and Preliminary Efficacy Study of CC-99282 in Combination With Obinutuzumab in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT04434196) | Celgene | 2020-12-21 |
| Ezrin Peptide (HEP-1) for Treatment of Coronavirus Disease (COVID-19) Infection (NCT04627233) | Shahid Beheshti University of Medical Sciences | 2020-12-20 |
| Efficacy of Fluoride Varnish Containing Xylitol Coated Calcium Phosphate Versus Conventional Fluoride Varnish in Management of Hypersensitivity of Exposed Root Surfaces in Adult Patients (NCT04472182) | Cairo University | 2020-12-20 |
| A Study of AL58805 in Patients With Advanced Tumors (NCT07179081) | Advenchen Laboratories Nanjing Ltd. | 2020-12-20 |
| Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects (NCT04729088) | Biolab Sanus Farmaceutica | 2020-12-20 |
| Tamoxifen Therapy for Myotubular Myopathy (NCT04915846) | James Dowling | 2020-12-18 |
| Effect of BMS-986165 on the Blood Levels of Metformin (NCT04671953) | Bristol-Myers Squibb | 2020-12-18 |
| Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants (NCT06190691) | Eli Lilly and Company | 2020-12-18 |
| Estimation of the Effect of Multiple Dose Ritlecitinib (PF-06651600) on the Pharmacokinetics of a Single Dose of Caffeine in Healthy Participants (NCT04655040) | Pfizer | 2020-12-18 |
| Leveraging Social Media to Identify and Connect Teens With Eating Disorders to a Mobile Guided Self-Help Mobile Intervention (NCT04636840) | Washington University School of Medicine | 2020-12-18 |
| A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod (NCT04639115) | Celgene | 2020-12-18 |
| Comparison of Daprodustat Formulations Produced by Two Methods of Manufacture for Bioequivalence and Dissolution in Healthy Participants (NCT04640311) | GlaxoSmithKline | 2020-12-18 |
| Single and Multiple-Ascending Dose Study of CRN04894 in Healthy Volunteers (NCT06048887) | Crinetics Pharmaceuticals Inc. | 2020-12-18 |
| First-in-Human Study of INT-1B3 in Patients With Advanced Solid Tumors (NCT04675996) | InteRNA | 2020-12-18 |
| Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment. (NCT03782363) | Italian Sarcoma Group | 2020-12-18 |
| A Pilot Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19 (NCT04622332) | Sironax USA, Inc. | 2020-12-18 |
| Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03) (NCT04626518) | Merck Sharp & Dohme LLC | 2020-12-17 |
| Romidepsin, CC-486 (5-azacitidine), Dexamethasone, and Lenalidomide (RAdR) for Relapsed/Refractory T-cell Malignancies (NCT04447027) | National Cancer Institute (NCI) | 2020-12-17 |
| Safety and Immunogenicity of a SARS-CoV-2 Vaccine (NBP2001) in Healthy Adults (COVID-19) (NCT04760743) | SK Bioscience Co., Ltd. | 2020-12-17 |
| A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer (NCT04556773) | AstraZeneca | 2020-12-17 |
| Chk2 Inhibitor for Recurrent EpitheliAl periToneal, fallopIan or oVarian cancEr (CREATIVE Phase IA Trial) (NCT04678102) | Seoul National University Hospital | 2020-12-17 |
| Study to Assess Safety, Tolerability and Pharmacokinetics of XC7 (Which is Planned Use in the Treatment of COVID-19) in Healthy Volunteers (NCT04679493) | NP Therapeutics | 2020-12-17 |
| Evaluation of the Potential CYP1A2-mediated Drug Drug Interaction Safety, and Tolerability of ABX464 (NCT05121714) | Abivax S.A. | 2020-12-17 |
| A Study of Fluzoparib in Combination With mFOLFIRINOX in Patients With Resectable Pancreatic Cancer (NCT04425876) | Jiangsu HengRui Medicine Co., Ltd. | 2020-12-17 |
| Study of TJ210001 Administered in Subjects With Relapsed or Refractory Advanced Solid Tumors (NCT04678921) | I-Mab Biopharma US Limited | 2020-12-17 |
| Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A) (NCT04626479) | Merck Sharp & Dohme LLC | 2020-12-16 |
| ApoGraft for the Prevention of Acute Graft Versus Host Disease in Haploidentical Hematopoietic Cell Transplant Recipients (NCT04006652) | Washington University School of Medicine | 2020-12-16 |
| Metabolism and Excretion of [14C]CC-90001 in Healthy Male Subjects (NCT04655898) | Celgene | 2020-12-16 |
| A First-in-Human Study of AV-001 in Healthy Subjects (NCT04737486) | Vasomune Therapeutics, Inc. | 2020-12-16 |
| A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) (NCT04590235) | AstraZeneca | 2020-12-16 |
| Development of a mHealth Intervention for Ambivalent Smokers (NCT04560868) | Kaiser Permanente | 2020-12-16 |
| Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults (NCT04425902) | ViiV Healthcare | 2020-12-16 |
| Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors (NCT04628780) | Pfizer | 2020-12-16 |
| The Efficacy of JS001 Combined With Chemotherapy in Patients With Locally Advanced Colon Cancer (NCT03985891) | Xiangya Hospital of Central South University | 2020-12-16 |
| Safety, Tolerability and Pharmacokinetics of AM1476 in Healthy Subjects (NCT04691115) | AnaMar AB | 2020-12-16 |
| Study of M5049 in CLE and SLE Participants (NCT04647708) | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 2020-12-16 |
| Dose Finding Study to Evaluate The Safety, Tolerability and Immunogenicity of an Inactiviated, Adjuvanted SARS-CoV-2 Virus Vaccine Candidate Against Covid-19 in Healthy Subjects (NCT04671017) | Valneva Austria GmbH | 2020-12-16 |
| Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities (NCT04683250) | Taiho Pharmaceutical Co., Ltd. | 2020-12-16 |
| A Study to Assess the Safety and Tolerability of E2730 After Multiple Dose and the Food Effect After Single Dose in Healthy Participants (NCT04676685) | Eisai Inc. | 2020-12-16 |
| Study of Intravenous Administration of Allogeneic Adipose Stem Cells for COVID-19 (NCT04486001) | Sorrento Therapeutics, Inc. | 2020-12-15 |
| Induction of Transplant Tolerance in LDLT Via iTS (NCT04950842) | Juntendo University | 2020-12-15 |
| LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors (NCT04666688) | PureTech | 2020-12-15 |
| A Study of PRA023 in Healthy Volunteers (NCT04676178) | Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2020-12-15 |
| Study To Evaluate The Effect Of Two Steady State Doses of PF 06882961 On Rosuvastatin And Midazolam Pharmacokinetics In Otherwise Healthy Adult Participants With Obesity (NCT04621227) | Pfizer | 2020-12-15 |
| A Study to Test Different Doses of BI 765063 Alone and in Combination With BI 754091 in Japanese Patients With Different Types of Advanced Cancer (Solid Tumors) (NCT04653142) | Boehringer Ingelheim | 2020-12-15 |
| Evaluate Umbilical Cord-derived Allogeneic Mesenchymal Stem Cells for the Treatment of Bradykinesia (NCT04385056) | IMAC Holdings, Inc. | 2020-12-15 |
| A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors (NCT04670679) | Erasca, Inc. | 2020-12-15 |
| A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma (NCT04586426) | Janssen Research & Development, LLC | 2020-12-15 |
| Safety and Tolerability Study of Suprachoroidal Injection of CLS-AX Following Anti-VEGF Therapy in Neovascular AMD (NCT04626128) | Clearside Biomedical, Inc. | 2020-12-15 |
| Ablation Combined With PD-1 in HCC: Phase II Study (NCT04652440) | Sun Yat-sen University | 2020-12-15 |
| Phase 1b Study of AEVI-007 in Subjects With Relapsed or Refractory Multiple Myeloma (NCT04671251) | Avalo Therapeutics, Inc. | 2020-12-15 |
| Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver, Gastrointestinal, Endocrine and Skin Toxicity (NCT04631731) | Western Sydney Local Health District | 2020-12-15 |
| A Study of APG-1252 in Patients With Myelofibrosis Who Progressed After Initial Therapy (NCT04354727) | Ascentage Pharma Group Inc. | 2020-12-15 |
| Influence of Bovine Lactoferrin on Feeding Intolerance and Intestinal Permeability in Preterm Neonates (NCT04738058) | Mansoura University Children Hospital | 2020-12-15 |
| To Assess the Safety and Tolerability of Tafasitamab Alone or in Combination With Other Drugs in Japanese Participants With Non-Hodgkins Lymphoma (NHL) (NCT04661007) | Incyte Biosciences Japan GK | 2020-12-15 |
| A Study to Evaluate the Effect of Pirtobrutinib (LOXO-305) on QTc Interval in Healthy Participants (NCT06215521) | Eli Lilly and Company | 2020-12-15 |
| Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC (NCT04947241) | Fifth Affiliated Hospital, Sun Yat-Sen University | 2020-12-15 |
| Bioequivalence of Dapagliflozin 10 mg Tablets Under Fasting Conditions (NCT04880993) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2020-12-14 |
| A Phase Ib/III Clinical Study to Evaluate the Efficacy and Safety of IBI318 in Combination With Paclitaxel Versus Placebo in Combination With Paclitaxel in Patients With Small Cell Lung Cancer Who Have Failed First-line or Above Chemotherapies (NCT04672928) | Innovent Biologics (Suzhou) Co. Ltd. | 2020-12-14 |
| SARS-CoV-2-Neutralizing Monoclonal COVID-19 Antibody DZIF-10c by Inhalation (NCT04631705) | University of Cologne | 2020-12-14 |
