| Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies (NCT04648826) | National Cancer Institute (NCI) | 2021-12-14 |
| A Drug-drug Interaction Study of SHR2150 on Healthy Chinese Volunteers (NCT05141422) | Jiangsu HengRui Medicine Co., Ltd. | 2021-12-13 |
| Evaluation of Home Use COVID-19 Frequent Antigen Testing and Data Reporting (NCT05884515) | IDX20 Inc | 2021-12-13 |
| Safety and Efficacy Study of CI-135 CAR-T Cells in Subjects with Relapsed or Refractory Acute Myeloid Leukemia (NCT05266950) | Beijing Boren Hospital | 2021-12-13 |
| Phase Ia/Ib Study of RS-0139 in Patients With a Recurrent, Locally Advanced or Metastatic Solid Tumors (NCT04261413) | RS Arastirma Egitim Danismanlik Ilac Sanayi Ticaret A.S. | 2021-12-13 |
| Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy of IBI345 (NCT05199519) | Innovent Biologics (Suzhou) Co. Ltd. | 2021-12-13 |
| Dose Escalation and Expansion Study of CPO107 for Patients With Advanced CD20-positive Non-Hodgkins Lymphoma (NCT04853329) | Conjupro Biotherapeutics, Inc. | 2021-12-13 |
| A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations (NCT05163028) | HUYABIO International, LLC. | 2021-12-13 |
| A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) (NCT04573140) | University of Florida | 2021-12-13 |
| Caring Relationships Expression Study (NCT05627687) | Arizona State University | 2021-12-13 |
| First-Time-in-Human (FTIH) Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of VH4004280 in Healthy Participants (NCT05163522) | ViiV Healthcare | 2021-12-13 |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir (NCT05169580) | Fulcrum Therapeutics | 2021-12-13 |
| GEN1047 for Solid Tumors - First in Human (FIH) Trial (NCT05180474) | Genmab | 2021-12-13 |
| Drug-drug Interaction Study of SPH3127 (NCT05359055) | Shanghai Pharmaceuticals Holding Co., Ltd | 2021-12-13 |
| A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause (NCT05153564) | Novo Nordisk A/S | 2021-12-13 |
| Efficacy and Safety of Belimumab in Neuromyelitis Optica Spectrum Disorders (NCT05154734) | Tianjin Medical University General Hospital | 2021-12-12 |
| Safety Evaluation of Intravenous Talineuren (TLN) in Parkinson's Disease-affected Patients (NCT04976127) | InnoMedica Schweiz AG | 2021-12-11 |
| Single Ascending Dose Study of CM338 in Healthy Volunteers (NCT05186285) | Keymed Biosciences Co.Ltd | 2021-12-11 |
| Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars (NCT03181087) | Maternal and Child Health Hospital of Foshan | 2021-12-11 |
| Development of AWZ1066S, a Small Molecule Anti-Wolbachia Candidate Macrofilaricide Drug (NCT05084560) | Liverpool School of Tropical Medicine | 2021-12-10 |
| Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma (NCT05079282) | Ono Pharmaceutical Co., Ltd. | 2021-12-10 |
| Pharmacokinetics Study of FIA586 in Participants With Mild and Moderate Hepatic Impairment (NCT04993157) | Novartis Pharmaceuticals | 2021-12-10 |
| Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV (NCT04902443) | National Cancer Institute (NCI) | 2021-12-10 |
| A Study in Healthy Adult Participants to Assess the Effects of Ciclosporin Administration on Rilematovir (NCT05155007) | Janssen Research & Development, LLC | 2021-12-10 |
| Lymphatic System Health in Alzheimer's Disease (NCT04205539) | Neurological Associates of West Los Angeles | 2021-12-10 |
| A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients (NCT05266105) | Olema Pharmaceuticals, Inc. | 2021-12-10 |
| The Efficacy and Safety of HLX208 in Advanced Anaplastic Thyroid Cancer (ATC) With BRAF V600 Mutation (NCT05102292) | Shanghai Henlius Biotech | 2021-12-10 |
