| Safety and Efficacy in Participants With Metastatic BRAF-mutant Melanoma Treated With Encorafenib With and Without Binimetinib in Combination With Nivolumab and Low-dose Ipilimuma (NCT04655157) | Jason J. Luke, MD | 2021-05-28 |
| Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines (NCT04889209) | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-05-28 |
| Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 is Administered in Combination With IV Modified FOLFIRINOX (mFFX) With or Without IV Budigalimab Compared to mFFX in Adult Participants With Untreated Pancreatic Cancer Metastasis (NCT04807972) | AbbVie | 2021-05-28 |
| LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer (NCT04560972) | City of Hope Medical Center | 2021-05-28 |
| Bioequivalence Study of Mofest® 400mg (Moxifloxacin) Tablet With Avelox® 400mg (Moxifloxacin) Tablet in Healthy Pakistani Subjects (NCT04873570) | University of Karachi | 2021-05-28 |
| Vestibulopathy as a Cause of Imbalance in Parkinson (NCT04768647) | VA Office of Research and Development | 2021-05-28 |
| Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor (NCT04596475) | University of California, San Diego | 2021-05-28 |
| Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study (NCT04505189) | Imperial College London | 2021-05-28 |
| Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 (NCT04795713) | Molecular Templates, Inc. | 2021-05-27 |
| Evaluate the Drug-drugs Interaction Between Lobeglitazone 0.5mg and Empagliflozin 25mg (NCT04869800) | Chong Kun Dang Pharmaceutical | 2021-05-27 |
| Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures (NCT04903314) | SK Life Science, Inc. | 2021-05-27 |
| Study of LM-102 in Subjects in Advanced Tumors (NCT04735796) | LaNova Medicines Limited | 2021-05-27 |
| A Study to Determine the Safety, Drug Levels and Drug Effects of BMS-986196 and Food and Formulation Effects on Relative Absorption Healthy Participants (NCT04882150) | Bristol-Myers Squibb | 2021-05-27 |
| Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer (NCT04789486) | Dana-Farber Cancer Institute | 2021-05-27 |
| A Study of HMPL-295S1 in Patients With Advanced Malignant Solid Tumors (NCT04908046) | Hutchmed | 2021-05-27 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of KRP-A218 in Healthy Subjects (NCT04908800) | Kyorin Pharmaceutical Co.,Ltd | 2021-05-27 |
| A Study of OPD5 Followed by Autologous Stem Cell Transplant for Patients With Relapsed Refractory Multiple Myeloma (NCT04918511) | Oncopeptides AB | 2021-05-27 |
| A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors (NCT04895709) | Bristol-Myers Squibb | 2021-05-27 |
| A Multiple-dose Study in Chinese Subjects to Evaluate Safety,Tolerability,PK and PD of ZM-H1505R (NCT05470829) | Shanghai Zhimeng Biopharma, Inc. | 2021-05-27 |
| XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer (NCT04825288) | XBiotech, Inc. | 2021-05-27 |
| Low-Dose-Rate Brachytherapy Combined With Immune Checkpoint Inhibition in Cancer (NCT04620603) | Case Comprehensive Cancer Center | 2021-05-27 |
| COV-CHIM01: SARS-CoV-2 (COVID-19) Dose Finding Infection Study (NCT04864548) | University of Oxford | 2021-05-27 |
| A Study of JNJ-68179280 in Healthy Participants (NCT04844463) | Janssen Research & Development, LLC | 2021-05-26 |
| A Study to Evaluate Lu AF90103 in Healthy Men (NCT04940949) | H. Lundbeck A/S | 2021-05-26 |
| CellMist™ Autologous Cells to Treat Deep Second-Degree Burns (NCT04890574) | RenovaCare, Inc | 2021-05-26 |
| A Study to Evaluate the DDI of DBPR108 With Metformin,Glibenclamide,Valsartan, or Simvastatin in Healthy Subjects (NCT04859452) | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 2021-05-26 |
| A Study in Healthy Men to Test How Well Different Doses of BI 1819479 Are Tolerated and Taken up by the Body With or Without Food (NCT04801693) | Boehringer Ingelheim | 2021-05-26 |
| To Evaluate the Safety, and Immunogenicity of Vaccine Candidate Against COVID-19, in Healthy Adults (NCT04885361) | OSE Immunotherapeutics | 2021-05-26 |
| CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER) (NCT04637763) | Caribou Biosciences, Inc. | 2021-05-26 |
| Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis (NCT04789915) | Bjorn H. Ebdrup | 2021-05-26 |
| APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors (NCT04785196) | Ascentage Pharma Group Inc. | 2021-05-26 |
| Study of TL117 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (NCT04843098) | Suzhou Junde Biotechnology Co., Ltd | 2021-05-26 |