| Neihulizumab for Standard-Risk Acute Graft Versus Host Disease (GVHD) (NCT04144036) | Sameem M. Abedin, MD | 2020-12-14 |
| FS222 First in Human Study in Patients With Advanced Malignancies (NCT04740424) | invoX Pharma Limited | 2020-12-14 |
| PROtocol for Coxsackievirus VaccinE in Healthy VoluNTteers (NCT04690426) | Provention Bio, Inc. | 2020-12-14 |
| GYNecological Cancers Treated with NETrin MAbs in Combination with Chemotherapy and /or Pembrolizumab (NCT04652076) | NETRIS Pharma | 2020-12-14 |
| A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001) (NCT04471727) | Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2020-12-14 |
| Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors (NCT03740256) | Baylor College of Medicine | 2020-12-14 |
| A Study to Evaluate the Pharmacokinetics (PK) of Medroxyprogesterone Acetate Following an Injection of TV-46046 in Healthy Women of Reproductive Age (NCT04682353) | Teva Branded Pharmaceutical Products R&D, Inc. | 2020-12-14 |
| Imaging of Solid Tumors Using FAP-2286 (NCT04621435) | Thomas Hope | 2020-12-14 |
| A Safety and Pharmacokinetics Study of UCB7853 in Healthy Study Participants and Study Participants With Parkinson's Disease (PD) (NCT04651153) | UCB Biopharma SRL | 2020-12-14 |
| Study to Investigate Relative Bioavailability of Different Formulations of SHR6390 in Healthy Subjects (NCT04667156) | Jiangsu HengRui Medicine Co., Ltd. | 2020-12-13 |
| The Therapeutic Effect of Dau-Di-Wu-Gong in Patient With Ankle Fracture (NCT03805347) | Changhua Christian Hospital | 2020-12-12 |
| A Study of the Cardiac Effects of ALXN2050 in Healthy Adults (NCT04660890) | Alexion Pharmaceuticals, Inc. | 2020-12-12 |
| Phase 1 Trial of LVGN7409 (CD40 Agonist Antibody) as Single Agent and Combination Therapies in Advanced or Metastatic Malignancy (NCT04635995) | Lyvgen Biopharma Holdings Limited | 2020-12-11 |
| Nilotinib in Preventing Paclitaxel-Induced Peripheral Neuropathy in Patients With Stage I-III Breast Cancer (NCT04205903) | Ohio State University Comprehensive Cancer Center | 2020-12-11 |
| Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19 (NCT04619628) | Codagenix, Inc | 2020-12-11 |
| Bioequivalence of Dapagliflozin 10 mg Tablets Under Fed Conditions (NCT04881006) | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 2020-12-10 |
| Study to Assess Adverse Events and How Intravenous (IV) ABBV-47D11 and IV ABBV-2B04 Given Alone and in Combination Moves Through the Body of Adult Participants With Coronavirus Disease 2019 (COVID-19) (NCT04644120) | AbbVie | 2020-12-10 |
| The Safety and Efficacy Study of PROTOXIN in Subjects With Moderate to Severe Glabellar Lines (NCT04996810) | Protox Inc. | 2020-12-10 |
| Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease (NCT04588545) | H. Lee Moffitt Cancer Center and Research Institute | 2020-12-10 |
| A Relative Bioavailability Study of FOR-6219 in Capsule and Tablet Formulations (NCT04686669) | Forendo Pharma Ltd | 2020-12-10 |
| Safety and Bioactivity of AXT107 in Subjects With Diabetic Macular Edema (NCT04697758) | AsclepiX Therapeutics, Inc. | 2020-12-10 |
| A Clinical Trial to Assess the Safety and Immunogenicity of Nanocovax in Heathy Volunteers (NCT04683484) | Nanogen Pharmaceutical Biotechnology Joint Stock Company | 2020-12-10 |
| Transplantation of Fibroblast for Correction of Nasolabial Folds (NCT03140319) | SCARM Institute, Tabriz, Iran | 2020-12-10 |
| A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients (NCT04635800) | Novartis Pharmaceuticals | 2020-12-10 |
| Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors (NCT04684940) | BioMarin Pharmaceutical | 2020-12-10 |
| Study to Evaluate Safety and Tolerability of PF-07242813 in Healthy Participants and Participants With Atopic Dermatitis (NCT04668066) | Pfizer | 2020-12-10 |
| BGB-DXP604 Alone and in Combination With BGB-DXP593 in Healthy Participants (NCT04669262) | BeiGene | 2020-12-09 |
| A Food-Effect Study of Hemay022 in Healthy Participants (NCT04673474) | Tianjin Hemay Oncology Pharmaceutical Co., Ltd | 2020-12-09 |
| PRevention Using EPA Against coloREctal Cancer (NCT04216251) | Massachusetts General Hospital | 2020-12-09 |
| A Study to Evaluate LY06006 and Prolia in Healthy Adults (NCT04973722) | Luye Pharma Group Ltd. | 2020-12-09 |
| A Study to Evaluate GBT021601 in Single and Multiple Doses in Healthy Participants (NCT05036512) | Pfizer | 2020-12-09 |