| Study of GSK3511294 in Healthy Chinese Participants (NCT05140200) | GlaxoSmithKline | 2021-12-10 |
| Peginterferon Alpha-2b Therapy in Chronic Hepatitis Patients With Normal ALT Level and Low Viremia (NCT05203055) | Fuzhou General Hospital | 2021-12-10 |
| To Evaluate the Safety and Primary Immunogenicity of Cell-free (Three-component) Combination Vaccine for Phase I Immunogenicity in Children and Infants (NCT05189548) | Changchun BCHT Biotechnology Co. | 2021-12-10 |
| Safety and Immunogenicity of SARS-CoV-2 Protein Subunit Recombinant Vaccine (NCT05067894) | PT Bio Farma | 2021-12-10 |
| A Study to Evaluate the Safety, Tolerability, Kinetics, Biodistribution and Repeatability of 11C-BMS-986196 After Intravenous (IV) Administration in Healthy Participants and After Repeat IV Administration in Participants With Multiple Sclerosis (NCT05064436) | Bristol-Myers Squibb | 2021-12-10 |
| NKG2D CAR-NK Cell Therapy in Patients With Refractory Metastatic Colorectal Cancer (NCT05213195) | Zhejiang University | 2021-12-10 |
| NTLA-2002 in Adults With Hereditary Angioedema (HAE) (NCT05120830) | Intellia Therapeutics | 2021-12-10 |
| The Drug Interaction of DWP16001 and DWC202010 After Oral Administration in Healthy Adults (NCT05321732) | Daewoong Pharmaceutical Co. LTD. | 2021-12-10 |
| A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics of DZD8586 in Healthy Adult Participants (NCT05176873) | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | 2021-12-09 |
| A Study to Assess Safety of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-Programmed Cell Death Protein 1 (Anti-PD-1) Treatment (NCT03978611) | Bristol-Myers Squibb | 2021-12-09 |
| A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Dolutegravir Sodium Tablets (DTG) (NCT07002229) | Henan Genuine Biotech Co., Ltd. | 2021-12-09 |
| A Research Study Looking at the Effect of Food Intake on How the Medicine NN0385-0434 Behaves in the Body of Healthy Participants (NCT05091073) | Novo Nordisk A/S | 2021-12-09 |
| PK/PD Study of Vicagrel and Clopidogrel in Healthy Subjects With Different CYP2C19 Metabolizers (NCT05162053) | Jiangsu vcare pharmaceutical technology co., LTD | 2021-12-09 |
| A Study of Laquinimod Eye-drops in Healthy Participants (NCT05187403) | Active Biotech AB | 2021-12-09 |
| Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma (NCT04977375) | Chirag G. Patil | 2021-12-09 |
| A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of TQB2858 Injection in Subjects With Advanced Malignancy (NCT05068921) | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2021-12-09 |
| IMU-935 in Patients With Progressive, Metastatic Castration Resistant Prostate Cancer (NCT05124795) | Immunic AG | 2021-12-09 |
| ADME Study of [14C]- Rongliflozin in Healthy Male Subjects (NCT05109078) | Sunshine Lake Pharma Co., Ltd. | 2021-12-09 |
| Imaging of Pathologic Fibrosis Using 68Ga-FAP-2286 (NCT05180162) | Thomas Hope | 2021-12-09 |
| Study Evaluating Techniques for Measuring Tear Production (NCT05497479) | Aerie Pharmaceuticals | 2021-12-09 |
| 4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration (NCT05197270) | 4D Molecular Therapeutics | 2021-12-09 |
| Viable Human SARS-CoV-2 Specific T Cell Transfer in Patients at Risk for Severe COVID-19 (NCT04762186) | Universitätsklinikum Köln | 2021-12-08 |
| PARP Inhibitor With 177Lu-DOTA-Octreotate PRRT in Patients With Neuroendocrine Tumours (NCT05053854) | Peter MacCallum Cancer Centre, Australia | 2021-12-08 |
| X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma (NCT04389281) | Immunolight, LLC | 2021-12-08 |