| A Study to Learn How Much Rosuvastatin Gets Into the Blood When Taken With or Without Elinzanetant and to Learn About the Safety of Elinzanetant in Healthy Participants (NCT04889287) | Bayer | 2021-05-26 |
| Interleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid Arthritis (NCT04842981) | University of Southern Denmark | 2021-05-25 |
| A Phase 1 Study of ABC008 in Ascending (Single Ascending Dose/Multiple Ascending Dose) Study in Patients With (IBM) (NCT04659031) | Abcuro, Inc. | 2021-05-25 |
| A Study of Nipocalimab in Healthy Male and Female Participants (NCT04848558) | Janssen Research & Development, LLC | 2021-05-25 |
| A Study of Ad26.COV2.S in Healthy Adults (COVID-19) (NCT04894305) | Janssen Vaccines & Prevention B.V. | 2021-05-25 |
| Multiple Ascending Dose Putative Cognitive Enhancer VU319 (NCT04051801) | Vanderbilt University Medical Center | 2021-05-25 |
| IBI188 Combination Therapy in Solid Tumors (NCT04861948) | Innovent Biologics (Suzhou) Co. Ltd. | 2021-05-25 |
| Evaluation of [18F]APN-1607 as a PET Biomarker (NCT05005819) | Invicro | 2021-05-25 |
| A Study in Healthy Subjects to Assess the Safety, Tolerability and Pharmacokinetics of HTL0022562 (NCT04941989) | Nxera Pharma UK Limited | 2021-05-25 |
| Endoscopic Assisted Calcium Electroporation in Esophageal Cancer (NCT04958044) | Michael Patrick Achiam | 2021-05-25 |
| A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients with Advanced Cancer. (NCT04855929) | Anaveon AG | 2021-05-25 |
| Safety, Immunogenicity and ex Vivo Efficacy of Pfs25-IMX313/Matrix-M in Healthy Volunteers in Bagamoyo, Tanzania. (NCT04271306) | University of Oxford | 2021-05-25 |
| Pharmacokinetics, Safety and Tolerability Study of AVT04 to EU Approved and US Licensed Stelara (Ustekinumab) (NCT04744363) | Alvotech Swiss AG | 2021-05-25 |
| First-in-Human Clinical Trial of a Mosaic Quadrivalent Influenza Vaccine Compared With a Licensed Inactivated Seasonal QIV in Healthy Adults (NCT04896086) | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-05-24 |
| Study of DNP002 in Patients With Solid Tumors (NCT06466265) | Kumho HT Inc. | 2021-05-24 |
| A Study of BGB-11417 in Participants With Myeloid Malignancies (NCT04771130) | BeOne Medicines | 2021-05-24 |
| A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM) (NCT04823208) | Eli Lilly and Company | 2021-05-24 |
| Safety, Tolerability and Pharmacokinetics of NTP42:KVA4 (NCT04919863) | ATXA Therapeutics Limited | 2021-05-24 |
| Oral Device Clinical Trial (NCT05022368) | Nationwide Children's Hospital | 2021-05-24 |
| Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation Solution (NCT04903730) | Aerami Therapeutics | 2021-05-24 |
| A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) (NCT04771897) | Bexion Pharmaceuticals, Inc. | 2021-05-24 |
| First-in-human Study of M4076 in Advanced Solid Tumors (DDRiver Solid Tumors 410) (NCT04882917) | EMD Serono Research & Development Institute, Inc. | 2021-05-24 |
| A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer (NCT04492488) | Shanghai Miracogen Inc. | 2021-05-24 |
| Recombinant Hyperimmune Polyclonal Antibody (GIGA-2050) in COVID-19 Patients (NCT04883138) | GigaGen, Inc. | 2021-05-24 |
| Safety, Tolerability and Pharmacokinetics of CBP-174 in Healthy Adults (NCT04811469) | Connect Biopharma Australia Pty Ltd | 2021-05-24 |
| Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia (NCT04774393) | M.D. Anderson Cancer Center | 2021-05-24 |
| Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma (NCT04609046) | National Cancer Institute (NCI) | 2021-05-24 |
| Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC73077 in Healthy Subjects (NCT05492630) | Sunshine Lake Pharma Co., Ltd. | 2021-05-24 |
| Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease (NCT04857606) | Amgen | 2021-05-24 |
| World Health Organization (WHO) , COVID19 Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt (NCT06267326) | Nasser Institute For Research and Treatment | 2021-05-23 |
| a Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B Cell Lymphoma (NCT04782193) | Chongqing Precision Biotech Co., Ltd | 2021-05-23 |
| T Lymphocytes for the Treatment of AdV, CMV, EBV, BKV and Aspergillus Fumigatus Infections After Allogeneic Stem Cell Transplantation (NCT05471661) | George Papanicolaou Hospital | 2021-05-22 |
| Clinical Study of Genakumab for Injection in Patients With Acute Gout (NCT05328531) | Changchun GeneScience Pharmaceutical Co., Ltd. | 2021-05-22 |
| Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer (NCT04585958) | National Cancer Institute (NCI) | 2021-05-21 |