| CPD-DARA in Patients With Relapsed/Refractory Multiple Myeloma. (NCT04667663) | Cancer Trials Ireland | 2021-12-08 |
| QYJD Compound Preparation Promotes Rapid Postoperative Recovery in Early-stage NSCLC Patients by Regulating Tissue Microecology: a Prospective, Randomized Controlled, Open-label, Phase I Clinical Study With Predefined Future Exploration (NCT06766565) | Fuzhou General Hospital | 2021-12-08 |
| First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer (NCT05216432) | Relay Therapeutics, Inc. | 2021-12-08 |
| A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma (NCT05081479) | Memorial Sloan Kettering Cancer Center | 2021-12-08 |
| Famitinib Plus SHR6390 and Endocrine Therapy in the Treatment of HR-positive, HER2-negative Advanced Breast Cancer (NCT05176080) | Henan Cancer Hospital | 2021-12-08 |
| GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies (NCT05003895) | National Cancer Institute (NCI) | 2021-12-08 |
| Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers (NCT05226013) | The Affiliated Hospital of Qingdao University | 2021-12-08 |
| First-in-human Study of SAR443579 Infusion in Male and Female Children and Adult Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) (NCT05086315) | Sanofi | 2021-12-08 |
| Safety and Efficacy of Anti-SARS-CoV-2 Equine Antibody F(ab')2 Fragments (INOSARS) for Adult Patients With Mild COVID-19 (NCT04514302) | TecSalud Investigación Clínica | 2021-12-07 |
| LYT-300 in Healthy Volunteers (NCT05129865) | PureTech | 2021-12-07 |
| HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma (NCT04995003) | Baylor College of Medicine | 2021-12-07 |
| Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types (NCT05000294) | University of Florida | 2021-12-07 |
| A COVID-19 Study to Evaluate Safety and PK of COVID-HIG Administered Through IM, SC, or IV Routes to SARS-CoV-2 Uninfected Adults (NCT05142306) | Emergent BioSolutions | 2021-12-07 |
| Evaluation of IGM-6268 in Healthy Volunteers (NCT05160402) | IGM Biosciences, Inc. | 2021-12-07 |
| A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC) (NCT05014139) | Astellas Pharma Global Development, Inc. | 2021-12-07 |
| Bioequivalence Study of Test and Reference 50 mg Eplerenone Film-coated Tablets in Healthy Volunteers (NCT05663372) | Darnitsa Pharmaceutical Company | 2021-12-07 |
| Bicalutamide Implants (Biolen) With Radiation Therapy in Patients With Localized Prostate Cancer (NCT04943536) | Alessa Therapeutics Inc. | 2021-12-07 |
| Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (NCT04997902) | Kura Oncology, Inc. | 2021-12-07 |
| NP-G2-044 as Monotherapy and Combination Therapy in Patients With Advanced or Metastatic Solid Tumor Malignancies (NCT05023486) | Novita Pharmaceuticals, Inc. | 2021-12-07 |
| A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome (NCT05211830) | Sixera Pharma | 2021-12-07 |
| Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab (NCT04784052) | Porteus, Matthew, MD | 2021-12-07 |
| Study of YH004 (4-1BB Agonist Antibody) in Advanced or Metastatic Malignancy (NCT05040932) | Eucure (Beijing) Biopharma Co., Ltd | 2021-12-07 |
| Safety, Tolerability, Pharmacokinetics, Immunogenicity and Efficacy of STP705 in Adult Patients With Hypertrophic Scars (NCT05196373) | Sirnaomics | 2021-12-07 |
| Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment (NCT05583643) | Misr University for Science and Technology | 2021-12-07 |
| The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers (NCT05200728) | Jiangsu Simcere Pharmaceutical Co., Ltd. | 2021-12-06 |
| Effect of Recombinant Human Bone Morphogenetic Protein-2 With an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study. (NCT05719181) | University of Baghdad | 2021-12-06 |
| Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases (NCT05034497) | Plus Therapeutics | 2021-12-06 |
| A Study of JNJ-73763989, JNJ-64300535, and Nucleos(t)Ide Analogs in Virologically Suppressed, Hepatitis B e Antigen (HBeAg)- Negative Participants With Chronic Hepatitis B Virus Infection (NCT05123599) | Janssen Research & Development, LLC | 2021-12-06 |
| A Dose Ranging Placebo-controlled Double-blind Study to Evaluate the Safety, Pharmacokinetics and Efficacy of 610 in Participants With Severe Eosinophilic Asthma (NCT05584306) | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 2021-12-06 |
| Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer (NCT04821284) | Flemming Forsberg | 2021-12-06 |
| A Safety and Tolerability Study of NC318 in Combination With Chemotherapy for Subjects With Advanced or Metastatic NSCLC (NCT04430933) | NextCure, Inc. | 2021-12-06 |
| The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia (NCT04594733) | Medical University of South Carolina | 2021-12-06 |
| Phase 1/2 Dose Confirmation Study of FLT180a in Hemophilia B (NCT05164471) | Spur Therapeutics | 2021-12-06 |
| CAM Procedure With BMAC for Shoulder OA (NCT04826224) | Shane A. Shapiro | 2021-12-06 |
| A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7503 in Healthy Participants (NCT05143905) | AstraZeneca | 2021-12-06 |
| Quadratic Phenotypic Optimisation Platform (QPOP) Utilisation to Enhance Selection of Patient Therapy Through Patient Derived Organoids in Breast Cancer (NCT05177432) | National University Hospital, Singapore | 2021-12-06 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HRS9531 in Healthy Subjects (NCT05152277) | Fujian Shengdi Pharmaceutical Co., Ltd. | 2021-12-06 |
| A Study of XZP-5955 Tablets in Patients With NTRK or ROS1 Fusion Positive Locally Advanced or Metastatic Solid Tumors (NCT04996121) | Xuanzhu Biopharmaceutical Co., Ltd. | 2021-12-06 |
| Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer (NCT05136846) | Ohio State University Comprehensive Cancer Center | 2021-12-06 |
| Single-Blind Study of STAT-205 in Mild COVID-19 (NCT04708327) | Cytocom, Inc. | 2021-12-05 |
| A Relative Bioavailability Study of Selpercatinib (LY3527723) in Healthy Participants (NCT05136404) | Loxo Oncology, Inc. | 2021-12-03 |
| A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Diroximel Fumarate (DRF) in Chinese and Caucasian Adult Healthy Participants (NCT05127564) | Biogen | 2021-12-03 |
| A Phase I/II Clinical Trial in Healthy People Aged 18 Years and Above (NCT05144139) | Stemirna Therapeutics | 2021-12-03 |
| Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors (NCT05081180) | EMD Serono Research & Development Institute, Inc. | 2021-12-03 |
| Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose Level of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Human Subjects (NCT05166096) | Rhoshan Pharmaceuticals Inc | 2021-12-03 |
| Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma (NCT04896658) | University of Maryland, Baltimore | 2021-12-03 |
| Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis (NCT06175676) | Tianjin Medical University Eye Hospital | 2021-12-03 |
| A Study to Evaluate HB0034 in Healthy Adult Participants (NCT05064345) | Shanghai Huaota Biopharmaceutical Co., Ltd. | 2021-12-03 |
| Neoantigen Vaccine in Esophagus Cancer Patients Following Neoadjuvant Therapy and Surgical Resection (NCT05307835) | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2021-12-02 |