| The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence (NCT02590393) | Duke University | 2021-05-21 |
| Effect of Nitrous Oxide on EEG (NCT04884893) | Tampere University Hospital | 2021-05-21 |
| Fasting Bioequivalence Study of 2 Metformin 500 mg Prolonged Release Tablets in 44 Healthy Male and Female Volunteers (NCT05124730) | Joint Stock Company "Farmak" | 2021-05-21 |
| Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption (NCT04340596) | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-05-21 |
| A Study of Q-1802 in Patients With Advanced Solid Tumors (NCT04856150) | QureBio Ltd. | 2021-05-21 |
| Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma (NCT04521335) | University of Utah | 2021-05-21 |
| Liposomal Cytarabine, Daunorubicin, and Gemtuzumab Ozogamicin for the Treatment of Relapsed Refractory Pediatric Patients With Acute Myeloid Leukemia (NCT04915612) | M.D. Anderson Cancer Center | 2021-05-21 |
| A Study to Assess the Absorption, Metabolism and Excretion of [14C]-ANG-3777 (NCT04931524) | Angion Biomedica Corp | 2021-05-21 |
| Pilot RECAP Study in Healthy Volunteers (NCT04842045) | University of Wisconsin, Madison | 2021-05-21 |
| A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD) (NCT04983264) | Pfizer | 2021-05-21 |
| Glucocorticoid Administration After Traumatic Birth (NCT04852458) | University of Michigan | 2021-05-21 |
| Study of Tumor Treating Fields With Hypofractionated Chemoradiotherapy in Newly Diagnosed Glioblastoma (NCT04474353) | Stanford University | 2021-05-21 |
| A Trial of AK112 (PD-1/VEGF Bispecific Antibody) in Patients With NSCLC (NCT04900363) | Akeso | 2021-05-21 |
| A Pharmacokinetic Study of TQB3101 in Chinese Healthy Subjects (NCT04804904) | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2021-05-20 |
| Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer (NCT04108858) | National Cancer Institute (NCI) | 2021-05-20 |
| A Clinical Study Preliminary Efficacy of LM-061 Tablet in Subjects With Advanced Tumours (NCT04882176) | LaNova Medicines Limited | 2021-05-20 |
| Personalized Autologous Transplant for Multiple Myeloma (NCT04483206) | Emory University | 2021-05-20 |
| A Trial of SHR2285 in Healthy Subjects (NCT04829305) | Atridia Pty Ltd. | 2021-05-20 |
| Sacituzumab Govitecan Plus EV in Metastatic UC (NCT04724018) | Dana-Farber Cancer Institute | 2021-05-20 |
| A Study of JNJ-64407564 in Japanese Participants With Relapsed or Refractory Multiple Myeloma (NCT04773522) | Janssen Pharmaceutical K.K. | 2021-05-20 |
| Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease (NCT04285827) | CSL Behring | 2021-05-20 |
| A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients (NCT04604782) | GE Healthcare | 2021-05-20 |
| AVIATION Study: A Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TERN-201 in Patients With Non-Cirrhotic Non-Alcoholic Steatohepatitis (NCT04897594) | Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 2021-05-20 |
| A Ph1/2 Study of EMB-06 in Participants With Relapsed or Refractory Myeloma (NCT04735575) | Shanghai EpimAb Biotherapeutics Co., Ltd. | 2021-05-20 |
| Ketamine Assisted Psychotherapy for Opioid Use Disorder (NCT04892251) | University of Utah | 2021-05-20 |
| PIPAC for Peritoneal Metastases (NCT04956068) | National Cancer Centre, Singapore | 2021-05-20 |
| Study of a Live rNDV Based Vaccine Against COVID-19 (NCT04871737) | Laboratorio Avi-Mex, S.A. de C.V. | 2021-05-20 |
| Measles and Rubella Vaccine Microneedle Patch Phase 1-2 Age De-escalation Trial (NCT04394689) | Micron Biomedical, Inc | 2021-05-19 |
| Bioequivalence Study of 8 mg Perindopril Tert-butylamine / 2.5 mg Indapamide Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide Film-coated Tablets in Healthy Volunteers (NCT05464745) | Darnitsa Pharmaceutical Company | 2021-05-19 |
| Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver Cirrhosis (NCT04874428) | Insel Gruppe AG, University Hospital Bern | 2021-05-19 |
| A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1) (NCT04811560) | Janssen Research & Development, LLC | 2021-05-19 |
| Partially Replicate Bioequivalence Study of Quetiapine 25 mg in Healthy Volunteers Under Fasting Condition (NCT05235230) | Future University in Egypt | 2021-05-19 |
| Drug-drug Interaction Study of CTP-543 and Rifampin in Healthy Adult Subjects (NCT04843540) | Concert Pharmaceuticals | 2021-05-19 |
| A Study to Evaluate the Pharmacokinetics and Safety of Brivaracetam in Healthy Chinese Subjects (NCT04882540) | UCB Biopharma SRL | 2021-05-19 |